{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:15:23Z","timestamp":1789038923126,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.medcli.2020.07.035","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:34:51Z","timestamp":1608856491000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Anemia de las enfermedades cr\u00f3nicas: fisiopatolog\u00eda, diagn\u00f3stico y tratamiento"],"prefix":"10.1016","volume":"156","author":[{"given":"Ricardo","family":"de las Cuevas Allende","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"D\u00edaz de Entresotos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Conde D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2020.07.035_bib0305","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra1804281","article-title":"Anemia of Inflammation","volume":"381","author":"Ganz","year":"2019","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2020.07.035_bib0310","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.medcli.2017.06.025","article-title":"Anemia del anciano","volume":"149","author":"G\u00f3mez Ram\u00edrez","year":"2017","journal-title":"Med Clin (Barc)."},{"key":"10.1016\/j.medcli.2020.07.035_bib0315","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1182\/blood-2018-06-856500","article-title":"Anemia of inflammation","volume":"133","author":"Weiss","year":"2019","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0320","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.medcli.2016.10.047","article-title":"Estado actual del metabolismo del hierro: implicaciones cl\u00ednicas y terap\u00e9uticas","volume":"148","author":"Conde Diez","year":"2017","journal-title":"Med Clin (Barc)."},{"key":"10.1016\/j.medcli.2020.07.035_bib0325","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.3389\/fphys.2019.01294","article-title":"Hepcidin and Anemia: A Tight Relationship","volume":"10","author":"Pagani","year":"2019","journal-title":"Front Physiol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0330","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/MOH.0000000000000236","article-title":"Hepcidin Regulation in the Anemia of Inflammation","volume":"23","author":"Wang","year":"2016","journal-title":"Curr Opin Hematol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0335","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/ph11040127","article-title":"Hepcidin therapeutics","volume":"11","author":"Katsarou","year":"2018","journal-title":"Pharmaceuticals (Basel)."},{"key":"10.1016\/j.medcli.2020.07.035_bib0340","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1182\/blood-2014-01-552281","article-title":"HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression","volume":"124","author":"Wu","year":"2014","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0345","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1182\/blood-2018-06-857995","article-title":"Erythroferrone inhibits the induction of hepcidin by BMP6","volume":"132","author":"Arezes","year":"2018","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0350","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood.2019002620","article-title":"Erythroferrone lowers hepcidin by sequestering BMP2\/6 heterodimer from binding to the BMP type I receptor ALK3","volume":"135","author":"Wang","year":"2020","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0355","doi-asserted-by":"crossref","first-page":"18354","DOI":"10.1074\/jbc.M117.801795","article-title":"Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway","volume":"292","author":"Wahedi","year":"2017","journal-title":"J Biol Chem."},{"key":"10.1016\/j.medcli.2020.07.035_bib0360","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MOH.0000000000000132","article-title":"New insights into iron regulation and erythropoiesis","volume":"22","author":"Kim","year":"2015","journal-title":"Curr Opin Hematol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0365","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.3390\/nu11102424","article-title":"Anemia of Inflammation with An Emphasis on Chronic Kidney Disease","volume":"11","author":"Begum","year":"2019","journal-title":"Nutrients."},{"key":"10.1016\/j.medcli.2020.07.035_bib0370","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1084\/jem.20170396","article-title":"Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor","volume":"215","author":"Khalil","year":"2018","journal-title":"J Exp Med."},{"key":"10.1016\/j.medcli.2020.07.035_bib0375","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1182\/blood-2018-08-869586","article-title":"A long sought after \u00abreceptor\u00bb for ERFE?","volume":"132","author":"Zhang","year":"2018","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0380","doi-asserted-by":"crossref","DOI":"10.3399\/bjgpopen18X101597","article-title":"Diagnostics in anaemia of chronic disease in general practice: a real-world retrospective cohort study","volume":"2","author":"Schop","year":"2018","journal-title":"BJGP Open."},{"key":"10.1016\/j.medcli.2020.07.035_bib0385","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.hoc.2014.04.005","article-title":"Anemia of Inflammation","volume":"28","author":"Nemeth","year":"2014","journal-title":"Hematol Oncol Clin North Am."},{"key":"10.1016\/j.medcli.2020.07.035_bib0390","doi-asserted-by":"crossref","first-page":"e3150","DOI":"10.1097\/MD.0000000000003150","article-title":"Hepcidin: A promising therapeutic target for iron disorders. A systematic review","volume":"95","author":"Liu","year":"2016","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.medcli.2020.07.035_bib0395","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1208\/s12248-016-9886-1","article-title":"Pharmacodynamic Model of Hepcidin Regulation of Iron Homeostasis in Cynomolgus Monkeys","volume":"18","author":"Krzyzanski","year":"2016","journal-title":"AAPS J."},{"key":"10.1016\/j.medcli.2020.07.035_bib0400","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3390\/ph12040170","article-title":"Therapeutic Advances in Regulating the Hepcidin\/Ferroportin Axis","volume":"12","author":"Hawula","year":"2019","journal-title":"Pharmaceuticals."},{"key":"10.1016\/j.medcli.2020.07.035_bib0405","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.7150\/ijbs.4666","article-title":"Targeting Interleukin-6: All the Way to Treat Autoimmune and Inflammatory Diseases","volume":"8","author":"Tanaka","year":"2012","journal-title":"Int J Biol Sci."},{"key":"10.1016\/j.medcli.2020.07.035_bib0410","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1158\/1078-0432.CCR-15-0134","article-title":"Analysis of Inflammatory and Anemia-Related Biomarkers in a Randomized, Double-Blind Placebo-Controlled Study of Siltuximab (Anti-IL6 Monoclonal Antibody) in Patients With Multicentric Castleman Disease","volume":"21","author":"Casper","year":"2015","journal-title":"Clin Cancer Res."},{"key":"10.1016\/j.medcli.2020.07.035_bib0415","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1111\/bph.13188","article-title":"Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats","volume":"172","author":"Barrett","year":"2015","journal-title":"Br J Pharmacol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0420","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/ijms19020389","article-title":"Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease","volume":"19","author":"Kaplan","year":"2018","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.medcli.2020.07.035_bib0425","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/bcp.13584","article-title":"First-in-man\u2013proof of concept study with molidustat: a novel selective oral FIH-prolyl hydroxylase inhibitor for the treatment of renal anaemia","volume":"84","author":"B\u00f6ttcher","year":"2018","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0430","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJMoa1813599","article-title":"Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis","volume":"381","author":"Chen","year":"2019","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2020.07.035_bib0435","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1901713","article-title":"Roxadustat treatment for anemia in patients undergoing long-term dialysis","volume":"381","author":"Chen","year":"2019","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2020.07.035_bib0440","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2018.07.003","article-title":"Erythropoietic regulators of iron metabolism","volume":"33","author":"Ganz","year":"2019","journal-title":"Free Radic Biol Med."},{"key":"10.1016\/j.medcli.2020.07.035_bib0445","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1182\/blood-2010-03-271791","article-title":"Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease","volume":"116","author":"Song","year":"2010","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0450","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1182\/blood-2016-09-740092","article-title":"Momelotinib inhibits ACVR1\/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents","volume":"129","author":"Asshoff","year":"2017","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0455","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1200\/JCO.2017.73.4418","article-title":"SIMPLIFY-1: a phase III randomized trial of momelotinib versus ruxolitinib in Janus kinase inhibitor-na\u00efve patients with myelofibrosis","volume":"35","author":"Mesa","year":"2017","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0460","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12885-016-2305-2","article-title":"Treatment with anti-IL-6 receptor antibody prevented increase in serum hepcidin levels and improved anemia in mice inoculated with IL-6\u2013producing lung carcinoma cells","volume":"16","author":"Noguchi-Sasaki","year":"2016","journal-title":"BMC Cancer."},{"key":"10.1016\/j.medcli.2020.07.035_bib0465","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1111\/hdi.12543","article-title":"Role of Hepcidin-Ferroportin Axis in the Pathophysiology Diagnosis, and Treatment of Anemia of Chronic Inflammation","volume":"21","author":"Langer","year":"2017","journal-title":"Hemodial Int."},{"key":"10.1016\/j.medcli.2020.07.035_bib0470","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1517\/17425255.2015.992779","article-title":"Tocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics\/pharmacodynamics and clinical efficacy","volume":"11","author":"Song","year":"2015","journal-title":"Expert Opin Drug Metab Toxicol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0475","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1093\/rheumatology\/kes381","article-title":"Effects of subcutaneous and intravenous golimumab on inflammatory biomarkers in patients with rheumatoid arthritis: results of a phase 1, randomized, open-label trial","volume":"52","author":"Doyle","year":"2013","journal-title":"Rheumatology."},{"key":"10.1016\/j.medcli.2020.07.035_bib0480","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1177\/0394632017714695","article-title":"Anti-TNF-\u03b1 effects on anemia in rheumatoid and psoriatic arthritis. et al","volume":"30","author":"Corrado","year":"2017","journal-title":"Int J Immunopathol Pharmacol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0485","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.3748\/wjg.v17.i45.5032","article-title":"AG490: an inhibitor of hepcidin expression in vivo","volume":"17","author":"Zhang","year":"2011","journal-title":"World J Gastroenterol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0490","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00109-009-0588-3","article-title":"Natural and synthetic\u00a0STAT3\u00a0inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated\u00a0STAT3\u00a0form","volume":"88","author":"Fatih","year":"2010","journal-title":"J Mol Med (Berl)."},{"key":"10.1016\/j.medcli.2020.07.035_bib0495","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1681\/ASN.2013040355","article-title":"Suppression of iron-regulatory hepcidin by vitamin D","volume":"25","author":"Bacchetta","year":"2014","journal-title":"J Am Soc Nephrol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0500","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1210\/en.2016-1150","article-title":"Effects of Testosterone on Erythropoiesis in a Female Mouse Model of Anemia of Inflammation","volume":"157","author":"Guo","year":"2016","journal-title":"Endocrinology."},{"key":"10.1016\/j.medcli.2020.07.035_bib0505","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1210\/en.2011-2045","article-title":"17\u03b2-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site","volume":"153","author":"Yang","year":"2012","journal-title":"Endocrinology."},{"key":"10.1016\/j.medcli.2020.07.035_bib0510","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/0886022X.2018.1535983","article-title":"Effect of atorvastatin on iron metabolism regulation in patients with chronic kidney disease \u2013 a randomized double blind crossover study","volume":"40","author":"Masajtis-Zagajewska","year":"2018","journal-title":"Ren Fail."},{"key":"10.1016\/j.medcli.2020.07.035_bib0515","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.1016\/j.bmcl.2017.10.031","article-title":"Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives","volume":"27","author":"Fukuda","year":"2017","journal-title":"Bioorg Med Chem Lett."},{"key":"10.1016\/j.medcli.2020.07.035_bib0520","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1016\/j.bmcl.2017.07.004","article-title":"Discovery of DS79182026: A potent orally active hepcidin production inhibitor","volume":"27","author":"Fukuda","year":"2017","journal-title":"Bioorg Med Chem Lett."},{"key":"10.1016\/j.medcli.2020.07.035_bib0525","doi-asserted-by":"crossref","first-page":"e0163289","DOI":"10.1371\/journal.pone.0163289","article-title":"S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6\/STAT3 Pathway","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One."},{"key":"10.1016\/j.medcli.2020.07.035_bib0530","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/fcp.12288","article-title":"Curcuma decreases serum hepcidin levels in healthy volunteers: a placebo-controlled, randomized, double-blind, cross-over study","volume":"31","author":"Lain\u00e9","year":"2017","journal-title":"Fundam Clin Pharmacol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0535","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3945\/jn.113.174201","article-title":"Screening identifies the Chinese medicinal plant Caulis spatholobi as an effective HAMP expression inhibitor","volume":"143","author":"Guan","year":"2013","journal-title":"J Nutr."},{"key":"10.1016\/j.medcli.2020.07.035_bib0540","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.3324\/haematol.2015.140772","article-title":"Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels","volume":"101","author":"Kovac","year":"2016","journal-title":"Haematologica."},{"key":"10.1016\/j.medcli.2020.07.035_bib0545","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1208\/s12248-015-9770-4","article-title":"Anti-repulsive guidance molecule C (RGMc) antibodies increases serum iron in rats and cynomolgus monkeys by hepcidin downregulation","volume":"17","author":"B\u00f6ser","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.medcli.2020.07.035_bib0550","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/bcp.13877","article-title":"Targeting the hepcidin\u2013ferroportin pathway in anaemia of chronic kidney disease","volume":"85","author":"Sheetz","year":"2019","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0555","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1182\/blood-2010-10-313064","article-title":"Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation","volume":"117","author":"Steinbicker","year":"2011","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0560","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1182\/blood-2011-03-345066","article-title":"Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats","volume":"118","author":"Theurl","year":"2011","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0565","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fphar.2014.00086","article-title":"Hepcidin antagonists for potential treatments of disorders with hepcidin excess","volume":"5","author":"Poli","year":"2014","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0570","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3390\/molecules22040598","article-title":"Non-Anticoagulant Heparins Are Hepcidin Antagonists for the Treatment of Anemia","volume":"22","author":"Poli","year":"2017","journal-title":"Molecules."},{"key":"10.1016\/j.medcli.2020.07.035_bib0575","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1182\/blood-2013-06-505792","article-title":"A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates","volume":"122","author":"Cooke","year":"2013","journal-title":"Blood."},{"key":"10.1016\/j.medcli.2020.07.035_bib0580","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13045-017-0427-x","article-title":"A first-in-human phase 1 study of a hepcidin monoclonal antibody LY2787106, in cancer-associated anemia","volume":"10","author":"Vadhan-Raj","year":"2017","journal-title":"J Hematol Oncol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0585","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s40259-018-0278-1","article-title":"Anticalin\u00ae Proteins as Therapeutic Agents in Human Diseases","volume":"32","author":"Rothe","year":"2018","journal-title":"BioDrugs."},{"key":"10.1016\/j.medcli.2020.07.035_bib0590","doi-asserted-by":"crossref","first-page":"e0212023","DOI":"10.1371\/journal.pone.0212023","article-title":"First-in-human Phase I studies of PRS-080#22, a hepcidin antagonist, in healthy volunteers and patients with chronic kidney disease undergoing hemodialysis","volume":"14","author":"Renders","year":"2019","journal-title":"PLoS One."},{"key":"10.1016\/j.medcli.2020.07.035_bib0595","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/bph.13433","article-title":"Safety, pharmacokinetics and pharmacodynamics of the anti-hepcidin Spiegelmer lexaptepid pegol in healthy subjects","volume":"173","author":"Boyce","year":"2016","journal-title":"Br J Pharmacol."},{"key":"10.1016\/j.medcli.2020.07.035_bib0600","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1124\/mol.112.083428","article-title":"High-Throughput Screening of Small Molecules Identifies Hepcidin Antagonists","volume":"83","author":"Fung","year":"2013","journal-title":"Mol Pharmacol."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775320306539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775320306539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:51:58Z","timestamp":1758419518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775320306539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0025775320306539"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2020.07.035","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anemia de las enfermedades cr\u00f3nicas: fisiopatolog\u00eda, diagn\u00f3stico y tratamiento","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2020.07.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}