{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:14:36Z","timestamp":1786994076625,"version":"build-2736575974"},"reference-count":42,"publisher":"IOP Publishing","issue":"10","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Med. Eng. Phys."],"published-print":{"date-parts":[[2016,10,1]]},"DOI":"10.1016\/j.medengphy.2016.06.024","type":"journal-article","created":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T20:45:40Z","timestamp":1468097140000},"page":"1044-1054","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Mechanical and material properties of cortical and trabecular bone from cannabinoid receptor-1-null (\n                    <i>\n                      Cnr1\n                      <sup>\u2212\/\u2212<\/sup>\n                    <\/i>\n                    ) mice"],"prefix":"10.1088","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-8919","authenticated-orcid":true,"given":"Aysha B.","family":"Khalid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Goodyear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0693-1194","authenticated-orcid":true,"given":"Richard M.","family":"Aspden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2016,7,9]]},"reference":[{"key":"bib0001","first-page":"991","type":"other","article-title":"Bone remodelling at a glance","volume":"124","author":"Crockett","year":"2011"},{"key":"bib0002","first-page":"3318","type":"other","article-title":"Pathogenesis of osteoporosis: concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005"},{"key":"bib0003","first-page":"11","type":"other","article-title":"A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait","volume":"70","author":"Little","year":"2002"},{"key":"bib0004","first-page":"1111","type":"other","article-title":"Localization of the gene causing autosomal dominant osteopetrosis type I to chromosome 11q12-13","volume":"17","author":"Van Hul","year":"2002"},{"key":"bib0005","first-page":"64","type":"other","article-title":"Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations","volume":"83","author":"Guerrini","year":"2008"},{"key":"bib0006","first-page":"197","type":"other","article-title":"Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass","volume":"100","author":"Ducy","year":"2000"},{"key":"bib0007","first-page":"305","type":"other","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002"},{"key":"bib0008","first-page":"15455","type":"other","article-title":"Skeletal parasympathetic innervation communicates central IL-1 signals regulating bone mass accrual","volume":"109","author":"Bajayo","year":"2012"},{"key":"bib0009","first-page":"285","type":"other","article-title":"Cannabinoids and bone: friend or foe?","volume":"87","author":"Idris","year":"2010"},{"key":"bib0010","first-page":"774","type":"other","article-title":"Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors","volume":"11","author":"Idris","year":"2005"},{"key":"bib0011","first-page":"786","type":"other","article-title":"Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling","volume":"70","author":"Tam","year":"2006"},{"key":"bib0012","first-page":"5619","type":"other","article-title":"Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type 2 cannabinoid receptor","volume":"149","author":"Idris","year":"2008"},{"key":"bib0013","first-page":"696","type":"other","article-title":"Peripheral cannabinoid receptor, CB2, regulates bone mass","volume":"103","author":"Ofek","year":"2006"},{"key":"bib0014","first-page":"285","type":"other","article-title":"The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling","volume":"22","author":"Tam","year":"2008"},{"key":"bib0015","first-page":"667","type":"other","article-title":"Review article: endocannabinoids and their receptors in the enteric nervous system","volume":"22","author":"Duncan","year":"2005"},{"key":"bib0016","first-page":"423","type":"other","article-title":"The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis","volume":"112","author":"Cota","year":"2003"},{"key":"bib0017","first-page":"25196","type":"other","article-title":"Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase","volume":"280","author":"Kola","year":"2005"},{"key":"bib0018","first-page":"145","type":"other","article-title":"Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees","volume":"58","author":"Schuelert","year":"2008"},{"key":"bib0019","first-page":"414","type":"other","article-title":"Regulation of skeletal remodeling by the endocannabinoid system","volume":"1116","author":"Bab","year":"2007"},{"key":"bib0020","first-page":"136","type":"other","article-title":"Role of cannabinoids in the regulation of bone remodeling","volume":"3","author":"Idris","year":"2012"},{"key":"bib0021","first-page":"560","type":"other","article-title":"Cannabinoids and the skeleton: from marijuana to reversal of bone loss","volume":"41","author":"Bab","year":"2009"},{"key":"bib0022","first-page":"873","type":"other","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003"},{"key":"bib0023","first-page":"393","type":"other","article-title":"Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system","volume":"83","author":"Tsou","year":"1998"},{"key":"bib0024","first-page":"637","type":"other","article-title":"Presence and functional regulation of cannabinoid receptors in immune cells","volume":"65","author":"Parolaro","year":"1999"},{"key":"bib0025","first-page":"61","type":"other","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993"},{"key":"bib0026","first-page":"139","type":"other","article-title":"Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells","volume":"10","author":"Idris","year":"2009"},{"key":"bib0027","first-page":"5780","type":"other","article-title":"Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice","volume":"96","author":"Zimmer","year":"1999"},{"key":"bib0028","first-page":"555","type":"other","article-title":"Mechanical properties of bone ex vivo","volume":"816","author":"Goodyear","year":"2012"},{"key":"bib0029","first-page":"369","author":"Aspden","year":"2003","type":"other"},{"key":"bib0030","first-page":"1066","type":"other","article-title":"PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures","volume":"48","author":"Huesa","year":"2011"},{"key":"bib0031","first-page":"107","type":"other","article-title":"A study of some properties of a sample of bovine cortical bone using ultrasound","volume":"29","author":"Lees","year":"1979"},{"key":"bib0032","first-page":"321","type":"other","article-title":"Effect of the proportion of organic material in bone on thermal decomposition of bone mineral: an investigation of a variety of bones from different species using thermogravimetric analysis coupled to mass spectrometry, high temperature x-ray diffraction and Fourier transform infra-red spectroscopy","volume":"75","author":"Mkukuma","year":"2003"},{"key":"bib0033","author":"Salmon","year":"2009","type":"other"},{"key":"bib0034","first-page":"1468","type":"other","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010"},{"key":"bib0035","author":"Goodyear","year":"2009","type":"other"},{"key":"bib0036","first-page":"899","type":"other","article-title":"A comparison of cortical and trabecular bone from C57 Black 6 mice using Raman spectroscopy","volume":"44","author":"Goodyear","year":"2009"},{"key":"bib0037","first-page":"467","type":"other","article-title":"A comparison of mechanical properties derived from multiple skeletal sites in mice","volume":"38","author":"Schriefer","year":"2005"},{"key":"bib0038","first-page":"469","type":"other","article-title":"Growth of C57B1\/6 mice and the material and mechanical properties of cortical bone from the tibia","volume":"74","author":"Somerville","year":"2004"},{"key":"bib0039","first-page":"387","type":"other","article-title":"Bone development and age-related bone loss in male C57BL\/6J mice","volume":"33","author":"Ferguson","year":"2003"},{"key":"bib0040","first-page":"1066","type":"other","article-title":"Genetic regulation of bone traits is influenced by sex and reciprocal cross in F(2) progeny from GK and F344 rats","volume":"24","author":"Lagerholm","year":"2009"},{"key":"bib0041","first-page":"4","type":"other","article-title":"Sex dependent regulation of osteoblast response to implant surface properties by systemic hormones","volume":"1","author":"Olivares-Navarrete","year":"2010"},{"key":"bib0042","first-page":"e1435","type":"other","article-title":"Sex specific gene regulation and expression QTLs in mouse macrophages from a strain intercross","volume":"3","author":"Bhasin","year":"2008"}],"container-title":["Medical Engineering &amp; Physics"],"original-title":[],"link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350453316301485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350453316301485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2016.06.024","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2016.06.024\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2016.06.024\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2016.06.024\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:46:58Z","timestamp":1769093218000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2016.06.024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,9]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,7,9]]},"published-print":{"date-parts":[[2016,10,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.medengphy.2016.06.024","relation":{},"ISSN":["1350-4533","1873-4030"],"issn-type":[{"value":"1350-4533","type":"print"},{"value":"1873-4030","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,9]]},"assertion":[{"value":"Mechanical and material properties of cortical and trabecular bone from cannabinoid receptor-1-null (\n                      \n                        Cnr1\n                        \u2212\/\u2212\n                      \n                      ) mice","name":"article_title","label":"Article Title"},{"value":"Medical Engineering & Physics","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2016 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2016-03-09","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2016-06-27","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2016-07-09","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}