{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:46:33Z","timestamp":1788684393739,"version":"build-2803163510"},"reference-count":103,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["949184"],"award-info":[{"award-number":["949184"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002345","name":"University of T\u00fcbingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["949735"],"award-info":[{"award-number":["949735"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.mcpro.2026.101567","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T07:52:05Z","timestamp":1775721125000},"page":"101567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deciphering Membrane Protein Complexes in Plasmodium falciparum Gametocytes via Integrative Structural Systems Biology"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-3285","authenticated-orcid":false,"given":"Siavash","family":"Mostafavi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7670-0586","authenticated-orcid":false,"given":"Valentin","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7220-406X","authenticated-orcid":false,"given":"Max","family":"Ruwolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korbinian","family":"Niederm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-8272","authenticated-orcid":false,"given":"Tim Wolf","family":"Gilberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Seuring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kosinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"L\u00f6w","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3514-1711","authenticated-orcid":false,"given":"Michael","family":"Filarsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2026.101567_bib1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0140-6736(25)00038-8","article-title":"Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum and Plasmodium vivax malaria, 2000-22: a spatial and temporal modelling study","volume":"405","author":"Weiss","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.mcpro.2026.101567_bib2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2016.07.055","article-title":"Malaria: biology and disease","volume":"167","author":"Cowman","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2026.101567_bib3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0035-9203(71)90036-8","article-title":"Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparum","volume":"65","author":"Hawking","year":"1971","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.mcpro.2026.101567_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008882","article-title":"Plasmodium falciparum transmission stages accumulate in the human bone marrow","volume":"6","author":"Joice","year":"2014","journal-title":"Sci. Transl Med."},{"key":"10.1016\/j.mcpro.2026.101567_bib5","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41467-018-04108-9","article-title":"A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2026.101567_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat3775","article-title":"Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow","volume":"4","author":"De Niz","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mcpro.2026.101567_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00625-18","article-title":"Bone marrow is a major parasite reservoir in Plasmodium vivax infection","volume":"9","author":"Obaldia","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.mcpro.2026.101567_bib8","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s42003-022-03510-w","article-title":"Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes","volume":"5","author":"Paonessa","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.pt.2022.01.011","article-title":"Transmission-blocking drugs for malaria elimination","volume":"38","author":"Birkholtz","year":"2022","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00013-19","article-title":"Host cytoskeleton remodeling throughout the blood stages of Plasmodium falciparum","volume":"83","author":"Warncke","year":"2019","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.mcpro.2026.101567_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1074\/mcp.M900479-MCP200","article-title":"Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum","volume":"9","author":"Silvestrini","year":"2010","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2026.101567_bib12","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.3389\/fmicb.2019.02652","article-title":"Erythrocyte membrane makeover by Plasmodium falciparum gametocytes","volume":"10","author":"Neveu","year":"2019","journal-title":"Front Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib13","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s42003-020-01454-7","article-title":"Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability","volume":"3","author":"Bouyer","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.611801","article-title":"The dynamic roles of the inner membrane complex in the multiple stages of the malaria parasite","volume":"10","author":"Ferreira","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib15","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.celrep.2019.07.019","article-title":"Landscape of the plasmodium interactome reveals both conserved and species-specific functionality","volume":"28","author":"Hillier","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2026.101567_bib16","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1038\/s41467-021-23919-x","article-title":"Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum","volume":"12","author":"Evers","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2026.101567_bib17","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1021\/acs.jproteome.4c00414","article-title":"Analysis of complexome profiles with the Gaussian Interaction Profiler (GIP) reveals novel protein complexes in Plasmodium falciparum","volume":"23","author":"van Strien","year":"2024","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2026.101567_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tibs.2021.10.006","article-title":"Structural parasitology of the malaria parasite Plasmodium falciparum","volume":"47","author":"Anton","year":"2022","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mcpro.2026.101567_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2026.101567_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2026.101567_bib21","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1038\/s41467-021-24954-4","article-title":"CRISPR\/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research","volume":"12","author":"Boltryk","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2026.101567_bib22","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Synchronization of Plasmodium falciparum erythrocytic stages in culture","volume":"65","author":"Lambros","year":"1979","journal-title":"J. Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molbiopara.2007.04.008","article-title":"Improved synchronous production of Plasmodium falciparum gametocytes in vitro","volume":"154","author":"Fivelman","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.15252\/msb.20145625","article-title":"Ultrasensitive proteome analysis using paramagnetic bead technology","volume":"10","author":"Hughes","year":"2014","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib25","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mcpro.2026.101567_bib26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41596-018-0082-x","article-title":"Single-pot, solid-phase-enhanced sample preparation for proteomics experiments","volume":"14","author":"Hughes","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mcpro.2026.101567_bib27","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1038\/s41592-024-02478-1","article-title":"Proteome-scale recombinant standards and a robust high-speed search engine to advance cross-linking MS-based interactomics","volume":"21","author":"Clasen","year":"2024","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2026.101567_bib28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nmeth.4256","article-title":"MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry\u2013based proteomics","volume":"14","author":"Kong","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2026.101567_bib29","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1074\/mcp.O114.042259","article-title":"xiNET: cross-link network maps with residue resolution","volume":"14","author":"Combe","year":"2015","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2026.101567_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btaf115","article-title":"AlphaPulldown2-a general pipeline for high-throughput structural modeling","volume":"41","author":"Molodenskiy","year":"2025","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mcpro.2026.101567_bib31","doi-asserted-by":"crossref","first-page":"D564","DOI":"10.1093\/nar\/gkae1091","article-title":"Updated resources for exploring experimentally-determined PDB structures and computed structure models at the RCSB protein data bank","volume":"53","author":"Burley","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2026.101567_bib32","series-title":"Improving AlphaFold 3 Structural Modeling by Incorporating Explicit Crosslinks","author":"Gilep","year":"2024"},{"key":"10.1016\/j.mcpro.2026.101567_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4792","article-title":"UCSF ChimeraX: tools for structure building and analysis","volume":"32","author":"Meng","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.mcpro.2026.101567_bib34","doi-asserted-by":"crossref","first-page":"W404","DOI":"10.1093\/nar\/gkad350","article-title":"PAE viewer: a webserver for the interactive visualization of the predicted aligned error for multimer structure predictions and crosslinks","volume":"51","author":"Elfmann","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2026.101567_bib35","article-title":"AlphaFold2 and AlphaFold3 leads to significantly different results in human-parasite interaction prediction","author":"Ozden","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mcpro.2026.101567_bib36","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.1073\/pnas.1520194113","article-title":"Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages","volume":"113","author":"Dearnley","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2026.101567_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.molbiopara.2019.111189","article-title":"The Plasmodium falciparum MESA erythrocyte cytoskeleton-binding (MEC) motif binds to erythrocyte ankyrin","volume":"231","author":"Kilili","year":"2019","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13123","article-title":"The PHIST protein GEXP02 targets the host cytoskeleton during sexual development of Plasmodium falciparum","volume":"22","author":"Warncke","year":"2020","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib39","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41594-022-00792-w","article-title":"Architecture of the human erythrocyte ankyrin-1 complex","volume":"29","author":"Vallese","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib40","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbamem.2012.11.030","article-title":"Stomatin interacts with GLUT1\/SLC2A1, band 3\/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains","volume":"1828","author":"Rungaldier","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcpro.2026.101567_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61295-w","article-title":"APEX2-based proximity proteomic analysis identifies candidate interactors for Plasmodium falciparum knob-associated histidine-rich protein in infected erythrocytes","volume":"14","author":"Charneau","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2026.101567_bib42","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1091\/mbc.e02-04-0240","article-title":"Etramps, a new Plasmodium falciparum gene family coding for developmentally regulated and highly charged membrane proteins located at the parasite-host cell interface","volume":"14","author":"Spielmann","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mcpro.2026.101567_bib43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1042\/BJ20121008","article-title":"Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology","volume":"448","author":"Wieschhaus","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.mcpro.2026.101567_bib44","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.1171085","article-title":"Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells","volume":"324","author":"Chandramohanadas","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2026.101567_bib45","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/mmi.15125","article-title":"Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells","volume":"121","author":"Sassmannshausen","year":"2024","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib46","doi-asserted-by":"crossref","first-page":"9592","DOI":"10.1038\/s41598-022-13415-7","article-title":"Identification and preliminary characterization of Plasmodium falciparum proteins secreted upon gamete formation","volume":"12","author":"Grasso","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2026.101567_bib47","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1038\/s41467-023-41721-9","article-title":"AlphaFold-Multimer predicts cross-kingdom interactions at the plant-pathogen interface","volume":"14","author":"Homma","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2026.101567_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1013168","article-title":"AI-first structural identification of pathogenic protein target interfaces","volume":"21","author":"Saluri","year":"2025","journal-title":"Plos Comput. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib49","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s42003-025-07933-z","article-title":"Multimodal SARS-CoV-2 interactome sketches the virus-host spatial organization","volume":"8","author":"Dugied","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib50","article-title":"AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry","author":"Baptista","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mcpro.2026.101567_bib51","doi-asserted-by":"crossref","first-page":"7721","DOI":"10.1038\/s41586-018-0469-4","article-title":"Malaria parasite translocon structure and mechanism of effector export","volume":"561","author":"Ho","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2026.101567_bib52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65282","article-title":"Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake","volume":"10","author":"Schureck","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.mcpro.2026.101567_bib53","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s42003-022-03290-3","article-title":"RhopH2 and RhopH3 export enables assembly of the RhopH complex on P. Falciparum-infected erythrocyte membranes","volume":"5","author":"Pasternak","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib54","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/jcp.1041250323","article-title":"Characterization of permeation pathways in the plasma membrane of human erythrocytes infected with early stages of plasmodium falciparum: association with parasite development","volume":"125","author":"Kutner","year":"1985","journal-title":"J. Cell Physiol"},{"key":"10.1016\/j.mcpro.2026.101567_bib55","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2011.05.002","article-title":"Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells","volume":"145","author":"Nguitragool","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2026.101567_bib56","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12733","article-title":"The plasmodium rhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth","volume":"19","author":"Ghosh","year":"2017","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib57","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1365-3024.1987.tb00511.x","article-title":"Target antigens of malaria transmission blocking immunity exist as a stable membrane bound complex","volume":"9","author":"Kumar","year":"1987","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.mcpro.2026.101567_bib58","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.molbiopara.2003.10.014","article-title":"Functional analysis of Plasmodium falciparum parasitophorous vacuole membrane protein (Pfs16) during gametocytogenesis and gametogenesis by targeted gene disruption","volume":"133","author":"Kongkasuriyachai","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104824","article-title":"Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity","volume":"299","author":"Ramelow","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2026.101567_bib60","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0166-6851(97)00123-0","article-title":"Developmentally regulated expression of pfs16, a marker for sexual differentiation of the human malaria parasite Plasmodium falciparum","volume":"89","author":"Dechering","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib61","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260506","article-title":"Time-resolved proximity biotinylation implicates a porin protein in export of transmembrane malaria parasite effectors","volume":"136","author":"Anaguano","year":"2023","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mcpro.2026.101567_bib62","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1128\/EC.00336-09","article-title":"Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages","volume":"9","author":"Mackellar","year":"2010","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.mcpro.2026.101567_bib63","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2958.2009.06762.x","article-title":"The Plasmodium falciparum protein Pfg27 is dispensable for gametocyte and gamete production, but contributes to cell integrity during gametocytogenesis","volume":"73","author":"Olivieri","year":"2009","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib64","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ijpara.2009.11.006","article-title":"Regulated oligomerisation and molecular interactions of the early gametocyte protein Pfg27 in Plasmodium falciparum sexual differentiation","volume":"40","author":"Camarda","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41467-024-55413-5","article-title":"Comparative 3D ultrastructure of Plasmodium falciparum gametocytes","volume":"16","author":"Evers","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2026.101567_bib66","doi-asserted-by":"crossref","first-page":"13327","DOI":"10.1074\/jbc.RA118.003640","article-title":"Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes","volume":"293","author":"Rosling","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mcpro.2026.101567_bib67","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2012.12.006","article-title":"Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials","volume":"13","author":"Spillman","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mcpro.2026.101567_bib68","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.1193225","article-title":"Spiroindolones, a potent compound class for the treatment of malaria","volume":"329","author":"Rottmann","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.mcpro.2026.101567_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.909060","article-title":"Heterologous expression and evaluation of novel Plasmodium falciparum transmission blocking vaccine candidates","volume":"13","author":"de Jong","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mcpro.2026.101567_bib70","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12936-016-1337-z","article-title":"An evolutionary approach to identify potentially protective B cell epitopes involved in naturally acquired immunity to malaria and the role of EBA-175 in protection amongst denizens of Bolifamba","volume":"15","author":"Nyasa","year":"2016","journal-title":"Cameroon. Malar. J."},{"key":"10.1016\/j.mcpro.2026.101567_bib71","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1093\/nar\/gkw536","article-title":"Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression","volume":"44","author":"Lasonder","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mcpro.2026.101567_bib72","article-title":"Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development","volume":"13","author":"Schneider","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.mcpro.2026.101567_bib73","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15781-z","article-title":"Photosensitized INA-labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for plasmodium parasite development","volume":"7","author":"Saini","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2026.101567_bib74","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ceb.2016.03.007","article-title":"Role of the ER and golgi in protein export by apicomplexa","volume":"41","author":"Coffey","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib75","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/mmi.14526","article-title":"A plasmodium homolog of ER tubule-forming proteins is required for parasite virulence","volume":"114","author":"Shi","year":"2020","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009293","article-title":"A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites","volume":"17","author":"Cobb","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.mcpro.2026.101567_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12843","article-title":"Identification of a golgi apparatus protein complex important for the asexual erythrocytic cycle of the malaria parasite Plasmodium falciparum","volume":"20","author":"Hall\u00e9e","year":"2018","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib78","doi-asserted-by":"crossref","DOI":"10.1017\/S0016672319000090","article-title":"Transmembrane emp24 domain proteins in development and disease","volume":"101","author":"Aber","year":"2019","journal-title":"Genet. Res. (Camb)"},{"key":"10.1016\/j.mcpro.2026.101567_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.774537","article-title":"Characterization of naturally acquired immunity to a panel of antigens expressed in mature P. falciparum gametocytes","volume":"11","author":"Muthui","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.mcpro.2026.101567_bib80","doi-asserted-by":"crossref","first-page":"624","DOI":"10.12688\/f1000research.6944.1","article-title":"The ubiquitous and ancient ER membrane protein complex (EMC): tether or not?","volume":"4","author":"Wideman","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.mcpro.2026.101567_bib81","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41586-020-2389-3","article-title":"Structure of the ER membrane complex, a transmembrane-domain insertase","volume":"584","author":"Bai","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2026.101567_bib82","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04164-22","article-title":"Phenotypic screens identify genetic factors associated with gametocyte development in the human malaria parasite Plasmodium falciparum","volume":"11","author":"Chawla","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.mcpro.2026.101567_bib83","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.jmb.2017.12.007","article-title":"A completely reimplemented MPI bioinformatics toolkit with a new HHpred server at its core","volume":"430","author":"Zimmermann","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib84","doi-asserted-by":"crossref","first-page":"5704","DOI":"10.1021\/pr3005315","article-title":"Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N-89 and N-251","volume":"11","author":"Morita","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2026.101567_bib85","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03078-19","article-title":"An endoplasmic reticulum CREC family protein regulates the egress proteolytic Cascade in Malaria parasites","volume":"11","author":"Fierro","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.mcpro.2026.101567_bib86","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.biochi.2006.11.001","article-title":"Biochemical properties and cellular localization of Plasmodium falciparum protein disulfide isomerase","volume":"89","author":"Mouray","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.mcpro.2026.101567_bib87","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.ijpara.2006.04.012","article-title":"Protein disulfide isomerase assisted protein folding in malaria parasites","volume":"36","author":"Mahajan","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib88","article-title":"Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis","volume":"119","author":"Wang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2026.101567_bib89","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.neuron.2017.12.038","article-title":"Clptm1 limits forward trafficking of GABAA receptors to scale inhibitory synaptic strength","volume":"97","author":"Ge","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.mcpro.2026.101567_bib90","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1128\/AAC.01096-10","article-title":"Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast","volume":"55","author":"Aminake","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.mcpro.2026.101567_bib91","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1128\/AAC.00088-09","article-title":"The proteasome inhibitor epoxomicin has potent Plasmodium falciparum gametocytocidal activity","volume":"53","author":"Czesny","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.mcpro.2026.101567_bib92","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1574-6976.2006.00027.x","article-title":"Metabolic maps and functions of the plasmodium mitochondrion","volume":"30","author":"van Dooren","year":"2006","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.mcpro.2026.101567_bib93","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cell.2009.08.005","article-title":"Importing mitochondrial proteins: machineries and mechanisms","volume":"138","author":"Chacinska","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2026.101567_bib94","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.celrep.2018.03.088","article-title":"An unusual prohibitin regulates malaria parasite mitochondrial membrane potential","volume":"23","author":"Matz","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.mcpro.2026.101567_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115567","article-title":"Characterization of Plasmodium falciparum prohibitins as novel targets to block infection in humans by impairing the growth and transmission of the parasite","volume":"212","author":"Saini","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.mcpro.2026.101567_bib96","series-title":"The Role of Stomatin-like Protein (STOML) in Plasmodium falciparum","author":"Verhoef","year":"2024"},{"key":"10.1016\/j.mcpro.2026.101567_bib97","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.bbamcr.2008.02.006","article-title":"SLP-2 interacts with prohibitins in the mitochondrial inner membrane and contributes to their stability","volume":"1783","author":"Da Cruz","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mcpro.2026.101567_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-60058-x","article-title":"Identification of domains in Plasmodium falciparum proteins of unknown function using DALI search on AlphaFold predictions","volume":"14","author":"Behrens","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2026.101567_bib99","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature04104","article-title":"A protein interaction network of the malaria parasite Plasmodium falciparum","volume":"438","author":"LaCount","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2026.101567_bib100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pt.2018.08.003","article-title":"Plasmodium parasites viewed through proteomics","volume":"34","author":"Swearingen","year":"2018","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.mcpro.2026.101567_bib101","article-title":"Protein complexes in cells by AI-assisted structural proteomics","volume":"19","author":"O\u2019Reilly","year":"2023","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.mcpro.2026.101567_bib102","article-title":"R\u0113s ipSAE loquuntur: what\u2019s wrong with AlphaFold\u2019s ipTM score and how to fix it","author":"Dunbrack","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.mcpro.2026.101567_bib103","doi-asserted-by":"crossref","first-page":"D543","DOI":"10.1093\/nar\/gkae1011","article-title":"The PRIDE database at 20 years: 2025 update","volume":"53","author":"Perez-Riverol","year":"2024","journal-title":"Nucleic Acids Res."}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947626000630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947626000630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T20:37:52Z","timestamp":1780864672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947626000630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":103,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1535947626000630"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2026.101567","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deciphering Membrane Protein Complexes in Plasmodium falciparum Gametocytes via Integrative Structural Systems Biology","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2026.101567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101567"}}