{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:08:14Z","timestamp":1761858494062,"version":"build-2065373602"},"reference-count":10,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.medcli.2021.12.020","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T16:35:53Z","timestamp":1646066153000},"page":"283-286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Importancia de la determinaci\u00f3n de actividad enzim\u00e1tica en el diagn\u00f3stico del d\u00e9ficit de adenosina desaminasa 2 (DADA2)"],"prefix":"10.1016","volume":"159","author":[{"given":"Adri\u00e1n","family":"Abbasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Batllori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Jose","family":"Gil-S\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignasi","family":"Rodr\u00edguez-Pint\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Ant\u00f3n L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Est\u00edbaliz","family":"Iglesias J\u00edmenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2021.12.020_bib0055","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa1307361","article-title":"Early-onset stroke and vasculopathy associated with mutations in ADA2","volume":"370","author":"Zhou","year":"2014","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2021.12.020_bib0060","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1189\/jlb.1109764","article-title":"Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages","volume":"88","author":"Zavialov","year":"2010","journal-title":"J Leukoc Biol."},{"key":"10.1016\/j.medcli.2021.12.020_bib0065","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1056\/NEJMoa1307362","article-title":"Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy","volume":"370","author":"Navon Elkan","year":"2014","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2021.12.020_bib0070","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s10875-018-0525-8","article-title":"Deficiency of adenosine deaminase 2 (DADA2): Updates on the phenotype, genetics, pathogenesis, and treatment","volume":"38","author":"Meyts","year":"2018","journal-title":"J Clin Immunol."},{"key":"10.1016\/j.medcli.2021.12.020_bib0075","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1056\/NEJMc1801927","article-title":"Treatment strategies for deficiency of adenosine deaminase 2","volume":"380","author":"Ombrello","year":"2019","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2021.12.020_bib0080","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/rheumatology\/keaa652","article-title":"Management of severe hyperinflammation in the COVID-19 era: the role of the rheumatologist","volume":"60","author":"Papadopoulou","year":"2021","journal-title":"Rheumatology."},{"key":"10.1016\/j.medcli.2021.12.020_bib0085","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/annrheumdis-2019-216030","article-title":"Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis","volume":"79","author":"Lee","year":"2019","journal-title":"Ann Rheum Dis."},{"key":"10.1016\/j.medcli.2021.12.020_bib0090","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0003-2697(90)90455-I","article-title":"Automated enzymatic measurement of adenosine deaminase isoenzyme activities in serum","volume":"187","author":"Muraoka","year":"1990","journal-title":"Anal Biochem."},{"key":"10.1016\/j.medcli.2021.12.020_bib0095","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1007\/s10067-021-05587-w","article-title":"Adult-onset deficiency of adenosine deaminase 2-a case report and literature review","volume":"40","author":"Zhang","year":"2021","journal-title":"Clin Rheumatol."},{"key":"10.1016\/j.medcli.2021.12.020_bib0100","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s10875-020-00817-3","article-title":"Deficiency of adenosine deaminase 2 (DADA2): hidden variants, reduced penetrance, and unusual inheritance","volume":"40","author":"Schnappauf","year":"2020","journal-title":"J Clin Immunol."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775322000446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775322000446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:55:07Z","timestamp":1758419707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775322000446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0025775322000446"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2021.12.020","relation":{},"ISSN":["0025-7753"],"issn-type":[{"type":"print","value":"0025-7753"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Importancia de la determinaci\u00f3n de actividad enzim\u00e1tica en el diagn\u00f3stico del d\u00e9ficit de adenosina desaminasa 2 (DADA2)","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2021.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}