{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:47:40Z","timestamp":1788583660803,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00219563"],"award-info":[{"award-number":["RS-2023-00219563"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2022R1F1A1069376"],"award-info":[{"award-number":["NRF-2022R1F1A1069376"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2022R1C1C1010979"],"award-info":[{"award-number":["NRF-2022R1C1C1010979"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2024-00348103"],"award-info":[{"award-number":["RS-2024-00348103"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.mcpro.2025.100944","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T19:50:13Z","timestamp":1741895413000},"page":"100944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6364-1284","authenticated-orcid":false,"given":"Yoon-Jin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Won","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinwon","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Yeol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Hee","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Mee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Song","family":"Gho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongho","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Han","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2516-5616","authenticated-orcid":false,"given":"Dongsic","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2025.100944_bib1","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1158\/0008-5472.CAN-16-0266","article-title":"Metabolic plasticity as a determinant of tumor growth and metastasis","volume":"76","author":"Lehuede","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.mcpro.2025.100944_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cmet.2016.09.010","article-title":"Circadian clock interaction with HIF1alpha mediates oxygenic metabolism and anaerobic glycolysis in skeletal muscle","volume":"25","author":"Peek","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.mcpro.2025.100944_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2025.100944_bib4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mcpro.2025.100944_bib5","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1126\/science.1058079","article-title":"Cooperation and competition in the evolution of ATP-producing pathways","volume":"292","author":"Pfeiffer","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2025.100944_bib6","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3389\/fonc.2019.01143","article-title":"Lactate in the regulation of tumor microenvironment and therapeutic approaches","volume":"9","author":"de la Cruz-Lopez","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mcpro.2025.100944_bib7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.semcancer.2017.03.001","article-title":"Cancer acidity: an ultimate frontier of tumor immune escape and a novel target of immunomodulation","volume":"43","author":"Huber","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.mcpro.2025.100944_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800169","article-title":"Oncogenic regulation of extracellular vesicle proteome and heterogeneity","volume":"19","author":"Choi","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.mcpro.2025.100944_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1256585","article-title":"Monitoring of single extracellular vesicle heterogeneity in cancer progression and therapy","volume":"13","author":"Lee","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mcpro.2025.100944_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0223-5","article-title":"Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking","volume":"51","author":"Murphy","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mcpro.2025.100944_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcdb.2017.01.003","article-title":"Extracellular vesicle communication pathways as regulatory targets of oncogenic transformation","volume":"67","author":"Choi","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2025.100944_bib12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41392-020-00359-5","article-title":"Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression","volume":"5","author":"Yang","year":"2020","journal-title":"Signal. Transduct. Target Ther."},{"key":"10.1016\/j.mcpro.2025.100944_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-020-03729-3","article-title":"Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis","volume":"469","author":"Wang","year":"2020","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.mcpro.2025.100944_bib14","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1096\/fj.201802675R","article-title":"Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2: a role for exosomes in metabolic switch of liver nonparenchymal cells","volume":"33","author":"Wan","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.mcpro.2025.100944_bib15","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.bbrc.2018.10.045","article-title":"Arctigenin shows preferential cytotoxicity to acidity-tolerant prostate carcinoma PC-3 cells through ROS-mediated mitochondrial damage and the inhibition of PI3K\/Akt\/mTOR pathway","volume":"505","author":"Lee","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mcpro.2025.100944_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8859181","article-title":"Curcumin targets both apoptosis and necroptosis in acidity-tolerant prostate carcinoma cells","volume":"2021","author":"Lee","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.mcpro.2025.100944_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7626405","article-title":"ERK1\/2-Dependent inhibition of glycolysis in curcumin-induced cytotoxicity of prostate carcinoma cells","volume":"2022","author":"Lee","year":"2022","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.mcpro.2025.100944_bib18","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.3390\/cancers15133473","article-title":"Lactate as key metabolite in prostate cancer progression: what are the clinical implications?","volume":"15","author":"Chetta","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mcpro.2025.100944_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-3-030-32656-2_10","article-title":"Prostate cancer energetics and biosynthesis","volume":"1210","author":"Lin","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mcpro.2025.100944_bib20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ajur.2019.12.003","article-title":"Lipogenic effects of androgen signaling in normal and malignant prostate","volume":"7","author":"Mah","year":"2020","journal-title":"Asian J. Urol."},{"key":"10.1016\/j.mcpro.2025.100944_bib21","first-page":"119","article-title":"Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect","volume":"38","author":"San-Millan","year":"2017","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mcpro.2025.100944_bib22","first-page":"916","article-title":"High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers","volume":"60","author":"Walenta","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.mcpro.2025.100944_bib23","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1002\/jex2.58","article-title":"Quantitative proteomics and biological activity of extracellular vesicles engineered to express SARS-CoV-2 spike protein","volume":"1","author":"Choi","year":"2022","journal-title":"J.\u00a0Extracell. Biol."},{"key":"10.1016\/j.mcpro.2025.100944_bib24","article-title":"Oncogenic RAS drives the CRAF-dependent extracellular vesicle uptake mechanism coupled with metastasis","volume":"10","author":"Choi","year":"2021","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.mcpro.2025.100944_bib25","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.3390\/cancers13112842","article-title":"Identification of nucleolin as a novel AEG-1-interacting protein in breast cancer via interactome profiling","volume":"13","author":"Lee","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mcpro.2025.100944_bib26","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A\u00a0statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.mcpro.2025.100944_bib27","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1074\/mcp.RA118.000644","article-title":"The impact of oncogenic EGFRvIII on the proteome of extracellular vesicles released from glioblastoma cells","volume":"17","author":"Choi","year":"2018","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2025.100944_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2025.100944_bib29","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2025.100944_bib30","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcpro.2025.100944_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2025.100944_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1110s43","article-title":"From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline","volume":"43","author":"Van der Auwera","year":"2013","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.mcpro.2025.100944_bib33","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/s41388-018-0582-8","article-title":"The ERK and JNK pathways in the regulation of metabolic reprogramming","volume":"38","author":"Papa","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.mcpro.2025.100944_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.581208","article-title":"Hexokinase 2 promotes cell growth and tumor formation through the Raf\/MEK\/ERK signaling pathway in cervical cancer","volume":"10","author":"Cui","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mcpro.2025.100944_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001450","article-title":"Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation","volume":"10","author":"Kalra","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mcpro.2025.100944_bib36","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.mcpro.2025.100944_bib37","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles","volume":"3","author":"Lotvall","year":"2014","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.mcpro.2025.100944_bib38","article-title":"Formation of a protein corona on the surface of extracellular vesicles in blood plasma","volume":"10","author":"Toth","year":"2021","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.mcpro.2025.100944_bib39","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1084\/jem.20190158","article-title":"Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis","volume":"216","author":"Dai","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.mcpro.2025.100944_bib40","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/s41419-020-03179-1","article-title":"Exosome-derived ENO1 regulates integrin alpha6beta4 expression and promotes hepatocellular carcinoma growth and metastasis","volume":"11","author":"Jiang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mcpro.2025.100944_bib41","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11033-015-3858-x","article-title":"Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K","volume":"42","author":"Courtnay","year":"2015","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.mcpro.2025.100944_bib42","doi-asserted-by":"crossref","first-page":"17380","DOI":"10.1073\/pnas.1304266110","article-title":"Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity","volume":"110","author":"Christianson","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.100944_bib43","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1074\/jbc.M115.686295","article-title":"Fibronectin on the surface of myeloma cell-derived exosomes mediates exosome-cell interactions","volume":"291","author":"Purushothaman","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.100944_bib44","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.100944_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fninf.2021.662967","article-title":"Bioinformatic analysis of the proteome in exosomes derived from plasma: exosomes involved in cholesterol metabolism process of patients with spinal cord injury in the acute phase","volume":"15","author":"Wu","year":"2021","journal-title":"Front. Neuroinform."},{"key":"10.1016\/j.mcpro.2025.100944_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612604","article-title":"Screening of exosome-derived proteins and their potential as biomarkers in diagnostic and prognostic for pancreatic cancer","volume":"24","author":"Marin","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcpro.2025.100944_bib47","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1194\/jlr.TR119000383","article-title":"The ins and outs of lipid rafts: functions in intracellular cholesterol homeostasis, microparticles, and cell membranes: thematic Review Series: biology of Lipid Rafts","volume":"61","author":"Ouweneel","year":"2020","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.mcpro.2025.100944_bib48","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature12138","article-title":"Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells","volume":"497","author":"Commisso","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.100944_bib49","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20200087","article-title":"Bad neighbours: hypoxia and genomic instability in prostate cancer","volume":"93","author":"Ashton","year":"2020","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.mcpro.2025.100944_bib50","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s41416-021-01435-5","article-title":"Metabolic reprogramming in prostate cancer","volume":"125","author":"Ahmad","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mcpro.2025.100944_bib51","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MOU.0000000000000129","article-title":"Genomic rearrangements in prostate cancer","volume":"25","author":"Barbieri","year":"2015","journal-title":"Curr. Opin. Urol."},{"key":"10.1016\/j.mcpro.2025.100944_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102515","article-title":"Proteomics protocol for obtaining extracellular vesicle from human plasma using asymmetrical flow field-flow fractionation technology","volume":"4","author":"Li","year":"2023","journal-title":"STAR Protoc."},{"key":"10.1016\/j.mcpro.2025.100944_bib53","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1021\/acsnano.9b10033","article-title":"Endocytosis of extracellular vesicles and release of their cargo from endosomes","volume":"14","author":"Joshi","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.mcpro.2025.100944_bib54","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1194\/jlr.R083725","article-title":"A\u00a0new role for extracellular vesicles: how small vesicles can feed tumors' big appetite","volume":"59","author":"Lazar","year":"2018","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.mcpro.2025.100944_bib55","article-title":"The role of metabolic reprogramming in pancreatic cancer chemoresistance","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mcpro.2025.100944_bib56","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/bph.13422","article-title":"The Warburg effect and drug resistance","volume":"173","author":"Bhattacharya","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mcpro.2025.100944_bib57","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1038\/sj.onc.1209603","article-title":"Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria","volume":"25","author":"Mathupala","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.mcpro.2025.100944_bib58","doi-asserted-by":"crossref","first-page":"7610","DOI":"10.1074\/jbc.M109950200","article-title":"Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis","volume":"277","author":"Pastorino","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.100944_bib59","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1111\/1759-7714.14147","article-title":"Proteomic profiling of extracellular vesicles and particles reveals the cellular response to cisplatin in NSCLC","volume":"12","author":"Xu","year":"2021","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.mcpro.2025.100944_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117131","article-title":"Organization of enzyme concentration across the metabolic network in cancer cells","volume":"10","author":"Madhukar","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2025.100944_bib61","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1083\/jcb.201506084","article-title":"Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER","volume":"213","author":"Heusermann","year":"2016","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.mcpro.2025.100944_bib62","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nprot.2015.138","article-title":"Studying extracellular vesicle transfer by a Cre-loxP method","volume":"11","author":"Zomer","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2025.100944_bib63","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ncb1725","article-title":"Intercellular transfer of the oncogenic receptor EGFRvIII by\u00a0microvesicles derived from tumour cells","volume":"10","author":"Al-Nedawi","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mcpro.2025.100944_bib64","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T01:21:50Z","timestamp":1746840110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947625000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1535947625000428"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.100944","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.100944","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100944"}}