{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:16:47Z","timestamp":1793063807596,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800724"],"award-info":[{"award-number":["31800724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202008"],"award-info":[{"award-number":["82202008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170875"],"award-info":[{"award-number":["32170875"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82321005"],"award-info":[{"award-number":["82321005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171751"],"award-info":[{"award-number":["82171751"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021524","name":"School of Life Sciences and Biotechnology Division of Life Sciences, Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX1114"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1114"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011360","name":"State Key Laboratory of Natural Medicines","doi-asserted-by":"publisher","award":["SN-011"],"award-info":[{"award-number":["SN-011"]}],"id":[{"id":"10.13039\/501100011360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2303200"],"award-info":[{"award-number":["2022YFC2303200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF0702000"],"award-info":[{"award-number":["2021YFF0702000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221029"],"award-info":[{"award-number":["BK20221029"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Med"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.medj.2024.03.018","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:31:44Z","timestamp":1713954704000},"page":"622-644.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination"],"prefix":"10.1016","volume":"5","author":[{"given":"Munire","family":"Maimaiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-5641","authenticated-orcid":false,"given":"Haiyang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medj.2024.03.018_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/17474930211065917","article-title":"World Stroke Organization (WSO): Global Stroke Fact Sheet 2022","volume":"17","author":"Feigin","year":"2022","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.medj.2024.03.018_bib2","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke","volume":"359","author":"Hacke","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.medj.2024.03.018_bib3","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/S0140-6736(12)60738-7","article-title":"Recombinant tissue\u00a0plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis","volume":"379","author":"Wardlaw","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.medj.2024.03.018_bib4","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2020.4123","article-title":"Association of Reperfusion After Thrombolysis With Clinical Outcome Across the 4.5- to 9-Hours and Wake-up Stroke Time Window","volume":"78","author":"Campbell","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.medj.2024.03.018_bib5","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nrneurol.2015.144","article-title":"Immune interventions in stroke","volume":"11","author":"Fu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.medj.2024.03.018_bib6","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s12264-019-00388-3","article-title":"Dual Functions of Microglia in Ischemic Stroke","volume":"35","author":"Qin","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.medj.2024.03.018_bib7","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1177\/0271678X18817282","article-title":"Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke","volume":"39","author":"Kurisu","year":"2019","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.medj.2024.03.018_bib8","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1523\/JNEUROSCI.4317-15.2016","article-title":"Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice","volume":"36","author":"Wattananit","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.medj.2024.03.018_bib9","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1523\/JNEUROSCI.4912-13.2014","article-title":"Differences in the phagocytic response of microglia and peripheral macrophages after spinal cord injury and its effects on cell death","volume":"34","author":"Greenhalgh","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.medj.2024.03.018_bib10","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.immuni.2022.09.005","article-title":"Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation","volume":"55","author":"De Vlaminck","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.medj.2024.03.018_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba6905","article-title":"Myelin: A gatekeeper of activity-dependent circuit plasticity?","volume":"374","author":"Bonetto","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.medj.2024.03.018_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.expneurol.2015.03.017","article-title":"Demyelination as a rational therapeutic target for ischemic or traumatic brain injury","volume":"272","author":"Shi","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.medj.2024.03.018_bib13","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/glia.22535","article-title":"Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression","volume":"61","author":"Plemel","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.medj.2024.03.018_bib14","doi-asserted-by":"crossref","first-page":"8077","DOI":"10.4049\/jimmunol.181.11.8077","article-title":"Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells","volume":"181","author":"Jeon","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.medj.2024.03.018_bib15","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","article-title":"Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia","volume":"43","author":"Hu","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.medj.2024.03.018_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41419-019-1716-9","article-title":"Microglia-derived TNF-alpha mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.medj.2024.03.018_bib17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pneurobio.2016.01.005","article-title":"The biphasic function of microglia in ischemic stroke","volume":"157","author":"Ma","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.medj.2024.03.018_bib18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1084\/jem.20141656","article-title":"Inefficient clearance of myelin debris by microglia impairs remyelinating processes","volume":"212","author":"Lampron","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.medj.2024.03.018_bib19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41582-019-0184-2","article-title":"The pro-remyelination properties of microglia in the central nervous system","volume":"15","author":"Lloyd","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.medj.2024.03.018_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41593-021-00829-1","article-title":"Microglia clean up toxic lipids in multiple\u00a0sclerosis","volume":"24","author":"Monroe","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.medj.2024.03.018_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12974-020-01899-x","article-title":"CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation","volume":"17","author":"Grajchen","year":"2020","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.medj.2024.03.018_bib22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.182.4109.296","article-title":"Proteins from human cerebrospinal fluid: binding with nucleic acids","volume":"182","author":"Kubinski","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.medj.2024.03.018_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat8657","article-title":"cGAS in action: Expanding roles in immunity and inflammation","volume":"363","author":"Ablasser","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.medj.2024.03.018_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.immuni.2020.05.013","article-title":"Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway","volume":"53","author":"Zhang","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.medj.2024.03.018_bib25","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.medj.2024.03.018_bib26","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41392-022-01252-z","article-title":"Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.medj.2024.03.018_bib27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tins.2020.10.008","article-title":"Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging","volume":"44","author":"Paul","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.medj.2024.03.018_bib28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING-induced inflammation","volume":"561","author":"Sliter","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.medj.2024.03.018_bib29","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1038\/s41467-021-26851-2","article-title":"Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.medj.2024.03.018_bib30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12974-018-1354-7","article-title":"STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury","volume":"15","author":"Abdullah","year":"2018","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.medj.2024.03.018_bib31","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911002","article-title":"Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke","volume":"12","author":"Li","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.medj.2024.03.018_bib32","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.1300530","article-title":"Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation","volume":"191","author":"Kaminski","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.medj.2024.03.018_bib33","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.4049\/jimmunol.171.3.1393","article-title":"Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation","volume":"171","author":"Gursel","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.medj.2024.03.018_bib34","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13348","article-title":"Sensing of HSV-1 by the cGAS\u2013STING pathway in microglia orchestrates antiviral defence in the CNS","volume":"7","author":"Reinert","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.medj.2024.03.018_bib35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-020-01830-4","article-title":"Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage","volume":"17","author":"Peng","year":"2020","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.medj.2024.03.018_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105465118","article-title":"STING inhibitors target the cyclic dinucleotide binding pocket","volume":"118","author":"Hong","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.medj.2024.03.018_bib37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-017-1667-0","article-title":"Ischemic stroke: experimental models and reality","volume":"133","author":"Sommer","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.medj.2024.03.018_bib38","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1602\/neurorx.2.3.396","article-title":"Rodent models of focal stroke: size, mechanism, and purpose","volume":"2","author":"Carmichael","year":"2005","journal-title":"NeuroRx"},{"key":"10.1016\/j.medj.2024.03.018_bib39","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.medj.2024.03.018_bib40","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS-STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.medj.2024.03.018_bib41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2017.08.039","article-title":"Human microglia and astrocytes express cGAS-STING viral sensing components","volume":"658","author":"Jeffries","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.medj.2024.03.018_bib42","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021691","article-title":"The striatum: where skills and habits meet","volume":"7","author":"Graybiel","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.medj.2024.03.018_bib43","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.neuron.2021.01.027","article-title":"White matter aging drives microglial diversity","volume":"109","author":"Safaiyan","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.medj.2024.03.018_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.950819","article-title":"Dynamics of Microglia Activation in the Ischemic Brain: Implications for Myelin Repair and Functional Recovery","volume":"16","author":"Raffaele","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.medj.2024.03.018_bib45","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1126\/science.aan4183","article-title":"Defective cholesterol clearance limits remyelination in the aged central nervous system","volume":"359","author":"Cantuti-Castelvetri","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.medj.2024.03.018_bib46","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190348","article-title":"Qki is an essential regulator of microglial phagocytosis in demyelination","volume":"218","author":"Ren","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.medj.2024.03.018_bib47","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.neuron.2019.12.007","article-title":"TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge","volume":"105","author":"Nugent","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.medj.2024.03.018_bib48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41593-020-00757-6","article-title":"Microglia facilitate repair of\u00a0demyelinated lesions via post-squalene\u00a0sterol synthesis","volume":"24","author":"Berghoff","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.medj.2024.03.018_bib49","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00401-020-02193-z","article-title":"TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis","volume":"140","author":"Cignarella","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.medj.2024.03.018_bib50","article-title":"ABCA1\/ApoE\/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke","volume":"21","author":"Li","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.medj.2024.03.018_bib51","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.tem.2016.03.018","article-title":"LXR Regulation of Brain Cholesterol: From Development to Disease","volume":"27","author":"Courtney","year":"2016","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.medj.2024.03.018_bib52","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1161\/STROKEAHA.120.029440","article-title":"Sustained Increases in Immune Transcripts and Immune Cell Trafficking During the Recovery of Experimental Brain Ischemia","volume":"51","author":"Fury","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.medj.2024.03.018_bib53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.chom.2016.01.010","article-title":"The cGAS-STING Defense Pathway and Its Counteraction by Viruses","volume":"19","author":"Ma","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.medj.2024.03.018_bib54","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00281-022-00943-7","article-title":"Inflammatory Responses After Ischemic Stroke","volume":"44","author":"DeLong","year":"2022","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.medj.2024.03.018_bib55","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S1474-4422(19)30078-X","article-title":"Global brain inflammation in stroke","volume":"18","author":"Shi","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.medj.2024.03.018_bib56","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1056\/NEJMct1007370","article-title":"Intravenous thrombolytic therapy for acute ischemic stroke","volume":"364","author":"Wechsler","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.medj.2024.03.018_bib57","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1161\/STROKEAHA.109.548750","article-title":"Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis","volume":"40","author":"F\u00f6rster","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.medj.2024.03.018_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108490","article-title":"Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5","volume":"33","author":"Cui","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.medj.2024.03.018_bib71","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.medj.2024.03.018_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.medj.2024.03.018_bib73","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13059-019-1758-4","article-title":"Cytoscape Automation: empowering workflow-based\u00a0network analysis","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.medj.2024.03.018_bib59","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/0271678X15606722","article-title":"The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke","volume":"36","author":"Sutherland","year":"2016","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.medj.2024.03.018_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000330","article-title":"The interleukin-4\/PPARgamma signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury","volume":"17","author":"Zhang","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.medj.2024.03.018_bib61","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.immuni.2021.04.022","article-title":"Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke","volume":"54","author":"Shi","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.medj.2024.03.018_bib62","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fncel.2016.00203","article-title":"A Novel Approach for Amplification and Purification of Mouse Oligodendrocyte Progenitor Cells","volume":"10","author":"Yang","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.medj.2024.03.018_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007435","article-title":"The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway","volume":"14","author":"Zhang","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.medj.2024.03.018_bib64","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jneumeth.2008.12.001","article-title":"A simple and rapid method to collect the cerebrospinal fluid of\u00a0rats and its application for the assessment of drug penetration into the central nervous system","volume":"178","author":"Nirogi","year":"2009","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.medj.2024.03.018_bib65","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.exger.2019.01.022","article-title":"Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner","volume":"119","author":"Huang","year":"2019","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.medj.2024.03.018_bib66","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8825954","article-title":"Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and\u00a0NLRP3 Pathway","volume":"2020","author":"Du","year":"2020","journal-title":"Neural Plast."},{"key":"10.1016\/j.medj.2024.03.018_bib67","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.medj.2024.03.018_bib68","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41593-020-0588-8","article-title":"Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory","volume":"23","author":"Wang","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.medj.2024.03.018_bib69","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbi.2016.02.020","article-title":"Cognitive impairment by\u00a0antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication","volume":"56","author":"Fr\u00f6hlich","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.medj.2024.03.018_bib70","doi-asserted-by":"crossref","first-page":"9115","DOI":"10.1073\/pnas.1821979116","article-title":"Protease-independent action of tissue\u00a0plasminogen activator in brain plasticity and neurological recovery after ischemic stroke","volume":"116","author":"Pu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Med"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666634024001302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666634024001302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:00:50Z","timestamp":1762639250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666634024001302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S2666634024001302"],"URL":"https:\/\/doi.org\/10.1016\/j.medj.2024.03.018","relation":{},"ISSN":["2666-6340"],"issn-type":[{"value":"2666-6340","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination","name":"articletitle","label":"Article Title"},{"value":"Med","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medj.2024.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}