{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:01:18Z","timestamp":1781359278294,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.mcpro.2024.100778","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T11:42:16Z","timestamp":1714131736000},"page":"100778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Proteomic Analysis Reveals Trilaciclib-Induced Senescence"],"prefix":"10.1016","volume":"23","author":[{"given":"Marina","family":"Hermosilla-Trespaderne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Xinchen","family":"Hu-Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Dannoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5194-447X","authenticated-orcid":false,"given":"Andrew M.","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-1626","authenticated-orcid":false,"given":"Amy L.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Trost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-0190","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Mar\u00edn-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2024.100778_bib1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s40265-021-01508-y","article-title":"Trilaciclib: first approval","volume":"81","author":"Dhillon","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.mcpro.2024.100778_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101206","article-title":"Concerning FDA approval of trilaciclib (Cosela) in extensive-stage small-cell lung cancer","volume":"14","author":"Powell","year":"2021","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib3","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1002\/cam4.4089","article-title":"Trilaciclib prior to chemotherapy reduces the usage of supportive care interventions for chemotherapy-induced myelosuppression in patients with small cell lung cancer: pooled analysis of three randomized phase 2 trials","volume":"10","author":"Ferrarotto","year":"2021","journal-title":"Cancer Med."},{"key":"10.1016\/j.mcpro.2024.100778_bib4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1158\/1078-0432.CCR-21-2272","article-title":"Trilaciclib prior to chemotherapy in patients with metastatic triple-negative breast cancer: final efficacy and subgroup analysis from a randomized phase II study","volume":"28","author":"Tan","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mcpro.2024.100778_bib5","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S1470-2045(19)30616-3","article-title":"Trilaciclib plus chemotherapy versus chemotherapy alone in patients with metastatic triple-negative breast cancer: a multicentre, randomised, open-label, phase 2 trial","volume":"20","author":"Tan","year":"2019","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib6","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1007\/s12325-023-02601-2","article-title":"Real-world outcomes of trilaciclib among patients with extensive-stage small cell lung cancer receiving chemotherapy","volume":"40","author":"Goldschmidt","year":"2023","journal-title":"Adv. Ther."},{"key":"10.1016\/j.mcpro.2024.100778_bib7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ajh.25792","article-title":"Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring","volume":"95","author":"Jabbour","year":"2020","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.mcpro.2024.100778_bib8","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood-2008-03-144790","article-title":"Molecular biology of bcr-abl1-positive chronic myeloid leukemia","volume":"113","author":"Quint\u00e1s-Cardama","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.mcpro.2024.100778_bib9","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1056\/NEJMoa1902328","article-title":"Asciminib in chronic myeloid leukemia after ABL kinase inhibitor failure","volume":"381","author":"Hughes","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mcpro.2024.100778_bib10","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s11899-018-0449-7","article-title":"Tyrosine kinase inhibitors in the treatment of chronic-phase CML: strategies for frontline decision-making","volume":"13","author":"Kennedy","year":"2018","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"10.1016\/j.mcpro.2024.100778_bib11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41408-023-00823-9","article-title":"Management of chronic myeloid leukemia in 2023 - common ground and common sense","volume":"13","author":"Senapati","year":"2023","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.mcpro.2024.100778_bib12","article-title":"Target inhibition of CBP induced cell senescence in BCR-ABL- T315I mutant chronic myeloid leukemia","volume":"10","author":"Yang","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib13","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1182\/blood-2009-09-245928","article-title":"Senescence induction in human fibroblasts and hematopoietic progenitors by leukemogenic fusion proteins","volume":"115","author":"Wajapeyee","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.mcpro.2024.100778_bib14","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.1182\/bloodadvances.2020003117","article-title":"Expansion of senescent megakaryocyte-lineage cells maintains CML cell leukemogenesis","volume":"4","author":"Tanabe","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.mcpro.2024.100778_bib15","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1038\/cddis.2012.111","article-title":"Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence","volume":"3","author":"Drullion","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mcpro.2024.100778_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107817","article-title":"Cellular senescence and hematological malignancies: from pathogenesis to therapeutics","volume":"223","author":"Hu","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mcpro.2024.100778_bib17","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/1878-0261.12807","article-title":"Cellular senescence in cancer: from mechanisms to detection","volume":"15","author":"Ou","year":"2021","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13045-022-01262-y","article-title":"The dual role of autophagy in acute myeloid leukemia","volume":"15","author":"Seo","year":"2022","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A\u00a0single-cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mcpro.2024.100778_bib20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/s13059-021-02540-7","article-title":"Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects","volume":"22","author":"Dempster","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcpro.2024.100778_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99460-0","article-title":"Mitochondrial and glycolytic extracellular flux analysis optimization for isolated pig intestinal epithelial cells","volume":"11","author":"Bekebrede","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2024.100778_bib22","doi-asserted-by":"crossref","first-page":"12014","DOI":"10.1021\/acs.jmedchem.2c00671","article-title":"A\u00a0matrix-assisted laser desorption\/ionization time-of-flight assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukemia","volume":"65","author":"Mar\u00edn-Rubio","year":"2022","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.mcpro.2024.100778_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2022.100279","article-title":"Rapid and in-depth coverage of the (Phospho-)Proteome with deep libraries and optimal window design for dia-PASEF","volume":"21","author":"Skowronek","year":"2022","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.mcpro.2024.100778_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2024.100778_bib25","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1021\/acs.jproteome.2c00145","article-title":"Protein contaminants matter: building universal protein contaminant libraries for DDA and DIA proteomics","volume":"21","author":"Frankenfield","year":"2022","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.mcpro.2024.100778_bib26","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2024.100778_bib27","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2024.100778_bib28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/pro.3711","article-title":"KEGG Mapper for inferring cellular functions from protein sequences","volume":"29","author":"Kanehisa","year":"2020","journal-title":"Protein Sci."},{"key":"10.1016\/j.mcpro.2024.100778_bib29","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2024.100778_bib30","article-title":"Cyclin-dependent kinase inhibitors function as potential immune regulators inducing pyroptosis in triple negative breast cancer","volume":"12","author":"Xu","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.167378","article-title":"Apoptosis, pyroptosis, and necroptosis-oh my! the many ways a cell can die","volume":"434","author":"Ketelut-Carneiro","year":"2022","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.mcpro.2024.100778_bib32","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10555-020-09940-4","article-title":"Cyclin-dependent kinase inhibitors in head and neck cancer and glioblastoma-backbone or add-on in immune-oncology?","volume":"40","author":"Riess","year":"2021","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.mcpro.2024.100778_bib33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41419-019-1433-4","article-title":"Type 3 inositol 1,4,5-trisphosphate receptor has antiapoptotic and proliferative role in cancer cells","volume":"10","author":"Rezuchova","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mcpro.2024.100778_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2019.111131","article-title":"Regulation of cellular senescence by retinoid X receptors and their partners","volume":"183","author":"Martin","year":"2019","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mcpro.2024.100778_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2017.75","article-title":"A\u00a0signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence","volume":"3","author":"Flor","year":"2017","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mcpro.2024.100778_bib36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s42255-023-00747-5","article-title":"Lysosomal control of senescence and inflammation through cholesterol partitioning","volume":"5","author":"Roh","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.mcpro.2024.100778_bib37","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13338","article-title":"Cellular aging beyond cellular senescence: markers of senescence prior to cell cycle arrest in\u00a0vitro and in\u00a0vivo","volume":"20","author":"Ogrodnik","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.mcpro.2024.100778_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.740002","article-title":"Palbociclib induces senescence in melanoma and breast cancer cells and leads to additive growth arrest in combination with irradiation","volume":"11","author":"Jost","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib39","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ccr.2011.10.001","article-title":"A\u00a0systematic screen for CDK4\/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells","volume":"20","author":"Anders","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mcpro.2024.100778_bib40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccell.2018.03.023","article-title":"CDK4\/6 inhibitors: the mechanism of action may not be as simple as once thought","volume":"34","author":"Klein","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mcpro.2024.100778_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13103","article-title":"Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function","volume":"19","author":"Alibhai","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.mcpro.2024.100778_bib42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ebiom.2019.11.004","article-title":"CDK4\/CDK6 inhibition as a novel strategy to suppress the growth and survival of BCR-ABL1+ clones in TKI-resistant CML","volume":"50","author":"Schneeweiss-Gleixner","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mcpro.2024.100778_bib43","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/0145-2126(93)90161-D","article-title":"Mutational inactivation of the p53 gene in the human erythroid leukemic K562 cell line","volume":"17","author":"Law","year":"1993","journal-title":"Leuk. Res."},{"key":"10.1016\/j.mcpro.2024.100778_bib44","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/annonc\/mdz278","article-title":"Myelopreservation with the CDK4\/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib\/randomized phase II trial","volume":"30","author":"Weiss","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib45","doi-asserted-by":"crossref","first-page":"724","DOI":"10.15252\/embj.201592862","article-title":"Mitochondria are required for pro-ageing features of the senescent phenotype","volume":"35","author":"Correia-Melo","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2024.100778_bib46","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41571-022-00668-4","article-title":"Senescence and cancer - role and therapeutic opportunities","volume":"19","author":"Schmitt","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.mcpro.2024.100778_bib47","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.1074\/jbc.M116.774471","article-title":"Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements","volume":"292","author":"Mookerjee","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2024.100778_bib48","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1002\/ijc.33453","article-title":"Trilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive-stage small cell lung cancer: a multicentre, randomised, double-blind, placebo-controlled Phase II trial","volume":"148","author":"Daniel","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mcpro.2024.100778_bib49","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ccell.2018.08.015","article-title":"The oncogenic transcription factor RUNX1\/ETO corrupts cell cycle regulation to drive leukemic transformation","volume":"34","author":"Martinez-Soria","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mcpro.2024.100778_bib50","doi-asserted-by":"crossref","first-page":"D1100","DOI":"10.1093\/nar\/gkw936","article-title":"The ProteomeXchange consortium in 2017: supporting the cultural change in proteomics public data deposition","volume":"45","author":"Deutsch","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2024.100778_bib51","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947624000689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947624000689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T07:12:41Z","timestamp":1737616361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947624000689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S1535947624000689"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2024.100778","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.12.584620","asserted-by":"object"}]},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic Analysis Reveals Trilaciclib-Induced Senescence","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2024.100778","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100778"}}