{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:05:30Z","timestamp":1764997530239,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medicina Intensiva"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.medin.2023.04.010","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T03:12:37Z","timestamp":1682478757000},"page":"583-593","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Debilidad pulmonar asociada a COVID-19 (DPAC): revisi\u00f3n sistem\u00e1tica y metaan\u00e1lisis"],"prefix":"10.1016","volume":"47","author":[{"given":"Pablo","family":"Redruello-Guerrero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ruiz-del-Pino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Jim\u00e9nez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Jim\u00e9nez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Carrascos-C\u00e1liz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Romero-Linares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Jes\u00fas","family":"L\u00e1inez Ramos-Bossini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Rivera-Izquierdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"C\u00e1rdenas-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medin.2023.04.010_bib0165","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.mayocp.2017.05.004","article-title":"Mechanical ventilation: State of the art","volume":"92","author":"Pham","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.medin.2023.04.010_bib0170","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0210-5691(07)74765-4","article-title":"Lesi\u00f3n pulmonar inducida por la ventilaci\u00f3n mec\u00e1nica","volume":"31","author":"Gordo Vidal","year":"2007","journal-title":"Med Intensiva"},{"key":"10.1016\/j.medin.2023.04.010_bib0175","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.medin.2011.10.011","article-title":"Incidencia, caracter\u00edsticas y evoluci\u00f3n del barotrauma durante la ventilaci\u00f3n mec\u00e1nica con apertura pulmonar","volume":"36","author":"Gil Cano","year":"2012","journal-title":"Med Intensiva"},{"key":"10.1016\/j.medin.2023.04.010_bib0180","doi-asserted-by":"crossref","first-page":"E252","DOI":"10.1148\/radiol.2020202352","article-title":"Increased incidence of barotrauma in patients with COVID-19 on invasive mechanical ventilation","volume":"297","author":"McGuinness","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.medin.2023.04.010_bib0185","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1007\/s00134-022-06816-9","article-title":"Comparison of radiographic pneumothorax and pneumomediastinum in COVID-19 vs. non-COVID-19 acute respiratory distress syndrome","volume":"48","author":"Knox","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.medin.2023.04.010_bib0190","first-page":"141","article-title":"Spontaneous pneumoperitoneum and pneumatosis intestinalis as sole manifestations of a COVID-19 infection. An extremely rare complication","volume":"113","author":"L\u00e1inez Ramos-Bossini","year":"2021","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.medin.2023.04.010_bib0195","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.medin.2023.04.010_bib0200","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/emermed-2020-209567","article-title":"Population, Intervention, Comparison, Outcomes and Study (PICOS) design as a framework to formulate eligibility criteria in systematic reviews","volume":"37","author":"Amir-Behghadami","year":"2020","journal-title":"Emerg Med J"},{"key":"10.1016\/j.medin.2023.04.010_bib0205","unstructured":"Ottawa Hospital Research Institute [Internet]. [cited 2022 Aug 29]. Disponible en: https:\/\/www.ohri.ca\/\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"10.1016\/j.medin.2023.04.010_bib0210","first-page":"00103","article-title":"Predictors of pneumothorax\/pneumomediastinum in mechanically ventilated COVID-19 patients","author":"Belletti","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.medin.2023.04.010_bib0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271964","article-title":"Incidence and risk factors of COVID-19 associated pneumothorax","volume":"17","author":"Taha","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.medin.2023.04.010_bib0220","doi-asserted-by":"crossref","first-page":"310","DOI":"10.5582\/ddt.2021.01105","article-title":"Pneumothorax and pneumomediastinum in patients with COVID-19: A retrospective study from tertiary care institute in India","volume":"15","author":"Paul","year":"2021","journal-title":"Drug Discov Ther"},{"key":"10.1016\/j.medin.2023.04.010_bib0225","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/icvts\/ivab258","article-title":"Incidence and risk factors for pneumomediastinum in COVID-19 patients in the intensive care unit","volume":"34","author":"\u00d6zdemir","year":"2021","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.medin.2023.04.010_bib0230","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1177\/08850666211023360","article-title":"Outcomes of barotrauma in critically ill COVID-19 patients with severe pneumonia","volume":"36","author":"Gazivoda","year":"2021","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.medin.2023.04.010_bib0235","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1017\/S0950268821001291","article-title":"Serious complications in COVID-19 ARDS cases: Pneumothorax, pneumomediastinum, subcutaneous emphysema and haemothorax","volume":"149","author":"Guven","year":"2021","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.medin.2023.04.010_bib0240","doi-asserted-by":"crossref","first-page":"132","DOI":"10.29271\/jcpsp.2021.02.132","article-title":"Is spontaneous pneumomediastinum a poor prognostic factor in COVID-19?","volume":"31","author":"Ozsoy","year":"2021","journal-title":"J Coll Physicians Surg Pak"},{"key":"10.1016\/j.medin.2023.04.010_bib0245","doi-asserted-by":"crossref","first-page":"102141","DOI":"10.1016\/j.amsu.2021.01.089","article-title":"Prevalence and risk factors of barotrauma in COVID-19 patients admitted to an intensive care unit in Kuwait; a retrospective cohort study","volume":"63","author":"Elsaaran","year":"2021","journal-title":"Ann Med Surg"},{"key":"10.1016\/j.medin.2023.04.010_bib0250","doi-asserted-by":"crossref","first-page":"e0210","DOI":"10.1097\/CCE.0000000000000210","article-title":"Subcutaneous emphysema, pneumomediastinum, and pneumothorax in critically ill patients with coronavirus disease 2019: A retrospective cohort study","volume":"2","author":"Jones","year":"2020","journal-title":"Critical Care Explorations"},{"key":"10.1016\/j.medin.2023.04.010_bib0255","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/0885066621989959","article-title":"High incidence of barotrauma in patients with severe coronavirus disease 2019","volume":"36","author":"Kahn","year":"2021","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.medin.2023.04.010_bib0260","doi-asserted-by":"crossref","unstructured":"Lemmers DHL, Hilal MA, Bn\u00e0 C, Prezioso C, Cavallo E, Nencini N, et al. Pneumomediastinum and subcutaneous emphysema in COVID-19: barotrauma or lung frailty? ERJ Open Research [Internet]. 2020 [consultado 29 Agos 2022]. Disponible en: http:\/\/openres.ersjournals.com\/content\/6\/4\/00385-2020","DOI":"10.1183\/23120541.00385-2020"},{"key":"10.1016\/j.medin.2023.04.010_bib0265","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/08850666211040417","article-title":"Epidemiology, risk factors and outcomes of pneumomediastinum in patients with coronavirus disease 2019: A case-control study","volume":"37","author":"Reis","year":"2022","journal-title":"J Intensive Care Med"},{"issue":"s1","key":"10.1016\/j.medin.2023.04.010_bib0270","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1046\/j.1440-1843.2003.00519.x","article-title":"SARS: Radiological features","volume":"8","author":"Ooi","year":"2003","journal-title":"Respirology"},{"key":"10.1016\/j.medin.2023.04.010_bib0275","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pharmthera.2010.06.003","article-title":"Trilogy of ACE2: A peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters","volume":"128","author":"Kuba","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.medin.2023.04.010_bib0280","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10528-020-10011-0","article-title":"Angiotensin-converting enzyme gene polymorphism influences gastrointestinal motility in type 2 diabetes mellitus","volume":"59","author":"Malik","year":"2021","journal-title":"Biochem Genet"},{"key":"10.1016\/j.medin.2023.04.010_bib0285","doi-asserted-by":"crossref","first-page":"n436","DOI":"10.1136\/bmj.n436","article-title":"Severe covid-19 pneumonia: Pathogenesis and clinical management","volume":"372","author":"Attaway","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.medin.2023.04.010_bib0290","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4329\/wjr.v6.i11.850","article-title":"Spontaneous pneumomediastinum and Macklin effect: Overview and appearance on computed tomography","volume":"6","author":"Murayama","year":"2014","journal-title":"World J Radiol"},{"key":"10.1016\/j.medin.2023.04.010_bib0295","first-page":"e22247","article-title":"A Case series of secondary spontaneous pneumomediastinum and pneumothorax in severe COVID-19 pneumonia","volume":"14","author":"Staiano","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.medin.2023.04.010_bib0300","first-page":"200490","article-title":"Coronavirus disease 2019 (COVID-19): A perspective from China","author":"Zu","year":"2020","journal-title":"Radiology"},{"key":"10.1016\/j.medin.2023.04.010_bib0305","first-page":"1","article-title":"Frequency and risk factors for spontaneous pneumomediastinum in COVID-19 patients","volume":"8","author":"Rodriguez-Arciniega","year":"2021","journal-title":"Frontier Med"},{"key":"10.1016\/j.medin.2023.04.010_bib0310","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.chest.2020.11.013","article-title":"Frequency, risk factors, clinical characteristics, and outcomes of spontaneous pneumothorax in patients with coronavirus disease 2019","volume":"159","author":"Mir\u00f3","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.medin.2023.04.010_bib0315","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12916-022-02292-6","article-title":"Long COVID 12 months after discharge: Persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes\u2014a multicentre cohort study","volume":"20","author":"Rivera-Izquierdo","year":"2022","journal-title":"BMC Medicine"},{"key":"10.1016\/j.medin.2023.04.010_bib0320","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12916-021-02003-7","article-title":"Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: The ANCOHVID multicentre 6-month follow-up study","volume":"19","author":"Romero-Duarte","year":"2021","journal-title":"BMC Med"}],"container-title":["Medicina Intensiva"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210569123000943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210569123000943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:42:03Z","timestamp":1759322523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0210569123000943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S0210569123000943"],"URL":"https:\/\/doi.org\/10.1016\/j.medin.2023.04.010","relation":{},"ISSN":["0210-5691"],"issn-type":[{"type":"print","value":"0210-5691"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Debilidad pulmonar asociada a COVID-19 (DPAC): revisi\u00f3n sistem\u00e1tica y metaan\u00e1lisis","name":"articletitle","label":"Article Title"},{"value":"Medicina Intensiva","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medin.2023.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}