{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:10:50Z","timestamp":1786986650083,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.medcli.2024.05.008","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T04:37:54Z","timestamp":1720931874000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Administraci\u00f3n sublingual y bucal de f\u00e1rmacos en situaciones de urgencia y emergencia vital"],"prefix":"10.1016","volume":"163","author":[{"given":"Joan Ramon","family":"Roma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Castro Rebollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Bastida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2024.05.008_bib0305","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3389\/fphar.2019.01328","article-title":"Advances in nanoparticulate drug delivery approaches for sublingual and buccal administration","volume":"10","author":"Hua","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.medcli.2024.05.008_bib0310","first-page":"385","article-title":"A review on bioadhesive buccal drug delivery systems: Current status of formulation and evaluation method","volume":"19","author":"Reddy","year":"2011","journal-title":"Daru"},{"key":"10.1016\/j.medcli.2024.05.008_bib0315","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/bja\/56.1.69","article-title":"Drug absorption by sublingual and rectal routes","volume":"56","author":"De Boer","year":"1984","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.medcli.2024.05.008_bib0320","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2020.01.006","article-title":"Novel and revisited approaches in nanoparticle systems for buccal drug delivery","volume":"320","author":"Macedo","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.medcli.2024.05.008_bib0325","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.addr.2013.08.011","article-title":"Oral transmucosal drug delivery for pediatric use","volume":"73","author":"Lam","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.medcli.2024.05.008_bib0330","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2165\/00003088-200241090-00003","article-title":"Oral Mucosal Drug Delivery Clinical Pharmacokinetics and Therapeutic Applications","volume":"41","author":"Zhang","year":"2002","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.medcli.2024.05.008_bib0335","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jconrel.2009.07.016","article-title":"Orotransmucosal drug delivery systems: A review","volume":"140","author":"Madhav","year":"2009","journal-title":"J Control Release"},{"key":"10.1016\/j.medcli.2024.05.008_bib0340","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/01.mop.0000193306.55635.24","article-title":"Update on the acute management of status epilepticus in children","volume":"18","author":"Walker","year":"2006","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.medcli.2024.05.008_bib0345","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7555\/JBR.27.20120136","article-title":"A clinical perspective on mucoadhesive buccal drug delivery systems","volume":"28","author":"Gilhotra","year":"2014","journal-title":"J Biomed Res"},{"issue":"Suppl","key":"10.1016\/j.medcli.2024.05.008_bib0350","first-page":"S57.e1","article-title":"Salivary dysfunction associated with systemic diseases: Systematic review and clinical management recommendations","volume":"103","author":"Von B\u00fcltzingsl\u00f6wen","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"10.1016\/j.medcli.2024.05.008_bib0355","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4321\/S1699-695X2008000300007","article-title":"Crisis Hipertensivas","volume":"2","author":"Caldevilla Bernardo","year":"2008","journal-title":"Rev Clin Med Fam"},{"key":"10.1016\/j.medcli.2024.05.008_bib0360","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/OAEM.S340513","article-title":"Nitroglycerin Use in the Emergency Department: Current Perspectives","volume":"14","author":"Twiner","year":"2022","journal-title":"Open Access Emerg Med"},{"key":"10.1016\/j.medcli.2024.05.008_bib0365","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2165\/00003088-199835010-00002","article-title":"Clinical Pharmacokinetics of Vasodilators Part II","volume":"35","author":"Kirsten","year":"1998","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.medcli.2024.05.008_bib0370","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1157\/13087920","article-title":"Role of Nitrates in the Treatment of Cardiovascular Diseases","volume":"6","author":"L\u00f3pez de S\u00e1","year":"2006","journal-title":"Rev Esp Cardiol Supl"},{"key":"10.1016\/j.medcli.2024.05.008_bib0375","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s003920050277","article-title":"Sublingual nitroglycerine or intravenous enalaprilat in the treatment of hypertensive patients with pulmonary edema","volume":"88","author":"Hirschl","year":"1999","journal-title":"Z Kardiol"},{"key":"10.1016\/j.medcli.2024.05.008_bib0380","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1365-2796.2009.02146.x","article-title":"Impact of a high-dose nitrate strategy on cardiac stress in acute heart failure: A pilot study","volume":"267","author":"Breidthardt","year":"2010","journal-title":"J Intern Med"},{"key":"10.1016\/j.medcli.2024.05.008_bib0385","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/s13104-018-3460-0","article-title":"Sublingual nitroglycerin for early blood pressure control in hypertensive emergencies: Observations from an emergency department clinical audit in Sri Lanka","volume":"11","author":"Prasanna","year":"2018","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.medcli.2024.05.008_bib0390","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/10903127.2018.1558318","article-title":"Safety and Effectiveness of Field Nitroglycerin in Patients with Suspected ST Elevation Myocardial Infarction","volume":"23","author":"Bosson","year":"2019","journal-title":"Prehosp Emerg Care"},{"key":"10.1016\/j.medcli.2024.05.008_bib0395","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5507\/bp.2018.022","article-title":"Mucosal delivery systems of antihypertensive drugs: A practical approach in general practice","volume":"162","author":"Bialy","year":"2018","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub."},{"key":"10.1016\/j.medcli.2024.05.008_bib0400","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1553-2712.1996.tb03422.x","article-title":"Rapid improvement of acute pulmonary edema with sublingual captopril","volume":"3","author":"Hamilton","year":"1996","journal-title":"Acad Emerg Med"},{"key":"10.1016\/j.medcli.2024.05.008_bib0405","first-page":"302","article-title":"Emergency Room Treatment of Hypertensive Crises","volume":"69","author":"Salkic","year":"2015","journal-title":"Med Arch."},{"key":"10.1016\/j.medcli.2024.05.008_bib0410","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jemermed.2015.07.017","article-title":"Sublingual vs Oral Captopril in Hypertensive Crisis","volume":"50","author":"Kaya","year":"2016","journal-title":"J Emerg Med"},{"key":"10.1016\/j.medcli.2024.05.008_bib0415","first-page":"1642","article-title":"Same effect of sublingual and oral captopril in hypertensive crisis","volume":"16","author":"Karakili\u00e7","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.medcli.2024.05.008_bib0420","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1001\/jama.1996.03540160050032","article-title":"Should a Moratorium Be Placed on Sublingual Nifedipine Capsules Given for Hypertensive Emergencies and Pseudoemergencies?","volume":"276","author":"Grossman","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.medcli.2024.05.008_bib0425","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3390\/healthcare10020325","article-title":"Antihypertensive Medications for Severe Hypertension in Pregnancy: A Systematic Review and Meta-Analysis","volume":"10","author":"Awaludin","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.medcli.2024.05.008_bib0430","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejim.2019.10.004","article-title":"Diagnosis and treatment of hypertensive emergencies and urgencies among Italian emergency and intensive care departments. Results from an Italian survey: Progetto GEAR (Gestione dell\u2019Emergenza e urgenza in ARea critica)","volume":"71","author":"Saladini","year":"2020","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.medcli.2024.05.008_bib0435","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"},{"key":"10.1016\/j.medcli.2024.05.008_bib0440","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.medcli.2024.05.008_bib0445","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4321\/S1134-80462014000100002","article-title":"Encuesta nacional sobre dolor en las urgencias hospitalarias","volume":"21","author":"Caba Barrientos","year":"2014","journal-title":"Rev Soc Esp Dolor"},{"key":"10.1016\/j.medcli.2024.05.008_bib0450","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/17425247.2020.1714588","article-title":"Sublingual analgesia: A promising proposal for the treatment of pain","volume":"17","author":"Miner","year":"2020","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.medcli.2024.05.008_bib0455","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.2165\/11200910-000000000-00000","article-title":"Fentanyl sublingual: In breakthrough pain in opioid-tolerant adults with cancer","volume":"70","author":"Chwieduk","year":"2010","journal-title":"Drugs"},{"key":"10.1016\/j.medcli.2024.05.008_bib0460","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40261-015-0268-8","article-title":"Efficacy and Safety of Sublingual Fentanyl Tablets for the Management of Breakthrough Pain in Patients with Chronic Musculoskeletal Pain with Neuropathic Component: Multicenter Prospective Study","volume":"35","author":"C\u00e1novas Mart\u00ednez","year":"2015","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.medcli.2024.05.008_bib0465","first-page":"113","article-title":"Tratamiento del dolor irruptivo con fentanilo sublingual en pacientes con \u00falceras cut\u00e1neas cr\u00f3nicas","volume":"27","author":"Domingo Triad\u00f3","year":"2020","journal-title":"Rev Soc Esp Dolor."},{"key":"10.1016\/j.medcli.2024.05.008_bib0470","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14740\/jocmr4841","article-title":"Improving the Emergency Department Management of Sickle Cell Vaso-Occlusive Pain Crisis: The Role and Options of Sublingual and\u00a0Intranasally Administered Analgesia","volume":"15","author":"Ojo","year":"2023","journal-title":"J Clin Med Res"},{"key":"10.1016\/j.medcli.2024.05.008_bib0475","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jopan.2019.08.009","article-title":"Pooled Dosing and Efficacy Analysis of the Sufentanil Sublingual Tablet 30 mcg Across Demographic Subgroups for the Management of Moderate-to-Severe Acute Pain","volume":"35","author":"Hutchins","year":"2020","journal-title":"J Perianesth Nurs"},{"key":"10.1016\/j.medcli.2024.05.008_bib0480","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ajem.2017.10.058","article-title":"Sufentanil sublingual tablet 30 mcg for moderate-to-severe acute pain in the ED","volume":"36","author":"Miner","year":"2018","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.medcli.2024.05.008_bib0485","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s40265-018-0953-z","article-title":"Treating Chronic Pain: An Overview of Clinical Studies Centered on the Buprenorphine Option","volume":"78","author":"Davis","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.medcli.2024.05.008_bib0490","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.annemergmed.2011.10.021","article-title":"Sublingual buprenorphine in acute pain management: A double-blind randomized clinical trial","volume":"59","author":"Jalili","year":"2012","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.medcli.2024.05.008_bib0495","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1865-1380-7-1","article-title":"Sublingual buprenorphine for acute renal colic pain management: A double-blind, randomized controlled trial","volume":"7","author":"Payandemehr","year":"2014","journal-title":"Int J Emerg Med"},{"key":"10.1016\/j.medcli.2024.05.008_bib0500","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s40122-017-0082-5","article-title":"Sublingual Buprenorphine Efficacy in Renal Colic Pain Relief: A Randomized Placebo-Controlled Clinical Trial","volume":"6","author":"Mozafari","year":"2017","journal-title":"Pain Ther"},{"key":"10.1016\/j.medcli.2024.05.008_bib0505","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/annonc\/mdy152","article-title":"Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines","volume":"29","author":"Fallon","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.medcli.2024.05.008_bib0510","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.2147\/PPA.S235104","article-title":"Transdermal asenapine in schizophrenia: A systematic review","volume":"14","author":"Carrithers","year":"2020","journal-title":"Patient Prefer Adherence"},{"key":"10.1016\/j.medcli.2024.05.008_bib0515","doi-asserted-by":"crossref","DOI":"10.1177\/20451253211035269","article-title":"Asenapine: An atypical antipsychotic with atypical formulations","volume":"11","author":"Musselman","year":"2021","journal-title":"Ther Adv Psychopharmacol"},{"key":"10.1016\/j.medcli.2024.05.008_bib0520","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.rpsm.2018.03.007","article-title":"Management of asenapine treatment in clinical practice: Recommendations from a panel of experts","volume":"12","author":"Vieta","year":"2019","journal-title":"Rev Psiquiatr Salud Ment"},{"key":"10.1016\/j.medcli.2024.05.008_bib0525","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/acps.12262","article-title":"A single-dose, randomized, double-blind, placebo-controlled trial of sublingual asenapine for acute agitation","volume":"130","author":"Pratts","year":"2014","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.medcli.2024.05.008_bib0530","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/PRA.0000000000000634","article-title":"How an Understanding of the Function of the Locus Coeruleus Led to Use of Dexmedetomidine to Treat Agitation in Bipolar Disorder: Example of Rational Development of Psychiatric Medications","volume":"28","author":"Preskorn","year":"2022","journal-title":"J Psychiatr Pract"},{"key":"10.1016\/j.medcli.2024.05.008_bib0535","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1001\/jama.2022.0799","article-title":"Effect of Sublingual Dexmedetomidine vs Placebo on Acute Agitation Associated With Bipolar Disorder","volume":"327","author":"Preskorn","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.medcli.2024.05.008_bib0540","doi-asserted-by":"crossref","first-page":"22m14447","DOI":"10.4088\/JCP.22m14447","article-title":"Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder","volume":"83","author":"Citrome","year":"2022","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.medcli.2024.05.008_bib0545","first-page":"356","article-title":"End-of-Life Care: Managing Common Symptoms","volume":"95","author":"Albert","year":"2017","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.medcli.2024.05.008_bib0550","doi-asserted-by":"crossref","first-page":"e035977","DOI":"10.1136\/bmjopen-2019-035977","article-title":"Seizure prevalence in children aged up to 3 years: A longitudinal population-based cohort study in Japan","volume":"10","author":"Nishiyama","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.medcli.2024.05.008_bib0555","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s40262-019-00838-1","article-title":"Midazolam Pharmacokinetics in Obese and Non-obese Children and Adolescents","volume":"59","author":"Gade","year":"2020","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.medcli.2024.05.008_bib0560","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pediatrneurol.2020.03.011","article-title":"Intramuscular Versus Buccal Midazolam for Pediatric Seizures: A Randomized Double-Blinded Trial","volume":"109","author":"Alansari","year":"2020","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.medcli.2024.05.008_bib0565","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/PEC.0000000000001114","article-title":"Buccal Midazolam Compared With Rectal Diazepam Reduces Seizure Duration in Children in the Outpatient Setting","volume":"35","author":"Moretti","year":"2019","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.medcli.2024.05.008_bib0570","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1177\/0883073813493501","article-title":"Efficacy of Sublingual Lorazepam Versus Intrarectal Diazepam for Prolonged Convulsions in Sub-Saharan Africa","volume":"29","author":"Malu","year":"2014","journal-title":"J Child Neurol"},{"key":"10.1016\/j.medcli.2024.05.008_bib0575","doi-asserted-by":"crossref","first-page":"109294","DOI":"10.1016\/j.yebeh.2023.109294","article-title":"Sublingual lorazepam as rescue therapy for seizure emergencies in adults","volume":"145","author":"Lelis","year":"2023","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.medcli.2024.05.008_bib0580","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5698\/1535-7597-16.1.48","article-title":"Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society","volume":"16","author":"Glauser","year":"2016","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.medcli.2024.05.008_bib0585","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1080\/10837450.2020.1753771","article-title":"Mucoadhesive formulations: Innovations, merits, drawbacks, and future outlook","volume":"25","author":"Kumar","year":"2020","journal-title":"Pharm Dev Technol"},{"key":"10.1016\/j.medcli.2024.05.008_bib0590","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3109\/03639045.2014.892959","article-title":"Mucoadhesive polymers for buccal drug delivery","volume":"40","author":"Laffleur","year":"2014","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.medcli.2024.05.008_bib0595","doi-asserted-by":"crossref","first-page":"122789","DOI":"10.1016\/j.ijpharm.2023.122789","article-title":"Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles \u2013 An update","volume":"636","author":"Nair","year":"2023","journal-title":"Int J Pharm"},{"key":"10.1016\/j.medcli.2024.05.008_bib0600","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3389\/fphar.2018.00790","article-title":"Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization","volume":"9","author":"Hua","year":"2018","journal-title":"Front Pharmacol."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775324003828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775324003828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T18:51:24Z","timestamp":1733856684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775324003828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0025775324003828"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2024.05.008","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Administraci\u00f3n sublingual y bucal de f\u00e1rmacos en situaciones de urgencia y emergencia vital","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2024.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}