{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:08:56Z","timestamp":1785456536380,"version":"3.56.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["J200006"],"award-info":[{"award-number":["J200006"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7244380"],"award-info":[{"award-number":["7244380"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.mcpro.2025.100967","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:21:52Z","timestamp":1744172512000},"page":"100967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum Disease-Specific IgG Fc Glycosylation as Potential Biomarkers for Nonproliferative and Proliferative Diabetic Retinopathy Using Mass Spectrometry"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1718-2777","authenticated-orcid":false,"given":"Yishuang","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangwanyu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1190-7949","authenticated-orcid":false,"given":"Zhili","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2025.100967_bib1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2337\/dc11-1909","article-title":"Global prevalence and major risk factors of diabetic retinopathy","volume":"35","author":"Yau","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mcpro.2025.100967_bib2","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1001\/jamaophthalmol.2017.2553","article-title":"Vision-related functional burden of diabetic retinopathy across severity levels in the United States","volume":"135","author":"Willis","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.mcpro.2025.100967_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-001026","article-title":"Association of the IgG N-glycome with the course of kidney function in type 2 diabetes","volume":"8","author":"Singh","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.mcpro.2025.100967_bib4","article-title":"Diabetic retinopathy","volume":"2","author":"Wong","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.mcpro.2025.100967_bib5","doi-asserted-by":"crossref","first-page":"P66","DOI":"10.1016\/j.ophtha.2019.09.025","article-title":"Diabetic retinopathy preferred practice Pattern\u00ae","volume":"127","author":"Flaxel","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.mcpro.2025.100967_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cca.2022.06.009","article-title":"Serum immunoinflammatory-related protein complexes as personalized biomarkers for monitoring disease progression and response to treatment in lung cancer patients","volume":"533","author":"Zhang","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.mcpro.2025.100967_bib7","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1007\/s12094-019-02100-3","article-title":"Serum immunoinflammation-related protein complexes discriminate between inflammatory bowel disease and colorectal cancer","volume":"21","author":"Sun","year":"2019","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.mcpro.2025.100967_bib8","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.2337\/dc22-0833","article-title":"Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease","volume":"45","author":"Birukov","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mcpro.2025.100967_bib9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jaut.2018.10.006","article-title":"IgG Fc N-glycosylation: alterations in neurologic diseases and potential therapeutic target?","volume":"96","author":"Kronimus","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.mcpro.2025.100967_bib10","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41584-021-00626-x","article-title":"Glycosylation influences IgG effects in LN","volume":"17","author":"Clarke","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.mcpro.2025.100967_bib11","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.str.2015.06.015","article-title":"The structural role of antibody N-glycosylation in receptor interactions","volume":"23","author":"Subedi","year":"2015","journal-title":"Structure"},{"key":"10.1016\/j.mcpro.2025.100967_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109555","article-title":"Serum disease-specific IgG Fc glycosylation as potential biomarkers for nonproliferative diabetic retinopathy using mass spectrometry","volume":"233","author":"Zhang","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mcpro.2025.100967_bib13","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1021\/pr4008255","article-title":"Elevated serum levels of circulating immunoinflammation-related protein complexes are associated with cancer","volume":"13","author":"Wang","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2025.100967_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/prca.201900016","article-title":"Disease-specific IgG Fc glycosylation ratios as personalized biomarkers to differentiate non-small cell lung cancer from benign lung diseases","volume":"14","author":"Zhang","year":"2020","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.mcpro.2025.100967_bib15","article-title":"Disease-specific IgG Fc N-glycosylation as personalized biomarkers to differentiate gastric cancer from benign gastric diseases","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2025.100967_bib16","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1039\/D1AN00580D","article-title":"Fe(3)O(4)@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides","volume":"146","author":"Lai","year":"2021","journal-title":"Analyst."},{"key":"10.1016\/j.mcpro.2025.100967_bib17","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/s41467-017-01525-0","article-title":"Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway","volume":"8","author":"Benedetti","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.100967_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3685","article-title":"IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes","volume":"39","author":"Memarian","year":"2023","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.mcpro.2025.100967_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta19510","article-title":"Pan-retinal photocoagulation and other forms of laser treatment and drug therapies for non-proliferative diabetic retinopathy: systematic review and economic evaluation","volume":"19","author":"Royle","year":"2015","journal-title":"Health Technol. Assess."},{"key":"10.1016\/j.mcpro.2025.100967_bib20","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.3390\/cells11213362","article-title":"Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.mcpro.2025.100967_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1188838","article-title":"The role of N-glycosylation in B-cell biology and IgG activity. The aspects of autoimmunity and anti-inflammatory therapy","volume":"14","author":"Trzos","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcpro.2025.100967_bib22","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00018-016-2366-z","article-title":"Regulation of antibody effector functions through IgG Fc N-glycosylation","volume":"74","author":"Quast","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.mcpro.2025.100967_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-chembioeng-102419-010001","article-title":"N-glycosylation of IgG and IgG-like recombinant therapeutic proteins: why is it important and how can we control it?","volume":"11","author":"Majewska","year":"2020","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"10.1016\/j.mcpro.2025.100967_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1158\/2326-6066.CIR-14-0125","article-title":"Afucosylated antibodies increase activation of Fc\u03b3RIIIa-dependent signaling components to intensify processes promoting ADCC","volume":"3","author":"Liu","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.mcpro.2025.100967_bib25","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1080\/19420862.2016.1218586","article-title":"The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc \u03b3 receptor","volume":"8","author":"Subedi","year":"2016","journal-title":"MAbs"},{"key":"10.1016\/j.mcpro.2025.100967_bib26","first-page":"63","article-title":"IgG Fc glycosylation in human immunity","volume":"423","author":"Wang","year":"2019","journal-title":"Curr. Top Microbiol. Immunol."},{"key":"10.1016\/j.mcpro.2025.100967_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2023.108201","article-title":"Modulating antibody effector functions by Fc glycoengineering","volume":"67","author":"Garc\u00eda-Alija","year":"2023","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.mcpro.2025.100967_bib28","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1074\/jbc.M210665200","article-title":"The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity","volume":"278","author":"Shinkawa","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.100967_bib29","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/1753-0407.13160","article-title":"Variation of IgG N-linked glycosylation profile in diabetic retinopathy","volume":"13","author":"Wu","year":"2021","journal-title":"J. Diabetes"},{"key":"10.1016\/j.mcpro.2025.100967_bib30","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev-anchem-071114-040240","article-title":"Carbohydrates on proteins: site-specific glycosylation analysis by mass spectrometry","volume":"8","author":"Zhu","year":"2015","journal-title":"Annu. Rev. Anal. Chem. (Palo Alto Calif.)"},{"key":"10.1016\/j.mcpro.2025.100967_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.smim.2018.05.003","article-title":"Antibody glycosylation in inflammation, disease and vaccination","volume":"39","author":"Alter","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.mcpro.2025.100967_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cellimm.2018.07.009","article-title":"Immunoglobulin G glycosylation in aging and diseases","volume":"333","author":"Gudelj","year":"2018","journal-title":"Cell Immunol."}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625000659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625000659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:08:21Z","timestamp":1762549701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947625000659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1535947625000659"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.100967","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Disease-Specific IgG Fc Glycosylation as Potential Biomarkers for Nonproliferative and Proliferative Diabetic Retinopathy Using Mass Spectrometry","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.100967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100967"}}