{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T05:05:09Z","timestamp":1695013509116},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Intensiva"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.medin.2014.05.002","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T13:15:42Z","timestamp":1406553342000},"page":"213-221","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["La actividad citot\u00f3xica de las c\u00e9lulas natural killer como herramienta diagn\u00f3stica en pacientes pedi\u00e1tricos cr\u00edticos con sospecha de s\u00edndrome hemofagoc\u00edtico"],"prefix":"10.1016","volume":"39","author":[{"given":"I.","family":"Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Valent\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chamorro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medin.2014.05.002_bib0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH 2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.medin.2014.05.002_bib0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/humu.20274","article-title":"Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: Molecular and functional analyses of PRF1, UNC13D, STX11 and RAB27A","volume":"27","author":"Zur Stadt","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.medin.2014.05.002_bib0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1086\/302187","article-title":"Localization of a gene for familial hemophagocytic lymphohistiocytosis at chromosome 9q21.3-22 by homozygosity mapping","volume":"64","author":"Ohadi","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.medin.2014.05.002_bib0020","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1182\/blood-2002-01-0172","article-title":"Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation","volume":"100","author":"Henter","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.medin.2014.05.002_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jim.2010.11.006","article-title":"Contemporary diagnostic methods for hemophagocytic lymphohistiocytic disorders","volume":"364","author":"Johnson","year":"2011","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.medin.2014.05.002_bib0030","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/cimm.1995.9974","article-title":"Fas involvement in cytotoxicity mediated by human NK cells","volume":"166","author":"Montel","year":"1995","journal-title":"Cell Immunol"},{"key":"10.1016\/j.medin.2014.05.002_bib0035","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.4049\/jimmunol.163.10.5358","article-title":"Constitutive expression and role of the TNF family ligands in apoptotic killing of tumor cells by human NK cells","volume":"163","author":"Kashii","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.medin.2014.05.002_bib0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1182\/blood-2011-06-363994","article-title":"Critical role for perforin and Fas-dependent killing of dendritic cells in the control of inflammation","volume":"119","author":"Chen","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.medin.2014.05.002_bib0045","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1046\/j.1365-2141.1999.01538.x","article-title":"Induction of apoptosis and caspase activation in cells obtained from familial haemophagocytic lymphohistiocytosis patients","volume":"106","author":"Fadeel","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.medin.2014.05.002_bib0050","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1182\/blood.V91.8.2793.2793_2793_2799","article-title":"Elevation of the serum Fas ligand in patients with hemophagocytic syndrome and Diamond-Blackfan anemia","volume":"91","author":"Hasegawa","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.medin.2014.05.002_bib0055","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0022-1759(95)00140-6","article-title":"The use of non-radioactive chromium as an alternative to 51Cr in NK assay","volume":"186","author":"Borella","year":"1995","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.medin.2014.05.002_bib0060","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3109\/08820139609055739","article-title":"Application of non-radioactive europium (Eu3+) release assay to a measurement of human natural killer activity of healthy and patient populations","volume":"25","author":"Nagao","year":"1996","journal-title":"Immunol Invest"},{"key":"10.1016\/j.medin.2014.05.002_bib0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0022-1759(96)00063-4","article-title":"Time-resolved fluorometric assay for natural killer activity using target cells labelled with a fluorescence enhancing ligand","volume":"193","author":"Blomberg","year":"1996","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.medin.2014.05.002_bib0070","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.anpedi.2009.04.008","article-title":"[Haemophagocytic syndrome: A common pathogenic mechanism of various aetiologies]","volume":"71","author":"Dapena D\u00edaz","year":"2009","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.medin.2014.05.002_bib0075","first-page":"401","article-title":"[Significance of soluble interleukin-2 receptor and NK cell activity in patients with hemophagocytic lymphohistiocytosis]","volume":"20","author":"Wang","year":"2012","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"10.1016\/j.medin.2014.05.002_bib0080","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3389\/fimmu.2013.00448","article-title":"Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice","volume":"4","author":"Jessen","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.medin.2014.05.002_bib0085","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/PCC.0b013e318198868b","article-title":"An unusual cause of multiple organ dysfunction syndrome in the pediatric intensive care unit: Hemophagocytic lymphohistiocytosis","volume":"10","author":"Karapinar","year":"2009","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.medin.2014.05.002_bib0090","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.jpedsurg.2012.12.024","article-title":"Hemophagocytic lymphohistiocytosis mimicking surgical symptoms and complications: Lessons learned from four cases","volume":"48","author":"Siminas","year":"2013","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.medin.2014.05.002_bib0095","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00296-011-2291-2","article-title":"Infection-associated haemophagocytic lymphohistiocytosis: A case series using steroids only protocol for management","volume":"33","author":"Giri","year":"2013","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.medin.2014.05.002_bib0100","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1751-553X.2009.01177.x","article-title":"Establishment of a reference interval for natural killer cell activity through flow cytometry and its clinical application in the diagnosis of hemophagocytic lymphohistiocytosis","volume":"32","author":"Chung","year":"2010","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.medin.2014.05.002_bib0105","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-94-007-4549-0_37","article-title":"Flow cytometry in detection of abnormalities of natural killer cell","volume":"756","author":"Popko","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.medin.2014.05.002_bib0110","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jaci.2013.07.020","article-title":"Natural killer cell deficiency","volume":"132","author":"Orange","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.medin.2014.05.002_bib0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yexcr.2014.03.014","article-title":"Pathophysiology and spectrum of diseases caused by defects in lymphocyte cytotoxicity","volume":"325","author":"Meeths","year":"2014","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.medin.2014.05.002_bib0120","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1696-2818(13)70144-6","article-title":"S\u00edndromes hemofagoc\u00edticos (I): concepto, clasificaci\u00f3n, fisiopatolog\u00eda y cl\u00ednica","volume":"11","author":"P\u00e9rez-Mart\u00ednez","year":"2013","journal-title":"An Pediatr Contin"},{"key":"10.1016\/j.medin.2014.05.002_bib0125","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood-2012-07-442558","article-title":"Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production","volume":"121","author":"Chiang","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.medin.2014.05.002_bib0130","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1182\/blood-2011-08-374199","article-title":"A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes","volume":"119","author":"Bryceson","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.medin.2014.05.002_bib0135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1696-2818(13)70145-8","article-title":"S\u00edndromes hemofagoc\u00edticos (II): diagn\u00f3stico y tratamiento","volume":"11","author":"P\u00e9rez-Mart\u00ednez","year":"2013","journal-title":"An Pediatr Contin"},{"key":"10.1016\/j.medin.2014.05.002_bib0140","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1182\/blood-2005-05-1819","article-title":"Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis","volume":"107","author":"Cooper","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.medin.2014.05.002_bib0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/MOP.0b013e32834ec9c1","article-title":"Hemophagocytic lymphohistiocytosis: Updates and evolving concepts","volume":"24","author":"Risma","year":"2012","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.medin.2014.05.002_bib0150","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1182\/asheducation-2013.1.605","article-title":"Hemophagocytic lymphohistiocytosis: Pathogenesis and treatment","volume":"2013","author":"Janka","year":"2013","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.medin.2014.05.002_bib0155","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4321\/S1887-85712012000300003","article-title":"Kill the killers: terapia con c\u00e9lulas natural killer en pacientes pedi\u00e1tricos con c\u00e1ncer refractario","volume":"68","author":"Valent\u00edn Quiroga","year":"2012","journal-title":"Sanid Mil"},{"key":"10.1016\/j.medin.2014.05.002_bib0160","doi-asserted-by":"crossref","first-page":"e44649","DOI":"10.1371\/journal.pone.0044649","article-title":"Familial hemophagocytic lymphohistiocytosis may present during adulthood: Clinical and genetic features of a small series","volume":"7","author":"Sieni","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.medin.2014.05.002_bib0165","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/hon.960","article-title":"Secondary hemophagocytic syndrome in adults: A case series of 18 patients in a single institution and a review of literature","volume":"29","author":"Shabbir","year":"2011","journal-title":"Hematol Oncol"}],"container-title":["Medicina Intensiva"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210569114001417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210569114001417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T14:36:33Z","timestamp":1689431793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0210569114001417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0210569114001417"],"URL":"https:\/\/doi.org\/10.1016\/j.medin.2014.05.002","relation":{},"ISSN":["0210-5691"],"issn-type":[{"value":"0210-5691","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"La actividad citot\u00f3xica de las c\u00e9lulas natural killer como herramienta diagn\u00f3stica en pacientes pedi\u00e1tricos cr\u00edticos con sospecha de s\u00edndrome hemofagoc\u00edtico","name":"articletitle","label":"Article Title"},{"value":"Medicina Intensiva","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medin.2014.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Espa\u00f1a, S.L.U. and SEMICYUC. All rights reserved.","name":"copyright","label":"Copyright"}]}}