{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:15:58Z","timestamp":1791605758192,"version":"4.3.4"},"reference-count":85,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007185","name":"University of California Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["TRAN1-16050"],"award-info":[{"award-number":["TRAN1-16050"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["DISC2-13015"],"award-info":[{"award-number":["DISC2-13015"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["DISC2-11157"],"award-info":[{"award-number":["DISC2-11157"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["TRAN1-12250"],"award-info":[{"award-number":["TRAN1-12250"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007186","name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007186","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Med"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.medj.2026.101272","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:45:10Z","timestamp":1788360310000},"page":"101272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adoptive MAIT cell therapy for liver cancer enhanced by multimodal modulation of immune receptors and checkpoints"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9858-300X","authenticated-orcid":false,"given":"Yan-Ruide","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral L.","family":"Clune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Dominguez-Vela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya","family":"Gumate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-9838","authenticated-orcid":false,"given":"Vatche G.","family":"Agopian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medj.2026.101272_bib1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41577-020-0345-y","article-title":"Thymic development of unconventional T cells: how NKT cells, MAIT cells and \u03b3\u03b4 T cells emerge","volume":"20","author":"Pellicci","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41577-023-00934-1","article-title":"MR1 antigen presentation to MAIT cells and other MR1-restricted T cells","volume":"24","author":"McWilliam","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib3","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41590-019-0444-8","article-title":"The biology and functional importance of MAIT cells","volume":"20","author":"Godfrey","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib4","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/s41590-023-01575-1","article-title":"Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity","volume":"24","author":"Garner","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12929-025-01125-x","article-title":"Biological functions and therapeutic applications of human mucosal-associated invariant T cells","volume":"32","author":"Fang","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.medj.2026.101272_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nature01433","article-title":"Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1","volume":"422","author":"Treiner","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.medj.2026.101272_bib7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ymthe.2022.11.019","article-title":"Mucosal-associated invariant T cells for cancer immunotherapy","volume":"31","author":"Li","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.medj.2026.101272_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/eji.201847759","article-title":"Tissue-resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL-17","volume":"49","author":"Sobkowiak","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fimmu.2015.00302","article-title":"Role of Innate T Cells in Anti-Bacterial Immunity","volume":"6","author":"Gao","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib10","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1182\/blood-2010-08-303339","article-title":"Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17\u2013secreting T cells","volume":"117","author":"Dusseaux","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.medj.2026.101272_bib11","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/ni.1890","article-title":"Antimicrobial activity of mucosal-associated invariant T cells","volume":"11","author":"Le Bourhis","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib12","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1371\/journal.pbio.1000054","article-title":"Stepwise development of MAIT cells in mouse and human","volume":"7","author":"Martin","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.medj.2026.101272_bib13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fimmu.2019.00260","article-title":"Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1158\/2326-6066.CIR-20-0925","article-title":"Activating Mucosal-Associated Invariant T Cells Induces a Broad Antitumor Response","volume":"9","author":"Ruf","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.medj.2026.101272_bib15","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1158\/1078-0432.CCR-18-3040","article-title":"Activated and Exhausted MAIT Cells Foster Disease Progression and Indicate Poor Outcome in Hepatocellular Carcinoma","volume":"25","author":"Duan","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.medj.2026.101272_bib16","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1038\/cti.2016.51","article-title":"MAIT cells: new guardians of the liver","volume":"5","author":"Kurioka","year":"2016","journal-title":"Clin. Transl. Immunology"},{"key":"10.1016\/j.medj.2026.101272_bib17","doi-asserted-by":"crossref","first-page":"460","DOI":"10.7150\/ijbs.39016","article-title":"Mucosal-Associated Invariant T cell in liver diseases","volume":"16","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.medj.2026.101272_bib18","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1016\/j.cell.2023.07.026","article-title":"Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin","volume":"186","author":"Ruf","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.medj.2026.101272_bib19","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/hep.32222","article-title":"Mucosal-associated invariant T-cell tumor infiltration predicts long-term survival in cholangiocarcinoma","volume":"75","author":"Zimmer","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.medj.2026.101272_bib20","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.3390\/cancers14112749","article-title":"Targeting Immunosuppressive Tumor-Associated Macrophages Using Innate T Cells for Enhanced Antitumor Reactivity","volume":"14","author":"Li","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.medj.2026.101272_bib21","article-title":"Target tumor microenvironment by innate T cells","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib22","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.4049\/jimmunol.2100856","article-title":"Engineering Human MAIT Cells with Chimeric Antigen Receptors for Cancer Immunotherapy","volume":"209","author":"Dogan","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib23","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.18632\/oncotarget.26866","article-title":"Tumor-infiltrating mucosal-associated invariant T (MAIT) cells retain expression of cytotoxic effector molecules","volume":"10","author":"Sundstr\u00f6m","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.medj.2026.101272_bib24","article-title":"MAIT Cells Modulate Innate Immune Cells and Inhibit Colon Cancer Growth","author":"Cheng","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.medj.2026.101272_bib25","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.jhep.2025.06.006","article-title":"Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD","volume":"83","author":"Deschler","year":"2025","journal-title":"J. Hepatol."},{"key":"10.1016\/j.medj.2026.101272_bib26","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ni.3565","article-title":"A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage","volume":"17","author":"Koay","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib27","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1182\/blood-2019-127722","article-title":"The Low Number of Mucosal-Associated Invariant T Cells in the Graft Was Associated with Occurrence of Gut Graft-Versus-Host Disease","volume":"134","author":"Mengge","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.medj.2026.101272_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1367","article-title":"Circulating CD8(+) mucosal-associated invariant T cells correlate with improved treatment responses and overall survival in anti-PD-1-treated melanoma patients","volume":"11","author":"Vorwald","year":"2022","journal-title":"Clin. Transl. Immunology"},{"key":"10.1016\/j.medj.2026.101272_bib29","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.7150\/jca.69415","article-title":"Participation of Increased Circulating MAIT Cells in Lung Cancer: a Pilot Study","volume":"13","author":"Zhang","year":"2022","journal-title":"J. Cancer"},{"key":"10.1016\/j.medj.2026.101272_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003685","article-title":"Activated but impaired IFN-\u03b3 production of mucosal-associated invariant T cells in patients with hepatocellular carcinoma","volume":"9","author":"Huang","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.medj.2026.101272_bib31","doi-asserted-by":"crossref","first-page":"7372","DOI":"10.1038\/s41467-023-43269-0","article-title":"Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease","volume":"14","author":"Gnirck","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.medj.2026.101272_bib32","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140074","article-title":"Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection","volume":"6","author":"Parrot","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.medj.2026.101272_bib33","article-title":"Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions","volume":"3","author":"Healy","year":"2021","journal-title":"JHEP Rep."},{"key":"10.1016\/j.medj.2026.101272_bib34","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41590-019-0465-3","article-title":"Molecular mechanisms of lineage decisions in metabolite-specific T cells","volume":"20","author":"Legoux","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01031","article-title":"Shared and distinct phenotypes and functions of human cD161++ V\u03b17.2+ T cell subsets","volume":"8","author":"Kurioka","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib36","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231487","article-title":"A conserved transcriptional program for MAIT cells across mammalian evolution","volume":"221","author":"Bugaut","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.medj.2026.101272_bib37","article-title":"Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy","volume":"2","author":"Li","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.medj.2026.101272_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.medj.2025.100804","article-title":"Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells","volume":"6","author":"Li","year":"2025","journal-title":"Med"},{"key":"10.1016\/j.medj.2026.101272_bib39","doi-asserted-by":"crossref","first-page":"10465","DOI":"10.1073\/pnas.2003136117","article-title":"Ligand-dependent downregulation of MR1 cell surface expression","volume":"117","author":"Salio","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.medj.2026.101272_bib40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1158\/2159-8290.CD-19-0569","article-title":"MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1","volume":"10","author":"Yan","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.medj.2026.101272_bib41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41587-024-02226-y","article-title":"Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method","volume":"43","author":"Li","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.medj.2026.101272_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.celbio.2025.100244","article-title":"Feeder-free advances in T cell development and therapy","volume":"2","author":"Zhu","year":"2026","journal-title":"Cell Biomater."},{"key":"10.1016\/j.medj.2026.101272_bib43","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/mt.sj.6300134","article-title":"Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules","volume":"15","author":"Suhoski","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.medj.2026.101272_bib44","doi-asserted-by":"crossref","first-page":"676","DOI":"10.4049\/jimmunol.1801137","article-title":"CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15- and IL-21-Driven NK Cell Proliferation","volume":"203","author":"Vidard","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13045-024-01525-w","article-title":"IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts","volume":"17","author":"Van den Eynde","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.medj.2026.101272_bib46","doi-asserted-by":"crossref","DOI":"10.1172\/JCI166028","article-title":"IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models","volume":"133","author":"Jaspers","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.medj.2026.101272_bib47","article-title":"Frontiers of cytokine engineering in CAR cell therapy for cancer","volume":"15","author":"Wu","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.medj.2026.101272_bib48","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1016\/j.ymthe.2026.02.039","article-title":"Igniting CAR-NKT cells with IL-18","volume":"34","author":"Shen","year":"2026","journal-title":"Mol. Ther."},{"key":"10.1016\/j.medj.2026.101272_bib49","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhang, B., and Wang, S. 2026 Stem cell mitochondrial transfer rejuvenates CAR- NKT cell metabolism and antitumor activity.","DOI":"10.21203\/rs.3.rs-8953703\/v1"},{"key":"10.1016\/j.medj.2026.101272_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1688995","article-title":"Metabolic reprogramming of CAR T cells: a new frontier in cancer immunotherapy","volume":"16","author":"Frlic","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib51","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.molmed.2025.05.014","article-title":"IL-15 in CAR engineering: striking an efficacy-safety balance","volume":"31","author":"Li","year":"2025","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.medj.2026.101272_bib52","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.trecan.2025.06.008","article-title":"IL-18 revives dysfunctional CAR-T cells","volume":"11","author":"Li","year":"2025","journal-title":"Trends Cancer"},{"key":"10.1016\/j.medj.2026.101272_bib53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-023-44310-y","article-title":"IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity","volume":"15","author":"Landoni","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.medj.2026.101272_bib54","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1016\/j.celrep.2017.11.063","article-title":"CAR T Cells Releasing IL-18 Convert to T-Bet(high) FoxO1(low) Effectors that Exhibit Augmented Activity against Advanced Solid Tumors","volume":"21","author":"Chmielewski","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.medj.2026.101272_bib55","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/s41586-024-08261-8","article-title":"Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers","volume":"637","author":"Steffin","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.medj.2026.101272_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adi8954","article-title":"MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis","volume":"9","author":"El Morr","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib57","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41467-025-56270-6","article-title":"Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.medj.2026.101272_bib58","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3389\/fimmu.2018.01943","article-title":"Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2\/HHD Mice","volume":"9","author":"Ehx","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib59","article-title":"Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors","volume":"11","author":"Li","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.medj.2026.101272_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.723544","article-title":"GVHD Pathogenesis, Prevention and Treatment: Lessons From Humanized Mouse Transplant Models","volume":"12","author":"Hess","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib61","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/s41385-018-0072-x","article-title":"Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation","volume":"11","author":"Tastan","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2025.103957","article-title":"Protocol for assessing pharmacokinetics and pharmacodynamics of human CAR-NKT cells in humanized mouse models using bioluminescence imaging","volume":"6","author":"Lyu","year":"2025","journal-title":"STAR Protoc."},{"key":"10.1016\/j.medj.2026.101272_bib63","doi-asserted-by":"crossref","first-page":"6942","DOI":"10.1038\/s41467-023-42619-2","article-title":"Unlocking the potential of allogeneic V\u03b42 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR\/IL-15 engineering","volume":"14","author":"Lee","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.medj.2026.101272_bib64","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.3390\/ijms23147547","article-title":"Tumor-Localized Administration of \u03b1-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors","volume":"23","author":"Li, Y.-R.","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.medj.2026.101272_bib65","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.4049\/jimmunol.1003965","article-title":"IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells","volume":"187","author":"Gordy","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib66","doi-asserted-by":"crossref","DOI":"10.1172\/JCI179014","article-title":"Off-the-shelf invariant NKT cells expressing anti-PSCA CAR and IL-15 promote pancreatic cancer regression in mice","volume":"135","author":"Dai","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.medj.2026.101272_bib67","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/s41385-021-00425-3","article-title":"Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates","volume":"14","author":"Sakai","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib68","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41577-024-01093-7","article-title":"From TCR fundamental research to innovative chimeric antigen receptor design","volume":"25","author":"Minguet","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib69","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41577-025-01174-1","article-title":"In vivo CAR engineering for immunotherapy","volume":"25","author":"Li","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib70","article-title":"Human Tumor-Infiltrating MAIT Cells Display Hallmarks of Bacterial Antigen Recognition in Colorectal Cancer","volume":"1","author":"Li","year":"2020","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.medj.2026.101272_bib71","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1007\/s00262-021-02939-y","article-title":"Exhaustion in tumor-infiltrating Mucosal-Associated Invariant T (MAIT) cells from colon cancer patients","volume":"70","author":"Rodin","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.medj.2026.101272_bib72","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13578-020-00518-9","article-title":"Decrease of peripheral blood mucosal-associated invariant T cells and impaired serum Granzyme-B production in patients with gastric cancer","volume":"11","author":"Shao","year":"2021","journal-title":"Cell Biosci."},{"key":"10.1016\/j.medj.2026.101272_bib73","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00262-017-2050-7","article-title":"Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment","volume":"66","author":"Shaler","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.medj.2026.101272_bib74","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1016\/j.cell.2025.04.032","article-title":"Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis","volume":"188","author":"Li","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.medj.2026.101272_bib75","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/mt.2013.8","article-title":"Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem\/progenitor cells","volume":"21","author":"Giannoni","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.medj.2026.101272_bib76","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1182\/blood-2005-11-4388","article-title":"Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus\/liver and CD34+ cell transplantation","volume":"108","author":"Lan","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.medj.2026.101272_bib77","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.stem.2019.08.004","article-title":"Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer","volume":"25","author":"Zhu","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.medj.2026.101272_bib78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/sji.12193","article-title":"The decrease in number and change in phenotype of mucosal-associated invariant T cells in the elderly and differences in men and women of reproductive age","volume":"80","author":"Novak","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib79","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.medj.2026.101272_bib80","doi-asserted-by":"crossref","first-page":"971","DOI":"10.4049\/jimmunol.1501402","article-title":"Engineering of Isogenic Cells Deficient for MR1 with a CRISPR\/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells","volume":"197","author":"Laugel","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.medj.2026.101272_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222313135","article-title":"The Curious Case of the HepG2 Cell Line: 40 Years of Expertise","volume":"22","author":"Arzumanian","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.medj.2026.101272_bib82","first-page":"2931","article-title":"SK-Hep1: not hepatocellular carcinoma cells but a cell model for liver sinusoidal endothelial cells","volume":"11","author":"Tai","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.medj.2026.101272_bib83","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40164-026-00746-8","article-title":"Stem cell engineering for the generation of allogeneic CAR-directed natural killer T cells targeting endometrial carcinoma","volume":"15","author":"Li","year":"2026","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.medj.2026.101272_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.bict.2025.100025","article-title":"Engineering optimal CAR constructs for allogeneic mesothelin-directed CAR-NKT cells in solid tumor immunotherapy","volume":"2","author":"Li","year":"2026","journal-title":"Blood Immunol. Cell. Ther."},{"key":"10.1016\/j.medj.2026.101272_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-026-01629-3","article-title":"Engineering an in vivo charging station for CAR-redirected invariant natural killer T cells to enhance cancer therapy","author":"Li","year":"2026","journal-title":"Nat. Biomed. Eng."}],"container-title":["Med"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666634026002758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666634026002758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:50:12Z","timestamp":1791561012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666634026002758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":85,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2666634026002758"],"URL":"https:\/\/doi.org\/10.1016\/j.medj.2026.101272","relation":{},"ISSN":["2666-6340"],"issn-type":[{"value":"2666-6340","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adoptive MAIT cell therapy for liver cancer enhanced by multimodal modulation of immune receptors and checkpoints","name":"articletitle","label":"Article Title"},{"value":"Med","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medj.2026.101272","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101272"}}