{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:12:33Z","timestamp":1793391153687,"version":"4.5.0"},"reference-count":208,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T00:00:00Z","timestamp":1720915200000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010098","name":"Shanghai Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-level Local University in Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241221"],"award-info":[{"award-number":["82241221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20Y11908900"],"award-info":[{"award-number":["20Y11908900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23XD1423100"],"award-info":[{"award-number":["23XD1423100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010905","name":"Major Research Plan","doi-asserted-by":"publisher","award":["92059205"],"award-info":[{"award-number":["92059205"]}],"id":[{"id":"10.13039\/501100010905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012472","name":"Shanghai Educational Science Research Project","doi-asserted-by":"publisher","award":["SHSMU-ZLCX20211602"],"award-info":[{"award-number":["SHSMU-ZLCX20211602"]}],"id":[{"id":"10.13039\/501100012472","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Med"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.medj.2023.05.002","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T10:33:52Z","timestamp":1685097232000},"page":"404-431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["A new paradigm in transplant immunology: At the crossroad of synthetic biology and biomaterials"],"prefix":"10.1016","volume":"4","author":[{"given":"Zi-jie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-yue","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-lei","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4066-8104","authenticated-orcid":false,"given":"Hao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medj.2023.05.002_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1001\/jama.1956.02960390027008","article-title":"Successful homotransplantation of the human kidney between identical twins","volume":"160","author":"Merrill","year":"1956","journal-title":"J.\u00a0Am. Med. Assoc."},{"key":"10.1016\/j.medj.2023.05.002_bib2","unstructured":"Global observatory on donation and transplantation home page (http:\/\/www.transplantobservatory.org\/)"},{"key":"10.1016\/j.medj.2023.05.002_bib3","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2471\/BLT.12.021012","article-title":"Keeping kidneys","volume":"90","author":"Jones","year":"2012","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.medj.2023.05.002_bib4","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/ajt.16978","article-title":"OPTN\/SRTR 2020 annual data report: liver","volume":"22","author":"Kwong","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nbt.3889","article-title":"The promise of organ and tissue preservation to transform medicine","volume":"35","author":"Giwa","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib11","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1056\/NEJM198910123211505","article-title":"Liver transplantation (1)","volume":"321","author":"Starzl","year":"1989","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/ajt.16982","article-title":"OPTN\/SRTR 2020 Annual data report: kidney","volume":"22","author":"Lentine","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/ajt.16977","article-title":"OPTN\/SRTR 2020 Annual data report: heart","volume":"22","author":"Colvin","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/ajt.16979","article-title":"OPTN\/SRTR 2020 Annual data report: pancreas","volume":"22","author":"Kandaswamy","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib9","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/ajt.16991","article-title":"OPTN\/SRTR 2020 Annual data report: lung","volume":"22","author":"Valapour","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib10","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/ajt.16992","article-title":"OPTN\/SRTR 2020 Annual data report: intestine","volume":"22","author":"Horslen","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib12","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41563-022-01231-3","article-title":"The living interface between synthetic biology and biomaterial design","volume":"21","author":"Liu","year":"2022","journal-title":"Nat. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jhep.2020.09.014","article-title":"Cell therapy for advanced liver diseases: repair or rebuild","volume":"74","author":"Dwyer","year":"2021","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.medj.2023.05.002_bib14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41581-022-00624-6","article-title":"Progress in xenotransplantation: overcoming immune barriers","volume":"18","author":"Sykes","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.medj.2023.05.002_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0140-6736(02)07529-3","article-title":"Hepatocyte transplantation as a treatment for glycogen storage disease type 1a","volume":"359","author":"Muraca","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.medj.2023.05.002_bib16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.transproceed.2013.10.042","article-title":"Monitoring of intrasplenic hepatocyte transplantation for acute-on-chronic liver failure: a prospective five-year follow-up study","volume":"46","author":"Wang","year":"2014","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.medj.2023.05.002_bib17","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.170108","article-title":"Human fetal liver cultures support multiple cell lineages that can engraft immunodeficient mice","volume":"7","author":"Fomin","year":"2017","journal-title":"Open Biol"},{"key":"10.1016\/j.medj.2023.05.002_bib18","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.stemcr.2017.06.003","article-title":"Adult mouse liver contains two distinct populations of cholangiocytes","volume":"9","author":"Li","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.medj.2023.05.002_bib19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ncb3203","article-title":"Hepatic progenitor cells of biliary origin with liver repopulation capacity","volume":"17","author":"Lu","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.medj.2023.05.002_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.stem.2016.10.007","article-title":"Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity","volume":"20","author":"Katsuda","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.medj.2023.05.002_bib21","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41419-019-1967-5","article-title":"Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.medj.2023.05.002_bib22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/sctm.18-0084","article-title":"Validation of current good manufacturing practice compliant human pluripotent stem cell-derived hepatocytes for cell-based therapy","volume":"8","author":"Blackford","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib23","article-title":"Human leukocyte antigen class I and II knockout human induced pluripotent stem cell-derived cells: universal donor for cell therapy","volume":"7","author":"Mattapally","year":"2018","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.medj.2023.05.002_bib24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.stem.2019.02.005","article-title":"Targeted disruption of HLA genes via CRISPR-cas9 generates iPSCs with enhanced immune compatibility","volume":"24","author":"Xu","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.medj.2023.05.002_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0352-x","article-title":"Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering","volume":"51","author":"Jang","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib26","doi-asserted-by":"crossref","first-page":"10441","DOI":"10.1073\/pnas.1902566116","article-title":"Generation of hypoimmunogenic human pluripotent stem cells","volume":"116","author":"Han","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.medj.2023.05.002_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41587-019-0016-3","article-title":"Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients","volume":"37","author":"Deuse","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib28","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.stem.2018.10.018","article-title":"In\u00a0vitro expansion of primary human hepatocytes with efficient liver repopulation capacity","volume":"23","author":"Zhang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.medj.2023.05.002_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100965","article-title":"Advances in encapsulation and delivery strategies for islet transplantation","volume":"10","author":"Wu","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrd.2017.67","article-title":"Advances in islet encapsulation technologies","volume":"16","author":"Desai","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.medj.2023.05.002_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fbioe.2019.00134","article-title":"Polymeric approaches to reduce tissue responses against devices applied for islet-cell encapsulation","volume":"7","author":"Hu","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.addr.2018.04.018","article-title":"Cell encapsulation: overcoming barriers in cell transplantation in diabetes and beyond","volume":"139","author":"Farina","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.medj.2023.05.002_bib33","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41551-018-0275-1","article-title":"Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques","volume":"2","author":"Bochenek","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.medj.2023.05.002_bib34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm.4030","article-title":"Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice","volume":"22","author":"Vegas","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib208","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jhep.2019.12.002","article-title":"Alginate microencapsulated human hepatocytes for the treatment of acute liver failure in children","volume":"72","author":"Dhawan","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.medj.2023.05.002_bib35","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41551-020-0538-5","article-title":"A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells","volume":"4","author":"Bose","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.medj.2023.05.002_bib36","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1021\/acsnano.7b01239","article-title":"Nanoporous immunoprotective device for stem-cell-derived beta-cell replacement therapy","volume":"11","author":"Chang","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.medj.2023.05.002_bib37","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/adhm.201300573","article-title":"Long-term survival of allograft murine islets coated via covalently stabilized polymers","volume":"3","author":"Rengifo","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib38","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.actbio.2016.02.018","article-title":"Heparinization of cell surfaces with short peptide-conjugated PEG-lipid regulates thromboinflammation in transplantation of human MSCs and hepatocytes","volume":"35","author":"Asif","year":"2016","journal-title":"Acta Biomater."},{"key":"10.1016\/j.medj.2023.05.002_bib39","doi-asserted-by":"crossref","first-page":"7961","DOI":"10.1016\/j.biomaterials.2011.06.068","article-title":"Surface camouflage of pancreatic islets using 6-arm-PEG-catechol in combined therapy with tacrolimus and anti-CD154 monoclonal antibody for xenotransplantation","volume":"32","author":"Jeong","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biomaterials.2016.01.039","article-title":"Combination strategy of multi-layered surface camouflage using hyperbranched polyethylene glycol and immunosuppressive drugs for the prevention of immune reactions against transplanted porcine islets","volume":"84","author":"Haque","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib41","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.actbio.2016.11.060","article-title":"The impact of cell surface PEGylation and short-course immunotherapy on islet graft survival in an allogeneic murine model","volume":"49","author":"Giraldo","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.medj.2023.05.002_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf7832","article-title":"Novel enzymatic cross-linking-based hydrogel nanofilm caging system on pancreatic \u03b2 cell spheroid for long-term blood glucose regulation","volume":"7","author":"Kim","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.medj.2023.05.002_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120460","article-title":"Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival","volume":"266","author":"Hu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib44","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/adhm.201400657","article-title":"Hydrogen-bonded multilayers of tannic acid as mediators of T-cell immunity","volume":"4","author":"Kozlovskaya","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biomaterials.2017.03.002","article-title":"Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T\u00a0cell trafficking","volume":"128","author":"Pham-Hua","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120162","article-title":"Millimeter-thick xenoislet-laden fibers as retrievable transplants mitigate foreign body reactions for long-term glycemic control in diabetic mice","volume":"255","author":"Watanabe","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.biomaterials.2016.06.028","article-title":"Overcoming foreign-body reaction through nanotopography: biocompatibility and immunoisolation properties of a nanofibrous membrane","volume":"102","author":"Wang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib48","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1016\/j.biomaterials.2013.03.041","article-title":"Inhibition of instant blood-mediated inflammatory responses by co-immobilization of sCR1 and heparin on islets","volume":"34","author":"Luan","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.biomaterials.2018.04.028","article-title":"Polymeric nano-shielded islets with heparin-polyethylene glycol in a non-human primate model","volume":"171","author":"Park","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.biomaterials.2011.09.051","article-title":"Surface modification of pancreatic islets using heparin-DOPA conjugate and anti-CD154 mAb for the prolonged survival of intrahepatic transplanted islets in a xenograft model","volume":"33","author":"Jung","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib51","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.biomaterials.2012.11.028","article-title":"The effects of 8-arm-PEG-catechol\/heparin shielding system and immunosuppressive drug, FK506 on the survival of intraportally allotransplanted islets","volume":"34","author":"Im","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib52","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1016\/j.biomaterials.2012.07.048","article-title":"Xenotransplantation of islets enclosed in agarose microcapsule carrying soluble complement receptor 1","volume":"33","author":"Luan","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib53","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.actbio.2020.12.047","article-title":"Polylysine-bilirubin conjugates maintain functional islets and promote M2 macrophage polarization","volume":"122","author":"Zhao","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.medj.2023.05.002_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biomaterials.2017.12.020","article-title":"Ex-vivo generation of drug-eluting islets improves transplant outcomes by inhibiting TLR4-Mediated NFkB upregulation","volume":"159","author":"Chang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.09.037","article-title":"Immunomodulatory injectable silk hydrogels maintaining functional islets and promoting anti-inflammatory M2 macrophage polarization","volume":"187","author":"Kumar","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib56","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1016\/j.biomaterials.2012.06.015","article-title":"Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel","volume":"33","author":"Davis","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib57","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.biomaterials.2017.10.049","article-title":"Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model","volume":"154","author":"Pham","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib58","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biomaterials.2018.08.017","article-title":"Tolerance induction by surface immobilization of Jagged-1 for immunoprotection of pancreatic islets","volume":"182","author":"Izadi","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib59","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.4049\/jimmunol.2000055","article-title":"Localized immunomodulation with PD-L1 results in sustained survival and function of allogeneic islets without chronic immunosuppression","volume":"204","author":"Batra","year":"2020","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.medj.2023.05.002_bib60","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/TP.0000000000000579","article-title":"Coaggregates of regulatory T\u00a0cells and islet cells allow long-term graft survival in liver without immunosuppression","volume":"99","author":"Takemoto","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120232","article-title":"Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation","volume":"257","author":"Paez-Mayorga","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib62","article-title":"Development of a coaxial 3D printing platform for biofabrication of implantable islet-containing constructs","volume":"8","author":"Liu","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib63","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1056\/NEJMra1913421","article-title":"Immune and genome engineering as the future of transplantable tissue","volume":"385","author":"Elisseeff","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau6298","article-title":"Transplanting organs from pigs to humans","volume":"4","author":"Sykes","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.medj.2023.05.002_bib65","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.3389\/fimmu.2019.03060","article-title":"Xenotransplantation: current status in preclinical research","volume":"10","author":"Lu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2023.05.002_bib66","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1097\/00007890-200006270-00008","article-title":"Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons","volume":"69","author":"Cowan","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib67","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1097\/01.TP.0000064335.50622.20","article-title":"Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness","volume":"75","author":"Barth","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib68","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1111\/j.1600-6143.2009.02849.x","article-title":"Results of gal-knockout porcine thymokidney xenografts","volume":"9","author":"Griesemer","year":"2009","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib69","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/j.1600-6143.2010.03147.x","article-title":"Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation","volume":"10","author":"Lin","year":"2010","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib70","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/j.transproceed.2011.09.024","article-title":"Xenotransplantation of galactosyl-transferase knockout, CD55, CD59, CD39, and fucosyl-transferase transgenic pig kidneys into baboons","volume":"43","author":"Le Bas-Bernardet","year":"2011","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.medj.2023.05.002_bib71","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/xen.12174","article-title":"Pig kidney graft survival in a baboon for 136\u00a0days: longest life-supporting organ graft survival to date","volume":"22","author":"Iwase","year":"2015","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib72","doi-asserted-by":"crossref","first-page":"e12293","DOI":"10.1111\/xen.12293","article-title":"Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts","volume":"24","author":"Iwase","year":"2017","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib73","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/SLA.0000000000002977","article-title":"Xenoantigen deletion and chemical immunosuppression can prolong renal xenograft survival","volume":"268","author":"Adams","year":"2018","journal-title":"Ann. Surg."},{"key":"10.1016\/j.medj.2023.05.002_bib74","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1111\/ajt.15329","article-title":"Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T\u00a0cell depletion","volume":"19","author":"Kim","year":"2019","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib75","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1056\/NEJMoa2120238","article-title":"Results of two cases of pig-to-human kidney xenotransplantation","volume":"386","author":"Montgomery","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib76","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S1053-2498(99)00099-6","article-title":"Life supporting function for over one month of a transgenic porcine heart in a baboon","volume":"19","author":"Vial","year":"2000","journal-title":"J.\u00a0Heart Lung Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib77","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1399-3089.2010.00620.x","article-title":"Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation","volume":"18","author":"Byrne","year":"2011","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib78","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-018-0765-z","article-title":"Consistent success in life-supporting porcine cardiac xenotransplantation","volume":"564","author":"L\u00e4ngin","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.medj.2023.05.002_bib79","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa2201422","article-title":"Genetically modified porcine-to-human cardiac xenotransplantation","volume":"387","author":"Griffith","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib80","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/00007890-200010150-00001","article-title":"Life-supporting human complement regulator decay accelerating factor transgenic pig liver xenograft maintains the metabolic function and coagulation in the nonhuman primate for up to 8\u00a0days","volume":"70","author":"Ramirez","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib81","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1016\/j.transproceed.2005.09.186","article-title":"Prevention of hyperacute rejection in a model of orthotopic liver xenotransplantation from pig to baboon using polytransgenic pig livers (CD55, CD59, and H-transferase)","volume":"37","author":"Ram\u00edrez","year":"2005","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.medj.2023.05.002_bib82","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-6143.2009.02945.x","article-title":"Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance","volume":"10","author":"Ekser","year":"2010","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib83","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1111\/ajt.14341","article-title":"Prolonged survival following pig-to-primate liver xenotransplantation utilizing exogenous coagulation factors and costimulation blockade","volume":"17","author":"Shah","year":"2017","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib84","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1067\/mtc.2000.106841","article-title":"The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants","volume":"120","author":"Lau","year":"2000","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.medj.2023.05.002_bib85","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1399-3089.2011.00621.x","article-title":"Coagulopathy in \u03b1-galactosyl transferase knockout pulmonary xenotransplants","volume":"18","author":"Bush","year":"2011","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib86","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12552","article-title":"Intra-bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60\u00a0days and promotes increased porcine lung transplant survival","volume":"27","author":"Watanabe","year":"2020","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib87","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/ajt.16930","article-title":"First clinical-grade porcine kidney xenotransplant using a human decedent model","volume":"22","author":"Porrett","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib88","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41586-020-2612-2","article-title":"Effects of extracellular matrix viscoelasticity on cellular behaviour","volume":"584","author":"Chaudhuri","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.medj.2023.05.002_bib89","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.biomaterials.2016.08.055","article-title":"Regenerative potential of human airway stem cells in lung epithelial engineering","volume":"108","author":"Gilpin","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib90","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.healun.2018.11.007","article-title":"Cell replacement in human lung bioengineering","volume":"38","author":"Guenthart","year":"2019","journal-title":"J.\u00a0Heart Lung Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib91","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biomaterials.2017.10.054","article-title":"Human embryonic stem cell-derived cardiovascular progenitor cells efficiently colonize in bFGF-tethered natural matrix to construct contracting humanized rat hearts","volume":"154","author":"Rajabi","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib92","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41551-019-0460-x","article-title":"Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs","volume":"4","author":"Shaheen","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.medj.2023.05.002_bib93","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nbt.3354","article-title":"Engineering pulmonary vasculature in decellularized rat and human lungs","volume":"33","author":"Ren","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib94","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.actbio.2021.10.017","article-title":"Ectopic expansion and vascularization of engineered hepatic tissue based on heparinized acellular liver matrix and mesenchymal stromal cell spheroids","volume":"137","author":"Wu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.medj.2023.05.002_bib95","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/liv.14267","article-title":"Heterotopic vascularization and functionalization of implantable bio engineered hepatic tissue alleviates liver injury in rats","volume":"40","author":"Li","year":"2020","journal-title":"Liver Int."},{"key":"10.1016\/j.medj.2023.05.002_bib96","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.ijbiomac.2022.04.188","article-title":"Gelatin\/sodium alginate hydrogel-coated decellularized porcine coronary artery to construct bilayer tissue engineered blood vessels","volume":"209","author":"Du","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.medj.2023.05.002_bib97","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biomaterials.2014.11.027","article-title":"Bioengineered transplantable porcine livers with re-endothelialized vasculature","volume":"40","author":"Ko","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120417","article-title":"Development of highly functional bioengineered human liver with perfusable vasculature","volume":"265","author":"Kim","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib99","first-page":"3851","article-title":"Covalent functionalization of decellularized tissues accelerates endothelialization","volume":"6","author":"Dal Sasso","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib100","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.actbio.2018.07.046","article-title":"Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain","volume":"78","author":"Devalliere","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.medj.2023.05.002_bib101","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.actbio.2018.12.042","article-title":"Construction of sinusoid-scale microvessels in perfusion culture of a decellularized liver","volume":"95","author":"Watanabe","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.medj.2023.05.002_bib102","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biomaterials.2018.01.054","article-title":"Fucoidan\/VEGF-based surface modification of decellularized pulmonary heart valve improves the antithrombotic and re-endothelialization potential of bioprostheses","volume":"172","author":"Marinval","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib103","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202102059","article-title":"Double-network hydrogel Armored decellularized porcine pericardium as durable bioprosthetic heart valves","volume":"11","author":"Cheng","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib104","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1021\/bm5003762","article-title":"Chondroitin sulfate coatings display low platelet but high endothelial cell adhesive properties favorable for vascular implants","volume":"15","author":"Thalla","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.medj.2023.05.002_bib105","article-title":"Hybrid heart valves with VEGF-loaded zwitterionic hydrogel coating for improved anti-calcification and re-endothelialization","volume":"17","author":"Tong","year":"2022","journal-title":"Mater. Today. Bio"},{"key":"10.1016\/j.medj.2023.05.002_bib106","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm.2170","article-title":"Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix","volume":"16","author":"Uygun","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib107","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm.2193","article-title":"Regeneration and orthotopic transplantation of a bioartificial lung","volume":"16","author":"Ott","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib108","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/SLA.0000000000002129","article-title":"Bioengineering human lung grafts on porcine matrix","volume":"267","author":"Zhou","year":"2018","journal-title":"Ann. Surg."},{"key":"10.1016\/j.medj.2023.05.002_bib109","article-title":"3D printing of personalized thick and perfusable cardiac patches and hearts","volume":"6","author":"Noor","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.medj.2023.05.002_bib110","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500758","article-title":"Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels","volume":"1","author":"Hinton","year":"2015","journal-title":"Sci. Adv."},{"key":"10.1016\/j.medj.2023.05.002_bib111","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1126\/science.aav9051","article-title":"3D bioprinting of collagen to rebuild components of the human heart","volume":"365","author":"Lee","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.medj.2023.05.002_bib112","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1126\/science.abl6395","article-title":"Recreating the heart's helical structure-function relationship with focused rotary jet spinning","volume":"377","author":"Chang","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.medj.2023.05.002_bib113","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.aav9750","article-title":"Multivascular networks and functional intravascular topologies within biocompatible hydrogels","volume":"364","author":"Grigoryan","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.medj.2023.05.002_bib114","article-title":"Production of multiple cell-laden microtissue spheroids with a biomimetic hepatic-lobule-like structure","volume":"33","author":"Hong","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib117","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41592-019-0325-y","article-title":"Flow-enhanced vascularization and maturation of kidney organoids in\u00a0vitro","volume":"16","author":"Homan","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.medj.2023.05.002_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119734","article-title":"Three-dimensional cell-printing of advanced renal tubular tissue analogue","volume":"232","author":"Singh","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib116","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/gutjnl-2019-319960","article-title":"Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure","volume":"70","author":"Yang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.medj.2023.05.002_bib118","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41563-020-00853-9","article-title":"Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation","volume":"20","author":"Lawlor","year":"2021","journal-title":"Nat. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib119","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0022-5223(00)70185-1","article-title":"In\u00a0vivo adenovirus-mediated endothelial nitric oxide synthase gene transfer ameliorates lung allograft ischemia-reperfusion injury","volume":"119","author":"Suda","year":"2000","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.medj.2023.05.002_bib120","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/00007890-199903270-00001","article-title":"Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation","volume":"67","author":"Bilbao","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib121","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1034\/j.1600-6143.2002.20805.x","article-title":"Successful six-day kidney preservation using trophic factor supplemented media and simple cold storage","volume":"2","author":"McAnulty","year":"2002","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib122","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1046\/j.1523-1755.2002.00473.x","article-title":"Polyethylene glycol reduces the inflammatory injury due to cold ischemia\/reperfusion in autotransplanted pig kidneys","volume":"62","author":"Hauet","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.medj.2023.05.002_bib123","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0022-3565(24)35284-X","article-title":"Pharmacological limitation of damage to renal medulla after cold storage and transplantation by trimetazidine","volume":"292","author":"Hauet","year":"2000","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.medj.2023.05.002_bib124","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1111\/ajt.14266","article-title":"Novel application of localized nanodelivery of anti-interleukin-6 protects organ transplant from ischemia-reperfusion injuries","volume":"17","author":"Solhjou","year":"2017","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib125","doi-asserted-by":"crossref","first-page":"12393","DOI":"10.1021\/acsnano.9b05115","article-title":"Nanodelivery of mycophenolate mofetil to the organ improves transplant vasculopathy","volume":"13","author":"Uehara","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.medj.2023.05.002_bib126","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/s41551-021-00777-y","article-title":"Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers","volume":"5","author":"Siren","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.medj.2023.05.002_bib127","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41551-018-0317-8","article-title":"DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury","volume":"2","author":"Jiang","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.medj.2023.05.002_bib128","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.healun.2019.07.006","article-title":"Mesenchymal stromal cell therapy during ex\u00a0vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation","volume":"38","author":"Nakajima","year":"2019","journal-title":"J.\u00a0Heart Lung Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib129","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1089\/scd.2020.0024","article-title":"Treating ischemically damaged porcine kidneys with human bone marrow- and adipose tissue-derived mesenchymal stromal cells during ex\u00a0vivo normothermic machine perfusion","volume":"29","author":"Pool","year":"2020","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.medj.2023.05.002_bib130","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13287-020-01736-1","article-title":"Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts","volume":"11","author":"Cao","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.medj.2023.05.002_bib131","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah4586","article-title":"Improved tissue cryopreservation using inductive heating of magnetic nanoparticles","volume":"9","author":"Manuchehrabadi","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib132","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201901624","article-title":"Preparation of scalable silica-coated iron oxide nanoparticles for nanowarming","volume":"7","author":"Gao","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.medj.2023.05.002_bib133","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe3005","article-title":"Perfusion, cryopreservation, and nanowarming of whole hearts using colloidally stable magnetic cryopreservation agent solutions","volume":"7","author":"Chiu-Lam","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.medj.2023.05.002_bib134","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202101691","article-title":"Vitrification and nanowarming of kidneys","volume":"8","author":"Sharma","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.medj.2023.05.002_bib135","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1021\/acsami.5b00655","article-title":"Nanoparticle-mediated intracellular delivery enables cryopreservation of human adipose-derived stem cells using trehalose as the sole cryoprotectant","volume":"7","author":"Rao","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.medj.2023.05.002_bib136","doi-asserted-by":"crossref","first-page":"9051","DOI":"10.1021\/acs.nanolett.9b04109","article-title":"Cold-responsive nanoparticle enables intracellular delivery and rapid release of trehalose for organic-solvent-free cryopreservation","volume":"19","author":"Zhang","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.medj.2023.05.002_bib137","article-title":"Cold-responsive nanocapsules enable the sole-cryoprotectant-trehalose cryopreservation of \u03b2 cell-laden hydrogels for diabetes treatment","volume":"15","author":"Cheng","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.medj.2023.05.002_bib138","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/TP.0b013e31829b759f","article-title":"Ultrasound molecular imaging of acute cellular cardiac allograft rejection in rat with T-cell-specific nanobubbles","volume":"96","author":"Wu","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.medj.2023.05.002_bib139","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.biomaterials.2018.02.017","article-title":"Ultrasound molecular imaging of acute cardiac transplantation rejection using nanobubbles targeted to T lymphocytes","volume":"162","author":"Liu","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib140","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41551-019-0358-7","article-title":"Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity","volume":"3","author":"Mac","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.medj.2023.05.002_bib141","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1016\/j.biomaterials.2011.08.070","article-title":"MRI of transplanted surface-labeled pancreatic islets with heparinized superparamagnetic iron oxide nanoparticles","volume":"32","author":"Jung","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib142","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nmat3525","article-title":"MRI-detectable pH nanosensors incorporated into hydrogels for in\u00a0vivo sensing of transplanted-cell viability","volume":"12","author":"Chan","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib143","doi-asserted-by":"crossref","first-page":"10646","DOI":"10.1021\/nn3037573","article-title":"Simultaneous diagnosis and gene therapy of immuno-rejection in rat allogeneic heart transplantation model using a T-cell-targeted theranostic nanosystem","volume":"6","author":"Guo","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.medj.2023.05.002_bib144","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1021\/acsnano.1c03029","article-title":"Biomimetic glucan particles with aggregation-induced emission characteristics for noninvasive monitoring of transplant immune response","volume":"15","author":"Gao","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.medj.2023.05.002_bib145","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41575-020-0334-4","article-title":"Understanding, predicting and achieving liver transplant tolerance: from bench to bedside","volume":"17","author":"Thomson","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.medj.2023.05.002_bib146","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCULATIONAHA.117.029753","article-title":"Honoring 50 Years of clinical heart transplantation in circulation: in-depth state-of-the-Art review","volume":"137","author":"Stehlik","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.medj.2023.05.002_bib147","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41581-018-0039-x","article-title":"HLA in transplantation","volume":"14","author":"Montgomery","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.medj.2023.05.002_bib148","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.kint.2021.11.029","article-title":"Allorecognition and the spectrum of kidney transplant rejection","volume":"101","author":"Callemeyn","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.medj.2023.05.002_bib149","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tibtech.2014.10.006","article-title":"Synthetic immunology: modulating the human immune system","volume":"33","author":"Geering","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib150","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/08923973.2021.1966033","article-title":"Transplantation and immunosuppression: a review of novel transplant-related immunosuppressant drugs","volume":"43","author":"Parlakpinar","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.medj.2023.05.002_bib151","doi-asserted-by":"crossref","first-page":"28.20","DOI":"10.4049\/jimmunol.206.Supp.28.20","article-title":"Selective expansion of regulatory T\u00a0cells by kidney-tethered 112 mutein","volume":"206","author":"Larkin","year":"2021","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.medj.2023.05.002_bib152","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1111\/j.1600-6143.2009.02735.x","article-title":"An anti-CD103 immunotoxin promotes long-term survival of pancreatic islet\u00a0allografts","volume":"9","author":"Zhang","year":"2009","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib153","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.intimp.2014.11.004","article-title":"Efficient elimination of CD103-expressing cells by anti-CD103 antibody drug conjugates in immunocompetent mice","volume":"24","author":"Mang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.medj.2023.05.002_bib154","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/ajt.14185","article-title":"Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T\u00a0cells in preventing human skin transplant rejection","volume":"17","author":"Boardman","year":"2017","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib155","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/ajt.14175","article-title":"Prevention of allograft rejection by use of regulatory T\u00a0cells with an MHC-specific chimeric antigen receptor","volume":"17","author":"Noyan","year":"2017","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib156","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1182\/bloodadvances.2019000411","article-title":"Human CD8+ Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice","volume":"3","author":"B\u00e9zie","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.medj.2023.05.002_bib157","article-title":"Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T\u00a0cells","volume":"4","author":"Dawson","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.medj.2023.05.002_bib158","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1111\/ajt.15787","article-title":"Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients","volume":"20","author":"Sicard","year":"2020","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib159","article-title":"Chimeric antigen receptor costimulation domains modulate human regulatory T\u00a0cell function","volume":"5","author":"Boroughs","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.medj.2023.05.002_bib160","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1111\/ajt.17063","article-title":"Anti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival","volume":"22","author":"Wagner","year":"2022","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib161","first-page":"834","article-title":"[Gene surgery: on the threshold of synthetic biology]","volume":"75","author":"Hobom","year":"1980","journal-title":"Med. Klin."},{"key":"10.1016\/j.medj.2023.05.002_bib162","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1089\/hum.2016.070","article-title":"Safety and efficacy of ex\u00a0vivo donor lung adenoviral IL-10 gene therapy in a large animal lung transplant survival model","volume":"28","author":"Machuca","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.medj.2023.05.002_bib163","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jtcvs.2018.05.003","article-title":"A novel combined ex\u00a0vivo and in\u00a0vivo lentiviral interleukin-10 gene delivery strategy at the time of transplantation decreases chronic lung allograft rejection in mice","volume":"156","author":"Oishi","year":"2018","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.medj.2023.05.002_bib164","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/gt.2016.68","article-title":"Local gene therapy with indoleamine 2,3-dioxygenase protects against development of transplant vasculopathy in chronic kidney transplant dysfunction","volume":"23","author":"Vavrincova-Yaghi","year":"2016","journal-title":"Gene Ther."},{"key":"10.1016\/j.medj.2023.05.002_bib165","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1089\/hum.1998.9.4-477","article-title":"Transient immunosuppression allows transgene expression following readministration of adeno-associated viral vectors","volume":"9","author":"Manning","year":"1998","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.medj.2023.05.002_bib166","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.trim.2018.03.004","article-title":"Immune modulation by silencing CD80 and CD86 production in dendritic cells using small hairpin RNA to reduce heart transplant rejection","volume":"49","author":"Yang","year":"2018","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.medj.2023.05.002_bib167","doi-asserted-by":"crossref","first-page":"8123","DOI":"10.1016\/j.biomaterials.2014.06.007","article-title":"Prevention of rejection of allogeneic endothelial cells in a biohybrid lung by silencing HLA-class I expression","volume":"35","author":"Wiegmann","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib168","first-page":"519","article-title":"Successful prophylaxis of antibody-mediated rejection by downregulation of C5 expression via RNA interference in a rat kidney transplant model","volume":"21","author":"Ishigooka","year":"2021","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.medj.2023.05.002_bib169","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nbt.1989","article-title":"Therapeutic siRNA silencing in inflammatory monocytes in mice","volume":"29","author":"Leuschner","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120366","article-title":"Targeted galectin-7 inhibition with ultrasound microbubble targeted gene therapy as a sole therapy to prevent acute rejection following heart transplantation in a Rodent model","volume":"263","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib171","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119302","article-title":"In situ repurposing of dendritic cells with CRISPR\/Cas9-based nanomedicine to induce transplant tolerance","volume":"217","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib172","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ymthe.2016.10.005","article-title":"A synthetic mammalian therapeutic gene circuit for sensing and suppressing inflammation","volume":"25","author":"Smole","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.medj.2023.05.002_bib173","doi-asserted-by":"crossref","first-page":"318ra201","DOI":"10.1126\/scitranslmed.aac4964","article-title":"Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis","volume":"7","author":"Schukur","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib174","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1016\/j.biomaterials.2012.06.003","article-title":"Controlled release of dexamethasone from peptide nanofiber gels to modulate inflammatory response","volume":"33","author":"Webber","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib175","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.biomaterials.2016.11.004","article-title":"Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages","volume":"114","author":"Jiang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib176","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf9221","article-title":"Localized drug delivery graphene bioscaffolds for cotransplantation of islets and mesenchymal stem cells","volume":"7","author":"Razavi","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.medj.2023.05.002_bib177","article-title":"In\u00a0vivo kidney allograft endothelial specific scavengers for on-site inflammation reduction under antibody-mediated rejection","volume":"18","author":"Liu","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.medj.2023.05.002_bib178","doi-asserted-by":"crossref","first-page":"249ra110","DOI":"10.1126\/scitranslmed.3008778","article-title":"A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft","volume":"6","author":"Gajanayake","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.medj.2023.05.002_bib179","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201805018","article-title":"Immune responsive release of tacrolimus to overcome organ transplant rejection","volume":"30","author":"Wu","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119415","article-title":"Engineering \"cell-particle hybrids\" of pancreatic islets and bioadhesive FK506-loaded polymeric microspheres for local immunomodulation in xenogeneic islet transplantation","volume":"221","author":"Nguyen","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib181","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001157","article-title":"Particulate-based single-dose local immunosuppressive regimen for inducing tolerogenic dendritic cells in xenogeneic islet transplantation","volume":"10","author":"Pathak","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib182","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1039\/C9BM00301K","article-title":"Improving acute cardiac transplantation rejection therapy using ultrasound-targeted FK506-loaded microbubbles in rats","volume":"7","author":"Liu","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.medj.2023.05.002_bib183","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.immuni.2018.09.008","article-title":"Inhibiting inflammation with myeloid cell-specific nanobiologics promotes organ transplant acceptance","volume":"49","author":"Braza","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.medj.2023.05.002_bib184","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe7853","article-title":"A modular approach toward producing nanotherapeutics targeting the innate immune system","volume":"7","author":"van Leent","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.medj.2023.05.002_bib185","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41565-021-01048-2","article-title":"Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of rapamycin to enhance allogeneic islet graft viability","volume":"17","author":"Burke","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib186","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2015.11.065","article-title":"Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets","volume":"80","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib187","article-title":"Immunosuppressive PLGA TGF-beta1 microparticles induce polyclonal and antigen-specific regulatory T\u00a0cells for local immunomodulation of allogeneic islet transplants","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2023.05.002_bib188","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.biomaterials.2017.04.029","article-title":"PEGylated bilirubin nanoparticle as an anti-oxidative and anti-inflammatory demulcent in pancreatic islet xenotransplantation","volume":"133","author":"Kim","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib189","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1021\/acsami.9b18986","article-title":"Localized controlled release of bilirubin from beta-cyclodextrin-conjugated epsilon-polylysine to attenuate oxidative stress and inflammation in transplanted islets","volume":"12","author":"Yao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.medj.2023.05.002_bib190","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2022.03.024","article-title":"Nanoformulation of a carbon monoxide releasing molecule protects against cyclosporin A-induced nephrotoxicity and renal fibrosis via the suppression of the NLRP3 inflammasome mediated TGF-beta\/Smad pathway","volume":"144","author":"Xia","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.medj.2023.05.002_bib191","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202105670","article-title":"Enzyme therapeutic for ischemia and reperfusion injury in organ transplantation","volume":"34","author":"Yan","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib192","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41563-018-0099-0","article-title":"Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance","volume":"17","author":"Headen","year":"2018","journal-title":"Nat. Mater."},{"key":"10.1016\/j.medj.2023.05.002_bib193","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.biomaterials.2018.11.015","article-title":"Localized immune tolerance from FasL-functionalized PLG scaffolds","volume":"192","author":"Skoumal","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib194","doi-asserted-by":"crossref","first-page":"eaba5573","DOI":"10.1126\/sciadv.aba5573","article-title":"Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival","volume":"6","author":"Coronel","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.medj.2023.05.002_bib195","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biomaterials.2018.08.049","article-title":"Regulation of human T\u00a0cell responses by dNP2-ctCTLA-4 inhibits human skin and microvessel graft rejection","volume":"183","author":"Lim","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib196","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.1021\/acsnano.9b09065","article-title":"Engineering programmed death ligand-1\/cytotoxic T-lymphocyte-associated antigen-4 dual-targeting nanovesicles for immunosuppressive therapy in transplantation","volume":"14","author":"Xu","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.medj.2023.05.002_bib197","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax8429","article-title":"In situ recruitment of regulatory T\u00a0cells promotes donor-specific tolerance in vascularized composite allotransplantation","volume":"6","author":"Fisher","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.medj.2023.05.002_bib198","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.1016\/j.biomaterials.2014.06.044","article-title":"Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation","volume":"35","author":"Bryant","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib199","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biomaterials.2019.04.030","article-title":"Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model","volume":"210","author":"Shah","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.medj.2023.05.002_bib200","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jhep.2016.03.020","article-title":"A synthetic biology-based device prevents liver injury in mice","volume":"65","author":"Bai","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.medj.2023.05.002_bib201","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nbt.1617","article-title":"Self-sufficient control of urate homeostasis in mice by a synthetic circuit","volume":"28","author":"Kemmer","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib202","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-022-05016-1","article-title":"Cellular recovery after prolonged warm ischaemia of the whole body","volume":"608","author":"Andrijevic","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.medj.2023.05.002_bib203","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.chembiol.2019.02.008","article-title":"Copying life: synthesis of an enzymatically active mirror-image DNA-ligase made of D-Amino acids","volume":"26","author":"Weidmann","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.medj.2023.05.002_bib204","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/s41587-022-01377-0","article-title":"Frequent aneuploidy in primary human T\u00a0cells after CRISPR-Cas9 cleavage","volume":"40","author":"Nahmad","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.medj.2023.05.002_bib205","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.aav9973","article-title":"Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos","volume":"364","author":"Zuo","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.medj.2023.05.002_bib206","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.aaw7166","article-title":"Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice","volume":"364","author":"Jin","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.medj.2023.05.002_bib207","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s41232-020-00125-8","article-title":"Immune reaction and regulation in transplantation based on pluripotent stem cell technology","volume":"40","author":"Otsuka","year":"2020","journal-title":"Inflamm. Regen."}],"container-title":["Med"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666634023001423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666634023001423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:57:20Z","timestamp":1763002640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666634023001423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":208,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2666634023001423"],"URL":"https:\/\/doi.org\/10.1016\/j.medj.2023.05.002","relation":{},"ISSN":["2666-6340"],"issn-type":[{"value":"2666-6340","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new paradigm in transplant immunology: At the crossroad of synthetic biology and biomaterials","name":"articletitle","label":"Article Title"},{"value":"Med","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medj.2023.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}