{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T13:47:12Z","timestamp":1772200032208,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.medcli.2016.07.030","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T11:48:02Z","timestamp":1476877682000},"page":"547-553","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Displasia fibrosa. Revisi\u00f3n cl\u00ednica y abordaje terap\u00e9utico"],"prefix":"10.1016","volume":"147","author":[{"given":"Helena","family":"Florez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Peris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"Gua\u00f1abens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2016.07.030_bib0175","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1053\/berh.1999.0071","article-title":"Fibrous dysplasia of bone","volume":"14","author":"Chapurlat","year":"2000","journal-title":"Baillieres Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.medcli.2016.07.030_bib0180","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1172\/JCI18399","article-title":"FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting","volume":"112","author":"Riminucci","year":"2003","journal-title":"J Clin Invest."},{"key":"10.1016\/j.medcli.2016.07.030_bib0185","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1016\/j.lfs.2005.09.052","article-title":"Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia","volume":"78","author":"Kobayashi","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.medcli.2016.07.030_bib0190","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11914-013-0144-5","article-title":"Fibrous dysplasia and fibroblast growth factor-23 regulation","volume":"11","author":"Boyce","year":"2013","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.medcli.2016.07.030_bib0195","unstructured":"Sal\u00f3 Bru G. Displasia fibrosa. Condrodisplasias. En: Sociedad Espa\u00f1ola de Reumatolog\u00eda, ed. Manual de enfermedades \u00f3seas. 2.a ed. Madrid: Editorial M\u00e9dica Panamericana; 2010. p. 449-51."},{"key":"10.1016\/j.medcli.2016.07.030_bib0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.berh.2007.11.004","article-title":"Fibrous dysplasia of bone and McCune-Albright syndrome","volume":"22","author":"Chapurlat","year":"2008","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"Suppl 1","key":"10.1016\/j.medcli.2016.07.030_bib0205","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1750-1172-7-S1-S4","article-title":"McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia","volume":"7","author":"Collins","year":"2012","journal-title":"Orphanet J Rare Dis."},{"key":"10.1016\/j.medcli.2016.07.030_bib0210","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/PLMI.S24866","article-title":"Fibrous dysplasia of bone: A clinicopathologic review","volume":"3","author":"Mohan","year":"2011","journal-title":"Pathol Lab Med Int"},{"key":"10.1016\/j.medcli.2016.07.030_bib0215","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/(SICI)1096-9896(199901)187:2<249::AID-PATH222>3.0.CO;2-J","article-title":"The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: Site-specific patterns and recurrent histological hallmarks","volume":"187","author":"Riminucci","year":"1999","journal-title":"J Pathol."},{"key":"10.1016\/j.medcli.2016.07.030_bib0220","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/modpathol.2012.223","article-title":"Diagnostic value of investigating GNAS mutations in fibro-osseous lesions: A retrospective study of 91 cases of fibrous dysplasia and 40 other fibro-osseous lesions","volume":"26","author":"Tabareau-Delalande","year":"2013","journal-title":"Mod Pathol."},{"issue":"Suppl 1","key":"10.1016\/j.medcli.2016.07.030_bib0225","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1750-1172-7-S1-S3","article-title":"Pathophysiology and medical treatment of pain in fibrous dysplasia of bone","volume":"7","author":"Chapurlat","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.medcli.2016.07.030_bib0230","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1359\/JBMR.041111","article-title":"An instrument to measure skeletal burden and predict functional outcome in fibrous dysplasia of bone","volume":"20","author":"Collins","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.medcli.2016.07.030_bib0235","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1359\/jbmr.1997.12.8.1314","article-title":"Long-term aminobisphosphonate treatment of fibrous dysplasia: Spectacular increase in bone density","volume":"12","author":"Weinstein","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.medcli.2016.07.030_bib0240","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/jc.2014-1371","article-title":"A randomized, double blind, placebo-controlled trial of alendronate treatment for fibrous dysplasia of bone","volume":"99","author":"Boyce","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.medcli.2016.07.030_bib0245","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bone.2004.03.004","article-title":"Treatment of fibrous dysplasia of bone with intravenous pamidronate: Predictors of response to treatment and long-term effectiveness","volume":"35","author":"Chapurlat","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.medcli.2016.07.030_bib0250","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S8756-3282(03)00221-7","article-title":"Effect of intravenous pamidronate on bone markers and local bone mineral density in fibrous dysplasia of bone","volume":"33","author":"Parisi","year":"2003","journal-title":"Bone"},{"issue":"Suppl 1","key":"10.1016\/j.medcli.2016.07.030_bib0255","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1750-1172-7-S1-S2","article-title":"Clinical guidelines for the management of craniofacial fibrous dysplasia","volume":"7","author":"Lee","year":"2012","journal-title":"Orphanet J Rare Dis."},{"issue":"Suppl 1","key":"10.1016\/j.medcli.2016.07.030_bib0260","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1750-1172-7-S1-S1","article-title":"The surgical management of fibrous dysplasia of bone","volume":"7","author":"Stanton","year":"2012","journal-title":"Orphanet J Rare Dis."},{"key":"10.1016\/j.medcli.2016.07.030_bib0265","first-page":"1","article-title":"The nonsurgical treatment of fibrous dysplasia","volume":"66","author":"Chapurlat","year":"1999","journal-title":"Rev Rhum Engl Ed."},{"key":"10.1016\/j.medcli.2016.07.030_bib0270","doi-asserted-by":"crossref","unstructured":"Collins MT, Riminucci M, Bianco P. Fibrous dysplasia. En: Primer on the metabolic bone diseases and disorders of mineral metabolism. 8.a ed. Oxford: John Wiley & Sons; 2013. p. 786-93.","DOI":"10.1002\/9781118453926.ch94"},{"key":"10.1016\/j.medcli.2016.07.030_bib0275","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00003086-200101000-00003","article-title":"Bisphosphonate therapy in fibrous dysplasia","volume":"382","author":"Lane","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.medcli.2016.07.030_bib0280","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00776-004-0809-0","article-title":"Oral alendronate treatment for polyostotic fibrous dysplasia: A case report","volume":"9","author":"Kitagawa","year":"2001","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.medcli.2016.07.030_bib0285","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0140-6736(94)90069-8","article-title":"Long-term effects of intravenous pamidronate in fibrous dysplasia of bone","volume":"343","author":"Liens","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2016.07.030_bib0290","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1359\/jbmr.1997.12.10.1746","article-title":"Long-term effects of intravenous pamidronate in fibrous dysplasia of bone","volume":"12","author":"Chapurlat","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.medcli.2016.07.030_bib0295","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1210\/jc.2003-030050","article-title":"Effect of pamidronate treatment in children with polyostotic fibrous dysplasia of bone","volume":"88","author":"Plotkin","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 2","key":"10.1016\/j.medcli.2016.07.030_bib0300","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1359\/jbmr.06s222","article-title":"Medical therapy in adults with fibrous dysplasia of bone","volume":"21","author":"Chapurlat","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.medcli.2016.07.030_bib0305","doi-asserted-by":"crossref","first-page":"851","DOI":"10.4158\/EP10136.CR","article-title":"Bisphosphonate treatment in polyostotic fibrous dysplasia of the cranium: Case report and literature review","volume":"16","author":"Mansoori","year":"2010","journal-title":"Endocr Pract"},{"key":"10.1016\/j.medcli.2016.07.030_bib0310","first-page":"670809","article-title":"Characteristics and treatment results of 5 patients with fibrous dysplasia and review of the literature","volume":"2015","author":"Ozdemir Kutbay","year":"2015","journal-title":"Case Rep Endocrinol."},{"key":"10.1016\/j.medcli.2016.07.030_bib0315","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00223-013-9829-0","article-title":"Clinical and radiological observations in a case series of 26 patients with fibrous fysplasia","volume":"94","author":"Thomsen","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.medcli.2016.07.030_bib0320","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00296-014-3132-x","article-title":"Continuous effect with long-term safety in zoledronic acid therapy for polyostitic fibrous displasia with severe bone destruction","volume":"35","author":"Wu","year":"2015","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.medcli.2016.07.030_bib0325","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/jbmr.1603","article-title":"Denosumab treatment for fibrous dysplasia","volume":"27","author":"Boyce","year":"2012","journal-title":"J Bone Miner Res."},{"key":"10.1016\/j.medcli.2016.07.030_bib0330","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jbspin.2014.04.013","article-title":"Transient improvement of severe pain from fibrous dysplasia of bone with denosumab treatment","volume":"81","author":"Benhamou","year":"2014","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.medcli.2016.07.030_bib0335","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00198-013-2585-1","article-title":"Rapid biochemical response to denosumab in fibrous dysplasia of bone: Report of two cases","volume":"25","author":"Ganda","year":"2014","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.medcli.2016.07.030_bib0340","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/rheumatology\/kev221","article-title":"Tocilizumab in the treatment of a polyostotic variant of fibrous dysplasia of bone","volume":"54","author":"De Boysson","year":"2015","journal-title":"Rheumatology (Oxford)"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775316303839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775316303839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T12:26:14Z","timestamp":1536323174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775316303839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0025775316303839"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2016.07.030","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Displasia fibrosa. Revisi\u00f3n cl\u00ednica y abordaje terap\u00e9utico","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2016.07.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}