{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:34:28Z","timestamp":1761647668825,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["M\u00e9decine et Maladies Infectieuses"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.medmal.2009.02.036","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T05:34:38Z","timestamp":1240983278000},"page":"493-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Degr\u00e9 d\u2019urgence de l\u2019antibioth\u00e9rapie d\u2019un patient pr\u00e9sentant une m\u00e9ningite pr\u00e9sum\u00e9e bact\u00e9rienne\u00a0: mod\u00e8les exp\u00e9rimentaux et donn\u00e9es cliniques"],"prefix":"10.1016","volume":"39","author":[{"given":"M.","family":"Wolff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-M.","family":"Decazes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.medmal.2009.02.036_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1056\/NEJM197702242960806","article-title":"Relation of concentrations of bacteria and bacterial antigen in cerebrospinal fluid to prognosis in patients with bacterial meningitis","volume":"296","author":"Feldman","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.036_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1128\/iai.41.1.275-279.1983","article-title":"Experimental pneumococcal meningitis: role of leucocytes in pathogenesis","volume":"41","author":"Ernst","year":"1983","journal-title":"Infect Immun"},{"key":"10.1016\/j.medmal.2009.02.036_bib3","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1073\/pnas.75.3.1534","article-title":"Haemophilus influenzae bacteremia and meningitis resulting from the survival of a sigle organism","volume":"75","author":"Moxon","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.medmal.2009.02.036_bib4","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1086\/344939","article-title":"Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury","volume":"186","author":"Scheld","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.036_bib5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1128\/iai.24.1.102-105.1979","article-title":"Clearance of bacteria from cerebrospinal fluid to blood in experimental meningitis","volume":"24","author":"Scheld","year":"1979","journal-title":"Infect Immun"},{"key":"10.1016\/j.medmal.2009.02.036_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1086\/524874","article-title":"Impact of bacteremia on the pathogenesis of experimental pneumococcal meningitis","volume":"197","author":"Brandt","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.036_bib7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/infdis\/151.3.528","article-title":"Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis","volume":"151","author":"Tauber","year":"1985","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.036_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1152\/japplphysiol.00697.2006","article-title":"Cerebral blood flow autoregulation in early experimental S.\u00a0pneumoniae meningitis","volume":"102","author":"Pedersen","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.medmal.2009.02.036_bib9","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1053\/hn.1999.v120.a92772","article-title":"Time course of hearing loss in an animal model of pneumococcal meningitis","volume":"120","author":"Kesser","year":"1999","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.medmal.2009.02.036_bib10","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/infdis\/167.3.675","article-title":"Progression of hearing loss in experimental pneumococcal meningitis: correlation with cerebrospinal fluid cytochemistry","volume":"167","author":"Bhatt","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.036_bib11","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1086\/314531","article-title":"Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac","volume":"179","author":"Rappaport","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.036_bib12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3181\/00379727-150-38989","article-title":"Experimental pneumococcal meningitis: III. Chemotactic activity in cerebrospinal fluid","volume":"150","author":"Nolan","year":"1975","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.medmal.2009.02.036_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1128\/iai.46.1.81-86.1984","article-title":"Complement (C5)-derived chemotactic activity accounts for accumulation of polymorphonuclear leukocytes in cerebrospinal fluid of rabbits with pneumococcal meningitis","volume":"46","author":"Ernst","year":"1984","journal-title":"Infect Immun"},{"key":"10.1016\/j.medmal.2009.02.036_bib14","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/infdis\/160.5.818","article-title":"Modulation of inflammation and cachectin activity in relation to treatment of experimental Haemophilus influenzae type b meningitis","volume":"160","author":"Mustafa","year":"1989","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.036_bib15","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI114292","article-title":"Tumor necrosis factor in mediating experimental Haemophilus influenzae type b meningitis","volume":"84","author":"Mustafa","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.medmal.2009.02.036_bib16","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1128\/AAC.01014-06","article-title":"Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis","volume":"51","author":"Grandgirard","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.medmal.2009.02.036_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1542\/peds.83.2.161","article-title":"Delayed cerebro-spinal fuild sterilization and adverse outcome of bacterial meningitis in infants and children","volume":"83","author":"Lebel","year":"1989","journal-title":"Pediatrics"},{"key":"10.1016\/j.medmal.2009.02.036_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1056\/NEJM199001183220301","article-title":"A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children","volume":"322","author":"Schaad","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.medmal.2009.02.036_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/bmj.305.6846.143","article-title":"Early treatment with parenteral penicillin in meningococcal diease","volume":"305","author":"Cartwight","year":"1992","journal-title":"BMJ"},{"key":"10.1016\/j.medmal.2009.02.036_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/bmj.305.6846.141","article-title":"Meningococcal infections: reducing the case fatality rate by giving penicillin before admission to hospital","volume":"305","author":"Strang","year":"1992","journal-title":"BMJ"},{"key":"10.1016\/j.medmal.2009.02.036_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0163-4453(95)80001-8","article-title":"Bacterial meningitis: cause for concern","volume":"30","author":"The Research Committee of the BSSI","year":"1995","journal-title":"J Infect"},{"key":"10.1016\/j.medmal.2009.02.036_bib22","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1136\/bmj.38789.723611.55","article-title":"Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study","volume":"332","author":"Harnden","year":"2006","journal-title":"BMJ"},{"key":"10.1016\/j.medmal.2009.02.036_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/clinids\/23.1.1","article-title":"Infectious disease issues in the emergency department","volume":"23","author":"Talan","year":"1996","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.medmal.2009.02.036_bib24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/qjmed\/hcl111","article-title":"Quality of in-hospital care for adults with bacterial meningitis: a national retrospective survey","volume":"99","author":"Gjni","year":"2006","journal-title":"QJM"},{"key":"10.1016\/j.medmal.2009.02.036_bib25","doi-asserted-by":"crossref","first-page":"862","DOI":"10.7326\/0003-4819-129-11_Part_1-199812010-00004","article-title":"Community-acquired bacterial meningitis: risk stratification for adverse outcome and effect of antibiotic timing","volume":"129","author":"Aronin","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.medmal.2009.02.036_bib26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0303-8467(02)00052-5","article-title":"Community-acquired bacterial meningitis in adults: the epidemiology, timing of appropriate antimicrobial therapy, and prognostic factors","volume":"104","author":"Lu","year":"2002","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.medmal.2009.02.036_bib27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0736-4679(01)00407-3","article-title":"Presentation, time to antibiotics, and mortality of patients with bacterial meningitis at an urban medical center","volume":"21","author":"Miner","year":"2001","journal-title":"J Emerg Med"},{"key":"10.1016\/j.medmal.2009.02.036_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/qjmed\/hci047","article-title":"Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis","volume":"98","author":"Proulx","year":"2005","journal-title":"QJM"},{"key":"10.1016\/j.medmal.2009.02.036_bib29","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1097\/01.CCM.0000239434.26669.65","article-title":"Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study","volume":"34","author":"Auburtin","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.medmal.2009.02.036_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s15010-007-6202-0","article-title":"Community-acquired bacterial meningitis in adults: antibiotic timing in disease course and outcome","volume":"35","author":"Lepur","year":"2007","journal-title":"Infection"},{"key":"10.1016\/j.medmal.2009.02.036_bib31","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1097\/01.CCM.0000217961.75225.E9","article-title":"Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock","volume":"34","author":"Kumar","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.medmal.2009.02.036_bib32","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1086\/425368","article-title":"Practice guidelines for the management of bacterial meningitis","volume":"39","author":"Tunkel","year":"2004","journal-title":"Clin Infect Dis"}],"container-title":["M\u00e9decine et Maladies Infectieuses"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0399077X09000973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0399077X09000973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:08:49Z","timestamp":1759972129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0399077X09000973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":32,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0399077X09000973"],"URL":"https:\/\/doi.org\/10.1016\/j.medmal.2009.02.036","relation":{},"ISSN":["0399-077X"],"issn-type":[{"type":"print","value":"0399-077X"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Degr\u00e9 d\u2019urgence de l\u2019antibioth\u00e9rapie d\u2019un patient pr\u00e9sentant une m\u00e9ningite pr\u00e9sum\u00e9e bact\u00e9rienne\u00a0: mod\u00e8les exp\u00e9rimentaux et donn\u00e9es cliniques","name":"articletitle","label":"Article Title"},{"value":"M\u00e9decine et Maladies Infectieuses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medmal.2009.02.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}