{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:17:34Z","timestamp":1781630254210,"version":"3.54.5"},"reference-count":59,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.medcli.2017.10.035","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T14:01:13Z","timestamp":1513000873000},"page":"348-353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Enfermedad de Still del adulto"],"prefix":"10.1016","volume":"150","author":[{"given":"Javier","family":"Narv\u00e1ez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2017.10.035_bib0300","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.autrev.2014.01.058","article-title":"Adult-onset Still's disease","volume":"13","author":"Gerfaud-Valentin","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.medcli.2017.10.035_bib0305","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/art.1780300209","article-title":"Adult-onset Still's disease. Clinical course and outcome","volume":"30","author":"Cush","year":"1987","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2017.10.035_bib0310","first-page":"1055","article-title":"Adult-onset Still's disease: Clinical and laboratory features, treatment and progress of 45 cases","volume":"61","author":"Wouters","year":"1986","journal-title":"QJ Med"},{"key":"10.1016\/j.medcli.2017.10.035_bib0315","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0049-0172(87)90015-1","article-title":"Adult onset Still's disease: Experience in 23 patients and literature review with emphasis on organ failure","volume":"17","author":"Reginato","year":"1987","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.medcli.2017.10.035_bib0320","first-page":"1058","article-title":"Adult-onset Still's disease: A multicenter survey of Japanese patients","volume":"17","author":"Ohta","year":"1990","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0325","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1097\/00005792-199103000-00004","article-title":"Adult Still's disease: Manifestations, disease course, and outcome in 62 patients","volume":"70","author":"Pouchot","year":"1991","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0330","first-page":"2345","article-title":"Clinical characteristics, treatment and outcome of adult onset Still's disease in Southern Chinese","volume":"25","author":"Mok","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0335","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/01.rhu.0000158544.38663.0a","article-title":"Adult-onset Still's disease in Southeast Brazil","volume":"11","author":"Appenzeller","year":"2005","journal-title":"J Clin Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0340","first-page":"331","article-title":"Adult onset Still's disease: Review of 41 cases","volume":"29","author":"Riera","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0345","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/cup.12935","article-title":"Clinical and histopathological features of cutaneous manifestations of adult-onset Still disease","volume":"44","author":"Santa","year":"2017","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0350","doi-asserted-by":"crossref","first-page":"e6318","DOI":"10.1097\/MD.0000000000006318","article-title":"Adult-onset Still's disease with atypical cutaneous manifestations","volume":"96","author":"Narv\u00e1ez Garcia","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0355","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.semarthrit.2012.05.003","article-title":"Evanescent and persistent pruritic eruptions of adult-onset Still disease: A clinical and pathologic study of 36 patients","volume":"42","author":"Lee","year":"2012","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.medcli.2017.10.035_bib0360","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jaad.2015.04.063","article-title":"Updates in adult-onset Still disease: Atypical cutaneous manifestations and associations with delayed malignancy","volume":"73","author":"Sun","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0365","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10067-014-2487-4","article-title":"Life-threatening complications of adult-onset Still's disease","volume":"33","author":"Efthimiou","year":"2014","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0370","doi-asserted-by":"crossref","first-page":"e4258","DOI":"10.1097\/MD.0000000000004258","article-title":"Parenchymal lung involvement in adult-onset Still disease: A STROBE-compliant case series and literature review","volume":"95","author":"Gerfaud-Valentin","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0375","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/1874312901307010125","article-title":"Adult onset Still's disease presenting with acute respiratory distress syndrome: Case report and review of the literature","volume":"7","author":"Dua","year":"2013","journal-title":"Open Rheumatol J"},{"key":"10.1016\/j.medcli.2017.10.035_bib0380","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/MD.0000000000000112","article-title":"Myocarditis in adult-onset Still disease","volume":"93","author":"Gerfaud-Valentin","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0385","first-page":"27","article-title":"Pulmonary arterial hypertension secondary to adult-onset Still's disease: Response to cyclosporine and sildenafil over 15 years of follow-up","volume":"19","author":"Weatherald","year":"2016","journal-title":"Respir Med Case Rep"},{"key":"10.1016\/j.medcli.2017.10.035_bib0390","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1007\/s00296-010-1529-8","article-title":"Aseptic meningitis in adult onset Stil\u013adisease","volume":"32","author":"Akkara Veetil","year":"2012","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.medcli.2017.10.035_bib0395","first-page":"375035","article-title":"Rare manifestation of a rare disease: Acute liver failure in adult onset Still's disease Dramatic response to methylprednisolone pulse therapy - A case report and review","volume":"2014","author":"Vallurun","year":"2014","journal-title":"Case Rep Med"},{"key":"10.1016\/j.medcli.2017.10.035_bib0400","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3109\/s10165-008-0061-0","article-title":"Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome and adult onset Still's disease: Case report and review of the literature","volume":"18","author":"Sayarlioglu","year":"2008","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0405","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.semarthrit.2015.11.002","article-title":"Macrophage activation syndrome complicating adult onset Still's disease: A single center case series and comparison with literature","volume":"45","author":"Lenert","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.medcli.2017.10.035_bib0410","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/archdischild-2016-310772","article-title":"Diagnosing haemophagocytic syndrome","volume":"102","author":"Sen","year":"2017","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.medcli.2017.10.035_bib0415","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12969-015-0055-3","article-title":"Evidence-based diagnosis and treatment of macrophage activation syndrome in systemic juvenile idiopathic arthritis","volume":"13","author":"Boom","year":"2015","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.medcli.2017.10.035_bib0420","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/annrheumdis-2015-208982","volume":"75","author":"Ravelli","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2017.10.035_bib0425","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3899\/jrheum.161286","article-title":"Application of the 2016 EULAR\/ACR\/PRINTO classification criteria for macrophage activation syndrome in patients with adult-onset Still disease","volume":"44","author":"Ahn","year":"2017","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0430","doi-asserted-by":"crossref","first-page":"e6656","DOI":"10.1097\/MD.0000000000006656","article-title":"Refractory adult-onset Still disease complicated by macrophage activation syndrome and acute myocarditis: A case report treated with high doses (8mg\/kg\/d) of anakinra","volume":"96","author":"Parisi","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0435","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.berh.2016.08.003","article-title":"Adult-onset Still's disease: Advances in the treatment","volume":"30","author":"Casta\u00f1eda","year":"2016","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0440","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrrheum.2015.179","article-title":"Macrophage activation syndrome in the era of biologic therapy","volume":"12","author":"Grom","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0445","article-title":"Biologic therapy modifies clinical and laboratory features of macrophage activation syndrome associated with juvenile idiopathic arthritis","author":"Schulert","year":"2017","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0450","first-page":"424","article-title":"Preliminary criteria for classification of adult Still's disease","volume":"19","author":"Yamaguchi","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0455","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00005792-200205000-00003","article-title":"Proposal for a new set of classification criteria for adult-onset Still disease","volume":"81","author":"Fautrel","year":"2002","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0460","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.semarthrit.2015.10.003","article-title":"Adult onset Still's disease associated with malignancy-Cause or coincidence?","volume":"45","author":"Hofheinz","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.medcli.2017.10.035_bib0465","first-page":"322","article-title":"Diagnostic value of ferritin and glycosylated ferritin in adult onset Still's disease","volume":"28","author":"Fautrel","year":"2001","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0470","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.medcli.2016.10.028","article-title":"Hepcidina y ferritina en enfermedad de Still","volume":"148","author":"L\u00f3pez Aparicio","year":"2017","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2017.05.011","article-title":"New markers for adult-onset Still's disease","author":"Mitrovic","year":"2017","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.medcli.2017.10.035_bib0480","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1093\/rheumatology\/kew300","article-title":"Elevated serum levels of free interleukin-18 in adult-onset Still's disease","volume":"55","author":"Girard","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0485","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.3899\/jrheum.130575","article-title":"Interleukin 18: A biomarker for differential diagnosis between adult-onset Still's disease and sepsis","volume":"41","author":"Priori","year":"2014","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0490","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3899\/jrheum.120079","article-title":"Serum S100A8\/A9, but not follistatin-like protein 1 and interleukin 18, may be a useful biomarker of disease activity in adult-onset Still's disease","volume":"39","author":"Kim","year":"2012","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0495","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.3899\/jrheum.100247","article-title":"Clinical manifestations but not cytokine profiles differentiate adult-onset still's disease and sepsis","volume":"37","author":"Rau","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0500","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MD.0000000000000021","article-title":"Adult-onset Still disease: Manifestations, treatment, outcome, and prognostic factors in 57 patients","volume":"93","author":"Gerfaud-Valentin","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0505","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12916-016-0738-8","article-title":"Adult-onset Still's disease: Evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers","volume":"14","author":"Ruscitti","year":"2016","journal-title":"BMC Med"},{"key":"10.1016\/j.medcli.2017.10.035_bib0510","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/ard.2010.132613","article-title":"A preliminary score for the assessment of disease activity in hereditary recurrent fevers: Results from the AIDAI (Auto-Inflammatory Diseases Activity Index) Consensus Conference","volume":"70","author":"Piram","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2017.10.035_bib0515","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3899\/jrheum.161354","article-title":"Elevated expression of the NLRP3 inflammasome and its correlation with disease activity in adult-onset Still disease","volume":"44","author":"Hsieh","year":"2017","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0520","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.clim.2016.05.010","article-title":"Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis","volume":"169","author":"Inoue","year":"2016","journal-title":"Clin Immunol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0525","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1586\/1744666X.2015.1037287","article-title":"Presentation and diagnosis of adult-onset Still's disease: The implications of current and emerging markers in overcoming the diagnostic challenge","volume":"11","author":"Colafrancesco","year":"2015","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0530","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/rheumatology\/keq397","article-title":"Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis","volume":"50","author":"Priori","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0535","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/1529-0131(200107)44:7<1716::AID-ART298>3.0.CO;2-I","article-title":"Interleukin-18 as a novel diagnostic indicator of disease severity in adult-onset Still's disease","volume":"44","author":"Kawaguchi","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2017.10.035_bib0540","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.autrev.2015.01.004","article-title":"Increased level of H-ferritin and its imbalance with L-ferritin, in bone marrow and liver of patients with adult onset Still's disease, developing macrophage activation syndrome, correlate with the severity of the disease","volume":"14","author":"Ruscitti","year":"2015","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.medcli.2017.10.035_bib0545","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/cei.12826","article-title":"H-ferritin and CD68(+)\/H-ferritin(+) monocytes\/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease","volume":"186","author":"Ruscitti","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.medcli.2017.10.035_bib0550","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.medcli.2016.03.034","article-title":"Enfermedad de Still del adulto","volume":"147","author":"Casta\u00f1eda","year":"2016","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0555","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12026-014-8561-9","article-title":"Pathogenesis of adult onset Still's disease: New insights from the juvenile counterpart","volume":"61","author":"Jamilloux","year":"2015","journal-title":"Immunol Res"},{"key":"10.1016\/j.medcli.2017.10.035_bib0560","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.autrev.2014.08.032","article-title":"Adult onset Still's disease (AOSD) in the era of biologic therapies: Dichotomous view for cytokine and clinical expressions","volume":"13","author":"Maria","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.medcli.2017.10.035_bib0565","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/acr.22194","article-title":"Clinical manifestations of adult-onset Still's disease presenting with erosive arthritis: Association with low levels of ferritin and interleukin-18","volume":"66","author":"Ichida","year":"2014","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0570","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cyto.2012.11.025","article-title":"Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles","volume":"61","author":"Shimizu","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.medcli.2017.10.035_bib0575","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/rheumatology\/keq133","article-title":"Distinct cytokine profiles of systemic onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis","volume":"49","author":"Shimizu","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2017.10.035_bib0580","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/art.23437","article-title":"The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic onset juvenile idiopathic arthritis","volume":"58","author":"Gattorno","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2017.10.035_bib0585","unstructured":"Dictamen de la Comissi\u00f3 Farmacoterap\u00e8utica de la Medicaci\u00f3 Hospital\u00e0ria de Dispensaci\u00f3 Ambulat\u00f2ria sobre l\u2019\u00fas d\u2019abatacept, adalimumab, anakinra, canakinumab, certolizumab pegol, etanercept, golimumab, infliximab, rituximab i tocilizumab per al tractament fora d\u2019indicaci\u00f3 de la malaltia d'Still de l\u2019adult refract\u00e0ria al tractament habitual. Comissi\u00f3 Assessora de Medicaments en Situacions Especials (CAMSE). Servei Catal\u00e0 de la Salut [consultado 20 Nov 2017]. Disponible en: http:\/\/catsalut.gencat.cat\/web\/.content\/minisite\/catsalut\/proveidors_professionals\/medicaments_farmacia\/phf_mhda\/informes_camse\/Still\/Dictamen-CAMSE-Still_web_nou.pdf"},{"key":"10.1016\/j.medcli.2017.10.035_bib0590","unstructured":"Therapeutic use of tadekinig alfa in adult-onset Still's disease. ClinicalTrials.gov Identifier: NCT02398435, Bethesda (MD): National Library of Medicine (US) [consultado 20 Nov 2017]. Disponible en: http:\/\/clinicaltrials.gov\/"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775317308436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775317308436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T20:53:52Z","timestamp":1570481632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775317308436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0025775317308436"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2017.10.035","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enfermedad de Still del adulto","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2017.10.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}