{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:33:11Z","timestamp":1793309591403,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["17-CE17-0001"],"award-info":[{"award-number":["17-CE17-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["23-CE17-0050"],"award-info":[{"award-number":["23-CE17-0050"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mcpro.2026.101659","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:11:26Z","timestamp":1789024286000},"page":"101659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global Proteomic Profiling of Cerebral Malaria-Infected Erythrocytes Reveals a Specific PfEMP1 Expression Pattern"],"prefix":"10.1016","volume":"25","author":[{"given":"J\u00e9r\u00e9my","family":"Fraering","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Salnot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Joste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertin","family":"Vianou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Argy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Copp\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9982-594X","authenticated-orcid":false,"given":"Florence","family":"Migot-Nabias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie-Fleur","family":"Gautier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2218-9591","authenticated-orcid":false,"given":"Gwladys Ir\u00e9n\u00e9e","family":"Bertin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mcpro.2026.101659_bib1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fcimb.2014.00100","article-title":"Pathogenesis of cerebral malaria\u2014inflammation and cytoadherence","volume":"4","author":"Storm","year":"2014","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.mcpro.2026.101659_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1203\/PDR.0b013e3181eee738","article-title":"Cerebral malaria; mechanisms of brain injury and strategies for improved Neuro-Cognitive outcome","volume":"68","author":"Idro","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.mcpro.2026.101659_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainresbull.2019.01.010","article-title":"Cerebral malaria","volume":"145","author":"Luzolo","year":"2019","journal-title":"Brain Res. Bull"},{"key":"10.1016\/j.mcpro.2026.101659_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/imr.12807","article-title":"Cerebral Plasmodium falciparum malaria: the role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it","volume":"293","author":"Jensen","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.mcpro.2026.101659_bib5","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1084\/jem.20040274","article-title":"Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes","volume":"199","author":"Jensen","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mcpro.2026.101659_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0010026","article-title":"Plasmodium falciparum variant surface antigen expression patterns during malaria","volume":"1","author":"Bull","year":"2005","journal-title":"Plos Pathog."},{"key":"10.1016\/j.mcpro.2026.101659_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.molbiopara.2006.08.005","article-title":"Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia","volume":"150","author":"Kyriacou","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.mcpro.2026.101659_bib8","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1128\/IAI.02073-05","article-title":"Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian children","volume":"74","author":"Rottmann","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mcpro.2026.101659_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1086\/600071","article-title":"Analysis of Plasmodium falciparum var genes expressed in children from Papua New Guinea","volume":"200","author":"Falk","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.mcpro.2026.101659_bib10","doi-asserted-by":"crossref","first-page":"E1791","DOI":"10.1073\/pnas.1120455109","article-title":"Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children","volume":"109","author":"Lavstsen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2026.101659_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004537","article-title":"Differential PfEMP1 expression is associated with cerebral malaria pathology","volume":"10","author":"Tembo","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.mcpro.2026.101659_bib12","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1120461109","article-title":"A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells","volume":"109","author":"Claessens","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mcpro.2026.101659_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068368","article-title":"Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin","volume":"8","author":"Bertin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2026.101659_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.chom.2017.02.009","article-title":"Structure-Guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria","volume":"21","author":"Lennartz","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mcpro.2026.101659_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.chom.2014.11.007","article-title":"Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria","volume":"17","author":"Lau","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mcpro.2026.101659_bib16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature12216","article-title":"Severe malaria is associated with parasite binding to endothelial protein C receptor","volume":"498","author":"Turner","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mcpro.2026.101659_bib17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the dependency of cellular protein levels on mRNA abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.mcpro.2026.101659_bib18","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1021\/acs.jproteome.0c00496","article-title":"Comprehensive analysis of transcript and protein relative abundance during blood stages of Plasmodium falciparum infection","volume":"20","author":"Kamaliddin","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mcpro.2026.101659_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218012","article-title":"From genomic to LC-MS\/MS evidence: analysis of PfEMP1 in Benin malaria cases","volume":"14","author":"Kamaliddin","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2026.101659_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41592-019-0638-x","article-title":"DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev","year":"2020","journal-title":"Nat. Methods."},{"key":"10.1016\/j.mcpro.2026.101659_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000933","article-title":"Plasmodium falciparum Erythrocyte membrane protein 1 diversity in seven genomes \u2013 divide and conquer","volume":"6","author":"Rask","year":"2010","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.mcpro.2026.101659_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12859-022-04573-6","article-title":"Varia: a tool for prediction, analysis and visualisation of variable genes","volume":"23","author":"Mackenzie","year":"2022","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.mcpro.2026.101659_bib23","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-027378","article-title":"Identification of Plasmodium falciparum and host factors associated with cerebral malaria: description of the protocol for a prospective, case-control study in Benin (NeuroCM)","volume":"9","author":"Joste","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.mcpro.2026.101659_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40249-022-00956-2","article-title":"Non-traumatic coma in young children in Benin: are viral and bacterial infections gaining ground on cerebral malaria?","volume":"11","author":"Brisset","year":"2022","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.mcpro.2026.101659_bib25","doi-asserted-by":"crossref","first-page":"e02103","DOI":"10.1128\/mBio.02103-20","article-title":"PfEMP1 A-Type ICAM-1-Binding domains are not associated with cerebral malaria in Beninese children","volume":"11","author":"Joste","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.mcpro.2026.101659_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiac086","article-title":"Transcriptome analysis of Plasmodium falciparum isolates from Benin reveals specific gene expression associated with cerebral malaria","volume":"225","author":"Guillochon","year":"2022","journal-title":"J. Infect. Dis."},{"issue":"9","key":"10.1016\/j.mcpro.2026.101659_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mcpro.2026.101659_bib28","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1182\/bloodadvances.2018023515","article-title":"Absolute proteome quantification of highly purified populations of circulating reticulocytes and mature erythrocytes","volume":"2","author":"Gautier","year":"2018","journal-title":"Blood Adv."},{"key":"10.1016\/j.mcpro.2026.101659_bib29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s44321-023-00010-0","article-title":"Infected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria","volume":"16","author":"Fraering","year":"2024","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mcpro.2026.101659_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.768182","article-title":"Oxidative stress and pathogenesis in malaria","volume":"11","author":"Vasquez","year":"2021","journal-title":"Front Cell Infect. Microbiol."},{"key":"10.1016\/j.mcpro.2026.101659_bib31","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of Reactive Oxygen Species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mcpro.2026.101659_bib32","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0035-9203(02)90100-8","article-title":"The role of reduced red cell deformability in the pathogenesis of severe falciparum malaria and its restoration by blood transfusion","volume":"96","author":"Dondorp","year":"2002","journal-title":"Trans. R Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.mcpro.2026.101659_bib33","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1182\/blood-2002-08-2437","article-title":"Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum","volume":"102","author":"Omodeo-Sal\u00e8","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mcpro.2026.101659_bib34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpara.2003.09.011","article-title":"Oxidative stress in malaria parasite-infected erythrocytes: host\u2013parasite interactions","volume":"34","author":"Becker","year":"2003","journal-title":"Int J Parasitol."},{"key":"10.1016\/j.mcpro.2026.101659_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF02628503","article-title":"Falciparum infected erythrocytes are capable of endocytosis","volume":"24","author":"Burns","year":"1988","journal-title":"In Vitro Cell Dev. Biol."},{"key":"10.1016\/j.mcpro.2026.101659_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ajh.2830370108","article-title":"Spontaneous endocytosis in human neonatal and adult red blood cells: Comparison to drug-induced endocytosis and to receptor-mediated endocytosis","volume":"37","author":"Colin","year":"1991","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.mcpro.2026.101659_bib37","doi-asserted-by":"crossref","first-page":"222","DOI":"10.7150\/ijms.8.222","article-title":"Characterization of human erythrocytes as potential carrier for pravastatin: an in vitro study","volume":"8","author":"Harisa","year":"2011","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.mcpro.2026.101659_bib38","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiag290","article-title":"Host reticulocyte redox attenuation creates a protective niche for artemisinin tolerance in Plasmodium falciparum","author":"Davis","year":"2026","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.mcpro.2026.101659_bib39","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1128\/MMBR.00014-16","article-title":"Plasmodium helical interspersed subtelomeric (PHIST) proteins, at the Center of host cell remodeling","volume":"80","author":"Warncke","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev. MMBR"},{"key":"10.1016\/j.mcpro.2026.101659_bib40","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bcmd.2013.06.003","article-title":"Remodeling of human red cells infected with Plasmodium falciparum and the impact of PHIST proteins","volume":"51","author":"Prajapati","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.mcpro.2026.101659_bib41","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1074\/jbc.M111.330779","article-title":"Structural analysis of the Plasmodium falciparum Erythrocyte membrane protein 1 (PfEMP1) intracellular domain reveals a conserved interaction epitope","volume":"287","author":"Mayer","year":"2012","journal-title":"J Biol Chem."},{"key":"10.1016\/j.mcpro.2026.101659_bib42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.chom.2014.06.004","article-title":"STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting","volume":"16","author":"Niang","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.mcpro.2026.101659_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114401","article-title":"Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers","volume":"9","author":"Almelli","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2026.101659_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069117","article-title":"Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1","volume":"8","author":"Berger","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mcpro.2026.101659_bib45","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809164","article-title":"Cerebral malaria is associated with differential cytoadherence to brain endothelial cells","volume":"11","author":"Storm","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mcpro.2026.101659_bib46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1371\/journal.pbio.2004328","article-title":"The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen\u2013encoding var genes","volume":"16","author":"Tonkin-Hill","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mcpro.2026.101659_bib47","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1021\/pr400394g","article-title":"Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development","volume":"12","author":"Pease","year":"2013","journal-title":"J. Proteome. Res."}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947626001556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947626001556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:27:42Z","timestamp":1793309262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947626001556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1535947626001556"],"URL":"https:\/\/doi.org\/10.1016\/j.mcpro.2026.101659","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global Proteomic Profiling of Cerebral Malaria-Infected Erythrocytes Reveals a Specific PfEMP1 Expression Pattern","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mcpro.2026.101659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101659"}}