{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:12:52Z","timestamp":1788343972344,"version":"build-2803163510"},"reference-count":40,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["CBET 0756154"],"award-info":[{"award-number":["CBET 0756154"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Med. Eng. Phys."],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1016\/j.medengphy.2017.02.018","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T09:46:12Z","timestamp":1493804772000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Backflow-free catheters for efficient and safe convection-enhanced delivery of therapeutics"],"prefix":"10.1088","volume":"45","author":[{"given":"Eric","family":"Lueshen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tangen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6931-6095","authenticated-orcid":true,"given":"Ankit I.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Linninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"bib0001","first-page":"2076","type":"other","article-title":"Convection-enhanced delivery of macromolecules in the brain","volume":"91","author":"Bobo","year":"1994"},{"key":"bib0002","first-page":"F42","type":"other","article-title":"Bulk flow of brain interstitial fluid under normal and hyperosmolar conditions","volume":"238","author":"Rosenberg","year":"1980"},{"key":"bib0003","author":"Prince","year":"2013","type":"other"},{"key":"bib0004","type":"other"},{"key":"bib0005","type":"other"},{"key":"bib0006","type":"other"},{"key":"bib0007","doi-asserted-by":"crossref","DOI":"10.1093\/neuonc\/nop066","type":"other","article-title":"Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology","author":"Porter","year":"2010"},{"key":"bib0008","type":"other"},{"key":"bib0009","first-page":"871","type":"other","article-title":"Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma","volume":"12","author":"Kunwar","year":"2010"},{"key":"bib0010","first-page":"168","type":"other","article-title":"Interleukin-13 receptor as a unique target for anti-glioblastoma therapy","volume":"92","author":"Husain","year":"2001"},{"key":"bib0011","first-page":"520","type":"other","article-title":"Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice","volume":"80","author":"Laske","year":"1994"},{"key":"bib0012","first-page":"672","type":"other","article-title":"Computer simulations and in vivo convection-enhanced delivery of fluorescent nanoparticles demonstrate variable distribution geometry","volume":"71","author":"Lueshen","year":"2014"},{"key":"bib0013","first-page":"267","type":"other","article-title":"Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study","volume":"101","author":"Mueller","year":"2011"},{"key":"bib0014","first-page":"301","type":"other","article-title":"Poor drug distribution as a possible explanation for the results of the PRECISE trial","volume":"113","author":"Sampson","year":"2010"},{"key":"bib0015","type":"other","article-title":"Experimental techniques for studying poroelasticity in brain phantom gels under high flow microinfusion","volume":"132","author":"Ivanchenko","year":"2010"},{"key":"bib0016","first-page":"441","type":"other","article-title":"Theory of porous media\u2014past and present","volume":"78","author":"de Boer","year":"1998"},{"key":"bib0017","first-page":"1129","type":"other","article-title":"Incompressible porous media models by use of the theory of mixtures","volume":"18","author":"Bowen","year":"1980"},{"key":"bib0018","first-page":"3837","type":"other","article-title":"Dynamics of porous media at finite strain","volume":"193","author":"Li","year":"2004"},{"key":"bib0019","first-page":"787","type":"other","article-title":"Mechanics of continuous porous media","volume":"18","author":"Pr\u00e9vost","year":"1980"},{"key":"bib0020","author":"Wang","year":"2000","type":"other"},{"key":"bib0021","first-page":"R1218","type":"other","article-title":"Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics","volume":"277","author":"Morrison","year":"1999"},{"key":"bib0022","first-page":"117","type":"other","article-title":"Future of convection-enhanced delivery in the treatment of brain tumors","volume":"6","author":"Bidros","year":"2010"},{"key":"bib0023","first-page":"85","type":"other","article-title":"Intraparenchymal drug delivery via positive-pressure infusion: experimental and modeling studies of poroelasticity in brain phantom gels","volume":"49","author":"Chen","year":"2002"},{"key":"bib0024","type":"other"},{"key":"bib0025","first-page":"252","type":"other","article-title":"Fabrication and characterization of microfluidic probes for convection enhanced drug delivery","volume":"111","author":"Neeves","year":"2006"},{"key":"bib0026","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.5.0923","type":"other"},{"key":"bib0027","first-page":"1","type":"other","article-title":"In vitro and in vivo testing of a novel recessed-step catheter for reflux-free convection-enhanced drug delivery to the brain","volume":"219","author":"Gill","year":"2013"},{"key":"bib0028","first-page":"314","type":"other","article-title":"A realistic brain tissue phantom for intraparenchymal infusion studies","volume":"101","author":"Chen","year":"2004"},{"key":"bib0029","first-page":"2303","type":"other","article-title":"Rigorous mathematical modeling techniques for optimal delivery of macromolecules to the brain","volume":"55","author":"Linninger","year":"2008"},{"key":"bib0030","author":"Hall","year":"1999","type":"other"},{"key":"bib0031","type":"other"},{"key":"bib0032","first-page":"568","type":"other","article-title":"Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter","volume":"107","author":"Seunguk","year":"2007"},{"key":"bib0033","first-page":"2302","type":"other","article-title":"Convection-enhanced delivery of nanocarriers for the treatment of brain tumors","volume":"30","author":"Allard","year":"2009"},{"key":"bib0034","first-page":"315","type":"other","article-title":"Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time","volume":"90","author":"Chen","year":"1999"},{"key":"bib0035","first-page":"2176","type":"other","article-title":"Computational methods for predicting drug transport in anisotropic and heterogeneous brain tissue","volume":"41","author":"Linninger","year":"2008"},{"key":"bib0036","first-page":"125","type":"other","article-title":"Prediction of convection-enhanced drug delivery to the human brain","volume":"250","author":"Linninger","year":"2008"},{"key":"bib0037","first-page":"89","type":"other","article-title":"Systematic design of drug delivery therapies","volume":"32","author":"Somayaji","year":"2008"},{"key":"bib0038","first-page":"668","type":"other","article-title":"Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans","volume":"69","author":"Sampson","year":"2011"},{"key":"bib0039","first-page":"123","type":"other","article-title":"Image-guided convection-enhanced delivery platform in the treatment of neurological diseases","volume":"5","author":"Fiandaca","year":"2008"},{"key":"bib0040","first-page":"S189","type":"other","article-title":"Image-guided convection-enhanced delivery of GDNF protein into monkey putamen","volume":"54","author":"Gimenez","year":"2011"}],"container-title":["Medical Engineering &amp; Physics"],"original-title":[],"link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350453317300875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350453317300875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2017.02.018","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2017.02.018\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2017.02.018\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2017.02.018\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:01:54Z","timestamp":1769094114000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2017.02.018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,5,3]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.medengphy.2017.02.018","relation":{},"ISSN":["1350-4533","1873-4030"],"issn-type":[{"value":"1350-4533","type":"print"},{"value":"1873-4030","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]},"assertion":[{"value":"Backflow-free catheters for efficient and safe convection-enhanced delivery of therapeutics","name":"article_title","label":"Article Title"},{"value":"Medical Engineering & Physics","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2017 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2015-11-16","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-02-26","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2017-05-03","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}