{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T20:00:53Z","timestamp":1649188853445},"reference-count":45,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Intensiva"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.medin.2014.10.010","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T14:52:47Z","timestamp":1427813567000},"page":"467-476","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Micafungina en pacientes cr\u00edticos ingresados en unidad de cuidados intensivos"],"prefix":"10.1016","volume":"39","author":[{"given":"F.","family":"\u00c1lvarez-Lerma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Grau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"Trasmonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medin.2014.10.010_bib0005","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(03)00801-6","article-title":"Epidemiology of Candida species infections in critically ill non-immunosuppressed patients","volume":"3","author":"Eggimann","year":"2003","journal-title":"Lancet Infect Dis."},{"key":"10.1016\/j.medin.2014.10.010_bib0010","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/01.CCM.0000201897.78123.44","article-title":"Invasive candidiasis in the intensive care unit","volume":"34","author":"Ostrosky-Zeichner","year":"2006","journal-title":"Crit Care Med."},{"key":"10.1016\/j.medin.2014.10.010_bib0015","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1001\/jama.2009.1754","article-title":"International study of the prevalence and outcomes of infection in intensive care units","volume":"302","author":"Vincent","year":"2009","journal-title":"JAMA."},{"key":"10.1016\/j.medin.2014.10.010_bib0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10096-008-0618-z","article-title":"Fungal colonization and\/or infection in non-neutropenic critically ill patients: Results of the EPCAN observational study","volume":"28","author":"Le\u00f3n","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"10.1016\/j.medin.2014.10.010_bib0025","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1097\/CCM.0b013e31819efac0","article-title":"Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: A multicenter, prospective, observational study in France (2005-2006)","volume":"37","author":"Leroy","year":"2009","journal-title":"Crit Care Med."},{"key":"10.1016\/j.medin.2014.10.010_bib0030","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/00000658-199412000-00008","article-title":"Candida colonization and subsequent infections in critically ill surgical patients","volume":"220","author":"Pittet","year":"1994","journal-title":"Ann Surg."},{"key":"10.1016\/j.medin.2014.10.010_bib0035","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/01.CCM.0000202208.37364.7D","article-title":"A bedside scoring system (\u00abCandida score\u00bb) for early antifungal treatment in non-neutropenic critically ill patients with Candida colonization","volume":"34","author":"Le\u00f3n","year":"2006","journal-title":"Crit Care Med."},{"key":"10.1016\/j.medin.2014.10.010_bib0040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10096-007-0270-z","article-title":"Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting","volume":"26","author":"Ostrosky-Zeichner","year":"2007","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"10.1016\/j.medin.2014.10.010_bib0045","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/596757","article-title":"Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America","volume":"48","author":"Pappas","year":"2009","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.medin.2014.10.010_bib0050","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s00134-008-1339-6","article-title":"Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part II. Treatment","volume":"35","author":"Guery","year":"2009","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.medin.2014.10.010_bib0055","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.eimc.2011.01.008","article-title":"Recomendaciones sobre el tratamiento de la candidiasis invasiva y otras infecciones por levaduras de la Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica (SEIMC). Actualizaci\u00f3n 2011","volume":"29","author":"Aguado","year":"2011","journal-title":"Enferm Infecc Microbiol Clin."},{"issue":"Suppl 7","key":"10.1016\/j.medin.2014.10.010_bib0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1469-0691.12039","article-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012: Non-neutropenic adult patients","volume":"18","author":"Cornely","year":"2012","journal-title":"Clin Microbiol Infect."},{"key":"10.1016\/j.medin.2014.10.010_bib0065","unstructured":"Micafungina. Ficha t\u00e9cnica [consultado 26 Jul 2014]. Disponible en: http:\/\/ec.europa.eu\/health\/documents\/community-register\/2008\/2008042543110\/anx_43110_es.pdf"},{"key":"10.1016\/j.medin.2014.10.010_bib0070","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/JCM.01901-07","article-title":"In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: six years of global surveillance","volume":"46","author":"Pfaller","year":"2008","journal-title":"J Clin Microbiol."},{"key":"10.1016\/j.medin.2014.10.010_bib0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijantimicag.2011.02.016","article-title":"Candida bloodstream infections: Comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009)","volume":"38","author":"Pfaller","year":"2011","journal-title":"Int J Antimicrob Agents."},{"key":"10.1016\/j.medin.2014.10.010_bib0080","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2147\/DDDT.S3242","article-title":"Review of the pharmacology and clinical studies of micafungin","volume":"3","author":"Bormann","year":"2009","journal-title":"Drug Des Devel Ther."},{"key":"10.1016\/j.medin.2014.10.010_bib0085","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1086\/520980","article-title":"Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis","volume":"45","author":"Pappas","year":"2007","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.medin.2014.10.010_bib0090","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S0140-6736(07)60605-9","article-title":"Micafungin versus liposomal amphotericin B for candidaemia and invasive candidiasis: A phase III randomised double-blind trial","volume":"369","author":"Kuse","year":"2007","journal-title":"Lancet."},{"key":"10.1016\/j.medin.2014.10.010_bib0095","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1186\/cc8117","article-title":"Treatment of candidemia and invasive candidiasis in the intensive care unit: Post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B","volume":"13","author":"Dupont","year":"2009","journal-title":"Crit Care."},{"key":"10.1016\/j.medin.2014.10.010_bib0100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2169\/internalmedicine.46.6021","article-title":"Efficacy and safety of micafungin in febrile neutropenic patients treated for hematological malignancies","volume":"46","author":"Toubai","year":"2007","journal-title":"Intern Med."},{"key":"10.1016\/j.medin.2014.10.010_bib0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1399-3062.2008.00349.x","article-title":"Micafungin alone or in combination with other systemic antifungal therapies in hematopoietic stem cell transplant recipients with invasive aspergillosis","volume":"11","author":"Kontoyiannis","year":"2009","journal-title":"Transpl Infect Dis."},{"key":"10.1016\/j.medin.2014.10.010_bib0110","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: A severity of disease classification system","volume":"13","author":"Knauss","year":"1985","journal-title":"Crit Care Med."},{"key":"10.1016\/j.medin.2014.10.010_bib0115","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.medin.2014.10.010_bib0120","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A model to predict survival in patients with end-stage liver disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology."},{"key":"10.1016\/j.medin.2014.10.010_bib0125","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices","volume":"60","author":"Pugh","year":"1973","journal-title":"Br J Surg."},{"issue":"RR-10","key":"10.1016\/j.medin.2014.10.010_bib0130","first-page":"1","article-title":"Revised surveillance case definitions for HIV infection among adults, adolescents, and children aged <18 months and for HIV infection and AIDS among children aged 18 months to <13 years\u2014United States, 2008","volume":"57","author":"Schneider","year":"2008","journal-title":"MMWR Recomm Rep."},{"key":"10.1016\/j.medin.2014.10.010_bib0135","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","article-title":"CDC\/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting","volume":"36","author":"Horan","year":"2008","journal-title":"Am J Infect Control."},{"key":"10.1016\/j.medin.2014.10.010_bib0140","unstructured":"Sociedad Espa\u00f1ola de Medicina Intensiva, Cr\u00edtica y Unidades Coronaria. Estudio Nacional de Vigilancia de Infecci\u00f3n Nosocomial (ENVIN). Grupo de Trabajo de Enfermedades Infecciosas. Manual de definiciones y t\u00e9rminos [consultado 26 Jul 2014]. Disponible en: http:\/\/hws.vhebron.net\/envin-helics\/"},{"key":"10.1016\/j.medin.2014.10.010_bib0145","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1086\/422312","article-title":"Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation","volume":"39","author":"Van Burik","year":"2004","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.medin.2014.10.010_bib0150","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12185-013-1396-7","article-title":"Micafungin for empirical antifungal therapy in patients with febrile neutropenia: Multicenter phase 2 study","volume":"98","author":"Mizuno","year":"2013","journal-title":"Int J Hematol."},{"key":"10.1016\/j.medin.2014.10.010_bib0155","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3109\/10428194.2012.729057","article-title":"Micafungin as empirical antifungal therapy in hematological patients: A retrospective, multicenter study in the Czech and Slovak Republics","volume":"54","author":"Racil","year":"2013","journal-title":"Leuk Lymphoma."},{"key":"10.1016\/j.medin.2014.10.010_bib0160","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00277-011-1277-1","article-title":"Efficacy and safety of micafungin as an empirical therapy for invasive fungal infections in patients with hematologic disorders: A multicenter, prospective study","volume":"90","author":"Yamaguchi","year":"2011","journal-title":"Ann Hematol."},{"key":"10.1016\/j.medin.2014.10.010_bib0165","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/ajh.21858","article-title":"Efficacy and safety of micafungin for treating febrile neutropenia in hematological malignancies","volume":"85","author":"Goto","year":"2010","journal-title":"Am J Hematol."},{"key":"10.1016\/j.medin.2014.10.010_bib0170","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000315558","article-title":"Efficacy and safety of micafungin as an empirical antifungal agent for febrile neutropenic patients with hematological diseases","volume":"124","author":"Park","year":"2010","journal-title":"Acta Haematol."},{"key":"10.1016\/j.medin.2014.10.010_bib0175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/10428190802635500","article-title":"Efficacy and safety of micafungin, an echinocandin antifungal agent, on invasive fungal infections in patients with hematological disorders","volume":"50","author":"Tamura","year":"2009","journal-title":"Leuk Lymphoma."},{"key":"10.1016\/j.medin.2014.10.010_bib0180","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1097\/CCM.0b013e31819daa14","article-title":"Usefulness of the \u00abCandida score\u00bb for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: A prospective multicenter study","volume":"37","author":"Leon","year":"2009","journal-title":"Crit Care Med."},{"key":"10.1016\/j.medin.2014.10.010_bib0185","series-title":"50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)","article-title":"Appropriate Dosage of Micafungin for Candida Peritonitis. (A1-132). ICAAC 2010","author":"Ohge","year":"2010"},{"key":"10.1016\/j.medin.2014.10.010_bib0190","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s10156-011-0240-3","article-title":"Distribution of micafungin in the tissue fluids of patients with invasive fungal infections","volume":"17","author":"Yamada","year":"2011","journal-title":"J Infect Chemother."},{"key":"10.1016\/j.medin.2014.10.010_bib0195","unstructured":"Sociedad Espa\u00f1ola de Medicina Intensiva, Cr\u00edtica y Unidades Coronaria. Grupo de Trabajo de Infecci\u00f3n Nosocomial. Estudio Nacional de Vigilancia de Infecci\u00f3n Nosocomial (ENVIN). Informe del a\u00f1o 2013 [consultado 26 Jul 2014]. Disponible en: http:\/\/hws.vhebron.net\/envin-helics\/"},{"key":"10.1016\/j.medin.2014.10.010_bib0200","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1093\/jac\/dku013","article-title":"Micafungin pharmacokinetic\/pharmacodynamic adequacy for the treatment of invasive candidiasis in critically ill patients on continuous venovenous haemofiltration","volume":"69","author":"Maseda","year":"2014","journal-title":"J Antimicrob Chemother."},{"key":"10.1016\/j.medin.2014.10.010_bib0205","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/jac\/dkq545","article-title":"Multiple-dose pharmacokinetics of anidulafungin during continuous venovenous haemofiltration","volume":"66","author":"Leitner","year":"2011","journal-title":"J Antimicrob Chemother."},{"key":"10.1016\/j.medin.2014.10.010_bib0210","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1128\/AAC.00335-13","article-title":"Pharmacokinetics of caspofungin in critically ill patients on continuous renal replacement therapy","volume":"57","author":"Weiler","year":"2013","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.medin.2014.10.010_bib0215","unstructured":"Caspofungina. Ficha t\u00e9cnica [consultado 26 Jul 2014]. Disponible en: http:\/\/www.ema.europa.eu\/docs\/es_ES\/document_library\/EPAR_Product_Information\/human\/000379\/WC500021033.pdf"},{"key":"10.1016\/j.medin.2014.10.010_bib0220","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1128\/JCM.00308-13","volume":"51","author":"Pfaller","year":"2013","journal-title":"J Clin Microbiol."},{"key":"10.1016\/j.medin.2014.10.010_bib0225","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jinf.2014.01.007","article-title":"Micafungin for the treatment of invasive aspergillosis","volume":"68","author":"Enoch","year":"2014","journal-title":"J Infect."}],"container-title":["Medicina Intensiva"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210569114002502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210569114002502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T01:56:11Z","timestamp":1537754171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0210569114002502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0210569114002502"],"URL":"https:\/\/doi.org\/10.1016\/j.medin.2014.10.010","relation":{},"ISSN":["0210-5691"],"issn-type":[{"value":"0210-5691","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Micafungina en pacientes cr\u00edticos ingresados en unidad de cuidados intensivos","name":"articletitle","label":"Article Title"},{"value":"Medicina Intensiva","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medin.2014.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Espa\u00f1a, S.L.U. and SEMICYUC. All rights reserved.","name":"copyright","label":"Copyright"}]}}