{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:51:25Z","timestamp":1791924685361,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.medcli.2025.106974","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:48:59Z","timestamp":1747892939000},"page":"106974","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Helicobacter pylori y enfermedad g\u00e1strica"],"prefix":"10.1016","volume":"165","author":[{"given":"Javier P.","family":"Gisbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2025.106974_bib0305","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41572-023-00431-8","article-title":"Helicobacter pylori infection","volume":"9","author":"Malfertheiner","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.medcli.2025.106974_bib0310","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1056\/NEJMcp1710945","article-title":"Helicobacter pylori Infection","volume":"380","author":"Crowe","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medcli.2025.106974_bib0315","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1136\/gutjnl-2022-327745","article-title":"Management of Helicobacter pylori infection: the Maastricht VI\/Florence consensus report","volume":"71","author":"Malfertheiner","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0320","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S2468-1253(23)00070-5","article-title":"Global prevalence of Helicobacter pylori infection between 1980 and 2022: A systematic review and meta-analysis","volume":"8","author":"Li","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.medcli.2025.106974_bib0325","doi-asserted-by":"crossref","first-page":"e12734","DOI":"10.1111\/hel.12734","article-title":"Review: Epidemiology of Helicobacter pylori","volume":"25","author":"Mezmale","year":"2020","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0330","doi-asserted-by":"crossref","first-page":"e12945","DOI":"10.1111\/hel.12945","article-title":"Transmission routes and patterns of Helicobacter pylori","volume":"28","author":"Duan","year":"2023","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0335","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.gastrohep.2013.01.011","article-title":"III Spanish Consensus Conference on Helicobacter pylori infection [Article in Spanish]","volume":"36","author":"Gisbert","year":"2013","journal-title":"Gastroenterol Hepatol"},{"key":"10.1016\/j.medcli.2025.106974_bib0340","doi-asserted-by":"crossref","first-page":"e13111","DOI":"10.1111\/hel.13111","article-title":"Indications of Helicobacter pylori Eradication Treatment and Its Influence on Prescriptions and Effectiveness (Hp-EuReg)","volume":"29","author":"Martinez-Dominguez","year":"2024","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0345","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Kyoto global consensus report on Helicobacter pylori gastritis","volume":"64","author":"Sugano","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0350","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1136\/gutjnl-2020-322368","article-title":"Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus","volume":"69","author":"Liou","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0355","doi-asserted-by":"crossref","first-page":"727e1","DOI":"10.1016\/j.aprim.2012.05.003","article-title":"Clinical practice guideline on the management of patients with dyspepsia. Update 2012 [Article in Spanish]","volume":"44","author":"Gisbert","year":"2012","journal-title":"Aten Primaria"},{"key":"10.1016\/j.medcli.2025.106974_bib0360","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1038\/ctg.2013.3","article-title":"Helicobacter Pylori \u201cTest-and-Treat\u201d Strategy for Management of Dyspepsia: A Comprehensive Review","volume":"4","author":"Gisbert","year":"2013","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.medcli.2025.106974_bib0365","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1136\/gutjnl-2021-326583","article-title":"Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis","volume":"71","author":"Ford","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0370","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(16)32404-7","article-title":"Peptic ulcer disease","volume":"390","author":"Lanas","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2025.106974_bib0375","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1136\/gutjnl-2020-320839","article-title":"Helicobacter pylori eradication therapy to prevent gastric cancer: Systematic review and meta-analysis","volume":"69","author":"Ford","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0380","doi-asserted-by":"crossref","first-page":"e13013","DOI":"10.1111\/hel.13013","article-title":"Effect of Helicobacter pylori eradication on gastric precancerous lesions: A systematic review and meta-analysis","volume":"28","author":"Zhu","year":"2023","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0385","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1365-2036.2011.04839.x","article-title":"Review article: Common misconceptions in the management of Helicobacter pylori-associated gastric MALT-lymphoma","volume":"34","author":"Gisbert","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.medcli.2025.106974_bib0390","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.3390\/jcm12134363","article-title":"Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management","volume":"12","author":"Garcia-Morales","year":"2023","journal-title":"J Clin Med"},{"issue":"Suppl 1","key":"10.1016\/j.medcli.2025.106974_bib0395","doi-asserted-by":"crossref","first-page":"e12735","DOI":"10.1111\/hel.12735","article-title":"Review: Diagnosis of Helicobacter pylori infection","volume":"25","author":"Godbole","year":"2020","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0400","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3390\/antibiotics10091058","article-title":"Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013-2020: Results of the European Registry on H. pylori Management (Hp-EuReg)","volume":"10","author":"Bujanda","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.medcli.2025.106974_bib0405","doi-asserted-by":"crossref","first-page":"269","DOI":"10.14309\/ajg.0000000000002045","article-title":"Rates of Antimicrobial Resistance in Helicobacter pylori Isolates From Clinical Trial Patients Across the US and Europe","volume":"118","author":"Megraud","year":"2023","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.medcli.2025.106974_bib0410","doi-asserted-by":"crossref","first-page":"646","DOI":"10.14309\/ajg.0000000000002600","article-title":"Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance","volume":"119","author":"Bujanda","year":"2024","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.medcli.2025.106974_bib0415","doi-asserted-by":"crossref","first-page":"e13015","DOI":"10.1111\/hel.13015","article-title":"Efficacy of genotypic susceptibility-guided tailored therapy for Helicobacter pylori infection: A systematic review and single arm meta-analysis","volume":"28","author":"Lin","year":"2023","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0420","doi-asserted-by":"crossref","first-page":"e12958","DOI":"10.1111\/hel.12958","article-title":"Individualized diagnosis and eradication therapy for Helicobacter pylori infection based on gene detection of clarithromycin resistance in stool specimens: A systematic review and meta-analysis","volume":"28","author":"Ren","year":"2023","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0425","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/apt.14319","article-title":"Systematic review with meta-analysis: The global recurrence rate of Helicobacter pylori","volume":"46","author":"Hu","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.medcli.2025.106974_bib0430","doi-asserted-by":"crossref","first-page":"e13034","DOI":"10.1111\/hel.13034","article-title":"Advances in Helicobacter pylori vaccine research: From candidate antigens to adjuvants-A review","volume":"29","author":"Yunle","year":"2024","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0435","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.gastrohep.2021.07.011","article-title":"V Spanish Consensus Conference on Helicobacter pylori infection treatment [Article in English, Spanish]","volume":"45","author":"Gisbert","year":"2022","journal-title":"Gastroenterol Hepatol"},{"key":"10.1016\/j.medcli.2025.106974_bib0440","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/gutjnl-2012-302254","article-title":"Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption","volume":"62","author":"Megraud","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0445","doi-asserted-by":"crossref","first-page":"1372e17","DOI":"10.1053\/j.gastro.2018.07.007","article-title":"Prevalence of Antibiotic Resistance in Helicobacter pylori: A Systematic Review and Meta-analysis in World Health Organization Regions","volume":"155","author":"Savoldi","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.medcli.2025.106974_bib0450","doi-asserted-by":"crossref","first-page":"973e1","DOI":"10.1016\/j.cgh.2021.03.026","article-title":"Primer for Development of Guidelines for Helicobacter pylori Therapy Using Antimicrobial Stewardship","volume":"20","author":"Graham","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.medcli.2025.106974_bib0455","doi-asserted-by":"crossref","first-page":"e13103","DOI":"10.1111\/hel.13103","article-title":"Global Primary Antibiotic Resistance Rate of Helicobacter pylori in Recent 10 years: A Systematic Review and Meta-Analysis","volume":"29","author":"Yu","year":"2024","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0460","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1097\/MCG.0000000000001482","article-title":"Room for Improvement in the Treatment of Helicobacter pylori Infection: Lessons from the European Registry on H. pylori Management (Hp-EuReg)","volume":"56","author":"Nyssen","year":"2022","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.medcli.2025.106974_bib0465","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1111\/j.1365-2036.2011.04887.x","article-title":"Review article: The effectiveness of standard triple therapy for Helicobacter pylori has not changed over the last decade, but it is not good enough","volume":"34","author":"Gisbert","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.medcli.2025.106974_bib0470","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.gastrohep.2013.02.006","article-title":"Update on the efficacy of triple therapy for Helicobacter pylori infection and clarithromycin resistance rates in Spain (2007-2012) [Article in Spanish]","volume":"36","author":"Molina-Infante","year":"2013","journal-title":"Gastroenterol Hepatol"},{"key":"10.1016\/j.medcli.2025.106974_bib0475","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/apt.13069","article-title":"Optimised empiric triple and concomitant therapy for Helicobacter pylori eradication in clinical practice: The OPTRICON study","volume":"41","author":"Molina-Infante","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.medcli.2025.106974_bib0480","article-title":"Sequential versus standard triple first-line therapy for Helicobacter pylori eradication","volume":"2016","author":"Nyssen","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.medcli.2025.106974_bib0485","doi-asserted-by":"crossref","first-page":"495e4","DOI":"10.1053\/j.gastro.2021.04.012","article-title":"Comparative Effectiveness of Multiple Different First-Line Treatment Regimens for Helicobacter pylori Infection: A Network Meta-analysis","volume":"161","author":"Rokkas","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.medcli.2025.106974_bib0490","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/antibiotics10010013","article-title":"European Registry on Helicobacter pylori Management: Effectiveness of First and Second-Line Treatment in Spain","volume":"10","author":"Caldas","year":"2020","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.medcli.2025.106974_bib0495","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/gutjnl-2020-321372","article-title":"European Registry on Helicobacter pylori management (Hp-EuReg): Patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients","volume":"70","author":"Nyssen","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0500","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1365-2036.2011.04770.x","article-title":"Review article: Non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori","volume":"34","author":"Gisbert","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.medcli.2025.106974_bib0505","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/gutjnl-2013-304820","article-title":"Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine clinical practice","volume":"63","author":"McNicholl","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0510","doi-asserted-by":"crossref","first-page":"e12392","DOI":"10.1111\/hel.12392","article-title":"Optimization strategies aimed to increase the efficacy of H. pylori eradication therapies","volume":"22","author":"Gisbert","year":"2017","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0515","doi-asserted-by":"crossref","first-page":"e12570","DOI":"10.1111\/hel.12570","article-title":"Meta-analysis of three-in-one single capsule bismuth-containing quadruple therapy for the eradication of Helicobacter pylori","volume":"24","author":"Nyssen","year":"2019","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0520","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/2050640620972615","article-title":"European Registry on Helicobacter pylori management: Single-capsule bismuth quadruple therapy is effective in real-world clinical practice","volume":"9","author":"Nyssen","year":"2021","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.medcli.2025.106974_bib0525","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/gutjnl-2024-332804","article-title":"Evolution of the use, effectiveness and safety of bismuth-containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-EuReg)","volume":"74","author":"Olmedo","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0530","doi-asserted-by":"crossref","first-page":"e12686","DOI":"10.1111\/hel.12686","article-title":"Helicobacter pylori first-line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on H. pylori management (Hp-EuReg)","volume":"25","author":"Nyssen","year":"2020","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0535","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/MCG.0b013e318254ebdd","article-title":"Second-line therapy with levofloxacin after failure of treatment to eradicate Helicobacter pylori infection: Time trends in a Spanish Multicenter Study of 1000 patients","volume":"47","author":"Gisbert","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.medcli.2025.106974_bib0540","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/apt.13128","article-title":"Helicobacter pylori second-line rescue therapy with levofloxacin- and bismuth-containing quadruple therapy, after failure of standard triple or non-bismuth quadruple treatments","volume":"41","author":"Gisbert","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.medcli.2025.106974_bib0545","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.3390\/molecules25215084","article-title":"Optimization Strategies Aimed to Increase the Efficacy of Helicobacter pylori Eradication Therapies with Quinolones","volume":"25","author":"Gisbert","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.medcli.2025.106974_bib0550","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.cgh.2021.12.025","article-title":"Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)","volume":"20","author":"Nyssen","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.medcli.2025.106974_bib0555","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s10620-013-2900-x","article-title":"Third-line rescue therapy with bismuth-containing quadruple regimen after failure of two treatments (with clarithromycin and levofloxacin) for H. pylori infection","volume":"59","author":"Gisbert","year":"2014","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.medcli.2025.106974_bib0560","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/j.1365-2036.2012.05117.x","article-title":"Third-line rescue therapy with levofloxacin after failure of two treatments to eradicate Helicobacter pylori infection","volume":"35","author":"Gisbert","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.medcli.2025.106974_bib0565","doi-asserted-by":"crossref","DOI":"10.1177\/1756284820968736","article-title":"Empirical or susceptibility-guided treatment for Helicobacter pylori infection? A comprehensive review","volume":"13","author":"Gisbert","year":"2020","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.medcli.2025.106974_bib0570","doi-asserted-by":"crossref","first-page":"913436","DOI":"10.3389\/fmicb.2022.913436","article-title":"Empirical vs. Susceptibility-Guided Treatment of Helicobacter pylori Infection: A Systematic Review and Meta-Analysis","volume":"13","author":"Nyssen","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.medcli.2025.106974_bib0575","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1136\/gutjnl-2022-328232","article-title":"Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg)","volume":"72","author":"Burgos-Santamaria","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.medcli.2025.106974_bib0580","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/pathogens10010015","article-title":"Rifabutin for the Treatment of Helicobacter Pylori Infection: A Review","volume":"10","author":"Gisbert","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.medcli.2025.106974_bib0585","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.14309\/ajg.0000000000001246","article-title":"Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg)","volume":"116","author":"Nyssen","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.medcli.2025.106974_bib0590","doi-asserted-by":"crossref","first-page":"e12989","DOI":"10.1111\/hel.12989","article-title":"Reinforced medication adherence improves Helicobacter pylori eradication rate in developing countries: A systematic review and meta-analysis of randomized controlled trials","volume":"28","author":"Zeng","year":"2023","journal-title":"Helicobacter"},{"key":"10.1016\/j.medcli.2025.106974_bib0595","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ueg2.12569","article-title":"Role of compliance in Helicobacter pylori eradication treatment: Results of the European Registry on H. pylori management","volume":"12","author":"Huguet","year":"2024","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.medcli.2025.106974_bib0600","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/MCG.0000000000001719","article-title":"Helicobacter pylori World Gastroenterology Organization Global Guideline","volume":"57","author":"Katelaris","year":"2023","journal-title":"J Clin Gastroenterol"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775325002003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775325002003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T14:03:35Z","timestamp":1765461815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775325002003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0025775325002003"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2025.106974","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helicobacter pylori y enfermedad g\u00e1strica","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2025.106974","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106974"}}