{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:36:10Z","timestamp":1788914170257,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.medcli.2020.08.020","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T12:37:15Z","timestamp":1610109435000},"page":"339-343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["El sistema glinf\u00e1tico y su implicaci\u00f3n en las enfermedades del sistema nervioso"],"prefix":"10.1016","volume":"156","author":[{"given":"Mar\u00eda","family":"Toriello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Gonz\u00e1lez-Quintanilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2020.08.020_bib0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(01)00150-8","article-title":"The physiology of the lymphatic system","volume":"50","author":"Swartz","year":"2001","journal-title":"Adv Drug Deliv Rev."},{"key":"10.1016\/j.medcli.2020.08.020_bib0200","first-page":"51","article-title":"Studies on cerebro-spinal fluid. No. III: the pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi","volume":"31","author":"Weed","year":"1914","journal-title":"J Med Res."},{"key":"10.1016\/j.medcli.2020.08.020_bib0205","doi-asserted-by":"crossref","first-page":"200","DOI":"10.14336\/AD.2020.0103","article-title":"The interstitial system of the brain in health and disease","volume":"11","author":"Shetty","year":"2020","journal-title":"Aging Dis."},{"key":"10.1016\/j.medcli.2020.08.020_bib0210","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med."},{"key":"10.1016\/j.medcli.2020.08.020_bib0215","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The glymphatic system: a beginner's guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem Res."},{"key":"10.1016\/j.medcli.2020.08.020_bib0220","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1479-5876-11-107","article-title":"Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer","volume":"11","author":"Yang","year":"2013","journal-title":"J Transl Med."},{"key":"10.1016\/j.medcli.2020.08.020_bib0225","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0006-8993(85)91383-6","article-title":"Evidence for a\u2019paravascular\u2019 fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subaracnoid space","volume":"326","author":"Rennels","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.medcli.2020.08.020_bib0230","first-page":"cer-09-18","article-title":"The brain's waste-removal system","volume":"2018","author":"Benveniste","year":"2018","journal-title":"Cerebrum."},{"key":"10.1016\/j.medcli.2020.08.020_bib0235","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatics vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature."},{"key":"10.1016\/j.medcli.2020.08.020_bib0240","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/joa.12381","article-title":"Lymphatic vessels of the dura matter: a new discovery?","volume":"227","author":"Bucchieri","year":"2015","journal-title":"J Anat."},{"key":"10.1016\/j.medcli.2020.08.020_bib0245","doi-asserted-by":"crossref","first-page":"e29738","DOI":"10.7554\/eLife.29738","article-title":"Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI","volume":"6","author":"Absinta","year":"2017","journal-title":"Elife."},{"key":"10.1016\/j.medcli.2020.08.020_bib0250","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jmri.26892","article-title":"Glymphatic imaging using MRI","volume":"51","author":"Taoka","year":"2020","journal-title":"J Magn Reson Imaging."},{"key":"10.1016\/j.medcli.2020.08.020_bib0255","doi-asserted-by":"crossref","first-page":"20190572","DOI":"10.1098\/rsif.2019.0572","article-title":"Fluid dynamics of the cerebrospinal fluid flow in perivascular spaces","volume":"16","author":"Thomas","year":"2019","journal-title":"J R Soc Interface."},{"key":"10.1016\/j.medcli.2020.08.020_bib0260","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/brain\/awx148","article-title":"Slow wave sleep disruption increases cerebrospinal fluid amyloid-\u03b2 levels","volume":"140","author":"Ju","year":"2017","journal-title":"Brain."},{"key":"10.1016\/j.medcli.2020.08.020_bib0265","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1073\/pnas.1914017117","article-title":"Imaging the effect of the circadian light-dark cycle on the glymphatic system in awake rats","volume":"117","author":"Cai","year":"2020","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.medcli.2020.08.020_bib0270","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1073\/pnas.1721694115","article-title":"\u03b2-amyloid accumulation in the human brain after one night sleep deprivation","volume":"115","author":"Shokri-Kojori","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"key":"10.1016\/j.medcli.2020.08.020_bib0275","doi-asserted-by":"crossref","first-page":"11034","DOI":"10.1523\/JNEUROSCI.1625-15.2015","article-title":"The effect of body posture on brain glymphatic transport","volume":"35","author":"Lee","year":"2015","journal-title":"J Neurosci."},{"key":"10.1016\/j.medcli.2020.08.020_bib0280","doi-asserted-by":"crossref","first-page":"R1450","DOI":"10.1152\/ajpregu.00215.2004","article-title":"Spinal CSF absorption in healthy individuals","volume":"287","author":"Edsbagge","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"10.1016\/j.medcli.2020.08.020_bib0285","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000490349","article-title":"The glymphatic system and waste clearance with brain aging: a review","volume":"65","author":"Benveniste","year":"2019","journal-title":"Gerontology."},{"key":"10.1016\/j.medcli.2020.08.020_bib0290","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bbadis.2015.10.014","article-title":"Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease","volume":"1862","author":"Simon","year":"2016","journal-title":"Biochim Biophys Acta."},{"key":"10.1016\/j.medcli.2020.08.020_bib0295","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1177\/1073858417691030","article-title":"The glymphatic pathway: waste removal from the CNS via cerebrospinal fluid transport","volume":"23","author":"Benveniste","year":"2017","journal-title":"Neuroscientist."},{"key":"10.1016\/j.medcli.2020.08.020_bib0300","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S1474-4422(18)30318-1","article-title":"The glymphatic pathway in neurological disorders","volume":"17","author":"Rasmussen","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.medcli.2020.08.020_bib0305","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.2967\/jnumed.118.223834","article-title":"Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer disease and multiple sclerosis","volume":"60","author":"Schubert","year":"2019","journal-title":"J Nucl Med."},{"key":"10.1016\/j.medcli.2020.08.020_bib0310","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13024-015-0056-1","article-title":"Deletion of aquaporin-4 in APP\/PS1 mice exacerbates brain A\u03b2 accumulation and memory deficits","volume":"10","author":"Xu","year":"2015","journal-title":"Mol Neurodegener."},{"key":"10.1016\/j.medcli.2020.08.020_bib0315","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainresbull.2018.10.007","article-title":"Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage","volume":"143","author":"Cao","year":"2018","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.medcli.2020.08.020_bib0320","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.aav2546","article-title":"The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans","volume":"363","author":"Holth","year":"2019","journal-title":"Science."},{"key":"10.1016\/j.medcli.2020.08.020_bib0325","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.nbscr.2016.08.002","article-title":"Sleep in Alzheimer's disease-beyond amyloid","volume":"2","author":"Holth","year":"2017","journal-title":"Neurobiol Sleep Circadian Rythms."},{"key":"10.1016\/j.medcli.2020.08.020_bib0330","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.neubiorev.2019.05.016","article-title":"Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson's disease","volume":"103","author":"Sundaram","year":"2019","journal-title":"Neurosci Biobehav Rev."},{"key":"10.1016\/j.medcli.2020.08.020_bib0335","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1523\/JNEUROSCI.3742-14.2015","article-title":"Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system","volume":"35","author":"Plog","year":"2015","journal-title":"J Neurosci."},{"key":"10.1016\/j.medcli.2020.08.020_bib0340","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.3389\/fimmu.2018.03116","article-title":"Pathogenic mechanisms associated with different clinical courses of multiple sclerosis","volume":"9","author":"Lassmann","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.medcli.2020.08.020_bib0345","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.3174\/ajnr.A5773","article-title":"Gadolinium and multiple sclerosis: vessels, barriers of the brain, and glymphatics","volume":"39","author":"Saade","year":"2018","journal-title":"AJNR Am J Neuroradiol."},{"key":"10.1016\/j.medcli.2020.08.020_bib0350","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/nyas.12794","article-title":"Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin-4 channelopathies: a decade later","volume":"1366","author":"Pittock","year":"2016","journal-title":"Ann N Y Acad Sci."},{"key":"10.1016\/j.medcli.2020.08.020_bib0355","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1093\/brain\/awx191","article-title":"Glymphatic MRI in idiopathic normal pressure hydrocephalus","volume":"140","author":"Ringstad","year":"2017","journal-title":"Brain."},{"key":"10.1016\/j.medcli.2020.08.020_bib0360","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3389\/fneur.2017.00734","article-title":"Pseudotumor cerebri and glymphatic dysfunction","volume":"8","author":"Bezerra","year":"2018","journal-title":"Front Neurol."},{"key":"10.1016\/j.medcli.2020.08.020_bib0365","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1523\/JNEUROSCI.3390-16.2017","article-title":"Cortical spreading depression closes paravascular space and impairs glymphatic flow: implications for migraine headache","volume":"37","author":"Schain","year":"2017","journal-title":"J Neurosci."},{"key":"10.1016\/j.medcli.2020.08.020_bib0370","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1111\/ene.14284","article-title":"No association between migraine frequency, white matter lesions and silent brain infarctions: a study in a series of women with chronic migraine","volume":"27","author":"Meil\u00e1n","year":"2020","journal-title":"Eur J Neurol."},{"key":"10.1016\/j.medcli.2020.08.020_bib0375","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-pathol-051217-111018","article-title":"The glymphatic system in central nervous system health and disease: past, present and future","volume":"13","author":"Plog","year":"2018","journal-title":"Annu Rev Pathol."},{"key":"10.1016\/j.medcli.2020.08.020_bib0380","first-page":"4948","article-title":"Aquaporin 4 in astrocytes is a target for therapy in Alzheimer's disease","volume":"23","author":"Lan","year":"2017","journal-title":"Curr Pharm Des."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775320308551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775320308551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:52:19Z","timestamp":1758419539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775320308551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S0025775320308551"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2020.08.020","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"El sistema glinf\u00e1tico y su implicaci\u00f3n en las enfermedades del sistema nervioso","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2020.08.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}