{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:12:21Z","timestamp":1772637141668,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.medcli.2022.11.022","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T15:33:40Z","timestamp":1676907220000},"page":"434-442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Left ventricular dysfunction and arrhythmias in asymptomatic patients with systemic sclerosis"],"prefix":"10.1016","volume":"160","author":[{"given":"Lilian","family":"L\u00f3pez N\u00fa\u00f1ez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Carri\u00f3n-Barber\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Padr\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Ciria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"T\u00edo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek Carlos","family":"Salman-Monte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Pros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2022.11.022_bib0155","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.CIR.53.3.483","article-title":"Myocardial lesions of progressive systemic sclerosis. A cause of cardiac dysfunction","volume":"53","author":"Bulkley","year":"1976","journal-title":"Circulation"},{"key":"10.1016\/j.medcli.2022.11.022_bib0160","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1002\/1529-0131(200011)43:11<2437::AID-ANR10>3.0.CO;2-U","article-title":"Severe organ involvement in systemic sclerosis with diffuse scleroderma","volume":"43","author":"Steen","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2022.11.022_bib0165","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3899\/jrheum.100480","article-title":"Implantable cardioverter defibrillator prevents sudden cardiac death in systemic sclerosis","volume":"38","author":"Bernardo","year":"2011","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2022.11.022_bib0170","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/ard.2009.114264","article-title":"Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database","volume":"69","author":"Tyndall","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2022.11.022_bib0175","first-page":"1172","article-title":"Cardiac arrhythmias and conduction defects in systemic sclerosis","volume":"53","author":"Vacca","year":"2014","journal-title":"Rheumatol (United Kingdom)"},{"key":"10.1016\/j.medcli.2022.11.022_bib0180","doi-asserted-by":"crossref","first-page":"38","DOI":"10.7326\/0003-4819-94-1-38","article-title":"The prevalence of conduction defects and cardiac arrhythmias in progressive systemic sclerosis","volume":"94","author":"Roberts","year":"1981","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.medcli.2022.11.022_bib0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-0736(96)80107-5","article-title":"Electrophysiologic abnormalities of cardiac function in progressive systemic sclerosis","volume":"29","author":"Rokas","year":"1996","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.medcli.2022.11.022_bib0190","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4137\/CMAMD.S4940","article-title":"Autonomic dysfunction predicts early cardiac affection in patients with systemic sclerosis","volume":"3","author":"Othman","year":"2010","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord"},{"key":"10.1016\/j.medcli.2022.11.022_bib0195","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1002\/art.30614","article-title":"Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias","volume":"63","author":"Yiu","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2022.11.022_bib0200","doi-asserted-by":"crossref","first-page":"993","DOI":"10.4330\/wjc.v6.i9.993","article-title":"Cardiac manifestations in systemic sclerosis","volume":"6","author":"Lambova","year":"2014","journal-title":"World J Cardiol"},{"key":"10.1016\/j.medcli.2022.11.022_bib0205","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.jacc.2018.07.068","article-title":"Left ventricular diastolic dysfunction predicts mortality in patients with systemic sclerosis","volume":"72","author":"Tenn\u00f8e","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.medcli.2022.11.022_bib0210","first-page":"55","article-title":"Left ventricular diastolic dysfunction in systemic sclerosis: clinical, immunological and survival differences in the Spanish RESCLE registry","author":"Garc\u00eda","year":"2022","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.medcli.2022.11.022_bib0215","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/rheumatology\/35.10.983","article-title":"Left ventricular function in scleroderma","volume":"35","author":"Armstrong","year":"1996","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.medcli.2022.11.022_bib0220","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/ard.2008.103382","article-title":"Prevalence and factors associated with left ventricular dysfunction in the EULAR Scleroderma Trial and Research group (EUSTAR) database of patients with systemic sclerosis","volume":"69","author":"Allanore","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2022.11.022_bib0225","doi-asserted-by":"crossref","first-page":"e0153012","DOI":"10.1371\/journal.pone.0153012","article-title":"Prognostic role of ventricular ectopic beats in systemic sclerosis: a prospective cohort study shows ECG indexes predicting the worse outcome","volume":"11","author":"De Luca","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.medcli.2022.11.022_bib0230","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1136\/ard.2008.098087","article-title":"N-terminal pro-brain natriuretic peptide in systemic sclerosis: a new cornerstone of cardiovascular assessment?","volume":"68","author":"Allanore","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2022.11.022_bib0235","first-page":"1747","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European league against rheumatism collaborative initiative","volume":"11","author":"Van Den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2022.11.022_bib0240","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/rheumatology\/kel451","article-title":"Skin involvement in scleroderma \u2013 where histological and clinical scores meet","volume":"46","author":"Verrecchia","year":"2007","journal-title":"Rheumatology"},{"key":"10.1016\/j.medcli.2022.11.022_bib0245","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0210-5691(04)70009-1","article-title":"Estimaci\u00f3n de las presiones de llenado de ventr\u00edculo izquierdo por ecocardiograf\u00eda Doppler en pacientes cr\u00edticos","volume":"28","author":"Ayuela","year":"2004","journal-title":"Med Intensiva"},{"key":"10.1016\/j.medcli.2022.11.022_bib0250","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/ard.2006.057760","article-title":"Evaluation of cardiac abnormalities by Doppler echocardiography in a large nationwide multicentric cohort of patients with systemic sclerosis","volume":"67","author":"De Groote","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2022.11.022_bib0255","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/art.23463","article-title":"Cardiac involvement in systemic sclerosis assessed by tissue-doppler echocardiography during routine care: a controlled study of 100 consecutive patients","volume":"58","author":"Meune","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2022.11.022_bib0260","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0002-9343(85)90008-7","article-title":"Study of 102 consecutive cases with functional correlations and review of the literature","volume":"79","author":"Follansbee","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.medcli.2022.11.022_bib0265","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/CIRCEP.119.007757","article-title":"Importance of diastolic function for the prediction of arrhythmic death: a prospective, observer-blinded, long-term study","volume":"13","author":"Pezawas","year":"2020","journal-title":"Circ Arrhythmia Electrophysiol"},{"key":"10.1016\/j.medcli.2022.11.022_bib0270","first-page":"906","article-title":"The role of NT-proBNP in the diagnosis of ventricular arrhythmias in patients with systemic sclerosis","volume":"46","author":"Muresan","year":"2017","journal-title":"Iran J Public Health"},{"key":"10.1016\/j.medcli.2022.11.022_bib0275","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ejheart.2004.12.010","article-title":"BNP as a marker of diastolic dysfunction in the general population: Importance of left ventricular hypertrophy","volume":"7","author":"Lukowicz","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.medcli.2022.11.022_bib0280","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/art.1780281110","article-title":"Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients","volume":"28","author":"Ferri","year":"1985","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2022.11.022_bib0285","doi-asserted-by":"crossref","first-page":"e78808","DOI":"10.1371\/journal.pone.0078808","article-title":"Right bundle branch block: a predictor of mortality in early systemic sclerosis","volume":"8","author":"Draeger","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.medcli.2022.11.022_bib0290","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/rheumatology\/kep394","article-title":"Heart rate turbulence assessment in systemic sclerosis: the role for the detection of cardiac autonomic nervous system dysfunction","volume":"49","author":"Bienias","year":"2010","journal-title":"Rheumatology"},{"key":"10.1016\/j.medcli.2022.11.022_bib0295","first-page":"1221","article-title":"Incidental significant arrhythmia in scleroderma associates with cardiac magnetic resonance measure of fibrosis and hs-TnI and NT-proBNP","volume":"58","author":"Bissell","year":"2019","journal-title":"Rheumatol (United Kingdom)"},{"key":"10.1016\/j.medcli.2022.11.022_bib0300","first-page":"1938","article-title":"Cardiac magnetic resonance predicts ventricular arrhythmias in scleroderma: The Scleroderma Arrhythmia Clinical Utility Study (SAnCtUS)","volume":"59","author":"Mavrogeni","year":"2020","journal-title":"Rheumatol (United Kingdom)"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775323000143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775323000143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:56:11Z","timestamp":1758419771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775323000143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0025775323000143"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2022.11.022","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left ventricular dysfunction and arrhythmias in asymptomatic patients with systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2022.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}