{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:13:52Z","timestamp":1785212032763,"version":"3.55.0"},"reference-count":38,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Med. Eng. Phys."],"published-print":{"date-parts":[[2019,11,1]]},"DOI":"10.1016\/j.medengphy.2019.07.014","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T17:24:21Z","timestamp":1565285061000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Computational simulations of thrombolysis in acute stroke: Effect of clot size and location on recanalisation"],"prefix":"10.1088","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1300-0467","authenticated-orcid":true,"given":"Boram","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andris","family":"Piebalgs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Roi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Lobotesis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Longstaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alun D.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Thom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-621X","authenticated-orcid":true,"given":"Xiao Yun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"bib0001","first-page":"179","type":"other","article-title":"Acute ischemic stroke: Overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia","volume":"87","author":"Durukan","year":"2007"},{"key":"bib0002","first-page":"90","type":"other","article-title":"Review of stroke thrombolytics","volume":"15","author":"Bivard","year":"2013"},{"key":"bib0003","first-page":"272","type":"other","article-title":"Thrombolytic therapies for ischemic stroke: triumphs and future challenges","volume":"134","author":"Moussaddy","year":"2018"},{"key":"bib0004","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.110.612358","type":"other","article-title":"Recombinant tissue-type plasminogen activator use for ischemic stroke in the united states: a doubling of treatment rates over the course of 5 years","author":"Adeoye","year":"2011"},{"key":"bib0005","first-page":"11","type":"other","article-title":"Collateral circulation is an independent radiological predictor of outcome after thrombolysis in acute ischaemic stroke","volume":"45","author":"Kucinski","year":"2003"},{"key":"bib0006","first-page":"707","type":"other","article-title":"Impact of collateral circulation status on favorable outcomes in thrombolysis treatment: a systematic review and meta-analysis","volume":"15","author":"Wufuer","year":"2018"},{"key":"bib0007","first-page":"268","type":"other","article-title":"Endovascular recanalization therapy in acute ischemic Stroke: updated meta-analysis of randomized controlled trials","volume":"17","author":"Hong","year":"2015"},{"key":"bib0008","first-page":"290","type":"other","article-title":"Clinical selection strategies to identify ischemic stroke patients with large anterior vessel occlusion: results from SITS-ISTR (Safe implementation of thrombolysis in stroke international stroke thrombolysis registry)","volume":"48","author":"Scheitz","year":"2017"},{"key":"bib0009","first-page":"559","type":"other","article-title":"M1 is not M1 in ischemic stroke: the disability-free survival after mechanical thrombectomy differs significantly between proximal and distal occlusions of the middle cerebral artery M1 segment","volume":"7","author":"Behme","year":"2015"},{"key":"bib0010","first-page":"252","type":"other","article-title":"Revolution in acute ischaemic stroke care: a practical guide to mechanical thrombectomy","volume":"17","author":"Evans","year":"2017"},{"key":"bib0011","first-page":"673","type":"other","article-title":"Mechanical thrombectomy of distal occlusions in the anterior cerebral artery: recanalization rates, periprocedural complications, and clinical outcome","volume":"37","author":"Pfaff","year":"2016"},{"key":"bib0012","first-page":"1662","type":"other","article-title":"Beyond large vessel occlusion Strokes: distal occlusion thrombectomy","volume":"49","author":"Grossberg","year":"2018"},{"key":"bib0013","first-page":"351","type":"other","article-title":"Stent retriever thrombectomy of small caliber intracranial vessels using pREset LITE: safety and efficacy","volume":"27","author":"Kurre","year":"2017"},{"key":"bib0014","first-page":"2450","type":"other","article-title":"Mechanical thrombectomy outcomes with and without intravenous thrombolysis in stroke patients: a meta-analysis","volume":"48","author":"Mistry","year":"2017"},{"key":"bib0015","first-page":"1584","type":"other","article-title":"Outcome after thrombectomy and intravenous thrombolysis in patients with acute ischemic stroke: a prospective observational study","volume":"47","author":"Minnerup","year":"2016"},{"key":"bib0016","first-page":"328","type":"other","article-title":"Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): a multicenter, randomized, controlled study","volume":"13","author":"Campbell","year":"2018"},{"key":"bib0017","first-page":"1573","type":"other","article-title":"Tenecteplase versus alteplase before thrombectomy for ischemic stroke","volume":"378","author":"Campbell","year":"2018"},{"key":"bib0018","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2015.0949","type":"other","article-title":"Towards a multi-physics modelling framework for thrombolysis under the influence of blood flow","author":"Piebalgs","year":"2015"},{"key":"bib0019","first-page":"15810","type":"other","article-title":"Computational simulations of thrombolytic therapy in acute ischaemic stroke","volume":"8","author":"Piebalgs","year":"2018"},{"key":"bib0020","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.115.011401","type":"other","article-title":"Thrombus length estimation on delayed gadolinium-enhanced t1","author":"Yan","year":"2016"},{"key":"bib0021","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.113.003079","type":"other","article-title":"Clot length distribution and predictors in anterior circulation stroke: Implications for intra-arterial therapy","author":"Kamalian","year":"2013"},{"key":"bib0022","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.114.008454","type":"other","article-title":"Distance to thrombus in acute middle cerebral artery occlusion: A predictor of outcome after intravenous thrombolysis for acute ischemic stroke","author":"Friedrich","year":"2015"},{"key":"bib0023","first-page":"948","type":"other","article-title":"Site of arterial occlusion identified by transcranial doppler predicts the response to intravenous thrombolysis for stroke","volume":"38","author":"Saqqur","year":"2007"},{"key":"bib0024","first-page":"2010","type":"other","article-title":"Length of occlusion predicts recanalization and outcome after intravenous thrombolysis in middle cerebral artery stroke","volume":"45","author":"Rohan","year":"2014"},{"key":"bib0025","first-page":"1775","type":"other","article-title":"The importance of size: successful recanalization by intravenous thrombolysis in acute anterior stroke depends on thrombus length","volume":"42","author":"Riedel","year":"2011"},{"key":"bib0026","first-page":"2108","type":"other","article-title":"Thrombus volume as a predictor of nonrecanalization after intravenous thrombolysis in acute stroke","volume":"49","author":"Yoo","year":"2018"},{"key":"bib0027","first-page":"1121","type":"other","article-title":"The mid-M1 segment of the middle cerebral artery is a cutoff clot location for good outcome in intravenous thrombolysis","volume":"19","author":"Saarinen","year":"2012"},{"key":"bib0028","type":"other","article-title":"Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow","volume":"14","author":"Xu","year":"2017"},{"key":"bib0029","doi-asserted-by":"crossref","DOI":"10.1007\/s10237-015-0683-z","type":"other","article-title":"Foam-like compression behavior of fibrin networks","author":"Kim","year":"2016"},{"key":"bib0030","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2013-08-523860","type":"other","article-title":"Clot contraction: Compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin","author":"Cines","year":"2014"},{"key":"bib0031","article-title":"Blood flow in major cerebral arteries measured by phase-contrast cine mR","author":"Enzmann","year":"1994","type":"other"},{"key":"bib0032","doi-asserted-by":"crossref","DOI":"10.1007\/s003300000378","type":"other","article-title":"Quantification of blood flow in the middle cerebral artery with phase-contrast MR imaging","author":"Stock","year":"2000"},{"key":"bib0033","doi-asserted-by":"crossref","DOI":"10.1002\/jmri.1880040110","type":"other","article-title":"Carotid and vertebral artery blood flow in left\u2010 and right\u2010handed healthy subjects measured with MR velocity mapping","author":"Bogren","year":"1994"},{"key":"bib0034","first-page":"2735","type":"other","article-title":"Study of the collateral capacity of the circle of willis of patients with severe carotid artery stenosis by 3D computational modeling","volume":"41","author":"Long","year":"2008"},{"key":"bib0035","first-page":"1794","type":"other","article-title":"Modelling the circle of willis to assess the effects of anatomical variations and occlusions on cerebral flows","volume":"40","author":"Alastruey","year":"2007"},{"key":"bib0036","first-page":"1812","type":"other","article-title":"Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke","volume":"31","author":"Christou","year":"2000"},{"key":"bib0037","first-page":"425","type":"other","article-title":"Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator","volume":"37","author":"Molina","year":"2006"},{"key":"bib0038","first-page":"2897","type":"other","article-title":"Speed of intracranial clot lysis with intravenous tissue","volume":"103","author":"Alexandrov","year":"2001"}],"container-title":["Medical Engineering &amp; Physics"],"original-title":[],"link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350453319301493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350453319301493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2019.07.014","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2019.07.014\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2019.07.014\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2019.07.014\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:54:53Z","timestamp":1769093693000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2019.07.014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,8]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,8,8]]},"published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.medengphy.2019.07.014","relation":{},"ISSN":["1350-4533","1873-4030"],"issn-type":[{"value":"1350-4533","type":"print"},{"value":"1873-4030","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,8]]},"assertion":[{"value":"Computational simulations of thrombolysis in acute stroke: Effect of clot size and location on recanalisation","name":"article_title","label":"Article Title"},{"value":"Medical Engineering & Physics","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2019 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2019-01-29","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-07-28","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2019-08-08","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}