{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:14:37Z","timestamp":1786994077467,"version":"build-2736575974"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.medcli.2022.04.017","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T07:16:32Z","timestamp":1659424592000},"page":"23-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efectividad del suero salino hipert\u00f3nico nebulizado en pacientes con hipersecreci\u00f3n bronquial"],"prefix":"10.1016","volume":"160","author":[{"given":"Almudena","family":"Gonz\u00e1lez-Montaos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ramos-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lojo-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"N\u00fa\u00f1ez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fern\u00e1ndez-Villar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2022.04.017_bib0055","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S2213-2600(19)30187-0","article-title":"Inhaled hypertonic saline in preschool children with cystic fibrosis (SHIP): A multicentre, randomised, double-blind, placebo-controlled trial","volume":"7","author":"Ratjen","year":"2019","journal-title":"Lancet Respir Med."},{"key":"10.1016\/j.medcli.2022.04.017_bib0060","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1136\/thx.52.10.900","article-title":"Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis","volume":"52","author":"Robinson","year":"1997","journal-title":"Thorax."},{"key":"10.1016\/j.medcli.2022.04.017_bib0065","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJMoa043900","article-title":"A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis","volume":"354","author":"Elkins","year":"2006","journal-title":"N Engl J Med."},{"key":"10.1016\/j.medcli.2022.04.017_bib0070","doi-asserted-by":"crossref","DOI":"10.1177\/1753466619866102","article-title":"Nebulized hypertonic saline in noncystic fibrosis bronchiectasis: A comprehensive review","volume":"13","author":"M\u00e1iz Carro","year":"2019","journal-title":"Ther Adv Respir Dis."},{"key":"10.1016\/j.medcli.2022.04.017_bib0075","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1136\/jim-2020-001479","article-title":"Therapeutic effect of nebulized hypertonic saline for muco-obstructive lung diseases: A systematic review and meta-analysis with trial sequential analysis","volume":"69","author":"Zhang","year":"2021","journal-title":"J Investig Med."},{"key":"10.1016\/j.medcli.2022.04.017_bib0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.rmed.2004.05.006","article-title":"Evaluation of nebulised hypertonic saline (7%) as an adjunct to physiotherapy in patients with stable bronchiectasis","volume":"99","author":"Kellett","year":"2005","journal-title":"Respir Med."},{"key":"10.1016\/j.medcli.2022.04.017_bib0085","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/jamp.2017.1443","article-title":"Impact of hypertonic saline solutions on sputum expectoration and their safety profile in patients with bronchiectasis: A randomized crossover trial","volume":"31","author":"Herrero-Cortina","year":"2018","journal-title":"J Aerosol Med Pulm Drug Deliv."},{"key":"10.1016\/j.medcli.2022.04.017_bib0090","doi-asserted-by":"crossref","DOI":"10.1177\/1753466618787385","article-title":"Addition of hyaluronic acid improves tolerance to 7% hypertonic saline solution in bronchiectasis patients","volume":"12","author":"M\u00e1iz","year":"2018","journal-title":"Ther Adv Respir Dis."},{"key":"10.1016\/j.medcli.2022.04.017_bib0095","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.rmed.2011.07.019","article-title":"Nebulised 7% hypertonic saline improves lung function and quality of life in bronchiectasis","volume":"105","author":"Kellett","year":"2011","journal-title":"Respir Med."},{"key":"10.1016\/j.medcli.2022.04.017_bib0100","first-page":"2018","article-title":"Nebulised hypertonic saline for cystic fibrosis","author":"Wark","year":"2018","journal-title":"Cochrane Libr"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775322003165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775322003165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:55:42Z","timestamp":1758419742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775322003165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0025775322003165"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2022.04.017","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efectividad del suero salino hipert\u00f3nico nebulizado en pacientes con hipersecreci\u00f3n bronquial","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2022.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}