{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T23:14:44Z","timestamp":1778368484825,"version":"3.51.4"},"reference-count":10,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.medcli.2016.07.031","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T03:48:41Z","timestamp":1476157721000},"page":"495-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Linfohistiocitosis hemofagoc\u00edtica: an\u00e1lisis de 18 casos"],"prefix":"10.1016","volume":"147","author":[{"given":"Pilar","family":"Hern\u00e1ndez-Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"D\u00edaz-Pedroche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Laureiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaya","family":"Madrid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Lumbreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2016.07.031_bib0055","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0140-6736(00)61951-7","article-title":"Histiocytic medullary reticulocytosis","volume":"2","author":"Scott","year":"1939","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2016.07.031_bib0060","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0140-6736(13)61048-X","article-title":"Adult haemophagocytic syndrome","volume":"383","author":"Ramos-Casals","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2016.07.031_bib0065","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/bjh.12293","article-title":"Advances in understanding the pathogenesis of HLH","volume":"161","author":"Usmani","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.medcli.2016.07.031_bib0070","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.medcli.2016.07.031_bib0075","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.mayocp.2013.12.012","article-title":"Prognostic factors and outcomes of adults with hemophagocytic lymphohistiocytosis","volume":"89","author":"Parikh","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.medcli.2016.07.031_bib0080","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1532\/IJH97.07012","article-title":"Nationwide survey of hemophagocytic lymphohistiocytosis in Japan","volume":"86","author":"Ishii","year":"2007","journal-title":"Int J Hematol"},{"key":"10.1016\/j.medcli.2016.07.031_bib0085","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/hon.960","article-title":"Secondary hemophagocytic syndrome in adults: A case series of 18 patients in a single institution and a review of literature","volume":"29","author":"Shabbir","year":"2011","journal-title":"Hematol Oncol"},{"key":"10.1016\/j.medcli.2016.07.031_bib0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/bjh.13102","article-title":"Prognostic factors of early death in a cohort of 162 adult haemophagocytic syndrome: Impact of triggering disease and early treatment with etoposide","volume":"168","author":"Arca","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.medcli.2016.07.031_bib0095","doi-asserted-by":"crossref","first-page":"20546","DOI":"10.2807\/1560-7917.ES2013.18.30.20546","article-title":"Re-emergence of leishmaniasis in Spain: Community outbreak in Madrid, Spain, 2009 to 2012","volume":"18","author":"Arce","year":"2013","journal-title":"Euro Surveill."},{"key":"10.1016\/j.medcli.2016.07.031_bib0100","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1182\/blood-2015-01-551622","article-title":"How I treat hemophagocytic lymphohistiocytosis in the adult patient","volume":"125","author":"Schram","year":"2015","journal-title":"Blood"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775316303840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775316303840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T15:24:54Z","timestamp":1536333894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775316303840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0025775316303840"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2016.07.031","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linfohistiocitosis hemofagoc\u00edtica: an\u00e1lisis de 18 casos","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2016.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}