{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:56:34Z","timestamp":1790733394873,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001858","name":"Sweden's Innovation Agency","doi-asserted-by":"publisher","award":["EPPERMED2024-590 - PerMel- AI"],"award-info":[{"award-number":["EPPERMED2024-590 - PerMel- AI"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004635","name":"Mrs Berta Kamprad Foundation for Research and Combating Cancer Diseases","doi-asserted-by":"publisher","award":["FBKS-2025-18 - (671)"],"award-info":[{"award-number":["FBKS-2025-18 - (671)"]}],"id":[{"id":"10.13039\/501100004635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2025-08202"],"award-info":[{"award-number":["2025-08202"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mcpro.2026.101620","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:38:57Z","timestamp":1783985937000},"page":"101620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["High-Throughput Acoustic FFPE Proteomics Reveals ATP5IF1-Associated Mitochondrial Alterations in Acral Melanoma"],"prefix":"10.1016","volume":"25","author":[{"given":"Diana Lashidua","family":"Fern\u00e1ndez-Coto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1449-1145","authenticated-orcid":false,"given":"Ramiro","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Palmqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma. Fernanda","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scarlett F.","family":"Balderas-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriett","family":"Oskolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Christersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Ful\u00f6p","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"Szigeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H.","family":"Olivera-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilda","family":"Marko-Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Horvatovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9365-7313","authenticated-orcid":false,"given":"Johan","family":"Malm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3605-839X","authenticated-orcid":false,"given":"Leticia","family":"Szadai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-2378","authenticated-orcid":false,"given":"Roberto","family":"Herrera-Goepfert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila Marcell","family":"Szasz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Encarnaci\u00f3n-Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Marko-Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3601-3893","authenticated-orcid":false,"given":"Jeovanis","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2026.101620_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.466","article-title":"A biobanking turning-point in the use of formalin-fixed, paraffin tumor blocks to unveil kinase signaling in melanoma","volume":"11","author":"Velasquez","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.mcpro.2026.101620_bib2","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.3390\/cancers13236105","article-title":"Deep proteomic analysis on biobanked paraffine-archived melanoma with prognostic\/predictive biomarker read-out","volume":"13","author":"Szadai","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mcpro.2026.101620_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2025.101044","article-title":"High-throughput proteomic and phosphoproteomic analysis of formalin-fixed paraffin-embedded tissues","volume":"24","author":"Haines","year":"2025","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.mcpro.2026.101620_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/path.5420","article-title":"A streamlined mass spectrometry\u2013based proteomics workflow for large-scale FFPE tissue analysis","volume":"251","author":"Coscia","year":"2020","journal-title":"J. Pathol."},{"key":"10.1016\/j.mcpro.2026.101620_bib5","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1038\/s41467-021-23855-w","article-title":"Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories","volume":"12","author":"Friedrich","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2026.101620_bib6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s44318-024-00289-w","article-title":"Towards routine proteome profiling of FFPE tissue: insights from a 1,220-case pan-cancer study","volume":"44","author":"T\u00fcshaus","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.mcpro.2026.101620_bib7","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1369\/0022155411400866","article-title":"Antigen retrieval causes protein unfolding: evidence for a linear epitope model of recovered immunoreactivity","volume":"59","author":"Fowler","year":"2011","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.mcpro.2026.101620_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-16935-w","article-title":"Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins","volume":"11","author":"Tayri-Wilk","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2026.101620_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/10520290903039078","article-title":"Molecular mechanisms of antigen retrieval: Antigen retrieval reverses steric interference caused by formalin-induced cross-links","volume":"84","author":"Bogen","year":"2009","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.mcpro.2026.101620_bib10","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1021\/acs.jproteome.8b00505","article-title":"S-Trap, an ultrafast sample-preparation approach for shotgun proteomics","volume":"17","author":"Hailemariam","year":"2018","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2026.101620_bib11","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1021\/acs.jproteome.9b00686","article-title":"HYPERsol: high-quality data from archival FFPE tissue for clinical proteomics","volume":"19","author":"Marchione","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2026.101620_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mex.2014.07.006","article-title":"A novel xylene-free deparaffinization method for the extraction of proteins from human derived formalin-fixed paraffin embedded (FFPE) archival tissue blocks","volume":"1","author":"Mansour","year":"2014","journal-title":"MethodsX"},{"key":"10.1016\/j.mcpro.2026.101620_bib13","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1021\/acs.jproteome.2c00409","article-title":"In-Depth mass spectrometry-based proteomics of formalin-fixed, paraffin-embedded tissues with a spatial resolution of 50\u2013200 \u03bcm","volume":"21","author":"Nwosu","year":"2022","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2026.101620_bib14","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1021\/jasms.3c00099","article-title":"A high-throughput workflow for FFPE tissue proteomics","volume":"34","author":"Pujari","year":"2023","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.mcpro.2026.101620_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.32074\/1591-951X-1006","article-title":"The 2023 WHO updates on skin tumors: advances since the 2018 edition","volume":"116","author":"Fortarezza","year":"2024","journal-title":"Pathologica"},{"key":"10.1016\/j.mcpro.2026.101620_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/pcmr.12885","article-title":"Acral lentiginous melanoma: basic facts, biological characteristics and research perspectives of an understudied disease","volume":"34","author":"Basurto-Lozada","year":"2021","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.mcpro.2026.101620_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/cancers17030468","article-title":"Acral melanoma in skin of color: current insights and future directions: a narrative review","volume":"17","author":"Nadelmann","year":"2025","journal-title":"Cancers"},{"key":"10.1016\/j.mcpro.2026.101620_bib18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jaad.2024.10.124","article-title":"Acral lentiginous melanoma. Part I. epidemiology, etiology, clinical presentation, and diagnosis","volume":"94","author":"Thakker","year":"2026","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.mcpro.2026.101620_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mcpro.2026.101620_bib20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1021\/acs.jproteome.0c00850","article-title":"Proteomic workflows for high-quality quantitative proteome and post-translational modification analysis of clinically relevant samples from formalin-fixed paraffin-embedded archives","volume":"20","author":"Kuras","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2026.101620_bib21","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1021\/ac501354y","article-title":"Measuring the formaldehyde Protein\u2013DNA cross-link reversal rate","volume":"86","author":"Kennedy-Darling","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.mcpro.2026.101620_bib22","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.3390\/cancers13236066","article-title":"An observational study on the molecular profiling of primary melanomas reveals a progression dependence on mitochondrial activation","volume":"13","author":"Gil","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mcpro.2026.101620_bib23","article-title":"The human melanoma proteome atlas\u2014defining the molecular pathology","volume":"11","author":"Betancourt","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.mcpro.2026.101620_bib24","article-title":"The human melanoma proteome atlas\u2014complementing the melanoma transcriptome","volume":"11","author":"Betancourt","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.mcpro.2026.101620_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature22071","article-title":"Whole-genome landscapes of major melanoma subtypes","volume":"545","author":"Hayward","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2026.101620_bib26","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.1038\/s41467-023-43980-y","article-title":"Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses","volume":"14","author":"Wei","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mcpro.2026.101620_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129704","article-title":"Periostin is a key niche component for wound metastasis of melanoma","volume":"10","author":"Fukuda","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2026.101620_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.908247","article-title":"Revisiting the tenascins: exploitable as cancer targets?","volume":"12","author":"Tucker","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mcpro.2026.101620_bib29","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260244","article-title":"Advances on the roles of tenascin-C in cancer","volume":"135","author":"Yilmaz","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mcpro.2026.101620_bib30","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1158\/0008-5472.CAN-16-1298","article-title":"Differential regulation of the melanoma proteome by eIF4A1 and eIF4E","volume":"77","author":"Joyce","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.mcpro.2026.101620_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1773","article-title":"Mitochondrial dysfunction and immune suppression in BRAF V600E-mutated metastatic melanoma","volume":"14","author":"Pinto de Almeida","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.mcpro.2026.101620_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1495","article-title":"Mitochondrial and immune response dysregulation in melanoma recurrence","volume":"13","author":"Szadai","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.mcpro.2026.101620_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00217","article-title":"The role of ARF family proteins and their regulators and effectors in cancer progression: a therapeutic perspective","volume":"8","author":"Casalou","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2026.101620_bib34","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tibs.2009.03.006","article-title":"IF1: setting the pace of the F1Fo-ATP synthase","volume":"34","author":"Campanella","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mcpro.2026.101620_bib35","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/ars.2012.4883","article-title":"Mitochondria-mediated energy adaption in cancer: the H+-ATP synthase-geared switch of metabolism in human tumors","volume":"19","author":"S\u00e1nchez-Arag\u00f3","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mcpro.2026.101620_bib36","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/j.1742-4658.2011.08026.x","article-title":"Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels","volume":"278","author":"Chinopoulos","year":"2011","journal-title":"FEBS J."}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947626001167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947626001167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:07:11Z","timestamp":1787814431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947626001167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1535947626001167"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2026.101620","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-Throughput Acoustic FFPE Proteomics Reveals ATP5IF1-Associated Mitochondrial Alterations in Acral Melanoma","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2026.101620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101620"}}