{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:00:08Z","timestamp":1787313608321,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.medcli.2025.106983","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T07:46:54Z","timestamp":1747295214000},"page":"106983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["S\u00edndrome de Beh\u00e7et"],"prefix":"10.1016","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-0163","authenticated-orcid":false,"given":"Gerard","family":"Espinosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2025.106983_bib0325","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1034\/j.1399-0039.1999.540301.x","article-title":"Beh\u00e7et's disease, the Silk Road and HLA-B51: Historical and geographical perspectives","volume":"54","author":"Verity","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.medcli.2025.106983_bib0330","first-page":"471","article-title":"Beh\u00e7et's disease, hospital-based prevalence and manifestations in the Rotterdam area","volume":"73","author":"Kappen","year":"2015","journal-title":"Neth J Med"},{"key":"10.1016\/j.medcli.2025.106983_bib0335","first-page":"703","article-title":"Epidemiologic and clinical aspects of Beh\u00e7et's disease in a defined area of Northwestern Spain, 1988-1997","volume":"27","author":"Gonzalez-Gay","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0340","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s10067-021-06027-5","article-title":"Mortality associated with Beh\u00e7et's disease in France assessed by multiple-cause-of-death analysis","volume":"41","author":"David","year":"2022","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0345","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/diagnostics13010041","article-title":"Update on the diagnosis of Beh\u00e7et disease","volume":"13","author":"Alibaz-Oner","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.medcli.2025.106983_bib0350","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1093\/rheumatology\/kead101","article-title":"When it looks like Beh\u00e7et's syndrome but is something else: Differential diagnosis of Behcet's syndrome: A two-centre retrospective analysis","volume":"62","author":"L\u00f6tscher","year":"2023","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2025.106983_bib0355","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/rheumatology\/kead681","article-title":"Organ damage is a major determinant of work productivity impairment in Beh\u00e7et's Syndrome: A post-hoc analysis of the BODI validation study","volume":"64","author":"Floris","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2025.106983_bib0360","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/annrheumdis-2018-213225","article-title":"2018 update of the EULAR recommendations for the management of Beh\u00e7et's syndrome","volume":"77","author":"Hatemi","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2025.106983_bib0365","first-page":"keae438","article-title":"British Association of Dermatologists and British Society for Rheumatology living guideline for managing people with Beh\u00e7ets 2024","author":"Murphy","year":"2024","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2025.106983_bib0370","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.reuma.2023.12.001","article-title":"Recomendaciones SER sobre el tratamiento del s\u00edndrome de Beh\u00e7et refractario","volume":"20","author":"Moriano Morales","year":"2024","journal-title":"Reumatol Clin"},{"key":"10.1016\/j.medcli.2025.106983_bib0375","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0140-6736(23)02629-6","article-title":"Beh\u00e7et's syndrome","volume":"403","author":"Emmi","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2025.106983_bib0380","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMra2305712","article-title":"Beh\u00e7et's Syndrome","volume":"390","author":"Saadoun","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medcli.2025.106983_bib0385","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/art.23450","article-title":"Increased enthesopathy among Beh\u00e7et's syndrome patients with acne and arthritis: An ultrasonography study","volume":"58","author":"Hatemi","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2025.106983_bib0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Artritis Rheum"},{"key":"10.1016\/j.medcli.2025.106983_bib0395","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12959-015-0047-z","article-title":"Thrombosis in vasculitis: From pathogenesis to treatment","volume":"13","author":"Emmi","year":"2015","journal-title":"Thromb J"},{"key":"10.1016\/j.medcli.2025.106983_bib0400","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00281-015-0502-8","article-title":"Pathogenesis of Beh\u00e7et's disease: Autoinflammatory features and beyond","volume":"37","author":"G\u00fcl","year":"2015","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.medcli.2025.106983_bib0405","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3109\/14397595.2013.844304","article-title":"Interleukin-1-related genes polymorphisms in Turkish patients with Beh\u00e7et disease: A meta-analysis","volume":"24","author":"Zou","year":"2014","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0410","doi-asserted-by":"crossref","first-page":"109630","DOI":"10.1016\/j.clim.2023.109630","article-title":"Beh\u00e7et disease, familial Mediterranean fever and MEFV variations: More than just an association","volume":"251","author":"Seyahi","year":"2023","journal-title":"Clin Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.medcli.2025.106983_bib0415","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.5152\/eurjrheum.2019.19121","article-title":"Pediatric Beh\u00e7et's disease - clinical aspects and current concepts","volume":"7","author":"Y\u0131ld\u0131z","year":"2020","journal-title":"Eur J Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0420","doi-asserted-by":"crossref","first-page":"1439371","DOI":"10.3389\/fimmu.2024.1439371","article-title":"How underappreciate autoinflammatory (innate immunity) mechanisms dominate disparate autoimmune disorders","volume":"15","author":"Abacar","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.medcli.2025.106983_bib0425","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/00005792-200301000-00006","article-title":"The long-term mortality and morbidity of Beh\u00e7et syndrome: A 2-decade outcome survey of 387 patients followed at a dedicated center","volume":"82","author":"Kural-Seyahi","year":"2003","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2025.106983_bib0430","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1167\/iovs.09-4313","article-title":"Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis","volume":"51","author":"Takeuchi","year":"2010","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"10.1016\/j.medcli.2025.106983_bib0435","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaut.2014.01.014","article-title":"Criteria for Beh\u00e7et's disease with reflections on all disease criteria","volume":"48-49","author":"Yazici","year":"2014","journal-title":"J Autoimmun"},{"key":"10.1016\/j.medcli.2025.106983_bib0440","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1007\/s00415-013-7209-3","article-title":"Diagnosis and management of Neuro-Beh\u00e7et's disease: International consensus recommendations","volume":"261","author":"Kalra","year":"2014","journal-title":"J Neurol"},{"key":"10.1016\/j.medcli.2025.106983_bib0445","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00535-020-01690-y","article-title":"Evidence-based diagnosis and clinical practice guidelines for intestinal Beh\u00e7et's disease 2020 edited by Intractable Diseases, the Health and Labour Sciences Research Grants","volume":"55","author":"Watanabe","year":"2020","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.medcli.2025.106983_bib0450","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1136\/annrheumdis-2015-208491","article-title":"Consensus classification criteria for paediatric Beh\u00e7et's disease from a prospective observational cohort: PEDBD","volume":"75","author":"Kon\u00e9-Paut","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2025.106983_bib0455","first-page":"1078","article-title":"International Study Group for Beh\u00e7et's Disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.medcli.2025.106983_bib0460","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/jdv.12107","article-title":"The International Criteria for Beh\u00e7et's Disease (ICBD): A collaborative study of 27 countries on the sensitivity, specificity of the new criteria","volume":"28","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"Suppl1 32","key":"10.1016\/j.medcli.2025.106983_bib0465","doi-asserted-by":"crossref","first-page":"43","DOI":"10.55563\/clinexprheumatol\/0hia54","article-title":"Initial visit symptoms in probable Beh\u00e7et's syndrome is predictive of ISG criteria fulfillment in Beh\u00e7et's syndrome: Data from New York and Amsterdam cohorts","volume":"39","author":"Kerstens","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0470","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12891-017-1463-y","article-title":"Birmingham Beh\u00e7et's service: Classification of disease and application of the 2014 International Criteria for Beh\u00e7et's Disease (ICBD) to a UK cohort","volume":"18","author":"Blake","year":"2017","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.medcli.2025.106983_bib0475","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00403-009-1008-9","article-title":"The skin pathergy test: Innately useful?","volume":"302","author":"Varol","year":"2010","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.medcli.2025.106983_bib0480","doi-asserted-by":"crossref","first-page":"613432","DOI":"10.3389\/fmed.2020.613432","article-title":"Mucocutaneous manifestations of Beh\u00e7et's disease","volume":"7","author":"Nakamura","year":"2021","journal-title":"Front Med"},{"key":"10.1016\/j.medcli.2025.106983_bib0485","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11739-022-03117-3","article-title":"The diagnostic role of pathergy test in patients with Beh\u00e7et's disease from the Western Europe","volume":"18","author":"Vitale","year":"2023","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.medcli.2025.106983_bib0490","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/BOR.0000000000000846","article-title":"The association of Beh\u00e7et's syndrome with HLA-B51 as understood in 2021","volume":"34","author":"Taken","year":"2022","journal-title":"Curr Op Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0495","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/art.24642","article-title":"HLA-B51\/B5and the risk of Beh\u00e7et's disease: A systematic review and meta-analysis of case-control genetic association studies","volume":"61","author":"De Menthon","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2025.106983_bib0500","doi-asserted-by":"crossref","first-page":"e0161305","DOI":"10.1371\/journal.pone.0161305","article-title":"Genetic analysis with the immunochip platform in Beh\u00e7et disease Identification of residues associated in the HLA class I region and new susceptibility loci","volume":"11","author":"Ortiz-Fernandez","year":"2016","journal-title":"Plos One"},{"key":"10.1016\/j.medcli.2025.106983_bib0505","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/rheumatology\/ker428","article-title":"Relationships of HLA-B51 or B5 genotype with Beh\u00e7et's disease clinical characteristics: Systematic review and meta-analyses of observational studies","volume":"51","author":"Maldini","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2025.106983_bib0510","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s11239-022-02637-1","article-title":"Arterial and venous involvement in Beh\u00e7et's syndrome: A narrative review","volume":"54","author":"Toledo-Samaniego","year":"2022","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.medcli.2025.106983_bib0515","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41584-022-00880-7","article-title":"Vascular Beh\u00e7et syndrome: From pathogenesis to treatment","volume":"19","author":"Bettiol","year":"2023","journal-title":"Nat Rev Rheumatology"},{"key":"10.1016\/j.medcli.2025.106983_bib0520","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s11739-019-02237-7","article-title":"Clinical features and management of venous thromboembolism in patients with Beh\u00e7et's syndrome: A single center case-control study","volume":"15","author":"Toledo-Samaniego","year":"2020","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.medcli.2025.106983_bib0525","doi-asserted-by":"crossref","first-page":"iii101","DOI":"10.1093\/rheumatology\/kez626","article-title":"Beh\u00e7et: The syndrome","volume":"59","author":"Bettiol","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.medcli.2025.106983_bib0530","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fimmu.2019.01085","article-title":"Beh\u00e7et's syndrome as a model of thrombo-infammation: The role of neutrophils","volume":"10","author":"Emmi","year":"2019","journal-title":"Front Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.medcli.2025.106983_bib0535","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/s13023-020-01620-4","article-title":"French recommendations for the management of Beh\u00e7et's disease","volume":"16","author":"Kone-Paut","year":"2021","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.medcli.2025.106983_bib0540","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/rheumatology\/kez352","article-title":"Clinical course of acute deep vein thrombosis of the legs in Beh\u00e7et's syndrome","volume":"59","author":"Ozguler","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2025.106983_bib0545","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/art.34450","article-title":"Immunosuppressants reduce venous thrombosis relapse in Beh\u00e7et's disease","volume":"64","author":"Desbois","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.medcli.2025.106983_bib0550","doi-asserted-by":"crossref","first-page":"e494","DOI":"10.1097\/MD.0000000000000494","article-title":"Beh\u00e7et disease with vascular involvement: Effects of different therapeutic regimens on the incidence of new relapses","volume":"94","author":"Alibaz-Oner","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2025.106983_bib0555","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1136\/ard.2007.080432","article-title":"EULAR recommendations for the management of Beh\u00e7et disease","volume":"67","author":"Hatemi","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2025.106983_bib0560","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10067-007-0685-z","article-title":"Treatment of venous thrombosis associated with Behcet's disease: Immunosuppressive therapy alone versus immunosuppressive therapy plus anticoagulation","volume":"27","author":"Ahn","year":"2008","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0565","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1093\/rheumatology\/key242","article-title":"Management of major organ involvement of Beh\u00e7et's syndrome: A systematic review for update of the EULAR recommendations","volume":"57","author":"Ozguler","year":"2018","journal-title":"Rheumatology"},{"key":"10.1016\/j.medcli.2025.106983_bib0570","doi-asserted-by":"crossref","first-page":"e1899","DOI":"10.1097\/MD.0000000000001899","article-title":"Clinical and ultrasonographic evaluation of lower-extremity vein thrombosis in Beh\u00e7et syndrome: An observational study","volume":"94","author":"Seyahi","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2025.106983_bib0575","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jvsv.2016.01.003","article-title":"Post-thrombotic syndrome and venous disease-specific quality of life in patients with vascular Beh\u00e7et's disease","volume":"4","author":"Alibaz-Oner","year":"2016","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.medcli.2025.106983_bib0580","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.medcli.2019.11.004","article-title":"Neurological manifestations of Beh\u00e7et's disease: Study of 57 patients [Article in English, Spanish]","volume":"154","author":"Toledo-Samaniego","year":"2020","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.medcli.2025.106983_bib0585","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/1756-185X.13778","article-title":"Efficacy of TNF\u03b1 inhibitors for refractory vascular Beh\u00e7et's disease: A multicenter observational study of 27 patients and a review of the literature","volume":"23","author":"Aksoy","year":"2020","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.medcli.2025.106983_bib0590","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1093\/rheumatology\/keac097","article-title":"Biologic therapy in refractory neuroBeh\u00e7et's disease: A multicentre study of 41 patients and literature review","volume":"61","author":"Herrero-Morant","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2025.106983_bib0595","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/09273948.2022.2157288","article-title":"Efficacy and safety of adalimumab in patients with Beh\u00e7et uveitis: A systematic review and meta-analysis","volume":"32","author":"Sener","year":"2023","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.medcli.2025.106983_bib0600","doi-asserted-by":"crossref","first-page":"109242","DOI":"10.1016\/j.clim.2023.109242","article-title":"Long-term data on efficacy and safety of adalimumab in Beh\u00e7et's disease","volume":"247","author":"Van der Houwen","year":"2023","journal-title":"Clin Immunol"},{"key":"10.1016\/j.medcli.2025.106983_bib0605","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2300354","article-title":"Infliximab versus cyclophosphamide for severe Beh\u00e7et's syndrome","volume":"3","author":"Saadoun","year":"2024","journal-title":"NEJM Evid"},{"key":"10.1016\/j.medcli.2025.106983_bib0610","doi-asserted-by":"crossref","first-page":"813","DOI":"10.18240\/ijo.2022.05.19","article-title":"Effects of anti-TNF biologic drugs on uveitis severity in Beh\u00e7et patients: Systematic review and meta-analysis","volume":"15","author":"Abolhasani","year":"2022","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.medcli.2025.106983_bib0615","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1007\/s12325-024-02993-9","article-title":"Real-world safety and effectiveness of infliximab in 255 patients with intestinal, neurological, and vascular Beh\u00e7et's disease: A post-marketing surveillance","volume":"41","author":"Hibi","year":"2024","journal-title":"Adv Ther"},{"key":"10.1016\/j.medcli.2025.106983_bib0620","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3899\/jrheum.200300","article-title":"Long-term follow-up and optimization of infliximab in refractory uveitis due to Beh\u00e7et disease: National study of 103 white patients","volume":"48","author":"Mart\u00edn-Varillas","year":"2021","journal-title":"J Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0625","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.ophtha.2018.02.020","article-title":"Successful optimization of adalimumab therapy in refractory uveitis due to Beh\u00e7et's disease","volume":"125","author":"Mart\u00edn-Varillas","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.medcli.2025.106983_bib0630","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1056\/NEJMoa1408684","article-title":"Apremilast for Behcet's syndrome - phase 2, placebo-controlled study","volume":"372","author":"Hatemi","year":"2015","journal-title":"N Engl J Med"},{"issue":"Suppl1 27","key":"10.1016\/j.medcli.2025.106983_bib0635","first-page":"69","article-title":"Apremilast in refractory orogenital ulcers and other manifestations of Beh\u00e7et's disease. A national multicentre study of 51 cases in clinical practice","volume":"38","author":"Atienza-Mateo","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.medcli.2025.106983_bib0640","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3899\/jrheum.221106","article-title":"Tocilizumab in Beh\u00e7et disease: A multicenter study of 30 patients","volume":"50","author":"Khitri","year":"2023","journal-title":"J Rheumatol"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775325002118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775325002118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T14:04:15Z","timestamp":1765461855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775325002118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0025775325002118"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2025.106983","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S\u00edndrome de Beh\u00e7et","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2025.106983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106983"}}