{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:35:21Z","timestamp":1783629321125,"version":"3.55.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341079"],"award-info":[{"award-number":["82341079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2024YFA1108400"],"award-info":[{"award-number":["2024YFA1108400"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2023-I2M-3-002"],"award-info":[{"award-number":["2023-I2M-3-002"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2023-I2M-QJ-001"],"award-info":[{"award-number":["2023-I2M-QJ-001"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z231100007223009"],"award-info":[{"award-number":["Z231100007223009"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.mcpro.2025.101482","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T16:54:00Z","timestamp":1765299240000},"page":"101482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spatially Resolved Proteomic Mapping in Skin Organoid for Hair Follicle Development"],"prefix":"10.1016","volume":"25","author":[{"given":"Luling","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3223-1446","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6519-012X","authenticated-orcid":false,"given":"Ling","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2025.101482_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/bies.20184","article-title":"Molecular principles of hair follicle induction and morphogenesis","volume":"27","author":"Schmidt-Ullrich","year":"2005","journal-title":"Bioessays"},{"key":"10.1016\/j.mcpro.2025.101482_bib2","doi-asserted-by":"crossref","first-page":"R132","DOI":"10.1016\/j.cub.2008.12.005","article-title":"The hair follicle as a dynamic miniorgan","volume":"19","author":"Schneider","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mcpro.2025.101482_bib3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1046\/j.1523-1747.1999.00740.x","article-title":"A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis","volume":"113","author":"Paus","year":"1999","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib4","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3390\/ijms15011647","article-title":"Signaling involved in hair follicle morphogenesis and development","volume":"15","author":"Rishikaysh","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcpro.2025.101482_bib5","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.2147\/DDDT.S214907","article-title":"Minoxidil and its use in hair disorders: a review","volume":"13","author":"Suchonwanit","year":"2019","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.mcpro.2025.101482_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12016-021-08883-0","article-title":"Alopecia areata: an update on etiopathogenesis, diagnosis, and management","volume":"61","author":"Zhou","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.mcpro.2025.101482_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41586-020-2352-3","article-title":"Hair-bearing human skin generated entirely from pluripotent stem cells","volume":"582","author":"Lee","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101482_bib8","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/s41596-022-00681-y","article-title":"Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells","volume":"17","author":"Lee","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2025.101482_bib9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.cell.2024.12.023","article-title":"High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning","volume":"188","author":"Hu","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101482_bib10","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1038\/s41467-022-31659-9","article-title":"Spatially resolved proteomic map shows that extracellular matrix regulates epidermal growth","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2025.101482_bib11","article-title":"Establishment of human pluripotent stem cell-derived skin organoids enabled pathophysiological model of SARS-CoV-2 infection","volume":"9","author":"Ma","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.mcpro.2025.101482_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110955","article-title":"Spatial region-resolved proteome map reveals mechanism of COVID-19-associated heart injury","volume":"39","author":"Leng","year":"2022","journal-title":"Cell. Rep."},{"key":"10.1016\/j.mcpro.2025.101482_bib13","doi-asserted-by":"crossref","first-page":"D1211","DOI":"10.1093\/nar\/gky869","article-title":"iProX: an integrated proteome resource","volume":"47","author":"Ma","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib14","doi-asserted-by":"crossref","first-page":"D1522","DOI":"10.1093\/nar\/gkab1081","article-title":"iProX in 2021: connecting proteomics data sharing with big data","volume":"50","author":"Chen","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib15","article-title":"Principal component analysis and biplots. A back-to-basics comparison of implementations","author":"Settanni","year":"2024","journal-title":"arXiv"},{"key":"10.1016\/j.mcpro.2025.101482_bib16","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/wics.147","article-title":"ggplot2","volume":"3","author":"Wickham","year":"2011","journal-title":"WIREs Comput. Stat."},{"key":"10.1016\/j.mcpro.2025.101482_bib17","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2025.101482_bib18","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.mcpro.2025.101482_bib19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","article-title":"Cytoscape 2.8: new features for data integration and network visualization","volume":"27","author":"Smoot","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2025.101482_bib20","doi-asserted-by":"crossref","first-page":"D730","DOI":"10.1093\/nar\/gkae1113","article-title":"The STRING database in 2025: protein networks with directionality of regulation","volume":"53","author":"Szklarczyk","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib21","doi-asserted-by":"crossref","first-page":"D1136","DOI":"10.1093\/nar\/gkz849","article-title":"MatrisomeDB: the ECM-protein knowledge database","volume":"48","author":"Shao","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib22","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","article-title":"Circlize implements and enhances circular visualization in R","volume":"30","author":"Gu","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2025.101482_bib23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.abd.2019.09.028","article-title":"Immunostaining study of cytokeratins in human hair follicle development","volume":"95","author":"Silva","year":"2020","journal-title":"Bras Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib24","article-title":"Integration analysis of hair follicle transcriptome and proteome reveals the mechanisms regulating wool fiber diameter in angora rabbits","volume":"25","author":"Huang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcpro.2025.101482_bib25","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101482_bib26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.mcpro.2025.101482_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99652-8","article-title":"Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase","volume":"11","author":"Figlak","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2025.101482_bib28","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1038\/jid.2015.248","article-title":"Photoactivation of ROS production in situ transiently activates cell proliferation in mouse skin and in the hair follicle stem cell niche promoting hair growth and wound healing","volume":"135","author":"Carrasco","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.smallrumres.2021.106408","article-title":"Proteomics analysis of the secondary hair follicle cycle in Liaoning cashmere goat","volume":"201","author":"Gao","year":"2021","journal-title":"Small Ruminant Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib30","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1681\/ASN.2006010083","article-title":"Protein degradation by the ubiquitin-proteasome pathway in normal and disease states","volume":"17","author":"Lecker","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mcpro.2025.101482_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165672","article-title":"Inhibition of Rab27a and Rab27b has opposite effects on the regulation of hair cycle and hair growth","volume":"21","author":"Ku","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcpro.2025.101482_bib32","doi-asserted-by":"crossref","first-page":"R81","DOI":"10.1186\/bcr3475","article-title":"A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients","volume":"15","author":"Chung","year":"2013","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib33","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1093\/hmg\/ddab123","article-title":"Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy","volume":"30","author":"Botta","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mcpro.2025.101482_bib34","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ajhg.2018.09.011","article-title":"Bi-allelic mutations in LSS, encoding lanosterol synthase, cause autosomal-recessive hypotrichosis simplex","volume":"103","author":"Romano","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mcpro.2025.101482_bib35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1159\/000511126","article-title":"New homozygous missense MSMO1 mutation in two siblings with SC4MOL deficiency presenting with psoriasiform dermatitis","volume":"160","author":"Kalay Yildizhan","year":"2020","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ygeno.2010.05.002","article-title":"Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures","volume":"96","author":"Subramanya","year":"2010","journal-title":"Genomics"},{"key":"10.1016\/j.mcpro.2025.101482_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.899095","article-title":"Morphogenesis, growth cycle and molecular regulation of hair follicles","volume":"10","author":"Lin","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2025.101482_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0303742","article-title":"Activation of the integrated stress response in human hair follicles","volume":"19","author":"Pye","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2025.101482_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230380","article-title":"\u03b1-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity","volume":"15","author":"Altst\u00e4tter","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2025.101482_bib40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0092-8674(03)00273-3","article-title":"Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris","volume":"113","author":"Kljuic","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2025.101482_bib41","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-0625.2008.00777.x","article-title":"Molecular elements of the regulatory control of keratin filament modulator AHF\/trichohyalin in the hair follicle","volume":"18","author":"Yamamoto","year":"2009","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31181","article-title":"M1 polarization of macrophages promotes stress-induced hair loss via interleukin-18 and interleukin-1\u03b2","volume":"239","author":"Xiao","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mcpro.2025.101482_bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41580-023-00662-3","article-title":"Local and systemic mechanisms that control the hair follicle stem cell niche","volume":"25","author":"Zhang","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mcpro.2025.101482_bib44","doi-asserted-by":"crossref","first-page":"0125","DOI":"10.34133\/bmr.0125","article-title":"High-Throughput screening of 3-Dimensional Co-culture hair follicle mimetic tissue with an enhanced extracellular matrix for the screening of hair growth-promoting compounds","volume":"28","author":"Pham","year":"2024","journal-title":"Biomater. Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad4395","article-title":"Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis","volume":"351","author":"Matsumura","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2025.101482_bib46","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41586-021-03624-x","article-title":"Obesity accelerates hair thinning by stem cell-centric converging mechanisms","volume":"595","author":"Morinaga","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2025.101482_bib47","article-title":"Rab10-CAV1 mediated intraluminal vesicle transport to migrasomes","volume":"121","author":"Li","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101482_bib48","article-title":"Integration analysis of transcriptome sequencing and whole-genome resequencing reveal wool quality-associated key genes in Zhexi Angora rabbits","volume":"11","author":"Zhao","year":"2024","journal-title":"Vet. Sci."},{"key":"10.1016\/j.mcpro.2025.101482_bib49","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.matbio.2018.06.004","article-title":"CD44-dependent inflammation, fibrogenesis, and collagenolysis regulates extracellular matrix remodeling and tensile strength during cutaneous wound healing","volume":"75-76","author":"Govindaraju","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.mcpro.2025.101482_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s12272-021-01305-x","article-title":"Skin barrier dysfunction and filaggrin","volume":"44","author":"Kim","year":"2021","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.mcpro.2025.101482_bib51","doi-asserted-by":"crossref","first-page":"19537","DOI":"10.1073\/pnas.1309576110","article-title":"Keratin 16 regulates innate immunity in response to epidermal barrier breach","volume":"110","author":"Lessard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2025.101482_bib52","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1172\/JCI84870","article-title":"Oxidative stress and dysfunctional NRF2 underlie pachyonychia congenita phenotypes","volume":"126","author":"Kerns","year":"2016","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.mcpro.2025.101482_bib53","article-title":"Keratin 17 is required for lipid metabolism in keratinocytes and benefits epidermal permeability barrier homeostasis","volume":"9","author":"Pang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2025.101482_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jdermsci.2011.08.008","article-title":"Exclusion of CTSB and FDFT1 as positional and functional candidate genes for keratolytic winter erythema (KWE)","volume":"65","author":"Hobbs","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.mcpro.2025.101482_bib55","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1007\/s00109-005-0721-x","article-title":"Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals","volume":"83","author":"Kulski","year":"2005","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.mcpro.2025.101482_bib56","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1086\/497707","article-title":"A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome","volume":"77","author":"Cassidy","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mcpro.2025.101482_bib57","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1242\/dev.076463","article-title":"Dermal \u03b2-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation","volume":"139","author":"Chen","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.mcpro.2025.101482_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011677","article-title":"The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated \u03b2-catenin degradation and through a mechanism independent of changes in \u03b2-catenin abundance","volume":"21","author":"McKenna","year":"2025","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mcpro.2025.101482_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2023.116756","article-title":"Fam83h mutation causes mandible underdevelopment via CK1\u03b1-mediated Wnt\/\u03b2-catenin signaling in male C57\/BL6J mice","volume":"172","author":"He","year":"2023","journal-title":"Bone"},{"key":"10.1016\/j.mcpro.2025.101482_bib60","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/jid.2012.27","article-title":"The cell cycle regulator protein 14-3-3\u03c3 is essential for hair follicle integrity and epidermal homeostasis","volume":"132","author":"Hammond","year":"2012","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib61","first-page":"435","article-title":"Cicatricial alopecia","volume":"16","author":"Kanti","year":"2018","journal-title":"J. Dtsch Dermatol. Ges."},{"key":"10.1016\/j.mcpro.2025.101482_bib62","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.celrep.2017.12.007","article-title":"Hair follicle development in Mouse pluripotent stem cell-derived skin organoids","volume":"22","author":"Lee","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2025.101482_bib63","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fcell.2020.00338","article-title":"Dicer- and Bulge stem cell-dependent MicroRNAs during induced anagen hair follicle development","volume":"8","author":"Vishlaghi","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2025.101482_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002403","article-title":"The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate","volume":"7","author":"Blanco","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mcpro.2025.101482_bib65","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200520","article-title":"Methionine can subside hair follicle development prejudice of heat-stressed rex rabbits","volume":"36","author":"Li","year":"2022","journal-title":"FASEB J"},{"key":"10.1016\/j.mcpro.2025.101482_bib66","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/jpn.13238","article-title":"Methionine promotes the development of hair follicles via the Wnt\/\u03b2-catenin signalling pathway in Rex rabbits","volume":"104","author":"Zhu","year":"2020","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl)"},{"key":"10.1016\/j.mcpro.2025.101482_bib67","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1096\/fj.99-0970com","article-title":"Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling","volume":"14","author":"Roth","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.mcpro.2025.101482_bib68","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12864-022-08422-x","article-title":"The fiber diameter traits of Tibetan cashmere goats are governed by the inherent differences in stress, hypoxic, and metabolic adaptations: an integrative study of proteome and transcriptome","volume":"23","author":"Zhao","year":"2022","journal-title":"BMC Genomics"},{"key":"10.1016\/j.mcpro.2025.101482_bib69","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/exd.13993","article-title":"Cholesterol homeostasis: links to hair follicle biology and hair disorders","volume":"29","author":"Palmer","year":"2020","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib70","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202403083","article-title":"Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment","volume":"224","author":"Peters","year":"2025","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mcpro.2025.101482_bib71","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.stemcr.2017.09.015","article-title":"Alkaline ceramidase 1 protects mice from premature hair loss by maintaining the homeostasis of hair follicle stem cells","volume":"9","author":"Lin","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.mcpro.2025.101482_bib72","article-title":"Integrated transcriptomics and metabolomics analyses of stress-induced murine hair follicle growth inhibition","volume":"9","author":"Wang","year":"2022","journal-title":"Front Mol. Biosci."},{"key":"10.1016\/j.mcpro.2025.101482_bib73","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1186\/s12864-023-09803-6","article-title":"Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs","volume":"24","author":"Zhou","year":"2023","journal-title":"BMC Genomics"},{"key":"10.1016\/j.mcpro.2025.101482_bib74","article-title":"Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice","volume":"24","author":"He","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.mcpro.2025.101482_bib75","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jdermsci.2015.04.009","article-title":"Update on autosomal recessive congenital ichthyosis: mRNA analysis using hair samples is a powerful tool for genetic diagnosis","volume":"79","author":"Sugiura","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.mcpro.2025.101482_bib76","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1523-1747.2001.00215.x","article-title":"A unique type I keratin intermediate filament gene family is abundantly expressed in the inner root sheaths of sheep and human hair follicles","volume":"116","author":"Bawden","year":"2001","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib77","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2133.2004.05775.x","article-title":"Gap junction development in the human fetal hair follicle and bulge region","volume":"150","author":"Arita","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib78","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1046\/j.1365-2133.2002.04869.x","article-title":"Formation of cornified cell envelope in human hair follicle development","volume":"146","author":"Akiyama","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib79","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/ijd.17406","article-title":"The efficacy of adipose stem cell-derived exosomes in hair regeneration based on a preclinical and clinical study","volume":"63","author":"Lee","year":"2024","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib80","doi-asserted-by":"crossref","DOI":"10.1093\/pcmedi\/pbac020","article-title":"JAM-A facilitates hair follicle regeneration in alopecia areata through functioning as ceRNA to protect VCAN expression in dermal papilla cells","volume":"5","author":"Wu","year":"2022","journal-title":"Precis Clin. Med."},{"key":"10.1016\/j.mcpro.2025.101482_bib81","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1038\/jid.2008.370","article-title":"Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin","volume":"129","author":"Wu","year":"2009","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib82","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/jid.2014.3","article-title":"Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation","volume":"134","author":"Miyai","year":"2014","journal-title":"J. Invest Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib83","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1365-2133.2009.09154.x","article-title":"Human hair follicle epithelium has an antimicrobial defence system that includes the inducible antimicrobial peptide psoriasin (S100A7) and RNase 7","volume":"161","author":"Reithmayer","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.mcpro.2025.101482_bib84","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70152","article-title":"Exosome-derived long non-coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8\/Wnt\/\u03b2-catenin signalling","volume":"15","author":"Chu","year":"2025","journal-title":"Clin. Transl Med."}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762500581X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762500581X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:25:39Z","timestamp":1778617539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153594762500581X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S153594762500581X"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.101482","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatially Resolved Proteomic Mapping in Skin Organoid for Hair Follicle Development","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2025.101482","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101482"}}