{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:06:02Z","timestamp":1787785562531,"version":"build-2784847793"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.medcli.2016.03.029","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T18:47:14Z","timestamp":1463597234000},"page":"56-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efecto del bloqueo del factor de necrosis tumoral \u03b1 sobre el metabolismo \u00f3seo en las enfermedades inflamatorias articulares cr\u00f3nicas"],"prefix":"10.1016","volume":"147","author":[{"given":"Francisco Javier","family":"Aguilar del Rey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Garc\u00eda Portales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Haro Liger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Rodr\u00edguez Andreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Casals S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"P\u00e9rez Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 55","key":"10.1016\/j.medcli.2016.03.029_bib0140","first-page":"S62","article-title":"Osteoporosis in rheumatoid arthritis and ankylosing spondylitis","volume":"27","author":"Vosse","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.medcli.2016.03.029_bib0145","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.rdc.2006.07.002","article-title":"Epidemiology of osteoporosis in rheumatic diseases","volume":"32","author":"Sinigaglia","year":"2006","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.medcli.2016.03.029_bib0150","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/art.10041","article-title":"The cutting edge of spondyloarthropathies research in the millennium","volume":"46","author":"Granfors","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2016.03.029_bib0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/ar67","article-title":"Mechanisms of bone loss in inflammatory arthritis: Diagnosis and therapeutic implications","volume":"2","author":"Goldring","year":"2000","journal-title":"Arthritis Res"},{"key":"10.1016\/j.medcli.2016.03.029_bib0160","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bone.2008.12.028","article-title":"Prevalence and risk factors of osteoporosis and vertebral fractures in patients with ankylosing spondylitis","volume":"44","author":"Ghozlani","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.medcli.2016.03.029_bib0165","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/ar3375","article-title":"Osteoimmunology and osteoporosis","volume":"13","author":"Geusens","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.medcli.2016.03.029_bib0170","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1084\/jem.188.5.997","article-title":"TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts","volume":"188","author":"Fuller","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.medcli.2016.03.029_bib0175","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2474-12-54","article-title":"Adalimumab reduces hand bone loss in rheumatoid arthritis independent of clinical response: Subanalysis of the PREMIER study","volume":"12","author":"Hoff","year":"2011","journal-title":"BMC Musculoskeletal Disord"},{"issue":"Supl 2","key":"10.1016\/j.medcli.2016.03.029_bib0180","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/S1699-258X(06)73097-2","article-title":"III Actualizaci\u00f3n del Consenso de la Sociedad Espa\u00f1ola de Reumatolog\u00eda sobre terapia biol\u00f3gica en la artritis reumatoide","author":"Rodr\u00edguez-Valverde","year":"2006","journal-title":"Reumatol Clin"},{"issue":"Suppl 11","key":"10.1016\/j.medcli.2016.03.029_bib0185","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1002\/acr.20621","article-title":"Measures of rheumatoid arthritis disease activity","volume":"63","author":"Anderson","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"Suppl 11","key":"10.1016\/j.medcli.2016.03.029_bib0190","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1002\/acr.20575","article-title":"Measures of symptoms and disease status in ankylosing spondylitis","volume":"63","author":"Zochling","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.medcli.2016.03.029_bib0195","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2016.03.029_bib0200","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0049-0172(79)80001-3","article-title":"Psoriatic arthritis: A clinical immunologic and HLA study of 100 patients","volume":"9","author":"Hammer","year":"1979","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.medcli.2016.03.029_bib0205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the spondylitis. New York Criteria","volume":"27","author":"Van der Unden","year":"1984","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2016.03.029_bib0210","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/ard.2005.044198","article-title":"Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NF\u03baB ligand serum levels during treatment with infliximab in patients with rheumatoid arthritis","volume":"65","author":"Vis","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2016.03.029_bib0215","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/ard.2008.091611","article-title":"Bone mineral density in rheumatoid arthritis patients 1 year after adalimumab therapy: Arrest of bone loss","volume":"68","author":"Wijbrandts","year":"2009","journal-title":"Ann Rheum Dis."},{"key":"10.1016\/j.medcli.2016.03.029_bib0220","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/rheumatology\/kei082","article-title":"Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-alpha antibody: A prospective open-label pilot study","volume":"44","author":"Lange","year":"2005","journal-title":"Rheumatology"},{"key":"10.1016\/j.medcli.2016.03.029_bib0225","first-page":"199","article-title":"Are there any positive effects of TNF-alpha blockers on bone metabolism?","volume":"58","author":"Seriolo","year":"2006","journal-title":"Reumatismo"},{"key":"10.1016\/j.medcli.2016.03.029_bib0230","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/ard.2004.028670","article-title":"Body weight, body composition, and bone turnover changes in patients with spondyloarthropathy receiving anti-tumour necrosis factor \u03b1 treatment","volume":"64","author":"Briot","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2016.03.029_bib0235","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/ard.62.10.1020","article-title":"Bone mineral density improvement in spondyloarthropathy after treatment with etanercept","volume":"62","author":"Marzo-Ortega","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2016.03.029_bib0240","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1186\/ar2961","article-title":"A rational use of glucocorticoids in patients with early arthritis has a minimal impact on bone mass","volume":"12","author":"Iba\u00f1ez","year":"2010","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.medcli.2016.03.029_bib0245","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.2310\/JIM.0b013e31818e82d7","article-title":"Effects of low-dose corticosteroids on the bone mineral density of patients with rheumatoid arthritis: A meta-analysis","volume":"56","author":"Lee","year":"2008","journal-title":"J Investig Med"},{"key":"10.1016\/j.medcli.2016.03.029_bib0250","first-page":"1753","article-title":"Changes of clinical response and bone biochemical markers in patients with ankylosing spondylitis taking etanercept","volume":"34","author":"Woo","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2016.03.029_bib0255","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/rheumatology\/kei280","article-title":"The effect of infliximab on bone metabolism markers in patients with rheumatoid arthritis","volume":"45","author":"Torikai","year":"2006","journal-title":"Rheumatology"},{"key":"10.1016\/j.medcli.2016.03.029_bib0260","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1136\/ard.62.6.561","article-title":"Up regulation of the production of tumour necrosis factor alpha and interferon gamma by T cells in ankylosing spondylitis during treatment with etanercept","volume":"62","author":"Zou","year":"2003","journal-title":"Ann Rheum Dis."},{"key":"10.1016\/j.medcli.2016.03.029_bib0265","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1136\/ard.2007.071910","article-title":"Baseline serum RANKL levels may serve to predict remission in rheumatoid arthritis patients treated with TNF antagonists","volume":"66","author":"Gonz\u00e1lez-Alvaro","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2016.03.029_bib0270","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.medcli.2013.06.012","article-title":"Protocolo de tratamiento de la deficiencia de vitamina D","volume":"142","author":"Aguilar","year":"2014","journal-title":"Med Clin (Barc)."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775316300616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775316300616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T19:53:53Z","timestamp":1536695633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775316300616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0025775316300616"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2016.03.029","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efecto del bloqueo del factor de necrosis tumoral \u03b1 sobre el metabolismo \u00f3seo en las enfermedades inflamatorias articulares cr\u00f3nicas","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2016.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}