{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:14:37Z","timestamp":1786994077677,"version":"build-2736575974"},"reference-count":56,"publisher":"IOP Publishing","issue":"1","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/publishingsupport.iopscience.iop.org\/iop-standard\/v1"},{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/iopscience.iop.org\/info\/page\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2008703"],"award-info":[{"award-number":["2020YFC2008703"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1202600"],"award-info":[{"award-number":["2022YFF1202600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iopscience.iop.org"],"crossmark-restriction":false},"short-container-title":["Med. Eng. Phys."],"published-print":{"date-parts":[[2023,11,1]]},"DOI":"10.1016\/j.medengphy.2023.104062","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T21:58:02Z","timestamp":1697147882000},"page":"104062","update-policy":"https:\/\/doi.org\/10.1088\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["The biomechanical effect of different types of ossification of the ligamentum flavum on the spinal cord during cervical dynamic activities"],"prefix":"10.1088","volume":"121","author":[{"given":"Yi-ting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-dong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9008-9875","authenticated-orcid":true,"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"266","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"bib0001","first-page":"51","type":"other","article-title":"Prevalence, distribution, and morphology of ossification of the ligamentum flavum: a population study of one thousand seven hundred thirty-six magnetic resonance imaging scans","volume":"35","author":"Guo","year":"2010"},{"key":"bib0002","first-page":"108","type":"other","article-title":"Degenerative cervical myelopathy \u2014 update and future directions","volume":"16","author":"Badhiwala","year":"2020"},{"key":"bib0003","first-page":"1216","type":"other","article-title":"Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury","volume":"59","author":"Zipser","year":"2021"},{"key":"bib0004","first-page":"2978","type":"other","article-title":"Tracking white and gray matter degeneration along the spinal cord axis in degenerative cervical myelopathy","volume":"38","author":"Vallotton","year":"2021"},{"key":"bib0005","first-page":"1675","type":"other","article-title":"Risk factors for the development of degenerative cervical myelopathy: a review of the literature","volume":"45","author":"Baucher","year":"2022"},{"key":"bib0006","first-page":"887","type":"other","article-title":"Brown-Sequard syndrome caused by ossification of the ligamentum flavum","volume":"14","author":"Chen","year":"2007"},{"key":"bib0007","first-page":"6","type":"other","article-title":"Ossification of the cervical ligamentum flavum and case report with myelopathy","author":"Rahimizadeh","year":"2018"},{"key":"bib0008","first-page":"897","type":"other","article-title":"Cervical ossification of ligamentum flavum: elaborating an underappreciated but occasional contributor to myeloradiculopathy in aging population based on synthesis of individual participant data","volume":"16","author":"Zhang","year":"2021"},{"key":"bib0009","first-page":"253","type":"other","article-title":"Epidemiology of ossification of the spinal ligaments and associated factors in the Chinese population: a cross-sectional study of 2000 consecutive individuals","volume":"20","author":"Liang","year":"2019"},{"key":"bib0010","first-page":"e842","type":"other","article-title":"Ossified ligamentum flavum: epidemiology, treatment, and outcomes","volume":"30","author":"Daniels","year":"2022"},{"key":"bib0011","first-page":"529","type":"other","article-title":"Ossification of ligamentum flavum in Middle East Arabs: a hospital-based study","volume":"21","author":"Al-Jarallah","year":"2012"},{"key":"bib0012","first-page":"e1","type":"other","article-title":"Cervical myelopathy resulting from combined ossification of the ligamentum flavum and posterior longitudinal ligament: report of two cases and literature review","volume":"13","author":"Kotani","year":"2013"},{"key":"bib0013","first-page":"83","type":"other","article-title":"Thin cervical spinal cord between ossifications of the ligamentum flavum and the posterior longitudinal ligament: case report and literature review","volume":"145","author":"Ishikawa","year":"2021"},{"key":"bib0014","first-page":"47","type":"other","article-title":"Pathophysiology of calcification and ossification of the ligamentum flavum in the cervical spine","volume":"29","author":"Takahashi","year":"2018"},{"key":"bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7289648","type":"other","article-title":"Application of simulation methods in cervical spine dynamics","author":"Sun","year":"2020"},{"key":"bib0016","first-page":"169","type":"other","article-title":"A graphical guide for constructing a finite element model of the cervical spine with digital orthopedic software","volume":"9","author":"Wu","year":"2021"},{"key":"bib0017","first-page":"58","type":"other","article-title":"Numerical investigation of the relative effect of disc bulging and ligamentum flavum hypertrophy on the mechanism of central cord syndrome","volume":"74","author":"Bailly","year":"2020"},{"key":"bib0018","first-page":"1266","type":"other","article-title":"Biomechanical effects of spinal cord compression due to ossification of posterior longitudinal ligament and ligamentum flavum: a finite element analysis","volume":"35","author":"Kim","year":"2013"},{"key":"bib0019","doi-asserted-by":"crossref","DOI":"10.1007\/s10237-022-01617-x","type":"other","article-title":"Effect of degenerative factors on cervical spinal cord during flexion and extension: a dynamic finite element analysis","author":"Xu","year":"2022"},{"key":"bib0020","first-page":"729","type":"other","article-title":"Development and validation of A C0\u2013C7 FE complex for biomechanical study","volume":"127","author":"Zhang","year":"2005"},{"key":"bib0021","first-page":"300","type":"other","article-title":"Ligamentum flavum buckling vs hypertrophy in cervical myelopathy using dynamic imaging: are instability and loss of disc height the culprits?","volume":"16","author":"Kumar Varma Kalidindi","year":"2022"},{"key":"bib0022","first-page":"69","type":"other","article-title":"Dynamic changes of the ligamentum flavum in the cervical spine assessed with kinetic magnetic resonance imaging","volume":"3","author":"Sayit","year":"2013"},{"key":"bib0023","first-page":"623","type":"other","article-title":"Geometric and mechanical properties of human cervical spine ligaments","volume":"122","author":"Yoganandan","year":"2000"},{"key":"bib0024","first-page":"1","type":"other","article-title":"Biomechanics of the cervical spine Part 2. Cervical spine soft tissue responses and biomechanical modeling","volume":"16","author":"Yoganandan","year":"2001"},{"key":"bib0025","first-page":"1737","type":"other","article-title":"Biomechanical effects of C2\u2013C7 intersegmental stability due to laminectomy with unilateral and bilateral facetectomy","volume":"29","author":"Hong-Wan","year":"2004"},{"key":"bib0026","first-page":"284","type":"other","article-title":"Analysis of dural sac thickness in the human cervical spine","volume":"93","author":"Kwon","year":"2018"},{"key":"bib0027","first-page":"43","type":"other","article-title":"The biomechanical analysis of the traumatic cervical spinal cord injury using finite element approach","volume":"10","author":"Czyz","year":"2008"},{"key":"bib0028","first-page":"276","type":"other","article-title":"Human head dynamic response to side impact by finite element modeling","volume":"113","author":"Ruan","year":"1991"},{"key":"bib0029","first-page":"1560","type":"other","article-title":"Ultrasonographic reference sizes of the median and ulnar nerves and the cervical nerve roots in healthy Japanese adults","volume":"39","author":"Sugimoto","year":"2013"},{"key":"bib0030","first-page":"278","type":"other","article-title":"Cerebrospinal fluid pressure in adults","volume":"34","author":"Lee","year":"2014"},{"key":"bib0031","first-page":"795","type":"other","article-title":"Finite element analysis of spinal cord injury in the rat","volume":"25","author":"Maikos","year":"2008"},{"key":"bib0032","first-page":"113","type":"other","article-title":"The importance of fluid-structure interaction in spinal trauma models","volume":"28","author":"Persson","year":"2011"},{"key":"bib0033","first-page":"E580","type":"other","article-title":"The effect of cerebrospinal fluid on the biomechanics of spinal cord: an ex vivo bovine model using bovine and physical surrogate spinal cord","volume":"33","author":"Jones","year":"2008"},{"key":"bib0034","first-page":"315","type":"other","article-title":"The effect of bone fragment size and cerebrospinal fluid on spinal cord deformation during trauma: an ex vivo study","volume":"10","author":"Persson","year":"2009"},{"key":"bib0035","type":"other","article-title":"Segmental vertebral motion in the assessment of neck range of motion in whiplash patients","volume":"118","author":"Puglisi","year":"2004"},{"key":"bib0036","first-page":"155","type":"other","article-title":"Kinematics of the cervical spine in lateral bending: in vivo three-dimensional analysis","volume":"31","author":"Ishii","year":"2006"},{"key":"bib0037","first-page":"1798","type":"other","article-title":"CT and MRI characteristics of ossification of the ligamenta flava in the thoracic spine","volume":"11","author":"Xiong","year":"2001"},{"key":"bib0038","first-page":"E139","type":"other","article-title":"Kinematics of the upper cervical spine in rotation: in vivo three-dimensional analysis","volume":"29","author":"Ishii","year":"2004"},{"key":"bib0039","first-page":"421","type":"other","article-title":"Immersed methods for fluid-structure interaction","volume":"52","author":"Griffith","year":"2020"},{"key":"bib0040","first-page":"1574","type":"other","article-title":"Maximum principal strain correlates with spinal cord tissue damage in contusion and dislocation injuries in the rat cervical spine","volume":"29","author":"Russell","year":"2012"},{"key":"bib0041","type":"other","article-title":"Biomechanical behaviors in three types of spinal cord injury mechanisms","volume":"138","author":"Khuyagbaatar","year":"2016"},{"key":"bib0042","first-page":"360","type":"other","article-title":"Spinal Cord Anatomy and Clinical Syndromes","volume":"37","author":"Diaz","year":"2016"},{"key":"bib0043","first-page":"15","type":"other","article-title":"Acute cervical cord injury without fracture or dislocation of the spinal column","volume":"93","author":"Koyanagi","year":"2000"},{"key":"bib0044","first-page":"198S","type":"other","article-title":"Central cord injury: pathophysiology, management, and outcomes","volume":"6","author":"Harrop","year":"2006"},{"key":"bib0045","first-page":"532","type":"other","article-title":"A histopathological analysis of the human cervical spinal cord in patients with acute traumatic central cord syndrome","volume":"38","author":"Jimenez","year":"2000"},{"key":"bib0046","first-page":"5","type":"other","article-title":"Acute traumatic central cord syndrome: a comprehensive review","volume":"60","author":"Molliqaj","year":"2014"},{"key":"bib0047","type":"other","article-title":"Thoracic ossification of the ligamentum flavum causing Brown-S\u00e9quard syndrome: a case report and literature review","volume":"50","author":"Xu","year":"2022"},{"key":"bib0048","first-page":"1946","type":"other","article-title":"Central neuropathic mechanisms in pain signaling pathways: current evidence and recommendations","volume":"37","author":"Viswanath","year":"2020"},{"key":"bib0049","type":"other","article-title":"Calcium crystal deposition in the ligamentum flavum of the cervical spine","volume":"18","author":"Baba","year":"1993"},{"key":"bib0050","first-page":"1","type":"other","article-title":"The spinal cord: a review of functional neuroanatomy","volume":"31","author":"Bican","year":"2013"},{"key":"bib0051","first-page":"361","type":"other","article-title":"Gray matter of the bovine cervical spinal cord is mechanically more rigid and fragile than the white matter","volume":"18","author":"Ichihara","year":"2001"},{"key":"bib0053","first-page":"122","type":"other","article-title":"Mechanical properties and function of the spinal pia mater","volume":"1","author":"Ozawa","year":"2004"},{"key":"bib0054","first-page":"975","type":"other","article-title":"Poisson's ratio and strain rate dependency of the constitutive behavior of spinal dura mater","volume":"38","author":"Persson","year":"2010"},{"key":"bib0055","first-page":"326","type":"other","article-title":"Density of lumbar cerebrospinal fluid in pregnant and nonpregnant humans","volume":"85","author":"Richardson","year":"1996"},{"key":"bib0056","first-page":"1669","type":"other","article-title":"Mechanical properties of spinal nerve roots subjected to tension at different strain rates","volume":"39","author":"Singh","year":"2006"},{"key":"bib0057","first-page":"165","type":"other","article-title":"Biomechanical characteristics of the porcine denticulate ligament in different vertebral levels of the cervical spine-preliminary results of an experimental study","volume":"34","author":"Polak","year":"2014"}],"container-title":["Medical Engineering & Physics"],"original-title":[],"link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350453323001170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1350453323001170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2023.104062","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2023.104062\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2023.104062\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2023.104062\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T15:00:57Z","timestamp":1769094057000},"score":1,"resource":{"primary":{"URL":"https:\/\/iopscience.iop.org\/article\/10.1016\/j.medengphy.2023.104062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,10,13]]},"published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.medengphy.2023.104062","relation":{},"ISSN":["1350-4533","1873-4030"],"issn-type":[{"value":"1350-4533","type":"print"},{"value":"1873-4030","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,13]]},"assertion":[{"value":"The biomechanical effect of different types of ossification of the ligamentum flavum on the spinal cord during cervical dynamic activities","name":"article_title","label":"Article Title"},{"value":"Medical Engineering & Physics","name":"journal_title","label":"Journal Title"},{"value":"paper","name":"article_type","label":"Article Type"},{"value":"\u00a9 2023 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved.","name":"copyright_information","label":"Copyright Information"},{"value":"2022-12-01","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2023-10-11","name":"date_accepted","label":"Date Accepted","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"2023-10-13","name":"date_epub","label":"Online publication date","group":{"name":"publication_dates","label":"Publication dates"}}]}}