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Alzheimer\u2019s Dis."},{"key":"10.1016\/j.mcpro.2025.101003_bib85","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tibs.2005.04.013","article-title":"Protein phosphorylation in signaling \u2013 50 years and counting","volume":"30","author":"Pawson","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mcpro.2025.101003_bib86","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0167-4889(95)00117-B","article-title":"Protein phosphorylation in apoptosis","volume":"1269","author":"Gjertsen","year":"1995","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.mcpro.2025.101003_bib87","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1073\/pnas.83.13.4913","article-title":"Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology","volume":"83","author":"Grundke-Iqbal","year":"1986","journal-title":"Proc. Natl. Acad. 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Chem."},{"key":"10.1016\/j.mcpro.2025.101003_bib94","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.bbadis.2018.11.002","article-title":"Analysis of post-translational modifications in Alzheimer\u2019s disease by mass spectrometry","volume":"1865","author":"Kelley","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.mcpro.2025.101003_bib95","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/jnc.15315","article-title":"Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer\u2019s disease and dementia","volume":"159","author":"Arber","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mcpro.2025.101003_bib96","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s43587-023-00405-1","article-title":"Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies","volume":"3","author":"Montoliu-Gaya","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.mcpro.2025.101003_bib97","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1021\/jasms.2c00324","article-title":"A quantitative LC-MS\/MS method for distinguishing the tau protein forms phosphorylated and nonphosphorylated at serine-396","volume":"34","author":"Jacobsen","year":"2023","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.mcpro.2025.101003_bib98","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. 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Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101003_bib102","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/brain\/awaa223","article-title":"Phosphorylated tau interactome in the human Alzheimer\u2019s disease brain","volume":"143","author":"Drummond","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.mcpro.2025.101003_bib103","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fnagi.2019.00121","article-title":"Tau phosphorylation rates measured by mass spectrometry differ in the intracellular brain vs. Extracellular cerebrospinal fluid compartments and are differentially affected by Alzheimer\u2019s disease","volume":"11","author":"Barth\u00e9lemy","year":"2019","journal-title":"Front. 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Mass Spectrom."},{"key":"10.1016\/j.mcpro.2025.101003_bib106","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200861","article-title":"Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer\u2019s disease","volume":"217","author":"Barth\u00e9lemy","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mcpro.2025.101003_bib107","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/brain\/awaa373","article-title":"CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer\u2019s disease","volume":"144","author":"Horie","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.mcpro.2025.101003_bib108","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1523\/JNEUROSCI.1549-07.2007","article-title":"Angiotensin-converting enzyme converts amyloid \u03b2-protein 1\u201342 (A\u03b21\u201342) to A\u03b21\u201340, and its inhibition enhances brain A\u03b2 deposition","volume":"27","author":"Zou","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcpro.2025.101003_bib109","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1111\/j.1742-4658.2006.05263.x","article-title":"Physiochemical characterization of the Alzheimer\u2019s disease-related peptides A\u03b21\u201342Arctic and A\u03b21\u201342wt","volume":"273","author":"Johansson","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.mcpro.2025.101003_bib110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neulet.2019.02.033","article-title":"A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer\u2019s disease","volume":"701","author":"Gkanatsiou","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mcpro.2025.101003_bib111","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer\u2019s amyloid \u03b2-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mcpro.2025.101003_bib112","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbrc.2012.10.129","article-title":"Soluble oligomers and fibrillar species of amyloid \u03b2-peptide differentially affect cognitive functions and hippocampal inflammatory response","volume":"429","author":"He","year":"2012","journal-title":"Biochem. Biophys. Res. 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Chem."},{"key":"10.1016\/j.mcpro.2025.101003_bib118","doi-asserted-by":"crossref","first-page":"24041","DOI":"10.1074\/jbc.M116.744722","article-title":"Alternative selection of \u03b2-site APP-cleaving enzyme 1 (BACE1) cleavage sites in amyloid \u03b2-protein precursor (APP) harboring protective and pathogenic mutations within the A\u03b2 sequence","volume":"291","author":"Kimura","year":"2016","journal-title":"J. Biol. 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Biochem."},{"key":"10.1016\/j.mcpro.2025.101003_bib122","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1021\/acs.biochem.5b00326","article-title":"LRRK2 facilitates tau phosphorylation through strong interaction with tau and cdk5","volume":"54","author":"Shanley","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.mcpro.2025.101003_bib123","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fnagi.2020.00242","article-title":"Clinically precedented protein kinases: rationale for their use in neurodegenerative disease","volume":"12","author":"Benn","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mcpro.2025.101003_bib124","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0169-328X(93)90164-K","article-title":"Soluble derivatives of \u03b2\/A4 amyloid protein precursor in human cerebrospinal fluid are both N- and O-glycosylated","volume":"19","author":"Saito","year":"1993","journal-title":"Mol. 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Adv."},{"key":"10.1016\/j.mcpro.2025.101003_bib127","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41420-023-01617-5","article-title":"New insight into protein glycosylation in the development of Alzheimer\u2019s disease","volume":"9","author":"Zhao","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.mcpro.2025.101003_bib128","article-title":"Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer\u2019s disease","author":"Fang","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.mcpro.2025.101003_bib129","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1756285612461679","article-title":"Current and future treatments for Alzheimer\u2019s disease","volume":"6","author":"Yiannopoulou","year":"2013","journal-title":"Ther. Adv. Neurol. 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