{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:09:43Z","timestamp":1789632583055,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["M\u00e9decine et Maladies Infectieuses"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.medmal.2009.02.033","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T04:18:13Z","timestamp":1240373893000},"page":"531-538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Corticosteroids for acute adult bacterial meningitis"],"prefix":"10.1016","volume":"39","author":[{"given":"D.","family":"van de Beek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medmal.2009.02.033_bib1","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1056\/NEJMp048246","article-title":"Bacterial meningitis--a view of the past 90 years","volume":"351","author":"Swartz","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib2","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1056\/NEJMoa040845","article-title":"Clinical features and prognostic factors in adults with bacterial meningitis","volume":"351","author":"van de Beek","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMra052116","article-title":"Community-acquired bacterial meningitis in adults","volume":"354","author":"van de Beek","year":"2006","journal-title":"N Engl Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ncpneuro0713","article-title":"Drug Insight: corticosteroids in CNS infectious diseases--new indications for an old therapy","volume":"4","author":"Fitch","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.medmal.2009.02.033_bib5","doi-asserted-by":"crossref","unstructured":"van de Beek D, de Gans J, McIntyre P, Prasad K. Corticocorticosteroids in acute bacterial meningitis. The Cochrane Library, issue 1, 2007. Chichester, UK: John Wiley & Sons, Ltd.","DOI":"10.1002\/14651858.CD004405.pub2"},{"key":"10.1016\/j.medmal.2009.02.033_bib6","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1056\/NEJMoa021334","article-title":"Dexamethasone in adults with bacterial meningitis","volume":"347","author":"de Gans","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2165\/00003088-200544010-00003","article-title":"Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids","volume":"44","author":"Czock","year":"2005","journal-title":"Clin Pharmacokin"},{"key":"10.1016\/j.medmal.2009.02.033_bib8","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2165\/00003495-200666040-00002","article-title":"Dexamethasone in adults with bacterial meningitis","volume":"66","author":"van de Beek","year":"2006","journal-title":"Drugs"},{"key":"10.1016\/j.medmal.2009.02.033_bib9","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S1474-4422(06)70409-4","article-title":"Pneumococcal meningitis in adults: new approaches to management and prevention","volume":"5","author":"Weisfelt","year":"2006","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.medmal.2009.02.033_bib10","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/ncpneuro0265","article-title":"Drug insight: adjunctive therapies in adults with bacterial meningitis","volume":"2","author":"van de Beek","year":"2006","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.medmal.2009.02.033_bib11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/jac\/dkg417","article-title":"Factors influencing the anti-inflammatory effect of dexamethasone therapy in experimental pneumococcal meningitis","volume":"52","author":"Lutsar","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.medmal.2009.02.033_bib12","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1001\/jama.1963.63700060029012","article-title":"The effectiveness of hydrocortisone in the management of severe infections","volume":"183","author":"Bennett","year":"1963","journal-title":"JAMA"},{"key":"10.1016\/j.medmal.2009.02.033_bib13","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1097\/00006454-198912000-00004","article-title":"Dexamethasone treatment for bacterial meningitis in children and adults","volume":"8","author":"Girgis","year":"1989","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.medmal.2009.02.033_bib14","first-page":"63","article-title":"Dexamethasone therapy for bacterial meningitis in adults: a double-blind placebo control study","volume":"50","author":"Gijwani","year":"2002","journal-title":"Neurol India"},{"key":"10.1016\/j.medmal.2009.02.033_bib15","first-page":"225","article-title":"Role of dexamethasone as adjunctive therapy in acute bacterial meningitis in adults","volume":"46","author":"Bhaumik","year":"1998","journal-title":"Neurol India"},{"key":"10.1016\/j.medmal.2009.02.033_bib16","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s001340050883","article-title":"Trial of dexamethasone treatment for severe bacterial meningitis in adults","volume":"25","author":"Thomas","year":"1999","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib17","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa070852","article-title":"Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis","volume":"357","author":"Nguyen","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib18","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa065711","article-title":"Corticocorticosteroids for bacterial meningitis in adults in sub-Saharan Africa","volume":"357","author":"Scarborough","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1473-3099(04)00937-5","article-title":"Corticosteroids in adults with bacterial meningitis: a systematic review","volume":"4","author":"van de Beek","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.033_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.7326\/0003-4819-141-4-200408170-00028","article-title":"Dexamethasone and pneumococcal meningitis","volume":"141","author":"van de Beek","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10096-006-0089-z","article-title":"Dexamethasone in adults with pneumococcal meningitis: risk factors for death","volume":"25","author":"Weisfelt","year":"2006","journal-title":"Eur J Clin Microb Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.033_bib22","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00415-005-0061-3","article-title":"Dexamethasone and prognostic factors in adults with bacterial meningitis","volume":"253","author":"Weisfelt","year":"2006","journal-title":"J Neurol"},{"key":"10.1016\/j.medmal.2009.02.033_bib23","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/infdis\/169.4.853","article-title":"Dexamethasone therapy for bacterial meningitis in children: 2- versus 4-day regimen","volume":"169","author":"Syrogiannopoulos","year":"1994","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.033_bib24","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1001\/jama.1989.03430190084036","article-title":"Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations","volume":"262","author":"Spanos","year":"1989","journal-title":"JAMA"},{"key":"10.1016\/j.medmal.2009.02.033_bib25","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1056\/NEJMe020131","article-title":"Corticocorticosteroids for everyone with meningitis?","volume":"347","author":"Tunkel","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib26","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/brain\/awg141","article-title":"Pneumococcal meningitis: antibiotics essential but insufficient","volume":"126","author":"Davis","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.medmal.2009.02.033_bib27","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/bmj.326.7397.996","article-title":"Management of bacterial meningitis in adults","volume":"326","author":"Cohen","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.medmal.2009.02.033_bib28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/jac\/49.4.661","article-title":"Antibiotic guidelines and antibiotic use in adult bacterial meningitis in The Netherlands","volume":"49","author":"Van de Beek","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.medmal.2009.02.033_bib29","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1097\/00003246-199508000-00019","article-title":"Corticocorticosteroid treatment for sepsis: a critical appraisal and meta-analysis of the literature","volume":"23","author":"Cronin","year":"1995","journal-title":"Crit Care Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib30","doi-asserted-by":"crossref","unstructured":"Annane D, Bellissant E, Bollaert P, Briegel J, Keh D, Kupfer Y. Corticocorticosteroids for treating severe sepsis and septic shock. The Cochrane Library, issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.","DOI":"10.1002\/14651858.CD002243.pub2"},{"key":"10.1016\/j.medmal.2009.02.033_bib31","first-page":"862","volume":"288","author":"Annane","year":"2002","journal-title":"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA"},{"key":"10.1016\/j.medmal.2009.02.033_bib32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa071366","article-title":"Hydrocortisone therapy for patients with septic shock","volume":"358","author":"Sprung","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.033_bib33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/jac\/45.3.315","article-title":"Evaluation of combined ceftriaxone and dexamethasone therapy in experimental cephalosporin-resistant pneumococcal meningitis","volume":"45","author":"Cabellos","year":"2000","journal-title":"J Antimicrob Chemoth"},{"key":"10.1016\/j.medmal.2009.02.033_bib34","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1128\/AAC.39.9.1988","article-title":"Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis","volume":"39","author":"Klugman","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.medmal.2009.02.033_bib35","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1128\/AAC.35.12.2467","article-title":"Evaluation of vancomycin for therapy of adult pneumococcal meningitis","volume":"35","author":"Viladrich","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.medmal.2009.02.033_bib36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1086\/510390","article-title":"Levels of vancomycin in cerebrospinal fluid of adult patients receiving adjunctive corticocorticosteroids to treat pneumococcal meningitis: a prospective multicenter observational study","volume":"44","author":"Ricard","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.033_bib37","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1086\/344229","article-title":"Cognitive impairment in adults with good recovery after bacterial meningitis","volume":"186","author":"van de Beek","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.033_bib38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1203\/01.PDR.0000079185.67878.72","article-title":"Dexamethasone aggravates hippocampal apoptosis and learning deficiency in pneumococcal meningitis in infant rats","volume":"54","author":"Leib","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.medmal.2009.02.033_bib39","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/ana.20944","article-title":"Dexamethasone and long-term outcome in adults with bacterial meningitis","volume":"60","author":"Weisfelt","year":"2006","journal-title":"Ann Neurol"}],"container-title":["M\u00e9decine et Maladies Infectieuses"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0399077X09000948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0399077X09000948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:09:49Z","timestamp":1759972189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0399077X09000948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":39,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0399077X09000948"],"URL":"https:\/\/doi.org\/10.1016\/j.medmal.2009.02.033","relation":{},"ISSN":["0399-077X"],"issn-type":[{"value":"0399-077X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Corticosteroids for acute adult bacterial meningitis","name":"articletitle","label":"Article Title"},{"value":"M\u00e9decine et Maladies Infectieuses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medmal.2009.02.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}