{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:30:22Z","timestamp":1760056222998,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.medcli.2025.107046","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T07:53:37Z","timestamp":1750492417000},"page":"107046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilidad cl\u00ednica de la monitorizaci\u00f3n mediante pupilometr\u00eda cuantitativa en pacientes con da\u00f1o cerebral agudo"],"prefix":"10.1016","volume":"165","author":[{"given":"Eusebio","family":"Campos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Esther","family":"Tejerina \u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 \u00c1ngel","family":"Lorente Balanza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2025.107046_bib0230","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1089\/neu.2006.0029","article-title":"Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: An IMPACT analysis","volume":"24","author":"Marmarou","year":"2007","journal-title":"J Neurotrauma."},{"key":"10.1016\/j.medcli.2025.107046_bib0235","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S1474-4422(23)00271-5","article-title":"The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): A prospective, observational, multicentre cohort study","volume":"22","author":"Oddo","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.medcli.2025.107046_bib0240","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s12028-015-0182-1","article-title":"Interrater reliability of pupillary assessments","volume":"24","author":"Olson","year":"2016","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0245","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/0885066619881124","article-title":"Quantitative pupillometry in the intensive care unit","volume":"36","author":"Bower","year":"2021","journal-title":"J Intensive Care Med."},{"key":"10.1016\/j.medcli.2025.107046_bib0250","first-page":"47","article-title":"Pupilometr\u00eda: conceptos fisiol\u00f3gicos y cl\u00ednicos aplicados al paciente neurocr\u00edtico [Pupillometry: Physiological and clinical concepts applied to the neurocritical patient]","volume":"33","author":"Arevalo-Martinez","year":"2019","journal-title":"Rev Argent Neurocir."},{"key":"10.1016\/j.medcli.2025.107046_bib0255","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/wcs.1323","article-title":"Pupillometry","volume":"5","author":"Sirois","year":"2014","journal-title":"Wiley Interdiscip Rev Cogn Sci."},{"key":"10.1016\/j.medcli.2025.107046_bib0260","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/diagnostics8010019","article-title":"Eyeing up the future of the pupillary light reflex in neurodiagnostics","volume":"8","author":"Hall","year":"2018","journal-title":"Diagnostics (Basel)."},{"key":"10.1016\/j.medcli.2025.107046_bib0265","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1148\/rg.2019190018","article-title":"Types of cerebral herniation and their imaging features","volume":"39","author":"Riveros Gilardi","year":"2019","journal-title":"Radiographics."},{"key":"10.1016\/j.medcli.2025.107046_bib0270","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1007\/s00134-018-5448-6","article-title":"Quantitative versus standard pupillary light reflex for early prognostication in comatose cardiac arrest patients: An international prospective multicenter double-blinded study","volume":"44","author":"Oddo","year":"2018","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.medcli.2025.107046_bib0275","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/JNN.0000000000000290","article-title":"Correlations between hourly pupillometer readings and intracranial pressure values","volume":"49","author":"McNett","year":"2017","journal-title":"J Neurosci Nurs."},{"key":"10.1016\/j.medcli.2025.107046_bib0280","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/2152-7806.82248","article-title":"Pupillary reactivity as an early indicator of increased intracranial pressure: The introduction of the Neurological Pupil index","volume":"2","author":"Chen","year":"2011","journal-title":"Surg Neurol Int."},{"key":"10.1016\/j.medcli.2025.107046_bib0285","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3171\/jns.2003.98.1.0205","article-title":"Quantitative pupillometry, a new technology: Normative data and preliminary observations in patients with acute head injury. Technical note","volume":"98","author":"Taylor","year":"2003","journal-title":"J Neurosurg."},{"key":"10.1016\/j.medcli.2025.107046_bib0290","first-page":"e0054","article-title":"Impact of increased intracranial pressure on pupillometry: A replication study","volume":"1","author":"Al-Obaidi","year":"2019","journal-title":"Crit Care Explor."},{"key":"10.1016\/j.medcli.2025.107046_bib0295","doi-asserted-by":"crossref","first-page":"155l","DOI":"10.1186\/s13054-019-2436-3","article-title":"Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury","volume":"23","author":"Jahns","year":"2019","journal-title":"Crit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0300","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1080\/02699052.2019.1605621","article-title":"Optical pupillometry in traumatic brain injury: Neurological pupil index and its relationship with intracranial pressure through significant event analysis","volume":"33","author":"Stevens","year":"2019","journal-title":"Brain Inj."},{"key":"10.1016\/j.medcli.2025.107046_bib0305","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s13054-020-03105-z","article-title":"Multimodal noninvasive assessment of intracranial hypertension: An observational study","volume":"24","author":"Robba","year":"2020","journal-title":"Crit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0310","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jss.2020.12.042","article-title":"Efficacy of noninvasive technologies in triaging traumatic brain injury and correlating with intracranial pressure: A prospective study","volume":"262","author":"Singer","year":"2021","journal-title":"J Surg Res."},{"key":"10.1016\/j.medcli.2025.107046_bib0315","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s12028-022-01518-y","article-title":"Can quantitative pupillometry be used to screen for elevated intracranial pressure? A retrospective cohort study","volume":"37","author":"Pansell","year":"2022","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0320","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/0885066618788022","article-title":"Multimodality monitoring in neurocritical care: Decision-making utilizing direct and indirect surrogate markers","volume":"34","author":"Al-Mufti","year":"2019","journal-title":"J Intensive Care Med."},{"key":"10.1016\/j.medcli.2025.107046_bib0325","first-page":"101","article-title":"Intracranial pressure management: Moving beyond guidelines","volume":"28","author":"Rubiano","year":"2022","journal-title":"Curr Opin Crit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0330","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.03.055","article-title":"Correlation of objective pupillometry to midline shift in acute stroke patients","volume":"28","author":"Osman","year":"2019","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"10.1016\/j.medcli.2025.107046_bib0335","doi-asserted-by":"crossref","first-page":"106410","DOI":"10.1016\/j.clineuro.2020.106410","article-title":"Supratentorial intracerebral hemorrhage volume and other CT variables predict the neurological pupil index","volume":"200","author":"Mazhar","year":"2021","journal-title":"Clin Neurol Neurosurg."},{"key":"10.1016\/j.medcli.2025.107046_bib0340","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s12028-020-01146-4","article-title":"Automated pupillometry identifies absence of intracranial pressure elevation in intracerebral hemorrhage patients","volume":"35","author":"Giede-Jeppe","year":"2021","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0345","doi-asserted-by":"crossref","first-page":"1046548","DOI":"10.3389\/fneur.2022.1046548","article-title":"Quantitative pupillometry and radiographic markers of intracranial midline shift: A pilot study","volume":"13","author":"Kim","year":"2022","journal-title":"Front Neurol."},{"key":"10.1016\/j.medcli.2025.107046_bib0350","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s12028-020-00936-0","article-title":"Neurological pupil index as an indicator of neurological worsening in large hemispheric strokes","volume":"33","author":"Kim","year":"2020","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0355","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/JNN.0000000000000584","article-title":"Neurological pupil index as an indicator of irreversible cerebral edema: A case series","volume":"53","author":"Cortes","year":"2021","journal-title":"J Neurosci Nurs."},{"key":"10.1016\/j.medcli.2025.107046_bib0360","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1007\/s10072-021-05218-x","article-title":"Abnormal neurological pupil index is associated with malignant cerebral edema after mechanical thrombectomy in large vessel occlusion patients","volume":"42","author":"Dowlati","year":"2021","journal-title":"Neurol Sci."},{"key":"10.1016\/j.medcli.2025.107046_bib0365","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1161\/STROKEAHA.110.589275","article-title":"Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: Proposal of a multidisciplinary research group","volume":"41","author":"Vergouwen","year":"2010","journal-title":"Stroke."},{"key":"10.1016\/j.medcli.2025.107046_bib0370","first-page":"e314","article-title":"2023 Guideline for the management of patients with aneurysmal subarachnoid hemorrhage: A guideline from the American Heart Association\/American Stroke Association","volume":"54","author":"Hoh","year":"2023","journal-title":"Stroke."},{"key":"10.1016\/j.medcli.2025.107046_bib0375","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3171\/2018.9.JNS181928","article-title":"Detection of delayed cerebral ischemia using objective pupillometry in patients with aneurysmal subarachnoid hemorrhage","volume":"132","author":"Aoun","year":"2020","journal-title":"J Neurosurg."},{"key":"10.1016\/j.medcli.2025.107046_bib0380","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s12028-023-01744-y","article-title":"Neurological pupil index and delayed cerebral ischemia after subarachnoid hemorrhage: A retrospective multicentric study","volume":"39","author":"Gouvea Bogossian","year":"2023","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0385","first-page":"e1135","article-title":"Dynamically normalized pupillometry for detecting delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage","volume":"6","author":"Klug","year":"2024","journal-title":"Crit Care Explor."},{"key":"10.1016\/j.medcli.2025.107046_bib0390","doi-asserted-by":"crossref","first-page":"107922","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107922","article-title":"Smartphone pupillometry for detection of cerebral vasospasm after aneurysmal subarachnoid hemorrhage","volume":"33","author":"Maxin","year":"2024","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"10.1016\/j.medcli.2025.107046_bib0395","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12028-014-0070-0","article-title":"Non-convulsive status epilepticus and non-convulsive seizures in neurological ICU patients","volume":"22","author":"Laccheo","year":"2014","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0400","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.seizure.2023.12.006","article-title":"More about nonconvulsive status epilepticus in children","volume":"114","author":"Le\u00f3n-Ruiz","year":"2024","journal-title":"Seizure."},{"key":"10.1016\/j.medcli.2025.107046_bib0405","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1212\/WNL.0000000000002281","article-title":"Seizure burden in subarachnoid hemorrhage associated with functional and cognitive outcome","volume":"86","author":"De Marchis","year":"2016","journal-title":"Neurology."},{"key":"10.1016\/j.medcli.2025.107046_bib0410","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12028-020-01149-1","article-title":"Quantitative infrared pupillometry in nonconvulsive status epilepticus","volume":"35","author":"Godau","year":"2021","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0415","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12028-021-01273-6","article-title":"Automated pupillometry for assessment of treatment success in nonconvulsive status epilepticus","volume":"36","author":"Godau","year":"2022","journal-title":"Neurocrit Care."},{"key":"10.1016\/j.medcli.2025.107046_bib0420","doi-asserted-by":"crossref","first-page":"867603","DOI":"10.3389\/fneur.2022.867603","article-title":"Automated pupillometry for prediction of electroencephalographic reactivity in critically ill patients: A prospective cohort study","volume":"13","author":"Peluso","year":"2022","journal-title":"Front Neurol."},{"key":"10.1016\/j.medcli.2025.107046_bib0425","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1097\/CCM.0000000000005045","article-title":"Neuroprognostic accuracy of quantitative versus standard pupillary light reflex for adult postcardiac arrest patients: A systematic review and meta-analysis","volume":"49","author":"Wang","year":"2021","journal-title":"Crit Care Med."},{"key":"10.1016\/j.medcli.2025.107046_bib0430","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1007\/s00134-024-07574-6","article-title":"Quantitative pupillometry for neuroprognostication in comatose post-cardiac arrest patients: A protocol for a predefined sub-study of the Blood pressure and Oxygenations Targets after Out-of-Hospital Cardiac Arrest (BOX)-trial","volume":"50","author":"Nyholm","year":"2024","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.medcli.2025.107046_bib0435","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/ANA.0000000000000553","article-title":"Portable infrared pupillometer in patients with subarachnoid hemorrhage: Prognostic value and circadian rhythm of the neurological pupil index (NPi)","volume":"31","author":"Natzeder","year":"2019","journal-title":"J Neurosurg Anesthesiol."},{"key":"10.1016\/j.medcli.2025.107046_bib0440","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1213\/ANE.0000000000000314","article-title":"Portable infrared pupillometry: A review","volume":"120","author":"Larson","year":"2015","journal-title":"Anesth Analg."},{"key":"10.1016\/j.medcli.2025.107046_bib0445","doi-asserted-by":"crossref","first-page":"995","DOI":"10.23736\/S0375-9393.19.13437-2","article-title":"Role of automated pupillometry in critically ill patients","volume":"85","author":"Morelli","year":"2019","journal-title":"Minerva Anestesiol."},{"key":"10.1016\/j.medcli.2025.107046_bib0450","doi-asserted-by":"crossref","first-page":"e629","DOI":"10.1212\/WNL.0000000000012984","article-title":"Automated quantitative pupillometry in the critically ill. A systematic review of the literature","volume":"97","author":"Opic","year":"2021","journal-title":"Neurology."}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002577532500274X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002577532500274X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:48:49Z","timestamp":1759999729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002577532500274X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S002577532500274X"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2025.107046","relation":{},"ISSN":["0025-7753"],"issn-type":[{"type":"print","value":"0025-7753"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Utilidad cl\u00ednica de la monitorizaci\u00f3n mediante pupilometr\u00eda cuantitativa en pacientes con da\u00f1o cerebral agudo","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2025.107046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107046"}}