{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:01:10Z","timestamp":1783378870161,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.medcli.2024.05.026","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T11:33:58Z","timestamp":1724844838000},"page":"84-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["S\u00edndrome de piernas inquietas. Fisiopatolog\u00eda, diagn\u00f3stico y tratamiento"],"prefix":"10.1016","volume":"164","author":[{"given":"Federico","family":"Castillo-\u00c1lvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Marzo-Sola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2024.05.026_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-021-00311-z","article-title":"Restless legs syndrome","volume":"7","author":"Manconi","year":"2021","journal-title":"Nat Rev Dis Primer."},{"key":"10.1016\/j.medcli.2024.05.026_bib0235","first-page":"1130","article-title":"Restless Legs Syndrome and Other Common Sleep-Related Movement Disorders","volume":"29","author":"Khan","year":"2023","journal-title":"Contin Minneap Minn."},{"key":"10.1016\/j.medcli.2024.05.026_bib0240","first-page":"140","article-title":"Restless Legs Syndrome: Contemporary Diagnosis and Treatment","volume":"18","author":"Gossard","year":"2021","journal-title":"Neurother J Am Soc Exp Neurother."},{"key":"10.1016\/j.medcli.2024.05.026_bib0245","doi-asserted-by":"crossref","first-page":"377","DOI":"10.33588\/rn.7110.2020365","article-title":"Trastornos del movimiento y de la conducta durante el sue\u00f1o en el adulto","volume":"71","author":"P\u00e9rez-Carbonell","year":"2020","journal-title":"Rev Neurol."},{"key":"10.1016\/j.medcli.2024.05.026_bib0250","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/archinte.164.2.196","article-title":"Sex and the risk of restless legs syndrome in the general population","volume":"164","author":"Berger","year":"2004","journal-title":"Arch Intern Med."},{"key":"10.1016\/j.medcli.2024.05.026_bib0255","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.smrv.2017.10.003","article-title":"Prevalence of restless legs syndrome during pregnancy: A systematic review and meta-analysis","volume":"40","author":"Chen","year":"2018","journal-title":"Sleep Med Rev."},{"key":"10.1016\/j.medcli.2024.05.026_bib0260","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S1474-4422(18)30311-9","article-title":"Comorbidities, treatment, and pathophysiology in restless legs syndrome","volume":"17","author":"Trenkwalder","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.medcli.2024.05.026_bib0265","first-page":"113","article-title":"New Insights into the Neurobiology of Restless Legs Syndrome","volume":"25","author":"Ferr\u00e9","year":"2019","journal-title":"Neurosci Rev J Bringing Neurobiol Neurol Psychiatry."},{"key":"10.1016\/j.medcli.2024.05.026_bib0270","first-page":"1","article-title":"Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches (Review)","volume":"23","author":"Vlasie","year":"2022","journal-title":"Exp Ther Med."},{"key":"10.1016\/j.medcli.2024.05.026_bib0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/zsx023","article-title":"Associations of Incident Cardiovascular Events With Restless Legs Syndrome and Periodic Leg Movements of Sleep in Older Men, for the Outcomes of Sleep Disorders in Older Men Study (MrOS Sleep Study)","volume":"40","author":"Winkelman","year":"2017","journal-title":"Sleep."},{"key":"10.1016\/j.medcli.2024.05.026_bib0280","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1212\/01.wnl.0000261016.90374.fd","article-title":"Canadian restless legs syndrome twin study","volume":"68","author":"Xiong","year":"2007","journal-title":"Neurology."},{"key":"10.1016\/j.medcli.2024.05.026_bib0285","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.smrv.2017.08.002","article-title":"Genetics of restless legs syndrome: An update","volume":"39","author":"Jim\u00e9nez-Jim\u00e9nez","year":"2018","journal-title":"Sleep Med Rev."},{"key":"10.1016\/j.medcli.2024.05.026_bib0290","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S1474-4422(17)30327-7","article-title":"Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis","volume":"16","author":"Schormair","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.medcli.2024.05.026_bib0295","doi-asserted-by":"crossref","first-page":"103024","DOI":"10.1016\/j.nicl.2022.103024","article-title":"Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging","volume":"34","author":"Beliveau","year":"2022","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.medcli.2024.05.026_bib0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/caff.2019.0001","article-title":"The Adenosine Hypothesis of Restless Legs Syndrome","volume":"9","author":"Ferr\u00e9","year":"2019","journal-title":"J Caffeine Adenosine Res."},{"key":"10.1016\/j.medcli.2024.05.026_bib0305","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12883-020-01709-0","article-title":"The prevalence of Restless Legs Syndrome\/Willis-ekbom disease (RLS\/WED) in the third trimester of pregnancy: a systematic review","volume":"20","author":"Darvishi","year":"2020","journal-title":"BMC Neurol."},{"key":"10.1016\/j.medcli.2024.05.026_bib0310","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jsmc.2015.05.021","article-title":"Differential Diagnoses of Restless Legs Syndrome\/Willis-Ekbom Disease: Mimics and Comorbidities","volume":"10","author":"Chokroverty","year":"2015","journal-title":"Sleep Med Clin."},{"key":"10.1016\/j.medcli.2024.05.026_bib0315","doi-asserted-by":"crossref","first-page":"e3378","DOI":"10.1002\/brb3.3378","article-title":"Global prevalence of restless legs syndrome among hemodialysis patients: A systematic review and meta-analysis","volume":"14","author":"Zhou","year":"2024","journal-title":"Brain Behav."},{"key":"10.1016\/j.medcli.2024.05.026_bib0320","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/00207454.2019.1608200","article-title":"Decreased serum ferritin may be associated with increased restless legs syndrome in Parkinson's disease (PD): a meta-analysis for the diagnosis of RLS in PD patients","volume":"129","author":"Li","year":"2019","journal-title":"Int J Neurosci."},{"key":"10.1016\/j.medcli.2024.05.026_bib0325","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1177\/1060028018760296","article-title":"Drug-Induced Restless Legs Syndrome","volume":"52","author":"Patatanian","year":"2018","journal-title":"Ann Pharmacother."},{"key":"10.1016\/j.medcli.2024.05.026_bib0330","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jsmc.2021.02.002","article-title":"Restless Legs Syndrome - Clinical Features","volume":"16","author":"Garc\u00eda-Malo","year":"2021","journal-title":"Sleep Med Clin."},{"key":"10.1016\/j.medcli.2024.05.026_bib0335","first-page":"79","article-title":"Pharmacologically induced\/exacerbated restless legs syndrome, periodic limb movements of sleep, and REM behavior disorder\/REM sleep without atonia: literature review, qualitative scoring, and comparative analysis","volume":"6","author":"Hoque","year":"2010","journal-title":"J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med."},{"key":"10.1016\/j.medcli.2024.05.026_bib0340","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1468-1331.2007.01862.x","article-title":"A single question for the rapid screening of restless legs syndrome in the neurological clinical practice","volume":"14","author":"Ferri","year":"2007","journal-title":"Eur J Neurol."},{"key":"10.1016\/j.medcli.2024.05.026_bib0345","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.sleep.2014.03.025","volume":"15","author":"Allen","year":"2014","journal-title":"Sleep Med"},{"key":"10.1016\/j.medcli.2024.05.026_bib0350","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1389-9457(02)00258-7","volume":"4","author":"Walters","year":"2003","journal-title":"Sleep Med"},{"key":"10.1016\/j.medcli.2024.05.026_bib0355","doi-asserted-by":"crossref","first-page":"e0167146","DOI":"10.1371\/journal.pone.0167146","article-title":"Choice of High-Dose Intravenous Iron Preparation Determines Hypophosphatemia Risk","volume":"11","author":"Schaefer","year":"2016","journal-title":"PloS One."},{"key":"10.1016\/j.medcli.2024.05.026_bib0360","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.mayocp.2020.12.026","article-title":"The Management of Restless Legs Syndrome: An Updated Algorithm","volume":"96","author":"Silber","year":"2021","journal-title":"Mayo Clin Proc."},{"key":"10.1016\/j.medcli.2024.05.026_bib0365","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.sleep.2023.10.022","article-title":"Association of low serum ferritin levels with augmentation in patients with restless legs syndrome: A systematic review and meta-analysis","volume":"112","author":"Li","year":"2023","journal-title":"Sleep Med."},{"key":"10.1016\/j.medcli.2024.05.026_bib0370","article-title":"Efficacy of intravenous iron for restless legs syndrome\u2014moving beyond monotherapy and into the \u201creal world\u201d","volume":"zsae022","author":"Matar","year":"2024","journal-title":"Sleep."},{"key":"10.1016\/j.medcli.2024.05.026_bib0375","doi-asserted-by":"crossref","first-page":"zsad181","DOI":"10.1093\/sleep\/zsad181","article-title":"You too can increase brain iron to treat restless legs syndrome","volume":"46","author":"Koo","year":"2023","journal-title":"Sleep."},{"key":"10.1016\/j.medcli.2024.05.026_bib0380","article-title":"AASM invites public comment on draft guideline for RLS and PLMD","author":"Celmer","year":"2024","journal-title":"American Academy of Sleep Medicine \u2013 Association for Sleep Clinicians and Researchers."},{"key":"10.1016\/j.medcli.2024.05.026_bib0385","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11940-020-0617-7","article-title":"Iron Replacement Therapy in Restless Legs Syndrome","volume":"22","author":"Garc\u00eda-Malo","year":"2020","journal-title":"Curr Treat Options Neurol."},{"key":"10.1016\/j.medcli.2024.05.026_bib0390","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.5665\/sleep.1986","article-title":"The Treatment of Restless Legs Syndrome and Periodic Limb Movement Disorder in Adults\u2014An Update for 2012: Practice Parameters with an Evidence-Based Systematic Review and Meta-Analyses: An American Academy of Sleep Medicine Clinical Practice Guideline","volume":"35","author":"Aurora","year":"2012","journal-title":"Sleep."},{"key":"10.1016\/j.medcli.2024.05.026_bib0395","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s40263-018-0502-z","article-title":"Use of \u03b12\u03b4 Ligands for Restless Legs Syndrome\/Willis Ekbom Disease","volume":"32","author":"Faulkner","year":"2018","journal-title":"CNS Drugs."},{"key":"10.1016\/j.medcli.2024.05.026_bib0400","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.sapharm.2018.06.018","article-title":"Reports of gabapentin and pregabalin abuse, misuse, dependence, or overdose: An analysis of the Food And Drug Administration Adverse Events Reporting System (FAERS)","volume":"15","author":"Evoy","year":"2019","journal-title":"Res Soc Adm Pharm RSAP."},{"key":"10.1016\/j.medcli.2024.05.026_bib0405","doi-asserted-by":"crossref","first-page":"zsab212","DOI":"10.1093\/sleep\/zsab212","article-title":"High national rates of high-dose dopamine agonist prescribing for restless legs syndrome","volume":"45","author":"Winkelman","year":"2022","journal-title":"Sleep."},{"key":"10.1016\/j.medcli.2024.05.026_bib0410","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.sleep.2007.03.022","volume":"8","author":"Garc\u00eda-Borreguero","year":"2007","journal-title":"Sleep Med"},{"key":"10.1016\/j.medcli.2024.05.026_bib0415","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.sleep.2011.03.003","article-title":"Restless legs syndrome (RLS) augmentation associated with dopamine agonist and levodopa usage in a community sample","volume":"12","author":"Allen","year":"2011","journal-title":"Sleep Med."},{"issue":"1160112","key":"10.1016\/j.medcli.2024.05.026_bib0420","article-title":"Exploring the causes of augmentation in restless legs syndrome","volume":"14","author":"Zeng","year":"2023","journal-title":"Front Neurol."},{"key":"10.1016\/j.medcli.2024.05.026_bib0425","first-page":"255","article-title":"Pharmacological treatments of augmentation in restless legs syndrome patients","volume":"84","author":"Trenkwalder","year":"2019","journal-title":"Adv Pharmacol San Diego Calif."},{"key":"10.1016\/j.medcli.2024.05.026_bib0430","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mayocp.2017.11.007","article-title":"The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome","volume":"93","author":"Silber","year":"2018","journal-title":"Mayo Clin Proc."},{"key":"10.1016\/j.medcli.2024.05.026_bib0435","first-page":"741","article-title":"Emergence of restless legs syndrome during opioid discontinuation","volume":"19","author":"McCarter","year":"2023","journal-title":"J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med."},{"key":"10.1016\/j.medcli.2024.05.026_bib0440","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.sleep.2017.03.012","article-title":"Treatment of restless legs syndrome with the selective AMPA receptor antagonist perampanel","volume":"34","author":"Garc\u00eda-Borreguero","year":"2017","journal-title":"Sleep Med."},{"key":"10.1016\/j.medcli.2024.05.026_bib0445","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2147\/NDT.S19177","article-title":"Nondrug-related aspect of treating Ekbom disease, formerly known as restless legs syndrome","volume":"7","author":"Mitchell","year":"2011","journal-title":"Neuropsychiatr Dis Treat."},{"key":"10.1016\/j.medcli.2024.05.026_bib0450","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jsmc.2020.02.013","article-title":"Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome","volume":"15","author":"Anguelova","year":"2020","journal-title":"Sleep Med Clin."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775324004044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775324004044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:35:51Z","timestamp":1743986151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775324004044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0025775324004044"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2024.05.026","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S\u00edndrome de piernas inquietas. Fisiopatolog\u00eda, diagn\u00f3stico y tratamiento","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2024.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}