{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:34:49Z","timestamp":1779392089582,"version":"3.53.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017415","name":"Peking University First Hospital","doi-asserted-by":"publisher","award":["2022CR38"],"award-info":[{"award-number":["2022CR38"]}],"id":[{"id":"10.13039\/100017415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.mcpro.2025.101068","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:30:32Z","timestamp":1757550632000},"page":"101068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multi-Omics Blood Atlas Reveals Host Immune Response Features of Immunocompromised Populations Following SARS-CoV-2 Infection"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-5865","authenticated-orcid":false,"given":"Xiaodi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wuchty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziding","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2025.101068_bib1","article-title":"Efficacy and safety of paxlovid in severe adult patients with SARS-Cov-2 infection: a multicenter randomized controlled study","volume":"33","author":"Liu","year":"2023","journal-title":"Lancet Reg. Heal. West. Pac."},{"key":"10.1016\/j.mcpro.2025.101068_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/cid\/ciac180","article-title":"Molnupiravir and nirmatrelvir-ritonavir: oral coronavirus disease 2019 antiviral drugs","volume":"76","author":"Saravolatz","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.mcpro.2025.101068_bib3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1056\/NEJMoa2116044","article-title":"Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients","volume":"386","author":"Jayk Bernal","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mcpro.2025.101068_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2551","article-title":"Azvudine versus Paxlovid in COVID-19: a systematic review and meta-analysis","volume":"34","author":"Amani","year":"2024","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.mcpro.2025.101068_bib5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-021-00592-1","article-title":"Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape","volume":"21","author":"Tregoning","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mcpro.2025.101068_bib6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41586-020-2918-0","article-title":"Age-specific mortality and immunity patterns of SARS-CoV-2","volume":"590","author":"O'Driscoll","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101068_bib7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/cid\/ciaa863","article-title":"COVID-19 in immunocompromised hosts: what we know so far","volume":"72","author":"Fung","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.mcpro.2025.101068_bib8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1182\/blood.2021012251","article-title":"COVID-19 in patients with hematologic malignancy","volume":"140","author":"Langerbeins","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.mcpro.2025.101068_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1158\/2159-8290.CD-21-1033","article-title":"Prolonged SARS-CoV-2 infection in patients with lymphoid malignancies","volume":"12","author":"Lee","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.mcpro.2025.101068_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110955","article-title":"Spatial region-resolved proteome map reveals mechanism of COVID-19-associated heart injury","volume":"39","author":"Leng","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2025.101068_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110271","article-title":"Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19","volume":"38","author":"Bi","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2025.101068_bib12","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.cell.2021.01.053","article-title":"COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas","volume":"184","author":"Ren","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41586-021-04352-y","article-title":"Evolution of enhanced innate immune evasion by SARS-CoV-2","volume":"602","author":"Thorne","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101068_bib14","article-title":"The systemic inflammatory landscape of COVID-19 in pregnancy: extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2","volume":"2","author":"Foo","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.mcpro.2025.101068_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71945","article-title":"SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome","volume":"11","author":"Zaffagni","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.mcpro.2025.101068_bib16","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1016\/j.cell.2023.07.019","article-title":"Epigenetic memory of coronavirus infection in innate immune cells and their progenitors","volume":"186","author":"Cheong","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib17","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1007\/s11427-021-2070-y","article-title":"A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options","volume":"65","author":"Liu","year":"2022","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.mcpro.2025.101068_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112613","article-title":"Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity","volume":"42","author":"Potts","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2025.101068_bib19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41587-022-01475-z","article-title":"A proteome-scale map of the SARS-CoV-2\u2013human contactome","volume":"41","author":"Kim","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mcpro.2025.101068_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41587-022-01474-0","article-title":"A comprehensive SARS-CoV-2\u2013human protein\u2013protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets","volume":"41","author":"Zhou","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mcpro.2025.101068_bib21","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114167","article-title":"High-resolution serum proteome trajectories in COVID-19 reveal patient-specific seroconversion","volume":"13","author":"Geyer","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mcpro.2025.101068_bib22","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.cell.2020.10.037","article-title":"Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19","volume":"183","author":"Su","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib23","doi-asserted-by":"crossref","first-page":"D539","DOI":"10.1093\/nar\/gkac1015","article-title":"CORUM: the comprehensive resource of mammalian protein complexes-2022","volume":"51","author":"Tsitsiridis","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101068_bib24","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202010016","article-title":"hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies","volume":"17","author":"Drew","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.mcpro.2025.101068_bib25","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/bib\/bbaa425","article-title":"HVIDB: a comprehensive database for human-virus protein-protein interactions","volume":"22","author":"Yang","year":"2021","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.mcpro.2025.101068_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00303-18","article-title":"Understanding human-virus protein-protein interactions using a human protein complex-based analysis framework","volume":"4","author":"Yang","year":"2019","journal-title":"mSystems"},{"key":"10.1016\/j.mcpro.2025.101068_bib27","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.cell.2022.01.012","article-title":"A blood atlas of COVID-19 defines hallmarks of disease severity and specificity","volume":"185","author":"Ahern","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib28","article-title":"Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions","volume":"2","author":"Filbin","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.mcpro.2025.101068_bib29","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1158\/2159-8290.CD-20-0773","article-title":"Clinical portrait of the SARS-CoV-2 epidemic in European patients with cancer","volume":"10","author":"Pinato","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.mcpro.2025.101068_bib30","series-title":"COVID-19 rapid guideline: managing the long-term effects of COVID-19","year":"2020"},{"key":"10.1016\/j.mcpro.2025.101068_bib31","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/eurheartj\/ehac031","article-title":"Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus","volume":"43","author":"Raman","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.mcpro.2025.101068_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01385-23","article-title":"Comparative analysis of dynamic transcriptomes reveals specific COVID-19 features and pathogenesis of immunocompromised populations","volume":"9","author":"Yang","year":"2024","journal-title":"mSystems"},{"key":"10.1016\/j.mcpro.2025.101068_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/gix120","article-title":"SOAPnuke: a MapReduce acceleration-supported software for integrated quality control and preprocessing of high-throughput sequencing data","volume":"7","author":"Chen","year":"2018","journal-title":"Gigascience"},{"key":"10.1016\/j.mcpro.2025.101068_bib34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2025.101068_bib35","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2025.101068_bib36","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.mcpro.2025.101068_bib37","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.mcpro.2025.101068_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105896","article-title":"Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage","volume":"39","author":"Chen","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2025.101068_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103525","article-title":"Identification of COVID-19 prognostic markers and therapeutic targets through meta-analysis and validation of Omics data from nasopharyngeal samples","volume":"70","author":"Biji","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mcpro.2025.101068_bib40","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/s41556-021-00796-6","article-title":"A single-cell transcriptomic landscape of the lungs of patients with COVID-19","volume":"23","author":"Wang","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mcpro.2025.101068_bib41","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.immuni.2023.05.007","article-title":"Multi-omics blood atlas reveals unique features of immune and platelet responses to SARS-CoV-2 Omicron breakthrough infection","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.mcpro.2025.101068_bib42","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.1038\/s41467-022-35454-4","article-title":"Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence","volume":"13","author":"Gisby","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101068_bib43","article-title":"Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology","volume":"16","author":"van Phan","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mcpro.2025.101068_bib44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/pro.3978","article-title":"The BioGRID database: a comprehensive biomedical resource of curated protein, genetic, and chemical interactions","volume":"30","author":"Oughtred","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.mcpro.2025.101068_bib45","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1016\/j.cell.2022.10.017","article-title":"The phenotypic landscape of essential human genes","volume":"185","author":"Funk","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib46","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.aac7557","article-title":"Gene essentiality and synthetic lethality in haploid human cells","volume":"350","author":"Blomen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2025.101068_bib47","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/s12859-017-1806-6","article-title":"ScaPD: a database for human scaffold proteins","volume":"18","author":"Han","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.mcpro.2025.101068_bib48","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cell.2020.10.028","article-title":"Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection","volume":"184","author":"Wei","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib49","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cell.2020.10.030","article-title":"Identification of required host factors for SARS-CoV-2 infection in human cells","volume":"184","author":"Daniloski","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cell.2020.12.006","article-title":"Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks","volume":"184","author":"Schneider","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib51","doi-asserted-by":"crossref","first-page":"D1228","DOI":"10.1093\/nar\/gks1147","article-title":"InnateDB: systems biology of innate immunity and beyond\u2014recent updates and continuing curation","volume":"41","author":"Breuer","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101068_bib52","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.mcpro.2025.101068_bib53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2105-4-2","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.mcpro.2025.101068_bib54","doi-asserted-by":"crossref","first-page":"D330","DOI":"10.1093\/nar\/gky1055","article-title":"The gene ontology resource: 20 years and still GOing strong","volume":"47","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101068_bib55","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101068_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2025.101068_bib57","doi-asserted-by":"crossref","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","article-title":"TTD: therapeutic target database describing target druggability information","volume":"52","author":"Zhou","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101068_bib58","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1261\/rna.078121.120","article-title":"The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation","volume":"27","author":"Tidu","year":"2021","journal-title":"RNA"},{"key":"10.1016\/j.mcpro.2025.101068_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011796","article-title":"Viral organization of human proteins","volume":"5","author":"Wuchty","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2025.101068_bib60","doi-asserted-by":"crossref","first-page":"D601","DOI":"10.1093\/nar\/gky967","article-title":"RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data","volume":"47","author":"Lang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101068_bib61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cell.2016.12.044","article-title":"ApoE2, ApoE3, and ApoE4 differentially stimulate APP transcription and A\u03b2 secretion","volume":"168","author":"Huang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib62","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cell.2021.12.040","article-title":"Complement activation induces excessive T cell cytotoxicity in severe COVID-19","volume":"185","author":"Georg","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib64","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.cell.2020.10.004","article-title":"SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses","volume":"183","author":"Banerjee","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib65","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41586-021-03610-3","article-title":"SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis","volume":"594","author":"Finkel","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101068_bib66","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/s41591-020-0944-y","article-title":"A single-cell atlas of the peripheral immune response in patients with severe COVID-19","volume":"26","author":"Wilk","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcpro.2025.101068_bib67","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.1038\/s41467-021-26602-3","article-title":"Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants","volume":"12","author":"Weigang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101068_bib68","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMc2202861","article-title":"SARS-CoV-2 evolution and immune escape in immunocompromised patients","volume":"386","author":"Scherer","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mcpro.2025.101068_bib69","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41591-020-1051-9","article-title":"An inflammatory cytokine signature predicts COVID-19 severity and survival","volume":"26","author":"Del Valle","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcpro.2025.101068_bib70","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1016\/j.cell.2023.08.026","article-title":"SARS-CoV-2 variants evolve convergent strategies to remodel the host response","volume":"186","author":"Bouhaddou","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101068_bib71","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cell.2020.06.034","article-title":"The global phosphorylation landscape of SARS-CoV-2 infection","volume":"182","author":"Bouhaddou","year":"2020","journal-title":"Cell"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625001677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625001677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T22:53:18Z","timestamp":1762815198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947625001677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1535947625001677"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.101068","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-Omics Blood Atlas Reveals Host Immune Response Features of Immunocompromised Populations Following SARS-CoV-2 Infection","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.101068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101068"}}