{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T04:02:43Z","timestamp":1743825763979,"version":"3.40.3"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.medcli.2024.10.007","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T12:45:47Z","timestamp":1732884347000},"page":"334-340","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uso de calcio por v\u00eda intravenosa en urgencias para tratar pacientes con hiperpotasemia e intoxicaci\u00f3n por digoxina y su impacto en la evoluci\u00f3n a corto plazo"],"prefix":"10.1016","volume":"164","author":[{"given":"Pere","family":"Llorens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Mataix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Gonz\u00e1lez Tejera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Herrero-Puente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"L\u00f3pez-Grima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Lucas-Imbern\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Pilar","family":"L\u00f3pez-D\u00edez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Gallardo Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Chico-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricio","family":"Mas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Lafuente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Calz\u00f3n Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d2scar","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2024.10.007_bib0170","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.amjmed.2019.04.022","article-title":"Digoxin use and associated adverse events among older adults","volume":"132","author":"Angraal","year":"2019","journal-title":"Am J Med."},{"key":"10.1016\/j.medcli.2024.10.007_bib0175","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1080\/15563650.2020.1834219","article-title":"2019 Annual Report of the American Association of Poison Control Centers\u2019 National Poison Data System (NPDS): 37th Annual Report","volume":"58","author":"Gummin","year":"2020","journal-title":"Clin Toxicol."},{"key":"10.1016\/j.medcli.2024.10.007_bib0180","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/15563657308990513","article-title":"Hyperkalemia in acute digitalis poisoning: Prognostic significance and therapeutic implications","volume":"6","author":"Bismuth","year":"1973","journal-title":"Clin Toxicol."},{"key":"10.1016\/j.medcli.2024.10.007_bib0185","first-page":"287","article-title":"Recommendations for the management of hyperkalemia in the emergency department","volume":"34","author":"\u00c1lvarez-Rodr\u00edguez","year":"2022","journal-title":"Emergencias."},{"key":"10.1016\/j.medcli.2024.10.007_bib0190","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1081\/CLT-120039538","article-title":"The effect of calcium chloride in treating hyperkalemia due to acute digoxin toxicity in a porcine model","volume":"42","author":"Hack","year":"2004","journal-title":"J Toxicol Clin Toxicol."},{"key":"10.1016\/j.medcli.2024.10.007_bib0195","first-page":"335","article-title":"Characteristics of emergency poisoning cases in elderly versus younger patients","volume":"5","author":"Superv\u00eda Caparr\u00f3s","year":"2017","journal-title":"Emergencias."},{"key":"10.1016\/j.medcli.2024.10.007_bib0200","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/j.archger.2010.07.003","article-title":"Clinical manifestations of elderly patients with digitalis intoxication in the emergency department","volume":"53","author":"Pita-Fern\u00e1ndez","year":"2011","journal-title":"Arch Gerontol Geriatr."},{"key":"10.1016\/j.medcli.2024.10.007_bib0205","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.medcli.2024.10.007_bib0210","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/jce.15759","article-title":"Atrial fibrillation: Epidemiology, pathophysiology, and clinical complications (literature review)","volume":"34","author":"Bizhanov","year":"2023","journal-title":"J Cardiovasc Electrophysiol."},{"key":"10.1016\/j.medcli.2024.10.007_bib0215","first-page":"437","article-title":"Use of digoxin in the emergency department to treat patients with acute heart failure and its impact on short-term outcomes","volume":"35","author":"Mojarro","year":"2023","journal-title":"Emergencias."},{"key":"10.1016\/j.medcli.2024.10.007_bib0220","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ccc.2012.07.005","article-title":"Cardiac glycoside toxicity: More than 200 years and counting","volume":"28","author":"Kanji","year":"2012","journal-title":"Crit Care Clin."},{"key":"10.1016\/j.medcli.2024.10.007_bib0225","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/MEJ.0000000000001065","article-title":"Diagnosis and practical management of digoxin toxicity: A narrative review and consensus","volume":"30","author":"Andrews","year":"2023","journal-title":"Eur J Emerg Med."},{"key":"10.1016\/j.medcli.2024.10.007_bib0230","doi-asserted-by":"crossref","first-page":"18","DOI":"10.18773\/austprescr.2016.006","article-title":"Management of digoxin toxicity","volume":"39","author":"Pincus","year":"20162024","journal-title":"Aust Prescr."},{"key":"10.1016\/j.medcli.2024.10.007_bib0235","first-page":"325","article-title":"Digoxin: friend or foe? Digoxina: \u00bfamiga o enemiga?","volume":"35","author":"Llorens","year":"2023","journal-title":"Emergencias."},{"key":"10.1016\/j.medcli.2024.10.007_bib0240","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2165\/00129784-200606020-00002","article-title":"Mechanisms, manifestations, and management of digoxin toxicity in the modern era","volume":"6","author":"Bauman","year":"2006","journal-title":"Am J Cardiovasc Drugs."},{"key":"10.1016\/j.medcli.2024.10.007_bib0245","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1001\/archinte.158.22.2444","article-title":"Digoxin toxicity: An evaluation in current clinical practice","volume":"158","author":"Williamson","year":"1998","journal-title":"Arch Intern Med."},{"key":"10.1016\/j.medcli.2024.10.007_bib0250","first-page":"328","article-title":"Characteristics of digoxin toxicity attended in Spanish emergency departments according to type of poisoning and administration of digoxin antibodies: The DIGITOX study","volume":"35","author":"Superv\u00eda Caparr\u00f3s","year":"2023","journal-title":"Emergencias."},{"key":"10.1016\/j.medcli.2024.10.007_bib0255","first-page":"90","article-title":"Use of digoxin antibodies to treat digoxin poisoning: a subanalysis of the DIGITOX study","volume":"3","author":"Superv\u00eda","year":"2024","journal-title":"Rev Esp Urg Emerg."},{"key":"10.1016\/j.medcli.2024.10.007_bib0260","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.3390\/ijerph20031674","article-title":"Risk factors for early hospital readmission in geriatric patients: A systematic review","volume":"20","author":"Cilla","year":"2023","journal-title":"Int J Environ Res Public Health."},{"key":"10.1016\/j.medcli.2024.10.007_bib0265","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.amjmed.2019.04.022","article-title":"Digoxin use and associated adverse events among older adults","volume":"132","author":"Angraal","year":"2019","journal-title":"Am J Med."},{"key":"10.1016\/j.medcli.2024.10.007_bib0270","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1161\/CIRCHEARTFAILURE.113.000784","article-title":"Emergency department visits and hospitalizations for digoxin toxicity: United States, 2005 to 2010","volume":"7","author":"See","year":"2014","journal-title":"Circ Heart Fail."},{"key":"10.1016\/j.medcli.2024.10.007_bib0275","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jchf.2016.01.011","article-title":"Digoxin toxicity and use of digoxin immune fab: Insights from a national hospital database","volume":"4","author":"Hauptman","year":"2016","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.medcli.2024.10.007_bib0280","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.amjcard.2022.08.004","article-title":"Characteristics and outcomes of suspected digoxin toxicity and immune fab treatment over the past two decades-2000-2020","volume":"183","author":"Peters","year":"2022","journal-title":"Am J Cardiol."},{"key":"10.1016\/j.medcli.2024.10.007_bib0285","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/bcp.12814","article-title":"Pharmacological treatment of cardiac glycoside poisoning","volume":"81","author":"Roberts","year":"2016","journal-title":"Br J Clin Pharmacol."},{"key":"10.1016\/j.medcli.2024.10.007_bib0290","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jemermed.2008.09.027","article-title":"The effects of intravenous calcium in patients with digoxin toxicity","volume":"40","author":"Levine","year":"2011","journal-title":"J Emerg Med."},{"key":"10.1016\/j.medcli.2024.10.007_bib0295","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0002-8703(70)90255-3","article-title":"Assessment of the synergistic relationship between serum calcium and digitalis","volume":"79","author":"Nola","year":"1970","journal-title":"Am Heart J."},{"key":"10.1016\/j.medcli.2024.10.007_bib0300","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0196-0644(96)70012-4","article-title":"Hyperkalemia and digoxin toxicity in a patient with kidney failure","volume":"28","author":"Fenton","year":"1996","journal-title":"Ann Emerg Med."},{"key":"10.1016\/j.medcli.2024.10.007_bib0305","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1081\/CLT-120022006","article-title":"Treatment of hyperkalemia in a patient with unrecognized digitalis toxicity","volume":"41","author":"Van Deusen","year":"2003","journal-title":"J Toxicol Clin Toxicol."},{"key":"10.1016\/j.medcli.2024.10.007_bib0310","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/jama.1936.02770140013004","article-title":"The additive effect of calcium and digitalis: A warning, with a report of two deaths","volume":"106","author":"Bower","year":"1936","journal-title":"JAMA."},{"key":"10.1016\/j.medcli.2024.10.007_bib0315","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1001\/archinte.1957.00260120025004","article-title":"Digitalis intoxication; a review and report of forty cases, with emphasis on etiology","volume":"100","author":"Shrager","year":"1957","journal-title":"AMA Arch Intern Med."},{"key":"10.1016\/j.medcli.2024.10.007_bib0320","first-page":"505","article-title":"Fatality from calcium chloride in a chronic digoxin toxic patient","volume":"5","author":"Kne","year":"1997","journal-title":"J Toxicol Clin Toxicol."},{"key":"10.1016\/j.medcli.2024.10.007_bib0325","first-page":"462","article-title":"Digitalis poisoning: The basis for treatment with antidigoxin antibodies","volume":"24","author":"Nogu\u00e9","year":"2012","journal-title":"Emergencias."},{"key":"10.1016\/j.medcli.2024.10.007_bib0330","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF03160949","article-title":"Case files of the medical toxicology fellowship of the California poison control system \u2014San Francisco: Calcium plus digoxin\u2014More taboo than toxic?","volume":"4","author":"Erickson","year":"2008","journal-title":"J Med Toxicol."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775324006663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775324006663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:44:26Z","timestamp":1743738266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775324006663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0025775324006663"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2024.10.007","relation":{},"ISSN":["0025-7753"],"issn-type":[{"type":"print","value":"0025-7753"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uso de calcio por v\u00eda intravenosa en urgencias para tratar pacientes con hiperpotasemia e intoxicaci\u00f3n por digoxina y su impacto en la evoluci\u00f3n a corto plazo","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2024.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}