{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:43:59Z","timestamp":1777524239650,"version":"3.51.4"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T00:00:00Z","timestamp":1463788800000},"content-version":"vor","delay-in-days":141,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/j.medici.2016.05.002","type":"journal-article","created":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T20:36:08Z","timestamp":1464640568000},"page":"171-179","source":"Crossref","is-referenced-by-count":10,"title":["Pilot study of safety and efficacy of polyprenols in combination with coenzyme Q10 in patients with statin-induced myopathy"],"prefix":"10.3390","volume":"52","author":[{"given":"Gustavs","family":"Latkovskis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-4158","authenticated-orcid":false,"given":"Vita","family":"Saripo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Sokolova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1410-7816","authenticated-orcid":false,"given":"Dana","family":"Upite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Vanaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugis","family":"Kletnieks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrejs","family":"Erglis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","reference":[{"key":"10.1016\/j.medici.2016.05.002_bib0130","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/eurheartj\/ehs092","article-title":"European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)","volume":"33","author":"Perk","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.medici.2016.05.002_bib0135","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/eurheartj\/ehr158","article-title":"ESC\/EAS Guidelines for the management of dyslipidaemias","volume":"32","author":"Reiner","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.medici.2016.05.002_bib0140","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/eurheartj\/ehv043","article-title":"Statin-associated muscle symptoms: impact on statin therapy \u2013 European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management","volume":"36","author":"Stroes","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.medici.2016.05.002_bib0145","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jacl.2014.03.004","article-title":"An assessment by the statin muscle safety task force: 2014 update","volume":"8","author":"Rosenson","year":"2014","journal-title":"J Clin Lipidol"},{"issue":"8A","key":"10.1016\/j.medici.2016.05.002_bib0150","doi-asserted-by":"crossref","first-page":"69C","DOI":"10.1016\/j.amjcard.2005.12.013","article-title":"National Lipid Association Statin Safety Task Force Muscle Safety Expert Panel. An assessment of statin safety by muscle experts","volume":"97","author":"Thompson","year":"2006","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.medici.2016.05.002_bib0155","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.clinthera.2008.11.012","article-title":"Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel","volume":"30","author":"Chodick","year":"2008","journal-title":"Clin Ther"},{"key":"10.1016\/j.medici.2016.05.002_bib0160","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10557-005-5686-z","article-title":"Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients \u2013 the PRIMO study","volume":"19","author":"Bruckert","year":"2005","journal-title":"Cardiovasc Drugs Ther"},{"issue":"10","key":"10.1016\/j.medici.2016.05.002_bib0165","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0735-1097(02)01827-2","article-title":"Statins and chronic heart failure: do we need a large-scale outcome trial?","volume":"39","author":"Krum","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.medici.2016.05.002_bib0170","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mayocp.2014.08.021","article-title":"Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials","volume":"90","author":"Banach","year":"2015","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"10.1016\/j.medici.2016.05.002_bib0175","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.atherosclerosis.2014.12.016","article-title":"A randomized trial of coenzyme Q10 in patients with confirmed statin myopathy","volume":"238","author":"Taylor","year":"2015","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.medici.2016.05.002_bib0180","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1019683212265","article-title":"Plant polyprenols and their biological activity","volume":"38","author":"Khidyrova","year":"2002","journal-title":"Chem Nat Compd"},{"key":"10.1016\/j.medici.2016.05.002_bib0185","unstructured":"Roschin, VI, Sultanov, VS, inventors. Method for processing vegetable raw materials. Russian patent number 8969517. 2004; 1; April 27."},{"key":"10.1016\/j.medici.2016.05.002_bib0190","unstructured":"http:\/\/www.pvd.gov.lv\/lat\/lab_izvlne\/registri\/uztura_bagatinataji\/uztura_bagatinataju_registrs [accessed 22.10.15]."},{"key":"10.1016\/j.medici.2016.05.002_bib0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.trsl.2008.11.002","article-title":"Low serum 25 (OH) vitamin D levels are associated with reversible myositis-myalgia in statin-treated patients","volume":"153","author":"Ahmed","year":"2009","journal-title":"Transl Res"},{"issue":"7","key":"10.1016\/j.medici.2016.05.002_bib0200","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/SMJ.0b013e3181e21088","article-title":"Resolution of statin-induced myalgias by correcting vitamin D deficiency","volume":"103","author":"Bell","year":"2010","journal-title":"South Med J"},{"key":"10.1016\/j.medici.2016.05.002_bib0205","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijcard.2014.10.118","article-title":"Analysis of vitamin D levels in patients with and without statin-associated myalgia \u2013 a systematic review and meta-analysis of 7 studies with 2420 patients. Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group","volume":"178","author":"Michalska-Kasiczak","year":"2015","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1016\/j.medici.2016.05.002_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/aoms.2015.49807","article-title":"Statin intolerance \u2013 an attempt at a unified definition. Position paper from an International Lipid Expert Panel","volume":"11","author":"Banach","year":"2015","journal-title":"Arch Med Sci"},{"issue":"Suppl. 1","key":"10.1016\/j.medici.2016.05.002_bib0215","first-page":"1047","article-title":"Futility of supplementation with Coenzyme Q10 for statin-induced myopathy: an updated (2015) meta-analysis of randomized controlled trials","volume":"26","author":"Banach","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.medici.2016.05.002_bib0220","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.phrs.2015.07.008","article-title":"Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. Statin therapy and plasma coenzyme Q10 concentrations \u2013 a systematic review and meta-analysis of placebo-controlled trials","volume":"99","author":"Banach","year":"2015","journal-title":"Pharmacol Res"},{"issue":"3","key":"10.1016\/j.medici.2016.05.002_bib0225","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.mayocp.2015.01.003","article-title":"In reply \u2013 coenzyme Q10 and statin-induced myopathy","volume":"90","author":"Banach","year":"2015","journal-title":"Mayo Clin Proc"},{"issue":"10","key":"10.1016\/j.medici.2016.05.002_bib0230","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.amjcard.2006.12.063","article-title":"Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins","volume":"99","author":"Caso","year":"2007","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.medici.2016.05.002_bib0235","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1139\/cjpp-2012-0118","article-title":"Coenzyme Q(10) and selenium in statin-associated myopathy treatment","volume":"91","author":"Fedacko","year":"2013","journal-title":"Can J Physiol Pharmacol"},{"issue":"9","key":"10.1016\/j.medici.2016.05.002_bib0240","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.amjcard.2007.06.030","article-title":"Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia","volume":"100","author":"Young","year":"2007","journal-title":"Am J Cardiol"},{"issue":"4","key":"10.1016\/j.medici.2016.05.002_bib0245","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.amjcard.2012.04.026","article-title":"Effect of coenzyme Q10 supplementation on statin-induced myalgias","volume":"110","author":"Bookstaver","year":"2012","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.medici.2016.05.002_bib0250","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3109\/14017431.2012.756119","article-title":"No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy","volume":"47","author":"Bogsrud","year":"2013","journal-title":"Scand Cardiovasc J"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1010660X16300209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1010660X16300209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T16:07:02Z","timestamp":1525709222000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1010660X16300209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"alternative-id":["S1010660X16300209"],"URL":"https:\/\/doi.org\/10.1016\/j.medici.2016.05.002","relation":{},"ISSN":["1010-660X"],"issn-type":[{"value":"1010-660X","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}