{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:14:22Z","timestamp":1792689262054,"version":"4.5.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","meddos.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Dosimetry"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.meddos.2021.02.001","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T08:46:01Z","timestamp":1614329161000},"page":"259-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Intensity-modulated proton therapy (IMPT) versus intensity-modulated radiation therapy (IMRT) for the treatment of head and neck cancer: A dosimetric comparison"],"prefix":"10.1016","volume":"46","author":[{"given":"My-Lien","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Nathan","family":"Cantrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salahuddin","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Henson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.meddos.2021.02.001_bib0001","doi-asserted-by":"crossref","first-page":"50","DOI":"10.21037\/cco.2016.07.06","article-title":"Proton therapy for the management of uveal melanoma and other ocular tumors","volume":"5","author":"Mishra","year":"2016","journal-title":"Chin. Clin. Oncol."},{"key":"10.1016\/j.meddos.2021.02.001_bib0002","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0360-3016(98)00225-9","article-title":"Conformal proton therapy for prostate carcinoma","volume":"42","author":"Slater","year":"1998","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.meddos.2021.02.001_bib0003","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00066-003-1065-5","article-title":"Radiation therapy for chorfoma and chondrosarcoma of the skull base and the cervical spine: prognostic factors and pattern of failure","volume":"179","author":"Noel","year":"2003","journal-title":"Strahlenther. Onkol."},{"issue":"3","key":"10.1016\/j.meddos.2021.02.001_bib0004","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0167-8140(01)00403-0","article-title":"A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumors","volume":"61","author":"Cozzi","year":"2001","journal-title":"Radiother. Oncol."},{"issue":"2","key":"10.1016\/j.meddos.2021.02.001_bib0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/1754-9485.12227","article-title":"Dosimetric and radiobiologic comparison of 3D conformal, IMRT, VMAT and proton therapy for the treatment of early-stage glottic cancer","volume":"59","author":"Matthiesen","year":"2015","journal-title":"J Med Imaging Radiat Oncol"},{"key":"10.1016\/j.meddos.2021.02.001_bib0006","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.oraloncology.2018.11.015","article-title":"Intensity modulated proton therapy (IMPT)\u2014the future of IMRT for head and neck cancer","volume":"88","author":"Moreno","year":"2019","journal-title":"Oral Oncol."},{"issue":"2","key":"10.1016\/j.meddos.2021.02.001_bib0007","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.semradonc.2017.12.002","article-title":"Comparing intensity-modulated proton therapy with intensity-modulated photon therapy for oropharyngeal cancer: the journey from clinical trial concept to activation","volume":"28","author":"Frank","year":"2018","journal-title":"Semin. Radiat. Oncol."},{"key":"10.1016\/j.meddos.2021.02.001_bib0008","first-page":"1","article-title":"Developing a Monte Carlo model for Mevion S250i with HYPERSCAN and Adaptive ApertureTM pencil beam scanning proton therapy system","author":"Chiang","year":"2020","journal-title":"J. Radiother. Pract."},{"issue":"3","key":"10.1016\/j.meddos.2021.02.001_bib0009","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative analysis of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.meddos.2021.02.001_bib0010","unstructured":"Varian Medical Systems Inc., Palo Alto, CA, USA"},{"key":"10.1016\/j.meddos.2021.02.001_bib0011","unstructured":"RaySearch Laboratories, Stockholm, Sweden."},{"issue":"4","key":"10.1016\/j.meddos.2021.02.001_bib0012","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/0971-6203.103606","article-title":"Homogeneity index: an objective tool for assessment of conformal radiation treatments","volume":"37","author":"Kataria","year":"2012","journal-title":"J. Med. Phys."},{"issue":"11","key":"10.1016\/j.meddos.2021.02.001_bib0013","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/acm2.12739","article-title":"A new homogeneity index definition for evaluation of radiotherapy plans","volume":"20","author":"Yan","year":"2019","journal-title":"J. Appl. Clin. Med. Phys."},{"issue":"2","key":"10.1016\/j.meddos.2021.02.001_bib0014","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.radonc.2015.12.008","article-title":"Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation","volume":"118","author":"Romesser","year":"2016","journal-title":"Radiother. Oncol"},{"key":"10.1016\/j.meddos.2021.02.001_bib0015","unstructured":"Study of proton versus photon beam radiotherapy in the treatment of head and neck cancer 2021, Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02923570"},{"issue":"1","key":"10.1016\/j.meddos.2021.02.001_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-020-1476-9","article-title":"Improve the dosimetric outcome in bilateral head and neck cancer (HNC) treatment using spot-scanning proton arc (SPArc) therapy: a feasibility study","volume":"15","author":"Liu","year":"2020","journal-title":"Radiat. Oncol."}],"container-title":["Medical Dosimetry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958394721000133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958394721000133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T09:31:52Z","timestamp":1760693512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958394721000133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"alternative-id":["S0958394721000133"],"URL":"https:\/\/doi.org\/10.1016\/j.meddos.2021.02.001","relation":{},"ISSN":["0958-3947"],"issn-type":[{"value":"0958-3947","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intensity-modulated proton therapy (IMPT) versus intensity-modulated radiation therapy (IMRT) for the treatment of head and neck cancer: A dosimetric comparison","name":"articletitle","label":"Article Title"},{"value":"Medical Dosimetry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meddos.2021.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}