{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:56:06Z","timestamp":1792508166181,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.medcli.2021.11.015","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T17:04:48Z","timestamp":1642179888000},"page":"431-436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["S\u00edndrome de Wernicke-Korsakoff y otras patolog\u00edas asociadas al d\u00e9ficit de tiamina"],"prefix":"10.1016","volume":"158","author":[{"given":"Ana-Mar\u00eda","family":"Mateos-D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Marcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio-Javier","family":"Chamorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2021.11.015_bib0185","article-title":"Wernicke-Korsakoff syndrome","author":"Akhouri","year":"2021","journal-title":"StatPearls. Treasure Island (FL)"},{"key":"10.1016\/j.medcli.2021.11.015_bib0190","series-title":"Lehrbuch der Gehirnkrankheiten f\u00fcr \u00c4erzte und Studirende","first-page":"229","article-title":"Die akute haemorrhagische polioencephalitis superior","author":"Wernicke","year":"1881"},{"key":"10.1016\/j.medcli.2021.11.015_bib0195","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF02229734","article-title":"Ueber eine besondere Form psychischer St\u00f6rung, combinirt mit multipler Neuritis","volume":"21","author":"Korsakow","year":"1890","journal-title":"Arch Psychiatr Nervenkr."},{"key":"10.1016\/j.medcli.2021.11.015_bib0200","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/0004563220939604","article-title":"Don\u2019t seek, don\u2019t find: The diagnostic challenge of Wernicke's encephalopathy","volume":"58","author":"Kohnke","year":"2021","journal-title":"Ann Clin Biochem."},{"key":"10.1016\/j.medcli.2021.11.015_bib0205","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1468-1331.2010.03153.x","article-title":"EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy","volume":"17","author":"Galvin","year":"2010","journal-title":"Eur J Neurol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0210","doi-asserted-by":"crossref","first-page":"117482","DOI":"10.1016\/j.jns.2021.117482","article-title":"Wernicke-Korsakoff syndrome despite no alcohol abuse: A summary of systematic reports","volume":"426","author":"Oudman","year":"2021","journal-title":"J Neurol Sci."},{"key":"10.1016\/j.medcli.2021.11.015_bib0215","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/ncp.10234","article-title":"Role of thiamin in health and disease","volume":"34","author":"Polegato","year":"2019","journal-title":"Nutr Clin Pract."},{"key":"10.1016\/j.medcli.2021.11.015_bib0220","unstructured":"World Health Organization (WHO). Thiamine deficiency and its prevention and control in major emergencies [consultado 16 Nov 2021]. Disponible en: http:\/\/www.who.int\/nutrition\/publications\/emergencies\/WHO_NHD_99.13\/en\/"},{"key":"10.1016\/j.medcli.2021.11.015_bib0225","doi-asserted-by":"crossref","DOI":"10.1177\/2045125320978106","article-title":"Wernicke's encephalopathy \u2014 from basic science to clinical practice. Part 1: Understanding the role of thiamine","volume":"10","author":"Ott","year":"2020","journal-title":"Ther Adv Psychopharmacol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0230","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1515\/jbcpp-2018-0075","article-title":"Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis","volume":"30","author":"Chandrakumar","year":"2018","journal-title":"J Basic Clin Physiol Pharmacol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0235","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1474-4422(07)70104-7","article-title":"Wernicke's encephalopathy: New clinical settings and recent advances in diagnosis and management","volume":"6","author":"Sechi","year":"2007","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0240","first-page":"134","article-title":"The role of thiamine deficiency in alcoholic brain disease","volume":"27","author":"Martin","year":"2003","journal-title":"Alcohol Res Health."},{"key":"10.1016\/j.medcli.2021.11.015_bib0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/alcalc\/agh249","article-title":"The natural history and pathophysiology of Wernicke's encephalopathy and Korsakoff's psychosis","volume":"41","author":"Thomson","year":"2006","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0250","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41430-021-00859-9","article-title":"High proportion of thiamine deficiency in referred cancer patients with delirium: A retrospective descriptive study","volume":"75","author":"Onishi","year":"2021","journal-title":"Eur J Clin Nutr."},{"key":"10.1016\/j.medcli.2021.11.015_bib0255","doi-asserted-by":"crossref","first-page":"100252","DOI":"10.1016\/j.bbih.2021.100252","article-title":"Encephalopathy responsive to thiamine in severe COVID-19 patients","volume":"14","author":"Branco de Oliveira","year":"2021","journal-title":"Brain Behav Immun Health."},{"key":"10.1016\/j.medcli.2021.11.015_bib0260","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/jnnp.49.4.341","article-title":"Clinical signs in the Wernicke-Korsakoff complex: A retrospective analysis of 131 cases diagnosed at necropsy","volume":"49","author":"Harper","year":"1986","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"10.1016\/j.medcli.2021.11.015_bib0265","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s11604-020-00989-3","article-title":"Comprehensive review of Wernicke encephalopathy: Pathophysiology, clinical symptoms and imaging findings","volume":"38","author":"Ota","year":"2020","journal-title":"Jpn J Radiol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0270","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.2147\/NDT.S130078","article-title":"Korsakoff's syndrome: A critical review","volume":"13","author":"Arts","year":"2017","journal-title":"Neuropsychiatr Dis Treat."},{"key":"10.1016\/j.medcli.2021.11.015_bib0275","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.mayocp.2017.02.019","article-title":"Differences between alcoholic and nonalcoholic patients with Wernicke encephalopathy: A multicenter observational study","volume":"92","author":"Chamorro","year":"2017","journal-title":"May Clin Proc."},{"key":"10.1016\/j.medcli.2021.11.015_bib0280","doi-asserted-by":"crossref","first-page":"109186","DOI":"10.1016\/j.drugalcdep.2021.109186","article-title":"Alcoholic liver disease among patients with Wernicke encephalopaty: A multicenter observational study","volume":"230","author":"Novo-Veleiro","year":"2022","journal-title":"Drug and Alcohol Depend."},{"key":"10.1016\/j.medcli.2021.11.015_bib0285","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.rce.2011.04.001","article-title":"Encefalopat\u00eda de Wernicke en pacientes alcoh\u00f3licos","volume":"211","author":"Chamorro Fern\u00e1ndez","year":"2011","journal-title":"Rev Clin Esp."},{"key":"10.1016\/j.medcli.2021.11.015_bib0290","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jnnp.62.1.51","article-title":"Operational criteria for the classification of chronic alcoholics: Identification of Wernicke's encephalopathy","volume":"62","author":"Caine","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"10.1016\/j.medcli.2021.11.015_bib0295","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.rce.2009.12.009","article-title":"Atenci\u00f3n urgente a un paciente alcoh\u00f3lico","volume":"210","author":"Chamorro Fern\u00e1ndez","year":"2010","journal-title":"Rev Clin Esp."},{"key":"10.1016\/j.medcli.2021.11.015_bib0300","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2214\/ajr.171.4.9763009","article-title":"Usefulness of CT and MR imaging in the diagnosis of acute Wernicke's encephalopathy","volume":"171","author":"Antunez","year":"1998","journal-title":"AJR Am J Roentgenol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0305","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1053\/j.sult.2013.09.004","article-title":"Wernicke encephalopathy and ethanol-related syndromes","volume":"35","author":"Kim","year":"2014","journal-title":"Semin Ultrasound CT MR."},{"key":"10.1016\/j.medcli.2021.11.015_bib0310","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.nrl.2011.03.001","article-title":"Encefalopat\u00eda de Wernicke en pacientes no alcoh\u00f3licos: una serie de 8 casos","volume":"26","author":"Gascon-Bayarri","year":"2011","journal-title":"Neurologia."},{"key":"10.1016\/j.medcli.2021.11.015_bib0315","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3174\/ajnr.A2979","article-title":"Spectrum of MR imaging findings in Wernicke encephalopathy: Are atypical areas of involvement only present in nonalcoholic patients?","volume":"33","author":"Ha","year":"2012","journal-title":"AJNR Am J Neuroradiol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0320","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s13760-020-01482-4","article-title":"The importance of knowing the typical and atypical imaging findings of Wernicke encephalopathy","volume":"121","author":"Zuccoli","year":"2021","journal-title":"Acta Neurol Belg."},{"key":"10.1016\/j.medcli.2021.11.015_bib0325","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/alcalc\/agx013","article-title":"Long-term mortality of patients with an alcohol-related Wernicke-Korsakoff syndrome","volume":"52","author":"Sanvisens","year":"2017","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0330","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000499039","article-title":"Thiamine substitution in alcohol use disorder: A narrative review of medical guidelines","volume":"25","author":"Pruckner","year":"2019","journal-title":"Eur Addict Res."},{"key":"10.1016\/j.medcli.2021.11.015_bib0335","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/alcalc\/agy091","article-title":"Incidence of adverse reactions to parenteral thiamine in the treatment of Wernicke's encephalopathy, and recommendations","volume":"54","author":"Thomson","year":"2019","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0340","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/imj.12522","article-title":"Thiamine in the treatment of Wernicke encephalopathy in patients with alcohol use disorders","volume":"44","author":"Latt","year":"2014","journal-title":"Intern Med J."},{"key":"10.1016\/j.medcli.2021.11.015_bib0345","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0196-0644(89)80215-X","article-title":"A toxicity study of parenteral thiamine hydrochloride","volume":"18","author":"Wrenn","year":"1989","journal-title":"Ann Emerg Med."},{"key":"10.1016\/j.medcli.2021.11.015_bib0350","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/alcalc\/agt034","article-title":"BNF recommendations for the treatment of Wernicke's encephalopathy: Lost in translation?","volume":"48","author":"Thomson","year":"2013","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.medcli.2021.11.015_bib0355","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/psychiatry.IndianJPsychiatry_440_20","article-title":"High-dose thiamine strategy in Wernicke-Korsakoff syndrome and related thiamine deficiency conditions associated with alcohol use disorder","volume":"63","author":"Praharaj","year":"2021","journal-title":"Indian J Psychiatry."},{"key":"10.1016\/j.medcli.2021.11.015_bib0360","first-page":"1","article-title":"The Wernicke-Korsakoff syndrome. A clinical and pathological study of 245 patients, 82 with post-mortem examinations","volume":"7","author":"Victor","year":"1971","journal-title":"Contemp Neurol Ser."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775321007223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775321007223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:54:29Z","timestamp":1758419669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775321007223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0025775321007223"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2021.11.015","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S\u00edndrome de Wernicke-Korsakoff y otras patolog\u00edas asociadas al d\u00e9ficit de tiamina","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2021.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}