{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:36:52Z","timestamp":1778852212600,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.medcli.2010.03.024","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T05:20:44Z","timestamp":1274160044000},"page":"459-463","source":"Crossref","is-referenced-by-count":3,"title":["Distancia anogenital en reci\u00e9n nacidos: un marcador sensible de disrupci\u00f3n hormonal intrauterina"],"prefix":"10.1016","volume":"137","author":[{"given":"Silvia","family":"Agramunt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manolis","family":"Kogevinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Carreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2010.03.024_bib0005","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1542\/peds.100.5.831","article-title":"Hypospadias trends in two American surveillance systems","volume":"100","author":"Paulozzi","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.medcli.2010.03.024_bib0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0303-7207(01)00430-0","article-title":"Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation","volume":"178","author":"Sultan","year":"2001","journal-title":"Mol Cel Endocrinol"},{"key":"10.1016\/j.medcli.2010.03.024_bib0015","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/bmj.305.6854.609","article-title":"Evidence for decreasing quality of semen during the past 50 years","volume":"305","author":"Carlsen","year":"1992","journal-title":"Br Med J"},{"key":"10.1016\/j.medcli.2010.03.024_bib0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1289\/ehp.95103s7137","article-title":"Declining semen quality and increasing incidence of testicular cancer: Is there a common cause?","volume":"103","author":"Carlsen","year":"1995","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0025","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.reprotox.2004.12.015","article-title":"In utero exposure to environmental estorgens and male reproductive health: A systematic review of biological and epidemiologic evidence","volume":"20","author":"Vidaeff","year":"2005","journal-title":"Reproduct Toxicol"},{"key":"10.1016\/j.medcli.2010.03.024_bib0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1191\/074823399678846682","article-title":"Inadvertent exposure to xenoestrogens in children","volume":"15","author":"Olea","year":"1999","journal-title":"Toxicol Ind Health"},{"key":"10.1016\/j.medcli.2010.03.024_bib0035","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/toxsci\/62.2.236","article-title":"Androgen-mediated development in male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues","volume":"62","author":"McIntyre","year":"2001","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.medcli.2010.03.024_bib0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/toxsci\/kfh018","article-title":"Interactive effects of vinclozolin and testosterone propionate on pregnancy and sexual differentiation of the male and female SD rat","volume":"28","author":"Wolf","year":"2004","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.medcli.2010.03.024_bib0045","series-title":"Embriolog\u00eda m\u00e9dica","author":"Langman","year":"2000"},{"key":"10.1016\/j.medcli.2010.03.024_bib0050","series-title":"Endocrinolog\u00eda cl\u00ednica y esterilidad","author":"Speroff","year":"2006"},{"key":"10.1016\/j.medcli.2010.03.024_bib0055","series-title":"Ginecolog\u00eda","author":"Gonz\u00e1lez-Merlo","year":"1993"},{"key":"10.1016\/j.medcli.2010.03.024_bib0060","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1289\/ehp.971051228","article-title":"Have sperm densities declined? A reanalysis of global trend data","volume":"105","author":"Swan","year":"1997","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0065","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1056\/NEJM199502023320501","article-title":"Decline in semen quality among fertile men in Paris during the past 20 years","volume":"332","author":"Auger","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medcli.2010.03.024_bib0070","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1289\/ehp.00108961","article-title":"The question of declining sperm density revisited: An analysis of 101 studies published","volume":"108","author":"Swan","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0075","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1289\/ehp.99107297","article-title":"International trends in rates of hypospadias and cryptorchidism","volume":"107","author":"Paulozzi","year":"1999","journal-title":"Environ Health Prespect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0080","first-page":"365","article-title":"Endocrine function of the testis in 125 cases of cryptorchism","volume":"125","author":"Canlorbe","year":"1974","journal-title":"Ann Med Interne"},{"key":"10.1016\/j.medcli.2010.03.024_bib0085","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/jnci\/56.4.731","article-title":"Cryptorchisdism, hernia and cancer of the testis","volume":"56","author":"Morrison","year":"1976","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.medcli.2010.03.024_bib0090","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","article-title":"Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects","volume":"16","author":"Skakkebaek","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.medcli.2010.03.024_bib0095","author":"Colborn","year":"1992"},{"key":"10.1016\/j.medcli.2010.03.024_bib0100","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1289\/ehp.99107s6907","article-title":"Pharmaceuticals and personal care products in the environment: Agents of subtle change","volume":"107","author":"Christian","year":"1999","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/58.2.339","article-title":"The plasticizer diethylhexyl phtalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat","volume":"58","author":"Parks","year":"2000","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.medcli.2010.03.024_bib0110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.reprotox.2003.10.006","article-title":"Reproductive toxicity evaluation of dietary butyl benzyl phtalate (BBP) in rats","volume":"18","author":"Tyl","year":"2004","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.medcli.2010.03.024_bib0115","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1095\/biolreprod17.5.645","article-title":"Effects of estrogens on testicular testosterone production in vitro","volume":"17","author":"Bartke","year":"1977","journal-title":"Biol Reprod"},{"key":"10.1016\/j.medcli.2010.03.024_bib0120","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/0140-6736(93)90953-E","article-title":"Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?","volume":"1","author":"Sharpe","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2010.03.024_bib0125","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.envres.2009.07.010","article-title":"Prenatal exposure to PCDDs\/PCDFs and dioxin-like PCBs in relation to birth weight","volume":"109","author":"Konishi","year":"2009","journal-title":"Environ Res"},{"key":"10.1016\/j.medcli.2010.03.024_bib0130","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/oem.2007.032763","article-title":"Effects of PCBs, p,p\u2019-DDT, p,p\u2019-DDE, HCB and beta-HCH on thyroid function in preschool children","volume":"65","author":"\u00c1lvarez-Pedrerol","year":"2008","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.medcli.2010.03.024_bib0135","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/humupd\/7.3.331","article-title":"Human health effects of dioxins: Cancer, reproductive and endocrine system effects","volume":"7","author":"Kogevinas","year":"2001","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.medcli.2010.03.024_bib0140","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1542\/peds.97.5.700","article-title":"Effects of poltchlorinated byphenil\/dioxin exposure and feeding type on infants\u2019 mental and psychomotor development","volume":"97","author":"Koopman-Esseboom","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.medcli.2010.03.024_bib0145","series-title":"Monographs on the evaluation of carcinogenic risks to humans (vol 69). Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans","year":"1997"},{"key":"10.1016\/j.medcli.2010.03.024_bib0150","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0025-7753(00)71679-4","article-title":"Dioxinas y salud","volume":"115","author":"Kogevinas","year":"2000","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.medcli.2010.03.024_bib0155","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1289\/ehp.0900677","article-title":"Chlorination disinfection by-products in drinking water and congenital anomalies: Review and meta-analyses","volume":"117","author":"Nieuwenhuijsen","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0160","unstructured":"Sixth Framework Programme; priority 5; food quality and safety: Newborns and genotoxic exposure risks: Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals and of biomarkers of early effects, using mother-child birth cohorts and biobanks (New Generis). Proposal\/Contract n.o: 016320-2. 2009 Dic [consultado 22\/12\/2009]. M\u00e1s informaci\u00f3n disponible en: www.newgeneris.org"},{"key":"10.1016\/j.medcli.2010.03.024_bib0165","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-3016.2007.00810.x","article-title":"Reliability and determinants of anogenital distance and penis dimensions in male newborns from Chiapas, Mexico","volume":"21","author":"Romano-Riquer","year":"2007","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.medcli.2010.03.024_bib0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-069X-3-8","article-title":"Anogenital distance in human male and female newborns: A descriptive, cross-sectional study","volume":"3","author":"Salazar-Mart\u00ednez","year":"2004","journal-title":"Environ Health"},{"key":"10.1016\/j.medcli.2010.03.024_bib0175","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.reprotox.2009.06.013","article-title":"Effects of in utero exposure to di-n-hexyl phthalate on the reproductive development of the male rat","volume":"28","author":"Saillenfait","year":"2009","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.medcli.2010.03.024_bib0180","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0890-6238(03)00037-6","article-title":"Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate","volume":"17","author":"Ema","year":"2003","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.medcli.2010.03.024_bib0185","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2605.2005.00563.x","article-title":"Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters","volume":"29","author":"Foster","year":"2006","journal-title":"Int J Androl"},{"key":"10.1016\/j.medcli.2010.03.024_bib0190","doi-asserted-by":"crossref","unstructured":"Jin MH, Hong CH, Lee HY, Kang HJ, Han SW. Toxic effects of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on development of male reproductive system: Involvement of antioxidants, oxidants, and p53 protein. Environ Toxicol [revista electr\u00f3nica]. 2008 Dec 11 [consultado 22\/12\/2009]. Disponible en: http:\/\/dx.doi.org\/10.1002\/tox.20466","DOI":"10.1002\/tox.20466"},{"key":"10.1016\/j.medcli.2010.03.024_bib0195","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1196\/annals.1454.004","article-title":"Dichlorodiphenyldichloroethylene exposure during the first trimester of pregnancy alters the anal position in male infants","volume":"1140","author":"Torres-S\u00e1nchez","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.medcli.2010.03.024_bib0200","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3349\/ymj.2008.49.5.843","article-title":"In utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin affects the development of reproductive system in mouse","volume":"49","author":"Jin","year":"2008","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.medcli.2010.03.024_bib0205","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1365-2605.2007.00838.x","article-title":"Endocrine-disrupting properties in vivo of widely used azole fungicides","volume":"31","author":"Taxvig","year":"2008","journal-title":"Int J Androl"},{"key":"10.1016\/j.medcli.2010.03.024_bib0210","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/toxsci\/kfm227","article-title":"Endocrine-disrupting activities in vivo of the fungicides tebuconazole and epoxiconazole","volume":"100","author":"Taxvig","year":"2007","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.medcli.2010.03.024_bib0215","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2164\/jandrol.107.003020","article-title":"Gestational exposure to atrazine: Effects on the postnatal development of male offspring","volume":"29","author":"Rosenberg","year":"2008","journal-title":"J Androl"},{"key":"10.1016\/j.medcli.2010.03.024_bib0220","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1289\/ehp.9360","article-title":"Combined exposure to anti-androgens exacerbates disruption of sexual differentiation in the rat","volume":"115","author":"Hass","year":"2007","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0225","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phtalate exposure","volume":"113","author":"Swan","year":"2005","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0230","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1289\/ehp.8663","article-title":"Estimated daily phthalate exposures in a population of mothers of male infants exhibiting reduced anogenital distance","volume":"114","author":"Marsee","year":"2006","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.medcli.2010.03.024_bib0235","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/aje\/kwk109","article-title":"In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, Mexico","volume":"165","author":"Longnecker","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.medcli.2010.03.024_bib0240","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.envint.2008.05.012","article-title":"Association between prenatal exposure to phthalates and the health of newborns","volume":"35","author":"Huang","year":"2009","journal-title":"Environ Int"},{"key":"10.1016\/j.medcli.2010.03.024_bib0245","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1289\/ehp.0900881","article-title":"Anogenital distance from birth to 2 years: A population study","volume":"117","author":"Thankamony","year":"2009","journal-title":"Environ Health Perspect"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775310004586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775310004586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T06:10:34Z","timestamp":1685599834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775310004586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0025775310004586"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2010.03.024","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}