{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:52:22Z","timestamp":1789912342810,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.medcli.2017.05.010","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T14:19:23Z","timestamp":1498054763000},"page":"211-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Relaci\u00f3n entre la enfermedad cardiovascular y la afecci\u00f3n dental. Revisi\u00f3n sistem\u00e1tica"],"prefix":"10.1016","volume":"149","author":[{"given":"Beatriz","family":"Gonz\u00e1lez Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Pint\u00f3 Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enric","family":"Jan\u00e9 Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2017.05.010_bib0165","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2013An inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2017.05.010_bib0170","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/CIR.0b013e31823ac046","article-title":"Heart disease and stroke statistics--2012 update: A report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation."},{"key":"10.1016\/j.medcli.2017.05.010_bib0175","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/154405910408300214","article-title":"Periodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers","volume":"83","author":"D\u2019Aiuto","year":"2004","journal-title":"J Dent Res."},{"key":"10.1016\/j.medcli.2017.05.010_bib0180","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1056\/NEJM198710153171605","article-title":"Causes and control of dental caries","volume":"317","author":"Shaw","year":"1987","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2017.05.010_bib0185","doi-asserted-by":"crossref","first-page":"946","DOI":"10.6061\/clinics\/2013(07)10","article-title":"The occurrence of dental caries is associated with atherosclerosis","volume":"68","author":"Glodny","year":"2013","journal-title":"Clinics (Sao Paulo)."},{"key":"10.1016\/j.medcli.2017.05.010_bib0190","series-title":"Essential endodontology: Prevention and treatment of apical periodontitis","first-page":"179","article-title":"Epidemiology of apical periodontitis","author":"Eriksen","year":"1998"},{"key":"10.1016\/j.medcli.2017.05.010_bib0195","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/154405910608501104","article-title":"Lesions of endodontic origin and risk of coronary heart disease","volume":"85","author":"Caplan","year":"2006","journal-title":"J Dent Res."},{"key":"10.1016\/j.medcli.2017.05.010_bib0200","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.joen.2009.01.012","article-title":"Association between chronic dental infection and acute myocardial infarction","volume":"35","author":"Willershausen","year":"2009","journal-title":"J Endod."},{"key":"10.1016\/j.medcli.2017.05.010_bib0205","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.joen.2012.08.013","article-title":"Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults","volume":"38","author":"Pasqualini","year":"2012","journal-title":"J Endod."},{"key":"10.1016\/j.medcli.2017.05.010_bib0210","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.tripleo.2009.10.036","article-title":"Radiographic quantification of chronic dental infection and its relationship to the atherosclerotic process in the carotid arteries","volume":"109","author":"Friedlander","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"10.1016\/j.medcli.2017.05.010_bib0215","first-page":"35","article-title":"Infectious dental diseases in patients with coronary artery disease: An orthopantomographic case-control study","volume":"75","author":"Oikarinen","year":"2009","journal-title":"J Can Dent Assoc."},{"key":"10.1016\/j.medcli.2017.05.010_bib0220","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/bmj.298.6676.779","article-title":"Association between dental health and acute myocardial infarction","volume":"298","author":"Mattila","year":"1989","journal-title":"BMJ."},{"key":"10.1016\/j.medcli.2017.05.010_bib0225","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1161\/01.STR.28.9.1724","article-title":"Association between acute cerebrovascular ischemia and chronic and recurrent infection","volume":"28","author":"Grau","year":"1997","journal-title":"Stroke."},{"key":"10.1016\/j.medcli.2017.05.010_bib0230","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1067\/moe.2003.22","article-title":"Oral health and health behavior in patients referred for open-heart surgery","volume":"95","author":"Meurman","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"10.1016\/j.medcli.2017.05.010_bib0235","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/01.CIR.0000118497.44961.1E","article-title":"Asymptotic dental score and prevalent coronary heart disease","volume":"109","author":"Janket","year":"2004","journal-title":"Circulation."},{"key":"10.1016\/j.medcli.2017.05.010_bib0240","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10266-013-0112-7","article-title":"Association between chronic periodontal and apical inflammation and acute myocardial infarction","volume":"102","author":"Willershausen","year":"2014","journal-title":"Odontology."},{"key":"10.1016\/j.medcli.2017.05.010_bib0245","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.joen.2011.09.006","article-title":"Association of endodontic infection with detection of an initial lesion to the cardiovascular system","volume":"37","author":"Cotti","year":"2011","journal-title":"J Endod."},{"key":"10.1016\/j.medcli.2017.05.010_bib0250","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1177\/00220345000790020901","article-title":"Age, dental infections, and coronary heart disease","volume":"79","author":"Mattila","year":"2000","journal-title":"J Dent Res."},{"key":"10.1016\/j.medcli.2017.05.010_bib0255","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jdent.2013.05.009","article-title":"Removable dental prostheses and cardiovascular survival: A 15-year follow-up study","volume":"41","author":"Janket","year":"2013","journal-title":"J Dent."},{"key":"10.1016\/j.medcli.2017.05.010_bib0260","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jcpe.12192","article-title":"Number of teeth, C-reactive protein, fibrinogen and cardiovascular mortality: A 15-year follow-up study in a Finnis cohort","volume":"41","author":"Janket","year":"2014","journal-title":"J Clin Periodontol."},{"key":"10.1016\/j.medcli.2017.05.010_bib0265","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1034\/j.1600-051X.2001.280807.x","article-title":"Relationship between oral health and mortality in cardiovascular diseases","volume":"28","author":"Jansson","year":"2001","journal-title":"J Clin Periodontol."},{"key":"10.1016\/j.medcli.2017.05.010_bib0270","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1136\/bmj.306.6879.688","article-title":"Dental disease and risk of coronary heart disease and mortality","volume":"306","author":"DeStefano","year":"1993","journal-title":"BMJ."},{"key":"10.1016\/j.medcli.2017.05.010_bib0275","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/iej.12468","article-title":"Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Ageing","volume":"49","author":"Gomes","year":"2016","journal-title":"Int Endod J."},{"key":"10.1016\/j.medcli.2017.05.010_bib0280","first-page":"w13236","article-title":"The impact of dental disease on mortality in patients with asymptomatic carotid atherosclerosis","volume":"141","author":"Hoke","year":"2011","journal-title":"Swiss Med Wkly."},{"key":"10.1016\/j.medcli.2017.05.010_bib0285","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/154405910608500116","article-title":"Radiographic assessment of dental health in middle-aged men following sudden cardiac death","volume":"85","author":"Karhunen","year":"2006","journal-title":"J Dent Res."},{"key":"10.1016\/j.medcli.2017.05.010_bib0290","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1902\/jop.2010.090680","article-title":"Number of teeth as a predictor of cardiovascular mortality in a cohort of 7,674 subjects followed for 12 years","volume":"81","author":"Holmlund","year":"2010","journal-title":"J Periodontol."},{"key":"10.1016\/j.medcli.2017.05.010_bib0295","doi-asserted-by":"crossref","first-page":"569675","DOI":"10.1155\/2014\/569675","article-title":"Dental calculus is associated with death from heart infarction","volume":"2014","author":"S\u00f6der","year":"2014","journal-title":"Biomed Res Int."},{"key":"10.1016\/j.medcli.2017.05.010_bib0300","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00784-013-1156-3","article-title":"The association of chronic apical periodontitis and endodontic therapy with atherosclerosis","volume":"18","author":"Petersen","year":"2014","journal-title":"Clin Oral Investig."},{"key":"10.1016\/j.medcli.2017.05.010_bib0305","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.joen.2013.10.026","article-title":"Association between chronic apical periodontitis and coronary artery disease","volume":"40","author":"Costa","year":"2014","journal-title":"J Endod."},{"key":"10.1016\/j.medcli.2017.05.010_bib0310","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/00016350310005510","article-title":"Endodontic variables and coronary heart disease","volume":"61","author":"Frisk","year":"2003","journal-title":"Acta Odontol Scand."},{"key":"10.1016\/j.medcli.2017.05.010_bib0315","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/01.don.0000168890.42903.2b","article-title":"Pilot study of correlation of pulp stones with cardiovascular disease","volume":"31","author":"Edds","year":"2005","journal-title":"J Endod."},{"key":"10.1016\/j.medcli.2017.05.010_bib0320","first-page":"456","article-title":"Can dental pulp calcification predict the risk of ischemic cardiovascular disease?","volume":"10","author":"Khojastepour","year":"2013","journal-title":"J Dent (Tehran)"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775317303809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775317303809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T14:58:11Z","timestamp":1535727491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775317303809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0025775317303809"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2017.05.010","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relaci\u00f3n entre la enfermedad cardiovascular y la afecci\u00f3n dental. Revisi\u00f3n sistem\u00e1tica","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2017.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}