{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:02:08Z","timestamp":1790136128621,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mcpro.2025.100992","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T19:10:30Z","timestamp":1747077030000},"page":"100992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Theileria annulata Hijacks Host Signaling: Integrated Phosphoproteomics and Transcriptomics Unveils ERK1\/2 as a Central Regulator of Host Transcription Factors"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0228-4732","authenticated-orcid":false,"given":"Debabrata","family":"Dandasena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vengatachala","family":"Moorthy A","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasundhra","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonti","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paresh","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2025.100992_bib1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pt.2015.04.001","article-title":"Theileria-transformed bovine leukocytes have cancer hallmarks","volume":"31","author":"Tretina","year":"2015","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.mcpro.2025.100992_bib2","doi-asserted-by":"crossref","first-page":"e66833","DOI":"10.1371\/journal.pone.0066833","article-title":"A bovine lymphosarcoma cell line infected with Theileria annulata exhibits an irreversible reconfiguration of host cell gene expression","volume":"8","author":"Kinnaird","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2025.100992_bib3","doi-asserted-by":"crossref","first-page":"e103821","DOI":"10.1371\/journal.pone.0103821","article-title":"Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins","volume":"9","author":"Wiens","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2025.100992_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijpara.2005.09.002","article-title":"Alteration of host cell phenotype by Theileria annulata and Theileria parva: mining for manipulators in the parasite genomes","volume":"36","author":"Shiels","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.mcpro.2025.100992_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1369-5274(03)00085-7","article-title":"Theileria-induced leukocyte transformation","volume":"6","author":"Dobbelaere","year":"2003","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.mcpro.2025.100992_bib6","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/j.1460-2075.1993.tb05807.x","article-title":"Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva","volume":"12","author":"ole-MoiYoi","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2025.100992_bib7","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1098\/rstb.2012.0374","article-title":"Preface","volume":"367","author":"Hunter","year":"2012","journal-title":"Philosophical Trans. R. Soc. B: Biol. Sci."},{"key":"10.1016\/j.mcpro.2025.100992_bib8","first-page":"1033","article-title":"Hijacking of host cell IKK signalosomes by the transforming parasite Theileria","volume":"298","author":"Heussler","year":"2002","journal-title":"Science (1979)"},{"key":"10.1016\/j.mcpro.2025.100992_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0166-6851(94)00216-A","article-title":"Infection with Theileria annulata induces expression of matrix metalloproteinase 9 and transcription factor AP-1 in bovine leucocytes","volume":"69","author":"Baylis","year":"1995","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.mcpro.2025.100992_bib10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.coi.2004.05.009","article-title":"The strategies of the Theileria parasite: a new twist in host\u2013pathogen interactions","volume":"16","author":"Dobbelaere","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.mcpro.2025.100992_bib11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1046\/j.1462-5822.2001.00134.x","article-title":"The Akt\/PKB pathway is constitutively activated in Theileria-transformed leucocytes, but does not directly control constitutive NF-kappaB activation","volume":"3","author":"Heussler","year":"2001","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.mcpro.2025.100992_bib12","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1093\/hmg\/9.19.2853","article-title":"Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding Delta1-pyrroline-5-carboxylate synthase","volume":"9","author":"Baumgartner","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2025.100992_bib13","doi-asserted-by":"crossref","first-page":"e12973","DOI":"10.1111\/cmi.12973","article-title":"Theileria highjacks JNK2 into a complex with the macroschizont GPI (GlycosylPhosphatidylInositol)-anchored surface protein p104","volume":"21","author":"Latr\u00e9 De Lat\u00e9","year":"2019","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.mcpro.2025.100992_bib14","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1158\/0008-5472.CAN-05-3861","article-title":"c-Jun NH2-terminal kinase\/c-Jun signaling promotes survival and metastasis of B lymphocytes transformed by Theileria","volume":"66","author":"Lizundia","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.mcpro.2025.100992_bib15","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1111\/j.1462-5822.2007.00925.x","article-title":"The JNK\/AP-1 pathway upregulates expression of the recycling endosome rab11a gene in B cells transformed by Theileria","volume":"9","author":"Lizundia","year":"2007","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.mcpro.2025.100992_bib16","doi-asserted-by":"crossref","first-page":"e1000499","DOI":"10.1371\/journal.pbio.1000499","article-title":"The transforming parasite Theileria Co-opts host cell mitotic and central spindles to persist in continuously dividing cells","volume":"8","author":"von Schubert","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mcpro.2025.100992_bib17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature14044","article-title":"Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation","volume":"520","author":"Marsolier","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.100992_bib18","doi-asserted-by":"crossref","first-page":"15441","DOI":"10.1038\/s41598-018-33721-3","article-title":"A Real-Time PCR based assay for determining parasite to host ratio and parasitaemia in the clinical samples of Bovine Theileriosis","volume":"8","author":"Dandasena","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2025.100992_bib19","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mcpro.2025.100992_bib20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2025.100992_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cels.2018.07.001","article-title":"Coral: clear and customizable visualization of human kinome data","volume":"7","author":"Metz","year":"2018","journal-title":"Cell Syst."},{"key":"10.1016\/j.mcpro.2025.100992_bib22","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.100992_bib23","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein\u2013protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.100992_bib24","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/pathogens12020296","article-title":"Multiplex ddPCR: a promising diagnostic assay for early detection and drug monitoring in bovine theileriosis","volume":"12","author":"Murthy","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.mcpro.2025.100992_bib25","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/sj.onc.1208314","article-title":"c-Myc activation by Theileria parasites promotes survival of infected B-lymphocytes","volume":"24","author":"Dessauge","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.mcpro.2025.100992_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1462-5822.2000.00045.x","article-title":"Theileria parva: taking control of host cell proliferation and survival mechanisms","volume":"2","author":"Dobbelaere","year":"2000","journal-title":"Microreview. Cell Microbiol."},{"key":"10.1016\/j.mcpro.2025.100992_bib27","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/bbrc.1998.8635","article-title":"AP-1 and ATF-2 are constitutively activated via the JNK pathway inTheileria parva-transformed T-cells","volume":"246","author":"Botteron","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mcpro.2025.100992_bib28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0166-6851(98)00070-X","article-title":"Upregulation of Jun and Fos family members and permanent JNK activity lead to constitutive AP-1 activation in Theileria-transformed leukocytes","volume":"94","author":"Chaussepied","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.mcpro.2025.100992_bib29","article-title":"Data-independent acquisition: a milestone and prospect in clinical mass spectrometry-based proteomics","volume":"24","author":"Fr\u00f6hlich","year":"2024","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2025.100992_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"ZHANG","year":"2002","journal-title":"Cell Res."},{"key":"10.1016\/j.mcpro.2025.100992_bib31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/carcin\/bgp270","article-title":"NPM phosphorylation stimulates Cdk1, overrides G 2\/M checkpoint and increases leukemic blasts in mice","volume":"31","author":"Du","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mcpro.2025.100992_bib32","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s004360050293","article-title":"Theileria -mediated constitutive expression of the casein kinase II-\u03b1 subunit in bovine lymphoblastoid cells","volume":"83","author":"Shayan","year":"1997","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.mcpro.2025.100992_bib33","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s42003-019-0386-6","article-title":"Secreted parasite Pin1 isomerase stabilizes host PKM2 to reprogram host cell metabolism","volume":"2","author":"Marsolier","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mcpro.2025.100992_bib34","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1158\/0008-5472.CAN-08-3125","article-title":"Cyclin-dependent kinase-3-mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation","volume":"69","author":"Cho","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.mcpro.2025.100992_bib35","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1128\/MCB.19.2.1301","article-title":"Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth","volume":"19","author":"Abe","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mcpro.2025.100992_bib36","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1073\/pnas.94.10.5119","article-title":"NH 2 -terminal kinase is constitutively activated in T cells transformed by the intracellular parasite Theileria parva","volume":"94","author":"Galley","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mcpro.2025.100992_bib37","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/329268a0","article-title":"Catalysis of protein folding by prolyl isomerase","volume":"329","author":"Lang","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.100992_bib38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/gb-2005-6-7-226","article-title":"The cyclophilins","volume":"6","author":"Wang","year":"2005","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcpro.2025.100992_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.02973","article-title":"Theileria annulata Cyclophilin1 (TaCyp1) interacts with host cell MED21","author":"Zhao","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.mcpro.2025.100992_bib40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/pathogens8020047","article-title":"ApiAP2 transcription factors in apicomplexan parasites","volume":"8","author":"Jeninga","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.mcpro.2025.100992_bib41","doi-asserted-by":"crossref","first-page":"e0003933","DOI":"10.1371\/journal.pntd.0003933","article-title":"ApiAP2 factors as candidate regulators of stochastic commitment to merozoite production in Theileria annulata","volume":"9","author":"Pieszko","year":"2015","journal-title":"Plos Negl. Trop. Dis."},{"key":"10.1016\/j.mcpro.2025.100992_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.01645","article-title":"The Hap complex in yeasts: structure, assembly mode, and gene regulation","author":"Mao","year":"2019","journal-title":"Front. Microbiol."}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625000908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625000908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:08:04Z","timestamp":1762549684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947625000908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S1535947625000908"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.100992","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Theileria annulata Hijacks Host Signaling: Integrated Phosphoproteomics and Transcriptomics Unveils ERK1\/2 as a Central Regulator of Host Transcription Factors","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.100992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"100992"}}