{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:17:23Z","timestamp":1790605043026,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","award":["H2023087"],"award-info":[{"award-number":["H2023087"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Cl\u00ednica"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.medcli.2025.107206","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:40:52Z","timestamp":1760114452000},"page":"107206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantitative analysis of chest CT with deep learning to assess the efficacy of tofacitinib in the treatment of anti-MDA5+ dermatomyositis"],"prefix":"10.1016","volume":"165","author":[{"given":"Na","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medcli.2025.107206_bib0165","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jaad.2017.12.010","article-title":"Anti-melanoma differentiation-associated gene 5 (mda5) dermatomyositis: a concise review with an emphasis on distinctive clinical features","volume":"78","author":"Kurtzman","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.medcli.2025.107206_bib0170","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/art.41105","volume":"72","author":"Tsuji","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.medcli.2025.107206_bib0175","doi-asserted-by":"crossref","first-page":"e29108","DOI":"10.1097\/MD.0000000000029108","article-title":"Combination therapy of tacrolimus, high doses of glucocorticosteroids, and cyclophosphamide against existing historical treatment for patients in severe conditions of interstitial lung diseases complicated with dermatomyositis: a retrospective analysis","volume":"101","author":"Lian","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.medcli.2025.107206_bib0180","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/1346-8138.15274","article-title":"Combined immunosuppressive therapy provides favorable prognosis and increased risk of cytomegalovirus reactivation in anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis","volume":"47","author":"Matsuda","year":"2020","journal-title":"J Dermatol"},{"key":"10.1016\/j.medcli.2025.107206_bib0185","first-page":"4","article-title":"Janus kinase and tyrosine kinase inhibitors in dermatology: a review of their utilization, safety profile and future applications","volume":"27","author":"Shalabi","year":"2022","journal-title":"Skin Therapy Lett"},{"key":"10.1016\/j.medcli.2025.107206_bib0190","doi-asserted-by":"crossref","first-page":"e14939","DOI":"10.1111\/dth.14939","article-title":"Jak-inhibitors for dermatomyositis: a concise literature review","volume":"34","author":"Paudyal","year":"2021","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.medcli.2025.107206_bib0195","doi-asserted-by":"crossref","first-page":"691","DOI":"10.25259\/IJDVL_1152_2022","article-title":"Jak-stat inhibitors in immune mediated diseases: an overview","volume":"89","author":"Shah","year":"2023","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1016\/j.medcli.2025.107206_bib0200","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S2213-2600(17)30433-2","article-title":"Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner society white paper","volume":"6","author":"Lynch","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.medcli.2025.107206_bib0205","doi-asserted-by":"crossref","DOI":"10.1148\/ryct.2020200075","article-title":"Serial quantitative chest ct assessment of covid-19: a deep learning approach","volume":"2","author":"Huang","year":"2020","journal-title":"Radiol Cardiothorac Imaging"},{"key":"10.1016\/j.medcli.2025.107206_bib0210","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nmd.2019.10.005","article-title":"239th ENMC international workshop: classification of dermatomyositis, Amsterdam, the Netherlands, 14\u201316 December 2018","volume":"30","author":"Mammen","year":"2020","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.medcli.2025.107206_bib0215","doi-asserted-by":"crossref","DOI":"10.3389\/fradi.2023.1153784","article-title":"Urp: an integrated research platform for one-stop analysis of medical images","volume":"3","author":"Wu","year":"2023","journal-title":"Front Radiol"},{"key":"10.1016\/j.medcli.2025.107206_bib0220","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/A:1011444826908","article-title":"Non-invasive imaging of regional lung function using X-ray computed tomography","volume":"16","author":"Simon","year":"2000","journal-title":"J Clin Monit Comput"},{"key":"10.1016\/j.medcli.2025.107206_bib0225","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/abe838","article-title":"Large-scale screening to distinguish between covid-19 and community-acquired pneumonia using infection size-aware classification","volume":"66","author":"Shi","year":"2021","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.medcli.2025.107206_bib0230","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1212\/WNL.0000000000009727","article-title":"Different phenotypes in dermatomyositis associated with anti-MDA5 antibody: study of 121 cases","volume":"95","author":"Allenbach","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.medcli.2025.107206_bib0235","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1164\/rccm.202112-2684OC","article-title":"Deep learning-based outcome prediction in progressive fibrotic lung disease using high-resolution computed tomography","volume":"206","author":"Walsh","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.medcli.2025.107206_bib0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104699","article-title":"Sharp u-net: depthwise convolutional network for biomedical image segmentation","volume":"136","author":"Zunair","year":"2021","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.medcli.2025.107206_bib0245","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/mp.14609","article-title":"Abnormal lung quantification in chest ct images of covid-19 patients with deep learning and its application to severity prediction","volume":"48","author":"Shan","year":"2021","journal-title":"Med Phys"},{"key":"10.1016\/j.medcli.2025.107206_bib0250","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1056\/NEJMc1900045","article-title":"Tofacitinib in amyopathic dermatomyositis-associated interstitial lung disease","volume":"381","author":"Chen","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medcli.2025.107206_bib0255","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01488-2024","article-title":"Effectiveness and safety of tofacitinib versus calcineurin inhibitor in interstitial lung disease secondary to anti-MDA5-positive dermatomyositis: a multicentre cohort study","volume":"65","author":"Wu","year":"2025","journal-title":"Eur Respir J"},{"key":"10.1016\/j.medcli.2025.107206_bib0260","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jaad.2021.07.003","article-title":"Tofacitinib as treatment for refractory dermatomyositis: a retrospective study from 2 academic medical centers","volume":"86","author":"Min","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.medcli.2025.107206_bib0265","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1093\/rheumatology\/keaf046","article-title":"Tofacitinib treatment for active dermatomyositis and anti-synthetase syndrome: a prospective cohort pilot study","volume":"64","author":"Xing","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2025.107206_bib0270","doi-asserted-by":"crossref","DOI":"10.1177\/17534666241294000","article-title":"The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis","volume":"18","author":"Wang","year":"2024","journal-title":"Ther Adv Respir Dis"},{"key":"10.1016\/j.medcli.2025.107206_bib0275","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1093\/rheumatology\/kead404","article-title":"Tofacitinib therapy in refractory inflammatory myositis: a retrospective cohort study of 41 patients","volume":"63","author":"Beckett","year":"2024","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.medcli.2025.107206_bib0280","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jaad.2019.05.105","article-title":"Dermatomyositis: diagnosis and treatment","volume":"82","author":"Waldman","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.medcli.2025.107206_bib0285","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.2147\/IJGM.S414267","article-title":"Efficacy of jak inhibitors versus dmards in the treatment of polymyalgia rheumatica in china","volume":"16","author":"Gu","year":"2023","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.medcli.2025.107206_bib0290","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1136\/annrheumdis-2019-216653","article-title":"Safety of synthetic and biological dmards: A systematic literature review informing the 2019 update of the eular recommendations for the management of rheumatoid arthritis","volume":"79","author":"Sepriano","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.medcli.2025.107206_bib0295","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/art.40189","article-title":"Herpes zoster and tofacitinib: clinical outcomes and the risk of concomitant therapy","volume":"69","author":"Winthrop","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.medcli.2025.107206_bib0300","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nrd.2017.201","article-title":"Jak inhibition as a therapeutic strategy for immune and inflammatory diseases","volume":"16","author":"Schwartz","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.medcli.2025.107206_bib0305","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nrrheum.2017.51","article-title":"The emerging safety profile of jak inhibitors in rheumatic disease","volume":"13","author":"Winthrop","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.medcli.2025.107206_bib0310","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.3390\/v15122326","article-title":"Herpes virus infection in lung transplantation: diagnosis, treatment and prevention strategies","volume":"15","author":"Patrucco","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.medcli.2025.107206_bib0315","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/acr.24007","article-title":"Efficacy and safety of long-term baricitinib with and without methotrexate for the treatment of rheumatoid arthritis: experience with baricitinib monotherapy continuation or after switching from methotrexate monotherapy or baricitinib plus methotrexate","volume":"72","author":"Fleischmann","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.medcli.2025.107206_bib0320","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/jama.2019.9055","article-title":"Effect of filgotinib vs placebo on clinical response in patients with moderate to severe rheumatoid arthritis refractory to disease-modifying antirheumatic drug therapy: the finch 2 randomized clinical trial","volume":"322","author":"Genovese","year":"2019","journal-title":"JAMA"}],"container-title":["Medicina Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775325004348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025775325004348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:14:28Z","timestamp":1777425268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025775325004348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0025775325004348"],"URL":"https:\/\/doi.org\/10.1016\/j.medcli.2025.107206","relation":{},"ISSN":["0025-7753"],"issn-type":[{"value":"0025-7753","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative analysis of chest CT with deep learning to assess the efficacy of tofacitinib in the treatment of anti-MDA5+ dermatomyositis","name":"articletitle","label":"Article Title"},{"value":"Medicina Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medcli.2025.107206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107206"}}