{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:11:03Z","timestamp":1790878263228,"version":"4.1.0"},"reference-count":144,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG061357"],"award-info":[{"award-number":["U01AG061357"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG075820"],"award-info":[{"award-number":["R01AG075820"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007623","name":"School of Medicine, Emory University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007623","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.mcpro.2025.101458","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T02:34:20Z","timestamp":1762482860000},"page":"101458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Proximity Labeling of the Tau Repeat Domain Enriches RNA-Binding Proteins That Are Altered in Alzheimer's Disease and Related Tauopathies"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-8664","authenticated-orcid":false,"given":"Sarah M.","family":"Shapley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1384-941X","authenticated-orcid":false,"given":"Anantharaman","family":"Shantaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7945-4886","authenticated-orcid":false,"given":"Joshna","family":"Gadhavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7222-6258","authenticated-orcid":false,"given":"Masin A.","family":"Kearney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2947-7606","authenticated-orcid":false,"given":"Eric B.","family":"Dammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc M.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6574-0833","authenticated-orcid":false,"given":"Caroline M.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritha","family":"Bagchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-9210","authenticated-orcid":false,"given":"Qi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikant","family":"Rangaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-624X","authenticated-orcid":false,"given":"Nicholas T.","family":"Seyfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2025.101458_bib1","first-page":"271","article-title":"Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2","volume":"387","author":"Neve","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.mcpro.2025.101458_bib2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/j.1460-2075.1989.tb03390.x","article-title":"Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain","volume":"8","author":"Goedert","year":"1989","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2025.101458_bib3","doi-asserted-by":"crossref","first-page":"11117","DOI":"10.1021\/bi00035a017","article-title":"Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau","volume":"34","author":"Panda","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.mcpro.2025.101458_bib4","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1091\/mbc.3.10.1141","article-title":"Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau","volume":"3","author":"Drechsel","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mcpro.2025.101458_bib5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0166-2236(98)01337-X","article-title":"Tau protein pathology in neurodegenerative diseases","volume":"21","author":"Spillantini","year":"1998","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.brainresbull.2016.08.018","article-title":"Tau and tauopathies","volume":"126","author":"Arendt","year":"2016","journal-title":"Brain Res. Bull"},{"key":"10.1016\/j.mcpro.2025.101458_bib7","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1073\/pnas.95.13.7737","article-title":"Mutation in the tau gene in familial multiple system tauopathy with presenile dementia","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101458_bib8","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101458_bib9","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/oxfordjournals.jbchem.a135625","article-title":"One of the antigenic determinants of paired helical filaments is related to tau protein","volume":"99","author":"Nukina","year":"1986","journal-title":"J. Biochem."},{"key":"10.1016\/j.mcpro.2025.101458_bib10","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","article-title":"Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease","volume":"83","author":"Kosik","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101458_bib11","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological alterations in Alzheimer disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"10.1016\/j.mcpro.2025.101458_bib12","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1038\/s41467-023-40208-x","article-title":"Compilation of reported protein changes in the brain in Alzheimer's disease","volume":"14","author":"Askenazi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib13","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0503-22.2023","article-title":"Characterization of the Tau interactome in human brain reveals isoform-dependent interaction with 14-3-3 family proteins","volume":"10","author":"Betters","year":"2023","journal-title":"eNeuro"},{"key":"10.1016\/j.mcpro.2025.101458_bib14","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cell.2021.12.041","article-title":"Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration","volume":"185","author":"Tracy","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101458_bib15","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/brain\/awaa223","article-title":"Phosphorylated tau interactome in the human Alzheimer's disease brain","volume":"143","author":"Drummond","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.mcpro.2025.101458_bib16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.celrep.2019.08.104","article-title":"Tau-mediated disruption of the spliceosome triggers cryptic RNA splicing and neurodegeneration in Alzheimer's Disease","volume":"29","author":"Hsieh","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.mcpro.2025.101458_bib17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13024-018-0282-4","article-title":"Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease","volume":"13","author":"Johnson","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101458_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41593-021-00999-y","article-title":"Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level","volume":"25","author":"Johnson","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib19","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41591-020-0815-6","article-title":"Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation","volume":"26","author":"Johnson","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.mcpro.2025.101458_bib20","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1177\/10738584231154551","article-title":"Tau, RNA, and RNA-binding proteins: complex interactions in health and neurodegenerative diseases","volume":"30","author":"Lester","year":"2024","journal-title":"Neuroscientist"},{"key":"10.1016\/j.mcpro.2025.101458_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40478-018-0574-5","article-title":"RNA binding proteins co-localize with small tau inclusions in tauopathy","volume":"6","author":"Maziuk","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib22","doi-asserted-by":"crossref","first-page":"16562","DOI":"10.1073\/pnas.1310249110","article-title":"U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease","volume":"110","author":"Bai","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101458_bib23","doi-asserted-by":"crossref","first-page":"35296","DOI":"10.1074\/jbc.M114.562959","article-title":"Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease","volume":"289","author":"Diner","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13024-022-00572-6","article-title":"Tau interactome and RNA binding proteins in neurodegenerative diseases","volume":"17","author":"Kavanagh","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101458_bib25","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.neuron.2021.03.026","article-title":"Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components","volume":"109","author":"Lester","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.mcpro.2025.101458_bib26","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2014188118","article-title":"TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau","volume":"118","author":"Ash","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101458_bib27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fnins.2020.00285","article-title":"Reduction of the RNA binding protein TIA1 exacerbates neuroinflammation in tauopathy","volume":"14","author":"LeBlang","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41593-017-0022-z","article-title":"Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo","volume":"21","author":"Apicco","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib29","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.celrep.2016.04.045","article-title":"Interaction of tau with the RNA-binding protein TIA1 regulates tau pathophysiology and toxicity","volume":"15","author":"Vanderweyde","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2025.101458_bib30","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1016\/j.molcel.2021.07.038","article-title":"Interaction of tau with HNRNPA2B1 and N(6)-methyladenosine RNA mediates the progression of tauopathy","volume":"81","author":"Jiang","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mcpro.2025.101458_bib31","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1038\/s41467-020-18022-6","article-title":"RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction","volume":"11","author":"Montalbano","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00401-020-02178-y","article-title":"SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer's disease","volume":"140","author":"Younas","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mcpro.2025.101458_bib33","doi-asserted-by":"crossref","first-page":"11047","DOI":"10.1074\/jbc.RA118.001747","article-title":"RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease","volume":"293","author":"Bishof","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib34","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1038\/s41467-022-30623-x","article-title":"Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain","volume":"13","author":"Rayaprolu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100546","article-title":"Cellular proteomic profiling using proximity labeling by TurboID-NES in microglial and neuronal cell lines","volume":"22","author":"Sunna","year":"2023","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2025.101458_bib36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13024-024-00783-z","article-title":"VCP regulates early tau seed amplification via specific cofactors","volume":"20","author":"Batra","year":"2025","journal-title":"Mol. Neurodegener"},{"key":"10.1016\/j.mcpro.2025.101458_bib37","article-title":"Immunoprecipitation","volume":"2020","author":"DeCaprio","year":"2020","journal-title":"Cold Spring Harb Protoc."},{"key":"10.1016\/j.mcpro.2025.101458_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2024.100809","article-title":"Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in Microglia","volume":"23","author":"Bowen","year":"2024","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2025.101458_bib39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41592-020-01010-5","article-title":"Deciphering molecular interactions by proximity labeling","volume":"18","author":"Qin","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2025.101458_bib40","doi-asserted-by":"crossref","first-page":"12143","DOI":"10.1073\/pnas.1919528117","article-title":"Split-TurboID enables contact-dependent proximity labeling in cells","volume":"117","author":"Cho","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101458_bib41","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1038\/s41596-020-0399-0","article-title":"Proximity labeling in mammalian cells with TurboID and split-TurboID","volume":"15","author":"Cho","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2025.101458_bib42","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.1074\/jbc.M808759200","article-title":"Propagation of tau misfolding from the outside to the inside of a cell","volume":"284","author":"Frost","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib43","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1074\/jbc.M507753200","article-title":"Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs","volume":"281","author":"Khlistunova","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101306","article-title":"Phosphorylation regulates arginine-rich RNA-binding protein solubility and oligomerization","volume":"297","author":"Kundinger","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100760","article-title":"TBK1 interacts with tau and enhances neurodegeneration in tauopathy","volume":"296","author":"Abreha","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib46","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot098541","article-title":"Freezing cell pellets for large-scale immunoprecipitation","volume":"2019","author":"Litovchick","year":"2019","journal-title":"Cold Spring Harb Protoc."},{"key":"10.1016\/j.mcpro.2025.101458_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1239116","article-title":"Genetic background influences the 5XFAD Alzheimer's disease mouse model brain proteome","volume":"15","author":"Hurst","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib144","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-1-4939-7493-1_7","article-title":"Perseus: a bioinformatics platform for integrative analysis of proteomics data in cancer research","volume":"1711","author":"Tyanova","year":"2018","journal-title":"Methods. Mol. Biol."},{"key":"10.1016\/j.mcpro.2025.101458_bib51","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/0049124189018002003","article-title":"An introduction to bootstrap methods","volume":"18","author":"Stine","year":"1989","journal-title":"Sociological. Methods Res."},{"key":"10.1016\/j.mcpro.2025.101458_bib52","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13024-023-00638-z","article-title":"Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease","volume":"18","author":"Modeste","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101458_bib53","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13195-022-01113-5","article-title":"Multi-platform proteomic analysis of Alzheimer's disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome","volume":"14","author":"Dammer","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.mcpro.2025.101458_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/alz.13821","article-title":"Proteomic changes in the human cerebrovasculature in Alzheimer's disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid","author":"Wojtas","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.mcpro.2025.101458_bib55","doi-asserted-by":"crossref","DOI":"10.1002\/acn3.52134","article-title":"Proteomic networks of gray and white matter reveal tissue-specific changes in human tauopathy","author":"Johnson","year":"2024","journal-title":"Ann. Clin. Transl Neurol."},{"key":"10.1016\/j.mcpro.2025.101458_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adn3504","article-title":"Proteomic analysis of Alzheimer's disease cerebrospinal fluid reveals alterations associated with APOE epsilon4 and atomoxetine treatment","volume":"16","author":"Dammer","year":"2024","journal-title":"Sci. Transl Med."},{"key":"10.1016\/j.mcpro.2025.101458_bib57","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13024-024-00757-1","article-title":"Heparin-enriched plasma proteome is significantly altered in Alzheimer's disease","volume":"19","author":"Guo","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101458_bib58","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13048-024-01556-4","article-title":"Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironment","volume":"17","author":"Carey","year":"2024","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.mcpro.2025.101458_bib59","article-title":"Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration","author":"Saloner","year":"2024","journal-title":"Res. Sq"},{"key":"10.1016\/j.mcpro.2025.101458_bib60","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13024-025-00838-9","article-title":"Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis","volume":"20","author":"Trautwig","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101458_bib61","article-title":"Nomination of a novel plasma protein biomarker panel capable of classifying Alzheimer's disease dementia with high accuracy in an African American cohort","author":"Kuchenbecker","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.mcpro.2025.101458_bib62","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13024-024-00749-1","article-title":"Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer's disease","volume":"19","author":"Shantaraman","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101458_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fsysb.2023.1092341","article-title":"Batch correction and harmonization of -Omics datasets with a tunable median Polish of ratio","volume":"3","author":"Dammer","year":"2023","journal-title":"Front. Syst. Biol."},{"key":"10.1016\/j.mcpro.2025.101458_bib64","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.mcpro.2025.101458_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.623659","article-title":"Targeted quantification of detergent-insoluble RNA-binding proteins in human brain reveals stage and disease specific Co-aggregation in Alzheimer's Disease","volume":"14","author":"Guo","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib66","article-title":"Large-scale deep proteomic analysis in Alzheimer's Disease brain regions across race and ethnicity","author":"Seifar","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.mcpro.2025.101458_bib67","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cels.2016.11.006","article-title":"A multi-network approach identifies protein-specific Co-expression in asymptomatic and symptomatic Alzheimer's Disease","volume":"4","author":"Seyfried","year":"2017","journal-title":"Cell Syst."},{"key":"10.1016\/j.mcpro.2025.101458_bib68","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3389\/fnmol.2018.00454","article-title":"Effects of APOE genotype on brain proteomic network and cell type changes in Alzheimer's Disease","volume":"11","author":"Dai","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib69","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13024-020-00377-5","article-title":"Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease","volume":"15","author":"Rayaprolu","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101458_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100542","article-title":"Integrated proteomics to understand the role of Neuritin (NRN1) as a mediator of cognitive resilience to Alzheimer's Disease","volume":"22","author":"Hurst","year":"2023","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2025.101458_bib71","article-title":"Integrative proteomics identifies a conserved Abeta amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease","volume":"5","author":"Levites","year":"2024","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.mcpro.2025.101458_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100608","article-title":"Dissecting detergent-insoluble proteome in Alzheimer's Disease by TMTc-Corrected quantitative mass spectrometry","volume":"22","author":"Zaman","year":"2023","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2025.101458_bib73","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1083\/jcb.118.3.573","article-title":"Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro","volume":"118","author":"Wille","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mcpro.2025.101458_bib74","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of Alzheimer paired helical filaments","volume":"261","author":"Grundke-Iqbal","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib75","doi-asserted-by":"crossref","first-page":"19440","DOI":"10.1074\/jbc.M112.346072","article-title":"Trans-cellular propagation of Tau aggregation by fibrillar species","volume":"287","author":"Kfoury","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib76","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1523\/JNEUROSCI.2590-20.2021","article-title":"Continuous monitoring of tau-induced neurotoxicity in patient-derived iPSC-Neurons","volume":"41","author":"Oakley","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib77","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1038\/s41598-017-02460-2","article-title":"Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2025.101458_bib78","article-title":"Self-cleaving peptides for expression of multiple genes in Dictyostelium discoideum","volume":"18","author":"Zhu","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2025.101458_bib79","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1074\/jbc.M113.515445","article-title":"Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology","volume":"289","author":"Michel","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib80","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12860-020-00320-y","article-title":"Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils","volume":"21","author":"Marreiro","year":"2020","journal-title":"BMC Mol. Cell Biol."},{"key":"10.1016\/j.mcpro.2025.101458_bib81","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1074\/mcp.M115.050724","article-title":"The human Tau interactome: binding to the ribonucleoproteome, and impaired binding of the proline-to-leucine mutant at position 301 (P301L) to chaperones and the proteasome","volume":"14","author":"Gunawardana","year":"2015","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2025.101458_bib82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/jnen\/nlx100","article-title":"Characterization of detergent insoluble proteome in chronic traumatic encephalopathy","volume":"77","author":"Cherry","year":"2018","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.mcpro.2025.101458_bib83","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798049","article-title":"Tau protein liquid-liquid phase separation can initiate tau aggregation","volume":"37","author":"Wegmann","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2025.101458_bib84","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1038\/s41467-021-24362-8","article-title":"Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils","volume":"12","author":"Chakraborty","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib85","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1002\/j.1460-2075.1990.tb07870.x","article-title":"Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization","volume":"9","author":"Goedert","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2025.101458_bib86","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1432-1033.1985.tb09342.x","article-title":"Localization of the tubulin binding site for tau protein","volume":"153","author":"Serrano","year":"1985","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.mcpro.2025.101458_bib87","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1038\/s41467-025-59457-z","article-title":"Spatiotemporal deciphering of dynamic the FUS interactome during liquid-liquid phase separation in living cells","volume":"16","author":"Song","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib88","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70079","article-title":"Proteomics analysis of the TDP-43 interactome in cellular models of ALS pathogenesis","volume":"169","author":"Cheng","year":"2025","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mcpro.2025.101458_bib89","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1172\/JCI29715","article-title":"The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins","volume":"117","author":"Dickey","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mcpro.2025.101458_bib90","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","article-title":"Tau PTM profiles identify patient heterogeneity and stages of Alzheimer's Disease","volume":"183","author":"Wesseling","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101458_bib91","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1002\/anie.201913001","article-title":"Site-Specific hyperphosphorylation inhibits, rather than promotes, tau fibrillization, seeding capacity, and its microtubule binding","volume":"59","author":"Haj-Yahya","year":"2020","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.mcpro.2025.101458_bib92","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1073\/pnas.0709180105","article-title":"Akt and CHIP coregulate tau degradation through coordinated interactions","volume":"105","author":"Dickey","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101458_bib93","first-page":"7679","article-title":"Microtubule-associated protein\/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262","volume":"270","author":"Drewes","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib94","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2051-5960-2-22","article-title":"MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies","volume":"2","author":"Lund","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib95","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/pmic.201400189","article-title":"Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins","volume":"15","author":"Dammer","year":"2015","journal-title":"Proteomics"},{"key":"10.1016\/j.mcpro.2025.101458_bib96","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1038\/s41467-025-58737-y","article-title":"A TLK2-mediated calcium-driven cell death pathway links neuronal degeneration to nuclear envelope disruption","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib97","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/01.jnen.0000218441.00040.82","article-title":"Atypical protein kinase C in neurodegenerative disease II: pkciota\/lambda in tauopathies and alpha-synucleinopathies","volume":"65","author":"Shao","year":"2006","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.mcpro.2025.101458_bib98","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-021-02394-0","article-title":"DTYMK is essential for genome integrity and neuronal survival","volume":"143","author":"Vanoevelen","year":"2022","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mcpro.2025.101458_bib99","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mcpro.2025.101458_bib100","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/jnr.10060","article-title":"Altered brain phosphocreatine and ATP regulation when mitochondrial creatine kinase is absent","volume":"66","author":"Kekelidze","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mcpro.2025.101458_bib101","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1124\/mol.64.3.557","article-title":"Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation","volume":"64","author":"Kang","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mcpro.2025.101458_bib102","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12964","article-title":"Comparative interactome mapping of Tau-protein in classical and rapidly progressive Alzheimer's disease identifies subtype-specific pathways","volume":"50","author":"Younas","year":"2024","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.mcpro.2025.101458_bib103","article-title":"Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins","volume":"9","author":"Wang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2025.101458_bib104","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41593-017-0047-3","article-title":"TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS\/FTD","volume":"21","author":"Chou","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib105","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021110242","article-title":"Tau target identification reveals NSF-dependent effects on AMPA receptor trafficking and memory formation","volume":"41","author":"Prikas","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2025.101458_bib106","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jalz.2013.06.003","article-title":"A platform for discovery: the University of Pennsylvania Integrated Neurodegenerative Disease Biobank","volume":"10","author":"Toledo","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.mcpro.2025.101458_bib107","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.36","article-title":"Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease","volume":"5","author":"Ping","year":"2018","journal-title":"Sci. Data"},{"key":"10.1016\/j.mcpro.2025.101458_bib108","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mcpro.2025.101458_bib109","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1016\/j.celrep.2019.11.093","article-title":"Dysregulation of RNA splicing in tauopathies","volume":"29","author":"Apicco","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.mcpro.2025.101458_bib110","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fnagi.2018.00075","article-title":"U1 snRNP alteration and neuronal cell cycle reentry in alzheimer disease","volume":"10","author":"Bai","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib111","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40478-021-01219-1","article-title":"Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease","volume":"9","author":"McMillan","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105130","article-title":"TDP-43 and tau oligomers in Alzheimer's Disease, amyotrophic lateral sclerosis, and frontotemporal dementia","volume":"146","author":"Montalbano","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mcpro.2025.101458_bib113","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41586-020-2077-3","article-title":"A large-scale binding and functional map of human RNA-binding proteins","volume":"583","author":"Van Nostrand","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101458_bib47","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000348406","article-title":"Altered expression of RNA splicing proteins in Alzheimer's disease patients: evidence from two microarray studies","volume":"3","author":"Wong","year":"2013","journal-title":"Dement Geriatr. Cogn. Dis. Extra"},{"key":"10.1016\/j.mcpro.2025.101458_bib48","doi-asserted-by":"crossref","first-page":"34088","DOI":"10.1074\/jbc.M111.243907","article-title":"Interactions of pathological hallmark proteins: tubulin polymerization promoting protein\/p25, beta-amyloid, and alpha-synuclein","volume":"286","author":"Olah","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2025.101458_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2024.111930","article-title":"Molecular mechanisms implicated in protein changes in the Alzheimer's disease human hippocampus","volume":"219","author":"Nguyen","year":"2024","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mcpro.2025.101458_bib114","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097955","article-title":"Exploring the genetic predisposition to epigenetic changes in Alzheimer's Disease","volume":"24","author":"Bryzgalov","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcpro.2025.101458_bib115","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100569R","article-title":"Systemic depletion of histone macroH2A1.1 boosts hippocampal synaptic plasticity and social behavior in mice","volume":"35","author":"Chiodi","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.mcpro.2025.101458_bib116","article-title":"Diagnostic implications of ubiquitination-related gene signatures in Alzheimer's disease","volume":"14","author":"Xu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2025.101458_bib117","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1242\/jcs.115.15.3033","article-title":"mRNA surveillance: the perfect persist","volume":"115","author":"Wagner","year":"2002","journal-title":"J. Cell Sci"},{"key":"10.1016\/j.mcpro.2025.101458_bib118","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.tibs.2011.07.005","article-title":"A brief survey of mRNA surveillance","volume":"36","author":"van Hoof","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mcpro.2025.101458_bib119","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000120","article-title":"The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay","volume":"7","author":"Gehring","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mcpro.2025.101458_bib120","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.15252\/embr.201541116","article-title":"The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches","volume":"16","author":"Daguenet","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mcpro.2025.101458_bib121","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1002\/pmic.201600057","article-title":"Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression","volume":"16","author":"Hales","year":"2016","journal-title":"Proteomics"},{"key":"10.1016\/j.mcpro.2025.101458_bib122","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00439-016-1683-5","article-title":"The hnRNP family: insights into their role in health and disease","volume":"135","author":"Geuens","year":"2016","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mcpro.2025.101458_bib123","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s40478-018-0615-0","article-title":"Formation of toxic oligomeric assemblies of RNA-binding protein: Musashi in Alzheimer's disease","volume":"6","author":"Sengupta","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib124","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/alz.12653","article-title":"Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration","volume":"19","author":"Zuniga","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.mcpro.2025.101458_bib125","article-title":"Enrichment of detergent-insoluble protein aggregates from Human postmortem brain","volume":"128","author":"Diner","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.mcpro.2025.101458_bib126","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1021\/pr5003593","article-title":"Integrated approaches for analyzing U1-70K cleavage in Alzheimer's disease","volume":"13","author":"Bai","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2025.101458_bib127","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101458_bib128","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.tibs.2015.08.012","article-title":"Emerging roles of disordered sequences in RNA-Binding proteins","volume":"40","author":"Calabretta","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mcpro.2025.101458_bib129","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41467-017-00480-0","article-title":"Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau","volume":"8","author":"Ambadipudi","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib130","doi-asserted-by":"crossref","first-page":"13056","DOI":"10.1021\/jacs.1c03078","article-title":"Conformational expansion of Tau in condensates promotes irreversible aggregation","volume":"143","author":"Wen","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mcpro.2025.101458_bib131","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/brain\/awad378","article-title":"Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments","volume":"147","author":"Kumar","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.mcpro.2025.101458_bib132","doi-asserted-by":"crossref","first-page":"13982","DOI":"10.1021\/ja305470p","article-title":"beta-Sheet core of tau paired helical filaments revealed by solid-state NMR","volume":"134","author":"Daebel","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.mcpro.2025.101458_bib133","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1073\/pnas.97.10.5129","article-title":"Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure","volume":"97","author":"von Bergen","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101458_bib134","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41419-024-06815-2","article-title":"Tau(P301L) disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability","volume":"15","author":"Hole","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mcpro.2025.101458_bib135","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13578-023-01164-7","article-title":"Differential interactome mapping of aggregation prone\/prion-like proteins under stress: novel links to stress granule biology","volume":"13","author":"Younas","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.mcpro.2025.101458_bib136","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1021\/acs.jproteome.0c00137","article-title":"Physiological Tau interactome in brain and its link to tauopathies","volume":"19","author":"Sinsky","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2025.101458_bib137","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s42003-020-0758-y","article-title":"Biotin proximity tagging favours unfolded proteins and enables the study of intrinsically disordered regions","volume":"3","author":"Minde","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mcpro.2025.101458_bib138","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3233\/JAD-150298","article-title":"Identification of novel tau interactions with endoplasmic reticulum proteins in Alzheimer's Disease brain","volume":"48","author":"Meier","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mcpro.2025.101458_bib139","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/s41467-024-47028-7","article-title":"Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer's pathology","volume":"15","author":"Kumar","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101458_bib140","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/acel.12501","article-title":"Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls","volume":"15","author":"Ayyadevara","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.mcpro.2025.101458_bib141","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41586-023-06437-2","article-title":"Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids","volume":"621","author":"Scheres","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101458_bib142","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13024-020-00389-1","article-title":"FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments","volume":"15","author":"Kaniyappan","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mcpro.2025.101458_bib143","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-81687-2","article-title":"Effects of the therapeutic correction of U1 snRNP complex on Alzheimer's disease","volume":"14","author":"Leal","year":"2024","journal-title":"Sci. Rep."}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625005572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947625005572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:27:22Z","timestamp":1770384442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947625005572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":144,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1535947625005572"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.101458","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proximity Labeling of the Tau Repeat Domain Enriches RNA-Binding Proteins That Are Altered in Alzheimer's Disease and Related Tauopathies","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.101458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"101458"}}