{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:18:51Z","timestamp":1778174331432,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.mcpro.2025.101040","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T16:52:35Z","timestamp":1753116755000},"page":"101040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Accurate MS-Based Diagnostic Amyloid Typing Using Endogenously Normalized Protein Intensities in Formalin-Fixed Paraffin-Embedded Tissue"],"prefix":"10.1016","volume":"24","author":[{"given":"Vanessa","family":"Hollfoth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arslan","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyyub","family":"Bag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Riemenschneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7362-0209","authenticated-orcid":false,"given":"Sven","family":"Mattern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Luibrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-235X","authenticated-orcid":false,"given":"Mohamed Ali","family":"Jarboui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Goeppert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirita","family":"Franz-Wachtel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1864-1925","authenticated-orcid":false,"given":"Martina","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8066-2443","authenticated-orcid":false,"given":"Shabnam","family":"Asadikomeleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Feilen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hentschker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Ribback","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1507-0402","authenticated-orcid":false,"given":"Elke","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-689X","authenticated-orcid":false,"given":"Karsten","family":"Boldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Dombrowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-7653","authenticated-orcid":false,"given":"Oliver","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Macek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Ueffing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-2498","authenticated-orcid":false,"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2025.101040_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/13506129.2020.1835263","article-title":"Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee","volume":"27","author":"Benson","year":"2020","journal-title":"Amyloid"},{"key":"10.1016\/j.mcpro.2025.101040_bib2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1080\/10409238.2021.1937926","article-title":"The amyloid proteome: a systematic review and proposal of a protein classification system","volume":"56","author":"Gottwald","year":"2021","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.mcpro.2025.101040_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/13506129.2022.2147636","article-title":"Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International society of amyloidosis (ISA) nomenclature committee","volume":"29","author":"Buxbaum","year":"2022","journal-title":"Amyloid"},{"key":"10.1016\/j.mcpro.2025.101040_bib4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000506696","article-title":"The pathology of amyloidosis in classification: a review","volume":"143","author":"Picken","year":"2020","journal-title":"Acta Haematol."},{"key":"10.1016\/j.mcpro.2025.101040_bib5","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1016\/S0140-6736(15)01274-X","article-title":"Systemic amyloidosis","volume":"387","author":"Wechalekar","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.mcpro.2025.101040_bib6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000508022","article-title":"Confirming the diagnosis of amyloidosis","volume":"143","author":"Wisniowski","year":"2020","journal-title":"Acta Haematol."},{"key":"10.1016\/j.mcpro.2025.101040_bib7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/jclinpath-2014-202722","article-title":"A comparison of immunohistochemistry and mass spectrometry for determining the amyloid fibril protein from formalin-fixed biopsy tissue","volume":"68","author":"Gilbertson","year":"2015","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.mcpro.2025.101040_bib8","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1182\/blood-2009-07-230722","article-title":"Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens","volume":"114","author":"Vrana","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.mcpro.2025.101040_bib9","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3390\/molecules26071913","article-title":"Clinical amyloid typing by proteomics: performance evaluation and data sharing between two centres","volume":"26","author":"Canetti","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.mcpro.2025.101040_bib10","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.mayocp.2020.06.029","article-title":"Amyloid typing by mass spectrometry in clinical practice: a comprehensive review of 16,175 samples","volume":"95","author":"Dasari","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.mcpro.2025.101040_bib11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s00508-020-01781-z","article-title":"Diagnosis and treatment of cardiac amyloidosis: an interdisciplinary consensus statement","volume":"132","author":"Bonderman","year":"2020","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.mcpro.2025.101040_bib12","doi-asserted-by":"crossref","DOI":"10.4414\/SMW.2021.w30053","article-title":"Management of transthyretin amyloidosis","volume":"151","author":"Condoluci","year":"2021","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.mcpro.2025.101040_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.seminhematol.2023.03.002","article-title":"Report of consensus panel 6 from the 11 th international workshop on waldenstr\u00f6m's macroglobulinemia on management of waldenstr\u00f6m's macroglobulinemia related amyloidosis","volume":"60","author":"Merlini","year":"2023","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.mcpro.2025.101040_bib14","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.2215\/CJN.02890310","article-title":"Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosis","volume":"5","author":"Sethi","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mcpro.2025.101040_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2019.100636","article-title":"New developments in diagnosis, risk assessment and management in systemic amyloidosis","volume":"40","author":"Vaxman","year":"2020","journal-title":"Blood Rev."},{"key":"10.1016\/j.mcpro.2025.101040_bib16","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1182\/blood-2011-07-365510","article-title":"Reliable typing of systemic amyloidoses through proteomic analysis of subcutaneous adipose tissue","volume":"119","author":"Brambilla","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.mcpro.2025.101040_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/13506129.2022.2127088","article-title":"Subtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies","volume":"30","author":"Noborn","year":"2023","journal-title":"Amyloid"},{"key":"10.1016\/j.mcpro.2025.101040_bib18","doi-asserted-by":"crossref","first-page":"12895","DOI":"10.1016\/S0021-9258(17)38809-9","article-title":"The primary structure of human tissue amyloid P component from a patient with primary idiopathic amyloidosis","volume":"260","author":"Prelli","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101040_bib19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanhausser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101040_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s44321-025-00194-7","article-title":"An AI-assisted morphoproteomic approach is a supportive tool in esophagitis-related precision medicine","volume":"17","author":"Mattern","year":"2025","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mcpro.2025.101040_bib21","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1038\/s41596-020-0356-y","article-title":"Spatially resolved analysis of FFPE tissue proteomes by quantitative mass spectrometry","volume":"15","author":"Buczak","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2025.101040_bib22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev-pathol-052016-100200","article-title":"Amyloidosis: insights from proteomics","volume":"12","author":"Dogan","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.mcpro.2025.101040_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2025.101040_bib24","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1007\/s13361-015-1204-0","article-title":"Novor: real-time peptide de novo sequencing software","volume":"26","author":"Ma","year":"2015","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.mcpro.2025.101040_bib25","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1021\/pr4008078","article-title":"DeNovoGUI: an open source graphical user interface for de novo sequencing of tandem mass spectra","volume":"13","author":"Muth","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2025.101040_bib26","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3324\/haematol.2013.102764","article-title":"Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics","volume":"99","author":"Vrana","year":"2014","journal-title":"Haematologica"},{"key":"10.1016\/j.mcpro.2025.101040_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCIMAGING.123.015259","article-title":"Rare forms of cardiac amyloidosis: diagnostic clues and phenotype in Apo AI and AIV amyloidosis","volume":"16","author":"Ioannou","year":"2023","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"10.1016\/j.mcpro.2025.101040_bib28","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1515\/cclm-2019-1007","article-title":"Diagnostic amyloid proteomics: experience of the UK National amyloidosis centre","volume":"58","author":"Canetti","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.mcpro.2025.101040_bib29","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00041552-200211000-00013","article-title":"Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis","volume":"11","author":"Hawkins","year":"2002","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.mcpro.2025.101040_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2024.05.009","article-title":"Serum amyloid P component: structure, biological activity, and application in diagnosis and treatment of immune-associated diseases","volume":"172","author":"Wang","year":"2024","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.mcpro.2025.101040_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3390\/ijms23010319","article-title":"Classification of amyloidosis by model-assisted mass spectrometry-based proteomics","volume":"23","author":"Palstrom","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcpro.2025.101040_bib32","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/jms.3264","article-title":"Shotgun-proteomics-based clinical testing for diagnosis and classification of amyloidosis","volume":"48","author":"Theis","year":"2013","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.mcpro.2025.101040_bib33","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2025.101040_bib34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/proteomes10010002","article-title":"Comparison of different label-free techniques for the semi-absolute quantification of protein abundance","volume":"10","author":"Millan-Oropeza","year":"2022","journal-title":"Proteomes"},{"key":"10.1016\/j.mcpro.2025.101040_bib35","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1016\/j.jprot.2012.06.020","article-title":"Comparison and applications of label-free absolute proteome quantification methods on Escherichia coli","volume":"75","author":"Arike","year":"2012","journal-title":"J. Proteomics"},{"key":"10.1016\/j.mcpro.2025.101040_bib36","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1021\/pr401017h","article-title":"Accurate label-free protein quantitation with high- and low-resolution mass spectrometers","volume":"13","author":"Krey","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2025.101040_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202300188","article-title":"Tissue-based absolute quantification using large-scale TMT and LFQ experiments","volume":"23","author":"Wang","year":"2023","journal-title":"Proteomics"},{"key":"10.1016\/j.mcpro.2025.101040_bib38","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1002\/ehf2.13375","article-title":"Proteomic profiling for detection of early-stage heart failure in the community","volume":"8","author":"Cauwenberghs","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.mcpro.2025.101040_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/11795468221133611","article-title":"XGBoost, A novel explainable AI technique, in the prediction of myocardial infarction: a UK biobank cohort study","volume":"16","author":"Moore","year":"2022","journal-title":"Clin. Med. Insights Cardiol."},{"key":"10.1016\/j.mcpro.2025.101040_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.12688\/openreseurope.15810.1","article-title":"Foresight in clinical proteomics: current status, ethical considerations, and future perspectives","volume":"3","author":"Mundt","year":"2023","journal-title":"Open Res. Eur."},{"key":"10.1016\/j.mcpro.2025.101040_bib41","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41597-022-01216-6","article-title":"A comprehensive LFQ benchmark dataset on modern day acquisition strategies in proteomics","volume":"9","author":"Van Puyvelde","year":"2022","journal-title":"Sci. Data"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625001392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625001392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T15:36:29Z","timestamp":1757604989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947625001392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1535947625001392"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.101040","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accurate MS-Based Diagnostic Amyloid Typing Using Endogenously Normalized Protein Intensities in Formalin-Fixed Paraffin-Embedded Tissue","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.101040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101040"}}