{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:08:23Z","timestamp":1791464903877,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.medcli.2018.10.023","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T14:48:39Z","timestamp":1543502919000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Adherencia al tratamiento de hipertensi\u00f3n arterial, hipercolesterolemia y diabetes en poblaci\u00f3n anciana de una cohorte espa\u00f1ola"],"prefix":"10.1016","volume":"153","author":[{"given":"Aida","family":"Moreno Juste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gimeno Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Poblador Plou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Gonz\u00e1lez Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Mercedes","family":"Aza Pascual-Salcedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Menditto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Prados Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2018.10.023_bib0155","first-page":"38","article-title":"The World Health Report 2008 - Primary healthcare: How wide is the gap between its agenda and implementation in 12 high-income health systems?","volume":"7","author":"Gauld","year":"2012","journal-title":"Health Policy"},{"key":"10.1016\/j.medcli.2018.10.023_bib0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032190","article-title":"Multimorbidity patterns in primary care: Interactions among chronic diseases using factor analysis","volume":"7","author":"Prados-Torres","year":"2012","journal-title":"PLoS One."},{"key":"10.1016\/j.medcli.2018.10.023_bib0165","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13012-017-0584-x","article-title":"Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy: Study protocol of a cluster randomized clinical trial (Multi-PAP project)","volume":"12","author":"Prados-Torres","year":"2017","journal-title":"Implement Sci"},{"key":"10.1016\/j.medcli.2018.10.023_bib0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084967","article-title":"Polypharmacy patterns: Unravelling systematic associations between prescribed medications","volume":"8","author":"Calder\u00f3n-Larra\u00f1aga","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.medcli.2018.10.023_bib0175","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1046\/j.1365-2710.2001.00363.x","article-title":"Patient adherence to treatment: Three decades of research: A comprehensive review","volume":"26","author":"Vermiere","year":"2001","journal-title":"J Clin Pharm Ther."},{"key":"10.1016\/j.medcli.2018.10.023_bib0180","doi-asserted-by":"crossref","first-page":"e821","DOI":"10.3399\/bjgp12X659295","article-title":"Multimorbidity, polypharmacy, referrals, and adverse drug events: Are we doing things well?","volume":"62","author":"Calder\u00f3n-Larra\u00f1aga","year":"2012","journal-title":"Br J Gen Pract."},{"key":"10.1016\/j.medcli.2018.10.023_bib0185","unstructured":"World Health Organization. Adherence to long-term therapies: Evidence for action [Internet]. 2015 [consultado 3 Jul 2018]. Disponible en: http:\/\/www.who.int\/chp\/knowledge\/publications\/adherence_report\/en\/."},{"issue":"0.","key":"10.1016\/j.medcli.2018.10.023_bib0190","article-title":"Cohort Profile: The Epidemiology of Chronic Diseases and Multimorbidity. The EpiChron Cohort Study","volume":"0","author":"Prados-Torres","year":"2018","journal-title":"Int J Epidemiol."},{"key":"10.1016\/j.medcli.2018.10.023_bib0195","unstructured":"World Health Organization. Collaborating Centre for Drugs Statistics Methodology - ATC\/DDD Index [Internet]. [consultado 19 Mar 2018]. Disponible en: https:\/\/www.whocc.no\/atc_ddd_index\/."},{"key":"10.1016\/j.medcli.2018.10.023_bib0200","unstructured":"Menditto E, Orlando V, Malo-Fumanal S, Prados-Torres A, Cahir C. Measuring medication adherence in health-related databases. En: Costa E, editor. Adherence to Medical Plans for Active and Healthy Ageing. Nueva York: Nova Science Publisher; 2017. p. 189-206."},{"key":"10.1016\/j.medcli.2018.10.023_bib0205","doi-asserted-by":"crossref","DOI":"10.1002\/pds.3535","article-title":"An observational study examining the effect of comorbidity on the rates of persistence and adherence to newly initiated oral anti-hyperglycaemic agents","volume":"22","author":"O'Shea","year":"2013","journal-title":"Pharmacoepidemiol Drug Saf."},{"key":"10.1016\/j.medcli.2018.10.023_bib0210","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000453037","article-title":"Self-reported adherence among individuals at high risk of metabolic syndrome: Effect of knowledge and attitude","volume":"26","author":"Alefishat","year":"2017","journal-title":"Med Princ Pract."},{"key":"10.1016\/j.medcli.2018.10.023_bib0215","first-page":"e105","article-title":"Adherence to statins and LDL-cholesterol goal attainment","volume":"20","author":"Chi","year":"2014","journal-title":"Am J Manag Care."},{"key":"10.1016\/j.medcli.2018.10.023_bib0220","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ijcard.2016.01.069","article-title":"Non-adherence to antihypertensive medication: The role of mental and physical comorbidity","volume":"207","author":"Calder\u00f3n-Larra\u00f1aga","year":"2016","journal-title":"Int J Cardiol."},{"key":"10.1016\/j.medcli.2018.10.023_bib0225","first-page":"746","article-title":"Compliance and persistence with concomitant statin and oral antihyperglycemic therapy","volume":"17","author":"Zhang","year":"2011","journal-title":"Am J Manag Care."},{"key":"10.1016\/j.medcli.2018.10.023_bib0230","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3121\/cmr.2013.1113","article-title":"Patient characteristics associated with medication adherence","volume":"11","author":"Rolnick","year":"2013","journal-title":"Clin Med Res."},{"key":"10.1016\/j.medcli.2018.10.023_bib0235","doi-asserted-by":"crossref","first-page":"487","DOI":"10.18553\/jmcp.2007.13.6.487","article-title":"Analysis of factors associated with statin adherence in a hierarchical model considering physician, pharmacy, patient, and prescription characteristics","volume":"13","author":"Pedan","year":"2007","journal-title":"J Manag Care Pharm."},{"key":"10.1016\/j.medcli.2018.10.023_bib0240","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0895-7061(97)00056-3","article-title":"The effects of initial drug choice and comorbidity on antihypertensive therapy compliance. Results from a population-based study in the elderly","volume":"10","author":"Monane","year":"1997","journal-title":"Am J Hypertens."},{"key":"10.1016\/j.medcli.2018.10.023_bib0245","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1177\/2047487312451252","article-title":"Factors influencing antihypertensive medication compliance in Taiwan: A nationwide population-based study","volume":"20","author":"Lee","year":"2013","journal-title":"Eur J Prev Cardiol."},{"key":"10.1016\/j.medcli.2018.10.023_bib0250","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2261-11-46","article-title":"Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: A cohort study","volume":"11","author":"Latry","year":"2011","journal-title":"BMC Cardiovasc Disord."},{"key":"10.1016\/j.medcli.2018.10.023_bib0255","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13300-017-0361-5","article-title":"A class comparison of medication persistence in people with type 2 diabetes: A retrospective observational study","volume":"9","author":"McGovern","year":"2018","journal-title":"Diabetes Ther."},{"key":"10.1016\/j.medcli.2018.10.023_bib0260","doi-asserted-by":"crossref","DOI":"10.5812\/numonthly.29863","article-title":"Adherence to antihypertensives in patients with comorbid condition","volume":"7","author":"Saadat","year":"2015","journal-title":"Nephrourol Mon."},{"key":"10.1016\/j.medcli.2018.10.023_bib0265","first-page":"235","article-title":"Actualizaci\u00f3n en Medicina de Familia: Cumplimiento terap\u00e9utico","volume":"34","author":"Orueta","year":"2008","journal-title":"Med Fam Semer."},{"key":"10.1016\/j.medcli.2018.10.023_bib0270","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/jhh.2015.86","article-title":"Association between adherence, treatment satisfaction and illness perception in hypertensive patients","volume":"30","author":"Saarti","year":"2016","journal-title":"J Hum Hypertens."},{"key":"10.1016\/j.medcli.2018.10.023_bib0275","doi-asserted-by":"crossref","first-page":"247","DOI":"10.18553\/jmcp.2013.19.3.247","article-title":"Adherence to evidence-based therapies after acute coronary syndrome: A retrospective population-based cohort study linking hospital, outpatient, and pharmacy health information systems in Valencia, Spain","volume":"19","author":"Sanf\u00e9lix-Gimeno","year":"2013","journal-title":"J Manag Care Pharm."},{"key":"10.1016\/j.medcli.2018.10.023_bib0280","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.2147\/PPA.S164819","article-title":"Adherence to chronic medication in older populations: Application of a common protocol among three European cohorts","volume":"12","author":"Menditto","year":"2018","journal-title":"Patient Prefer Adherence."},{"key":"10.1016\/j.medcli.2018.10.023_bib0285","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2147\/PPA.S122556","article-title":"Medication adherence and persistence in type 2 diabetes mellitus: Perspectives of patients, physicians and pharmacists on the Spanish health care system","volume":"11","author":"Labrador Barba","year":"2017","journal-title":"Patient Prefer Adherence."},{"key":"10.1016\/j.medcli.2018.10.023_bib0290","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. 8. Pharmacologic approaches to glycemic treatment: Standards of medical care in diabetes-2018. Diabetes Care. 2017;41(Supp 1):S64-S74.","DOI":"10.2337\/dc17-S011"},{"key":"10.1016\/j.medcli.2018.10.023_bib0295","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.HYP.0000222373.59104.3d","article-title":"Recommendations for evaluating compliance and persistence with hypertension therapy using retrospective data","volume":"47","author":"Halpern","year":"2006","journal-title":"Hypertension."},{"key":"10.1016\/j.medcli.2018.10.023_bib0300","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3346\/jkms.2015.30.12.1800","article-title":"Persistence with antihypertensive medications in uncomplicated treatment-na\u00efve patients: Effects of initial therapeutic classes","volume":"30","author":"Ah","year":"2015","journal-title":"J Korean Med Sci."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775318306547?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775318306547?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T21:10:19Z","timestamp":1654636219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775318306547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0025775318306547"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2018.10.023","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adherencia al tratamiento de hipertensi\u00f3n arterial, hipercolesterolemia y diabetes en poblaci\u00f3n anciana de una cohorte espa\u00f1ola","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2018.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}