{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:07:52Z","timestamp":1791216472216,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.medcli.2024.04.004","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T17:23:29Z","timestamp":1724174609000},"page":"S1-S3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"S1","title":["Hughes syndrome: The discovery of the antiphospholipid syndrome"],"prefix":"10.1016","volume":"163","author":[{"given":"Munther","family":"Khamashta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham R.V.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2024.04.004_bib0130","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/bmj.287.6399.1088","article-title":"Thrombosis, abortion, cerebral disease, and the lupus anticoagulant","volume":"287","author":"Hughes","year":"1983","journal-title":"Br Med J"},{"key":"10.1016\/j.medcli.2024.04.004_bib0135","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(83)91267-9","article-title":"Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in SLE","volume":"ii","author":"Harris","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2024.04.004_bib0140","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2230.1984.tb00856.x","article-title":"The Prosser-White oration 1983 \u2013 connective tissue disease and the skin","volume":"9","author":"Hughes","year":"1984","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0145","first-page":"285","article-title":"The anticardiolipin syndrome","volume":"3","author":"Hughes","year":"1985","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0150","first-page":"100","article-title":"Hughes syndrome \u2013 the syndrome behind the name (otherwise known as antiphospholipid syndrome)","volume":"1","author":"Hughes","year":"1999","journal-title":"Isr Med Ass J"},{"key":"10.1016\/j.medcli.2024.04.004_bib0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/01443618509067758","article-title":"Fetal loss in systemic lupus: association with anticardiolipin antibodies","volume":"2","author":"Derue","year":"1985","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0160","first-page":"47","article-title":"Cerebral infarction in systemic lupus association with anticardiolipin antibodies","volume":"2","author":"Harris","year":"1984","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0165","first-page":"72","article-title":"Portal and pulmonary hypertension in a case of systemic lupus erythematosus: possible relationship with clotting abnormality","volume":"7","author":"Mackworth-Young","year":"1984","journal-title":"Eur J Rheumatol Inflamm"},{"key":"10.1016\/j.medcli.2024.04.004_bib0170","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/bmj.287.6398.1024-a","article-title":"Pulmonary hypertension in systemic lupus erythematosus","volume":"287","author":"Asherson","year":"1983","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.medcli.2024.04.004_bib0175","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/ard.44.4.281","article-title":"Lupoid sclerosis: a possible pathogenetic role for antiphospholipid antibodies","volume":"44","author":"Harris","year":"1985","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2024.04.004_bib0180","first-page":"377","article-title":"Antiphospholipid antibodies and chorea","volume":"15","author":"Asherson","year":"1988","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0185","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/BF02030977","article-title":"Arterial occlusion causing large bowel infarction in SLE. Reflection of clotting diathesis","volume":"5","author":"Asherson","year":"1986","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0190","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2141.1985.tb02989.x","article-title":"Anticardiolipin antibodies in autoimmune thrombocytopenic purpura","volume":"59","author":"Harris","year":"1985","journal-title":"Br J Haematol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0195","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/ard.46.8.605","article-title":"Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies","volume":"46","author":"Asherson","year":"1987","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2024.04.004_bib0200","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0140-6736(93)91477-4","article-title":"The antiphospholipid syndrome. Ten years on","volume":"342","author":"Hughes","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2024.04.004_bib0205","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/art.1780370418","article-title":"Association between antiphospholipid antibodies and epilepsy in patients with systemic lupus erythematosus","volume":"37","author":"Herranz","year":"1994","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0210","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/0140-6736(90)91373-I","article-title":"Association of antibodies against phospholipids with heart valve disease in systemic lupus erythematosus","volume":"335","author":"Khamashta","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2024.04.004_bib0215","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0140-6736(89)93051-1","article-title":"Addison's disease and primary antiphospholipid syndrome","volume":"ii","author":"Asherson","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2024.04.004_bib0220","first-page":"215","article-title":"Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986","volume":"68","author":"Harris","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0225","series-title":"Hughes syndrome: antiphospholipid syndrome","author":"Khamashta","year":"2006"},{"key":"10.1016\/j.medcli.2024.04.004_bib0230","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/ard.2003.006163","article-title":"Seronegative antiphospholipid syndrome","volume":"62","author":"Hughes","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2024.04.004_bib0235","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3899\/jrheum.170044","article-title":"Closing the serological gap in the antiphospholipid syndrome: the value of \u201cnon-criteria\u201d antiphospholipid antibodies","volume":"44","author":"Zohoury","year":"2017","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0240","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fimmu.2019.00376","article-title":"Reliability of lupus anticoagulant and anti-phosphatidylserine\/prothrombin autoantibodies in antiphospholipid syndrome: a multicenter study","volume":"10","author":"Sciascia","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.medcli.2024.04.004_bib0245","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJM199504133321504","article-title":"The management of thrombosis in the antiphospholipid syndrome","volume":"332","author":"Khamashta","year":"1995","journal-title":"N Eng J Med"},{"key":"10.1016\/j.medcli.2024.04.004_bib0250","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.autrev.2016.09.010","article-title":"Catastrophic antiphospholipid syndrome (CAPS): descriptive analysis of 500 patients from the International CAPS Registry","volume":"15","author":"Rodr\u00edguez-Pint\u00f3","year":"2016","journal-title":"Autoimmun Rev"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775324002537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775324002537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T23:51:34Z","timestamp":1726617094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775324002537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":25,"alternative-id":["S0025775324002537"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2024.04.004","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hughes syndrome: The discovery of the antiphospholipid syndrome","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2024.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}