{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:16:51Z","timestamp":1760746611913,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","meddos.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Dosimetry"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.meddos.2022.01.004","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T16:41:10Z","timestamp":1646066470000},"page":"161-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The radiobiological effect of using Acuros XB vs anisotropic analytical algorithm on hepatocellular carcinoma stereotactic body radiation therapy"],"prefix":"10.1016","volume":"47","author":[{"given":"Michael L.M.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica W.K.","family":"Kan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa T.Y.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren M.C.","family":"Poon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.M.","family":"Kam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis K.Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony T.C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.meddos.2022.01.004_bib0001","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"A global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0002","doi-asserted-by":"crossref","DOI":"10.1177\/1533033818790217","article-title":"Stereotactic body radiation therapy for hepatocellular carcinoma: current trends and controversies","volume":"17","author":"Schaub","year":"2018","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.meddos.2022.01.004_bib0003","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jhepr.2019.05.004","article-title":"Radiotherapy for HCC: ready for prime time?","volume":"1","author":"Bang","year":"2019","journal-title":"JHEP Rep"},{"key":"10.1016\/j.meddos.2022.01.004_bib0004","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jhep.2017.02.022","article-title":"Stereotactic body radiotherapy vs. TACE or RFA as a bridge to transplant in patients with hepatocellular carcinoma. An intention-to-treat analysis","volume":"67","author":"Sapisochin","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0005","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1002\/cncr.26404","article-title":"Evaluation of response after stereotactic body radiotherapy for hepatocellular carcinoma","volume":"118","author":"Price","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.meddos.2022.01.004_bib0006","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1088\/0031-9155\/51\/22\/005","article-title":"Comparison of dose calculation algorithms for treatment planning in external photon beam therapy for clinical situations","volume":"51","author":"Kn\u00f6\u00f6s","year":"2006","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0007","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1120\/jacmp.v9i2.2786","article-title":"Inhomogeneity correction and the analytic anisotropic algorithm","volume":"9","author":"Robinson","year":"2008","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0008","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/02841860802287108","article-title":"Validation of Varian's AAA algorithm with focus on lung treatments","volume":"48","author":"R\u00f8nde","year":"2009","journal-title":"Acta Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0009","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1088\/0031-9155\/52\/13\/002","article-title":"Collapsed cone convolution and analytical anisotropic algorithm dose calculations compared to VMC++ Monte Carlo simulations in clinical cases","volume":"52","author":"Hasenbalg","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0010","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1118\/1.2727314","article-title":"Monte carlo evaluation of the AAA treatment planning algorithm in a heterogeneous multilayer phantom and IMRT clinical treatments for an Elekta SL25 linear accelerator","volume":"34","author":"Sterpin","year":"2007","journal-title":"Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0011","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1088\/0031-9155\/51\/6\/004","article-title":"Dosimetric validation of the anisotropic analytical algorithm for photon dose calculation: fundamental characterization in water","volume":"51","author":"Fogliata","year":"2006","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0012","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1118\/1.2358333","article-title":"Testing of the analytical anisotropic algorithm for photon dose calculation","volume":"33","author":"Van Esch","year":"2006","journal-title":"Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0013","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1088\/0031-9155\/55\/3\/002","article-title":"Validation of a new grid-based Boltzmann equation solver for dose calculation in radiotherapy with photon beams","volume":"55","author":"Vassiliev","year":"2010","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0014","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1088\/0031-9155\/56\/6\/022","article-title":"Dosimetric validation of the Acuros XB advanced dose calculation algorithm: fundamental characterization in water","volume":"56","author":"Fogliata","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1748-717X-6-82","article-title":"Dosimetric evaluation of Acuros XB advanced dose calculation algorithm in heterogeneous media","volume":"19","author":"Fogliata","year":"2011","journal-title":"Radiat Oncol."},{"key":"10.1016\/j.meddos.2022.01.004_bib0016","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1118\/1.3582690","article-title":"Dosimetric comparison of Acuros XB deterministic radiation transport method with Monte Carlo and model-based convolution methods in heterogeneous media","volume":"38","author":"Han","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0017","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1118\/1.3567146","article-title":"Dosimetric validation of Acuros XB with Monte Carlo methods for photon dose calculations","volume":"38","author":"Bush","year":"2011","journal-title":"Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0018","doi-asserted-by":"crossref","first-page":"02TR01","DOI":"10.1088\/1361-6560\/aaf0e2","article-title":"Calculation of absorbed dose in radiotherapy by solution of the linear Boltzmann transport equations","volume":"64","author":"Bedford","year":"2019","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0019","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.ijrobp.2011.10.078","article-title":"Critical appraisal of Acuros XB and anisotropic analytic algorithm dose calculation in advanced non-small-cell lung cancer treatments","volume":"83","author":"Fogliata","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0020","doi-asserted-by":"crossref","DOI":"10.1118\/1.4802216","article-title":"Dosimetric impact of Acuros XB deterministic radiation transport algorithm for heterogeneous dose calculation in lung cancer","volume":"40","author":"Han","year":"2013","journal-title":"Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0021","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1120\/jacmp.v17i5.6338","article-title":"Difference in dose-volumetric data between the analytical anisotropic algorithm, the dose-to-medium, and the dose-to-water reporting modes of the Acuros XB for lung stereotactic body radiation therapy","volume":"17","author":"Mampuya","year":"2016","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0022","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.meddos.2017.05.005","article-title":"Dosimetric comparison of peripheral NSCLC SBRT using Acuros XB and AAA calculation algorithms","volume":"42","author":"Ong","year":"2017","journal-title":"Med Dosim"},{"key":"10.1016\/j.meddos.2022.01.004_bib0023","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1118\/1.4736819","article-title":"Verification and dosimetric impact of Acuros XB algorithm on intensity modulated stereotactic radiotherapy for locally persistent nasopharyngeal carcinoma","volume":"39","author":"Kan","year":"2012","journal-title":"Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0024","doi-asserted-by":"crossref","DOI":"10.1118\/1.4792308","article-title":"Experimental verification of the Acuros XB and AAA dose calculation adjacent to heterogeneous media for IMRT and RapidArc of nasopharygeal carcinoma","volume":"40","author":"Kan","year":"2013","journal-title":"Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0025","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.ijrobp.2012.08.031","article-title":"Dosimetric impact of using the Acuros XB algorithm for intensity modulated radiation therapy and RapidArc planning in nasopharyngeal carcinomas","volume":"85","author":"Kan","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1748-717X-6-103","article-title":"On the dosimetric impact of inhomogeneity management in the Acuros XB algorithm for breast treatment","volume":"6","author":"Fogliata","year":"2011","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0027","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/acm2.12329","article-title":"Clinical implementation of AXB from AAA for breast: plan quality and subvolume analysis","volume":"19","author":"Guebert","year":"2018","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0028","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1120\/jacmp.v15i4.4853","article-title":"The photon dose calculation algorithm used in breast radiotherapy has significant impact on the parameters of radiobiological models","volume":"15","author":"Petillion","year":"2014","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0029","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13014-014-0286-3","article-title":"Comparison of Acuros (AXB) and anisotropic analytical algorithm (AAA) for dose calculation in treatment of oesophageal cancer: effects on modelling tumour control probability","volume":"9","author":"Padmanaban","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13014-015-0578-2","article-title":"Radiobiological impact of dose calculation algorithms on biologically optimized IMRT lung stereotactic body radiation therapy plans","volume":"11","author":"Liang","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0031","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13014-020-01591-7","article-title":"Clinical implication in the use of the AAA algorithm versus the AXB in nasopharyngeal carcinomas by comparison of TCP and NTCP values","volume":"15","author":"Bufacchi","year":"2020","journal-title":"Radiat Oncol"},{"journal-title":"Clinicaltrials.gov identifier NCT01730937","article-title":"Randomized Phase III Study of Sorafenib versus Stereotactic Body Radiation Therapy followed by Sorabenib in Hepatocellular Carcinoma","year":"2020","key":"10.1016\/j.meddos.2022.01.004_bib0032"},{"key":"10.1016\/j.meddos.2022.01.004_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.adro.2021.100739","article-title":"Analysis of hepatocellular carcinoma stereotactic body radiation therapy dose prescription method using uncomplicated tumour control probability model","author":"Cheung","year":"2021","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0034","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/0360-3016(85)90341-4","article-title":"Strategies for treating possible tumor extension: some theoretical considerations","volume":"11","author":"Goiten","year":"1985","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0035","first-page":"1100","article-title":"A generalized concept of equivalent uniform dose (EUD)","volume":"26","author":"Niemierko","year":"1999","journal-title":"Med Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0036","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0360-3016(02)02846-8","article-title":"Analysis of radiation-induced liver disease using the Lyman NTCP model","volume":"53","author":"Dawson","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0037","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1080\/02841860600936369","article-title":"Individualized image guided iso-NTCP based liver cancer SBRT","volume":"45","author":"Dawson","year":"2006","journal-title":"Acta Oncol."},{"key":"10.1016\/j.meddos.2022.01.004_bib0038","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.radonc.2005.10.001","article-title":"Normal tissue complication probability modeling for acute esophagitis in patients treated with conformal radiation therapy for non-small cell lung cancer","volume":"77","author":"Chapet","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0039","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ijrobp.2012.02.029","article-title":"Dosimetric analysis of radiation-induced gastric bleeding","volume":"84","author":"Feng","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2 Suppl","key":"10.1016\/j.meddos.2022.01.004_bib0040","doi-asserted-by":"crossref","first-page":"S217","DOI":"10.1016\/S0360-3016(03)01031-9","article-title":"Analysis of radiation-induced gastric and duodenal bleeds using the Lyman-Kutcher-Burman model","volume":"57","author":"Pan","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0041","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.ijrobp.2009.09.075","article-title":"A dosimetric model of duodenal toxicity after stereotactic body radiotherapy for pancreatic cancer","volume":"78","author":"Murphy","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0042","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.radonc.2017.04.024","article-title":"Modelling duodenum radiotherapy toxicity using cohort dose-volume-histogram data","volume":"123","author":"Holyoake","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0043","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.adro.2018.05.003","article-title":"A simulation study to assess the potential impact of developing normal tissue complication probability models with accumulated dose","volume":"3","author":"McCulloch","year":"2018","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0044","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.3109\/0284186X.2013.813072","article-title":"Comparing dose-volume histogram and radiobiological endpoints for ranking intensity-modulated arc therapy and 3D-radiotherapy treatment plans for locally-advanced pancreatic cancer","volume":"52","author":"Warren","year":"2013","journal-title":"Acta Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0045","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1016\/j.prro.2013.05.003","article-title":"Consolidating duodenal and small bowel toxicity data via isoeffective dose calculations based on compiled clinical data","volume":"4","author":"Prior","year":"2014","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0046","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.meddos.2008.04.001","article-title":"Preoperative radiation treatment for rectal cancer: comparison of target coverage and small bowel NTCP in conventional vs. 3D-conformal planning","volume":"34","author":"Cella","year":"2009","journal-title":"Med Dosim"},{"key":"10.1016\/j.meddos.2022.01.004_bib0047","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13014-020-01650-z","article-title":"Evaluation of small bowel motion and feasibility of using the peritoneal space to replace bowel loops for dose constraints during intensity-modulated radiotherapy for rectal cancer","volume":"15","author":"Li","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.meddos.2022.01.004_bib0048","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0360-3016(90)90037-K","article-title":"Optimization of uncomplicated control for head and neck tumors","volume":"19","author":"Agren","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.meddos.2022.01.004_bib0049","doi-asserted-by":"crossref","first-page":"673","DOI":"10.21037\/tlcr.2016.11.04","article-title":"Impact of dose calculation models on radiotherapy outcomes and quality adjusted life years for lung cancer treatment: do we need to measure radiotherapy outcomes to tune the radiobiological parameters of a normal tissue complication probability model?","volume":"5","author":"Chaikh","year":"2016","journal-title":"Transl Lung Cancer Res"},{"key":"10.1016\/j.meddos.2022.01.004_bib0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13014-019-1318-9","article-title":"Calculating the individualized fraction regime in stereotactic body radiotherapy for non-small cell lung cancer based on uncomplicated tumor control probability function","volume":"14","author":"Lu","year":"2019","journal-title":"Radiat Oncol"}],"container-title":["Medical Dosimetry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958394722000140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0958394722000140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T09:32:18Z","timestamp":1760693538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0958394722000140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"alternative-id":["S0958394722000140"],"URL":"https:\/\/doi.org\/10.1016\/j.meddos.2022.01.004","relation":{},"ISSN":["0958-3947"],"issn-type":[{"type":"print","value":"0958-3947"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The radiobiological effect of using Acuros XB vs anisotropic analytical algorithm on hepatocellular carcinoma stereotactic body radiation therapy","name":"articletitle","label":"Article Title"},{"value":"Medical Dosimetry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.meddos.2022.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}