{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:27:46Z","timestamp":1789705666593,"version":"4.0.1"},"reference-count":101,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["M\u00e9decine et Maladies Infectieuses"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.medmal.2018.08.003","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T17:57:18Z","timestamp":1537898238000},"page":"213-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Management of severe imported malaria in adults"],"prefix":"10.1016","volume":"50","author":[{"given":"F.","family":"Bruneel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Raffetin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Corne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Llitjos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Mourvillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Argaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Jaur\u00e9guiberry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.medmal.2018.08.003_bib0005","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S1473-3099(16)30326-7","article-title":"The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics","volume":"17","author":"Tatem","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"10.1016\/j.medmal.2018.08.003_bib0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s12936-017-1936-3","article-title":"Malaria after international travel: a GeoSentinel analysis, 2003\u20132016","volume":"16","author":"Angelo","year":"2017","journal-title":"Malar J"},{"key":"10.1016\/j.medmal.2018.08.003_bib0015","article-title":"Management and prevention of imported malaria (Revision 2018 of the 2007 Recommendations for clinical practice). Long text","author":"Soci\u00e9t\u00e9 de pathologie infectieuse de langue fran\u00e7aise","year":"2018","journal-title":"Med Mal Infect"},{"issue":"2","key":"10.1016\/j.medmal.2018.08.003_bib0020","first-page":"68","article-title":"[Management and prevention of imported Plasmodium falciparum malaria (Revision 2007 of the 1999 Consensus Conference). Long text in French]","volume":"38","author":"Soci\u00e9t\u00e9 de pathologie infectieuse de langue fran\u00e7aise","year":"2008","journal-title":"Med Mal Infect"},{"key":"10.1016\/j.medmal.2018.08.003_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/tmi.12313_2","article-title":"Severe malaria","volume":"19","year":"2014","journal-title":"Trop Med Int Health"},{"issue":"1","key":"10.1016\/j.medmal.2018.08.003_bib0030","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12936-016-1673-z","article-title":"Severe malaria in Europe: an 8-year multi-centre observational study","volume":"16","author":"Kurth","year":"2017","journal-title":"Malar J"},{"issue":"10","key":"10.1016\/j.medmal.2018.08.003_bib0035","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1007\/s00134-016-4356-x","article-title":"Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study","volume":"42","author":"Bruneel","year":"2016","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1016\/j.medmal.2018.08.003_bib0040","first-page":"1","article-title":"Artesunate to treat severe malaria in travellers: review of efficacy and safety and practical implications","volume":"24","author":"Roussel","year":"2016","journal-title":"J Travel Med"},{"issue":"10","key":"10.1016\/j.medmal.2018.08.003_bib0045","doi-asserted-by":"crossref","first-page":"e13236","DOI":"10.1371\/journal.pone.0013236","article-title":"Severe imported falciparum malaria: a cohort study in 400 critically ill adults","volume":"5","author":"Bruneel","year":"2010","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0050","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1164\/rccm.200206-631OC","article-title":"The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults","volume":"167","author":"Bruneel","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.medmal.2018.08.003_bib0055","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1086\/374224","article-title":"Age as a risk factor for severe manifestations and fatal outcome of falciparum malaria in European patients: observations from TropNetEurop and SIMPID Surveillance Data","volume":"36","author":"M\u00fchlberger","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.medmal.2018.08.003_bib0060","doi-asserted-by":"crossref","first-page":"e2116","DOI":"10.1136\/bmj.e2116","article-title":"Risk factors for mortality from imported falciparum malaria in the United Kingdom over 20 years: an observational study","volume":"344","author":"Checkley","year":"2012","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.medmal.2018.08.003_bib0065","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/cid\/civ575","article-title":"Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet Severe Malaria Study","volume":"61","author":"Kurth","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.medmal.2018.08.003_bib0070","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood-2014-02-555953","article-title":"Postartesunate delayed hemolysis is a predictable event related to the lifesaving effect of artemisinins","volume":"124","author":"Jaur\u00e9guiberry","year":"2014","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0075","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3201\/eid1705.101229","article-title":"Intravenous artesunate for severe malaria in travelers, Europe","volume":"17","author":"Zoller","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.medmal.2018.08.003_bib0080","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1475-2875-11-102","article-title":"Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium","volume":"11","author":"Kreeftmeijer-Vegter","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.medmal.2018.08.003_bib0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1475-2875-12-241","article-title":"Artesunate versus quinine in the treatment of severe imported malaria: comparative analysis of adverse events focussing on delayed haemolysis","volume":"12","author":"Rolling","year":"2013","journal-title":"Malar J"},{"key":"10.1016\/j.medmal.2018.08.003_bib0090","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-2334-13-118","article-title":"Severe imported falciparum malaria among adults requiring intensive care: a retrospective study at the hospital for tropical diseases, London","volume":"13","author":"Marks","year":"2013","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.medmal.2018.08.003_bib0095","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1475-2875-11-96","article-title":"Severe imported malaria in an intensive care unit: a review of 59 cases","volume":"11","author":"Santos","year":"2012","journal-title":"Malar J"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0100","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3201\/eid1306.060955","article-title":"Risk factors for imported fatal Plasmodium falciparum malaria, France, 1996\u20132003","volume":"13","author":"Legros","year":"2007","journal-title":"Emerg Infect Dis"},{"issue":"7","key":"10.1016\/j.medmal.2018.08.003_bib0105","doi-asserted-by":"crossref","first-page":"498","DOI":"10.7326\/M15-0910","article-title":"Intravenous artesunate for the treatment of severe and complicated malaria in the United States: clinical use under an investigational new drug protocol","volume":"163","author":"Twomey","year":"2015","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0110","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3201\/eid2105.141171","article-title":"Delayed-onset hemolytic anemia in patients with travel-associated severe malaria treated with artesunate, France, 2011\u20132013","volume":"21","author":"Jaur\u00e9guiberry","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.medmal.2018.08.003_bib0115","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1475-2875-13-79","article-title":"Imported falciparum malaria among adults requiring intensive care: analysis of the literature","volume":"13","author":"Marks","year":"2014","journal-title":"Malar J"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0120","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3201\/eid1705.101527","article-title":"Severe imported Plasmodium falciparum malaria, France, 1996\u20132003","volume":"17","author":"Seringe","year":"2011","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"10.1016\/j.medmal.2018.08.003_bib0125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4269\/ajtmh.17-0101","article-title":"Malaria-related hospitalizations in the United States, 2000\u20132014","volume":"97","author":"Khuu","year":"2017","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0130","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/cid\/cix437","article-title":"Obesity and diabetes as risk factors for severe Plasmodium falciparum malaria: results from a Swedish nationwide study","volume":"65","author":"Wyss","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0135","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jinf.2016.02.001","article-title":"UK malaria treatment guidelines 2016","volume":"72","author":"Lalloo","year":"2016","journal-title":"J Infect"},{"issue":"328","key":"10.1016\/j.medmal.2018.08.003_bib0140","first-page":"10","article-title":"Management of imported malaria in Europe","volume":"11","author":"Askling","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.medmal.2018.08.003_bib0145","series-title":"Guidelines for the treatment of malaria","year":"2010"},{"key":"10.1016\/j.medmal.2018.08.003_bib0150","series-title":"Guidelines for the treatment of malaria","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.medmal.2018.08.003_bib0155","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12916-015-0324-5","article-title":"The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis","volume":"13","author":"Hanson","year":"2015","journal-title":"BMC Med"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0160","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.eimc.2013.12.014","article-title":"[Diagnosis and treatment of imported malaria in Spain: Recommendations from the Malaria Working Group of the Spanish Society of Tropical Medicine and International Health (SEMTSI)]","volume":"33","author":"Mu\u00f1oz","year":"2015","journal-title":"Enfermedades Infecc Microbiol Cl\u00ednica"},{"issue":"8","key":"10.1016\/j.medmal.2018.08.003_bib0165","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0170","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1086\/649928","article-title":"A simple score to predict the outcome of severe malaria in adults","volume":"50","author":"Hanson","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.medmal.2018.08.003_bib0175","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1475-2875-12-229","article-title":"Prognostic indicators in adults hospitalized with falciparum malaria in Western Thailand","volume":"12","author":"Newton","year":"2013","journal-title":"Malar J"},{"issue":"1","key":"10.1016\/j.medmal.2018.08.003_bib0180","doi-asserted-by":"crossref","first-page":"e87020","DOI":"10.1371\/journal.pone.0087020","article-title":"Rapid clinical assessment to facilitate the triage of adults with falciparum malaria, a retrospective analysis","volume":"9","author":"Hanson","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.medmal.2018.08.003_bib0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1475-2875-6-24","article-title":"Prediction of outcome in adults with severe falciparum malaria: a new scoring system","volume":"6","author":"Mishra","year":"2007","journal-title":"Malar J"},{"key":"10.1016\/j.medmal.2018.08.003_bib0190","first-page":"119","article-title":"The malaria severity score: a method for severity assessment and risk prediction of hospital mortality for falciparum malaria in adults","volume":"57","author":"Mohapatra","year":"2009","journal-title":"J Assoc Physicians India"},{"issue":"1","key":"10.1016\/j.medmal.2018.08.003_bib0195","first-page":"14","article-title":"GCRBS score: a new scoring system for predicting outcome in severe falciparum malaria","volume":"62","author":"Mohapatra","year":"2014","journal-title":"J Assoc Physicians India"},{"issue":"7","key":"10.1016\/j.medmal.2018.08.003_bib0200","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1128\/AAC.41.7.1413","article-title":"Assessment of the pharmacodynamic properties of antimalarial drugs in vivo","volume":"41","author":"White","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.medmal.2018.08.003_bib0205","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/1475-2875-11-255","article-title":"Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8mg\/kg in healthy volunteers: phase 1b study","volume":"11","author":"Miller","year":"2012","journal-title":"Malar J"},{"issue":"3","key":"10.1016\/j.medmal.2018.08.003_bib0210","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/infdis\/173.3.691","article-title":"Antimalarial drugs reduce cytoadherence and rosetting Plasmodium falciparum","volume":"173","author":"Udomsangpetch","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2018.08.003_bib0215","first-page":"CD005967","article-title":"Artesunate versus quinine for treating severe malaria","volume":"6","author":"Sinclair","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"10.1016\/j.medmal.2018.08.003_bib0220","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1038\/psp.2014.43","article-title":"Population pharmacokinetics of intravenous artesunate: a pooled analysis of individual data from patients with severe malaria","volume":"3","author":"Zaloumis","year":"2014","journal-title":"CPT Pharmacomet Syst Pharmacol"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0225","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/clpt.2013.26","article-title":"Population pharmacokinetics of intramuscular artesunate in African children with severe malaria: implications for a practical dosing regimen","volume":"93","author":"Hendriksen","year":"2013","journal-title":"Clin Pharmacol Ther"},{"issue":"9487","key":"10.1016\/j.medmal.2018.08.003_bib0230","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(05)67176-0","article-title":"Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial","volume":"366","author":"Dondorp","year":"2005","journal-title":"Lancet"},{"issue":"9753","key":"10.1016\/j.medmal.2018.08.003_bib0235","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(10)61924-1","article-title":"Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial","volume":"376","author":"Dondorp","year":"2010","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0240","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3109\/10408441003610571","article-title":"Toxicity of the antimalarial artemisinin and its dervatives","volume":"40","author":"Efferth","year":"2010","journal-title":"Crit Rev Toxicol"},{"issue":"7\u20138","key":"10.1016\/j.medmal.2018.08.003_bib0245","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1345\/aph.1M732","article-title":"Intravenous artesunate for the treatment of severe malaria","volume":"44","author":"Hess","year":"2010","journal-title":"Ann Pharmacother"},{"issue":"3 Suppl.","key":"10.1016\/j.medmal.2018.08.003_bib0250","first-page":"50","article-title":"Safety of artemisinin and its derivatives. A review of published and unpublished clinical trials","volume":"58","author":"Ribeiro","year":"1998","journal-title":"Med Trop Rev Corps Sante Colon"},{"issue":"17","key":"10.1016\/j.medmal.2018.08.003_bib0255","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1056\/NEJMct0709050","article-title":"Artesunate for the treatment of severe falciparum malaria","volume":"358","author":"Rosenthal","year":"2008","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.medmal.2018.08.003_bib0260","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1182\/blood-2014-06-578922","article-title":"Case definition: postartemisinin delayed hemolysis","volume":"124","author":"Arguin","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.medmal.2018.08.003_bib0265","series-title":"Avis relatif \u00e0 la place de l\u2019art\u00e9sunate injectable dans le traitement du paludisme grave chez l\u2019adulte et l\u2019enfant","author":"HCSP","year":"2013"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0270","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N Engl J Med"},{"issue":"7481","key":"10.1016\/j.medmal.2018.08.003_bib0275","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"issue":"217","key":"10.1016\/j.medmal.2018.08.003_bib0280","first-page":"10","article-title":"Severe malaria in Battambang Referral Hospital, an area of multidrug resistance in Western-Cambodia: a retrospective analysis of cases from 2006\u20132009","volume":"12","author":"Lon","year":"2013","journal-title":"Malar J"},{"issue":"12","key":"10.1016\/j.medmal.2018.08.003_bib0285","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1473-3099(13)70252-4","article-title":"Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies","volume":"13","author":"Witkowski","year":"2013","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"10.1016\/j.medmal.2018.08.003_bib0290","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1056\/NEJMp1108322","article-title":"The threat of artemisinin-resistant malaria","volume":"365","author":"Dondorp","year":"2011","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0295","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ijantimicag.2017.01.032","article-title":"Absence of association between polymorphisms in the K13 gene and the presence of Plasmodium falciparum parasites at day 3 after treatment with artemisinin derivatives in Senegal","volume":"49","author":"Madamet","year":"2017","journal-title":"Int J Antimicrob Agents"},{"issue":"10","key":"10.1016\/j.medmal.2018.08.003_bib0300","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMc1612765","article-title":"Emergence of indigenous artemisinin-resistant Plasmodium falciparum in Africa","volume":"376","author":"Lu","year":"2017","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0305","doi-asserted-by":"crossref","first-page":"e19283","DOI":"10.1371\/journal.pone.0019283","article-title":"Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial","volume":"6","author":"Bethell","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0310","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1093\/cid\/cis958","article-title":"Effect of high-dose or split-dose artesunate on parasite clearance in artemisinin-resistant falciparum malaria","volume":"56","author":"Das","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.medmal.2018.08.003_bib0315","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1128\/AAC.00686-12","article-title":"Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010","volume":"57","author":"Leang","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.medmal.2018.08.003_bib0320","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12936-016-1160-6","article-title":"The influence of pregnancy on the pharmacokinetic properties of artemisinin combination therapy (ACT): a systematic review","volume":"15","author":"Burger","year":"2016","journal-title":"Malar J"},{"issue":"191","key":"10.1016\/j.medmal.2018.08.003_bib0325","first-page":"10","article-title":"Uncomplicated Plasmodium vivax malaria in pregnancy associated with mortality from acute respiratory distress syndrome","volume":"13","author":"McGready","year":"2014","journal-title":"Malar J"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0330","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4269\/ajtmh.2002.67.473","article-title":"Diuretic effect of sodium artesunate in patients with malaria","volume":"67","author":"Seguro","year":"2002","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"10.1016\/j.medmal.2018.08.003_bib0335","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1179\/2047773212Y.0000000032","article-title":"Intravenous artesunate versus intravenous quinine in the treatment of severe falciparum malaria: a retrospective evaluation from a UK centre","volume":"106","author":"Eder","year":"2012","journal-title":"Pathog Glob Health"},{"issue":"1","key":"10.1016\/j.medmal.2018.08.003_bib0340","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/0971-4065.83737","article-title":"Outcome and prognostic factors of malaria-associated acute kidney injury requiring hemodialysis: a single center experience","volume":"22","author":"Kute","year":"2012","journal-title":"Indian J Nephrol"},{"issue":"952","key":"10.1016\/j.medmal.2018.08.003_bib0345","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/pgmj.2004.028399","article-title":"Artemisinins","volume":"81","author":"Woodrow","year":"2005","journal-title":"Postgrad Med J"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0350","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4269\/ajtmh.2001.65.690","article-title":"Artemisinin for treatment of uncomplicated falciparum malaria: is there a place for monotherapy?","volume":"65","author":"Giao","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.medmal.2018.08.003_bib0355","series-title":"Protocol for the therapeutic use of artesunate","author":"French Agency for the Safety of Health Products (ANSM)","year":"2013"},{"issue":"8","key":"10.1016\/j.medmal.2018.08.003_bib0360","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1086\/319743","article-title":"Resurgence of blackwater fever in long-term European expatriates in Africa: report of 21 cases and review","volume":"32","author":"Bruneel","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.medmal.2018.08.003_bib0365","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1475-2875-13-177","article-title":"Magnetic resonance imaging of the brain in adults with severe falciparum malaria","volume":"13","author":"Maude","year":"2014","journal-title":"Malar J"},{"issue":"12","key":"10.1016\/j.medmal.2018.08.003_bib0370","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1056\/NEJMoa1400116","article-title":"Brain swelling and death in children with cerebral malaria","volume":"372","author":"Seydel","year":"2015","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.medmal.2018.08.003_bib0375","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3174\/ajnr.A3035","article-title":"Acute brain MRI findings in 120 Malawian children with cerebral malaria: new insights into an ancient disease","volume":"33","author":"Potchen","year":"2012","journal-title":"AJNR Am J Neuroradiol"},{"issue":"4","key":"10.1016\/j.medmal.2018.08.003_bib0380","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/cid\/cir405","article-title":"Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial","volume":"53","author":"Mohanty","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0385","first-page":"152","article-title":"Neuropaludisme\u00a0: de la physiopathologie \u00e0 la clinique","volume":"XXI","author":"Laurent","year":"2017","journal-title":"Lett Neurol"},{"issue":"5","key":"10.1016\/j.medmal.2018.08.003_bib0390","doi-asserted-by":"crossref","first-page":"790","DOI":"10.4269\/ajtmh.2006.75.790","article-title":"Malarial retinopathy: a newly established diagnostic sign in severe malaria","volume":"75","author":"Beare","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"7","key":"10.1016\/j.medmal.2018.08.003_bib0395","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.trstmh.2009.03.001","article-title":"The spectrum of retinopathy in adults with Plasmodium falciparum malaria","volume":"103","author":"Maude","year":"2009","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"1","key":"10.1016\/j.medmal.2018.08.003_bib0400","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4269\/ajtmh.2011.10-0205","article-title":"Malarial retinopathy in Bangladeshi adults","volume":"84","author":"Abu Sayeed","year":"2011","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0405","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jcrc.2013.09.001","article-title":"Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial","volume":"28","author":"Gwer","year":"2013","journal-title":"J Crit Care"},{"issue":"9205","key":"10.1016\/j.medmal.2018.08.003_bib0410","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0140-6736(99)07148-2","article-title":"Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study","volume":"355","author":"Crawley","year":"2000","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.medmal.2018.08.003_bib0415","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/infdis\/jis400","article-title":"Relative contributions of macrovascular and microvascular dysfunction to disease severity in falciparum malaria","volume":"206","author":"Hanson","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2018.08.003_bib0420","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/1475-2875-12-348","article-title":"The reliability of the physical examination to guide fluid therapy in adults with severe falciparum malaria: an observational study","volume":"12","author":"Hanson","year":"2013","journal-title":"Malar J"},{"issue":"4","key":"10.1016\/j.medmal.2018.08.003_bib0425","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1097\/CCM.0b013e31827466d2","article-title":"Fluid resuscitation of adults with severe falciparum malaria: effects on Acid-base status, renal function, and extravascular lung water","volume":"41","author":"Hanson","year":"2013","journal-title":"Crit Care Med"},{"issue":"10","key":"10.1016\/j.medmal.2018.08.003_bib0430","doi-asserted-by":"crossref","first-page":"e25523","DOI":"10.1371\/journal.pone.0025523","article-title":"A retrospective analysis of the haemodynamic and metabolic effects of fluid resuscitation in Vietnamese adults with severe falciparum malaria","volume":"6","author":"Nguyen","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.medmal.2018.08.003_bib0435","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/1475-2875-10-342","article-title":"Central venous catheter use in severe malaria: time to reconsider the World Health Organization guidelines?","volume":"10","author":"Hanson","year":"2011","journal-title":"Malar J"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0440","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1186\/s13054-014-0642-6","article-title":"The fluid management of adults with severe malaria","volume":"18","author":"Hanson","year":"2014","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0445","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s001340050396","article-title":"Shock complicating severe falciparum malaria in European adults","volume":"23","author":"Bruneel","year":"1997","journal-title":"Intensive Care Med"},{"issue":"10","key":"10.1016\/j.medmal.2018.08.003_bib0450","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s001340000651","article-title":"Hemodynamic aspects and oxygenation variables in severe malaria of adults in Africa","volume":"26","author":"Sa\u00efssy","year":"2000","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.medmal.2018.08.003_bib0455","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/1475-2875-10-160","article-title":"Reduced cardiac output in imported Plasmodium falciparum malaria","volume":"10","author":"Herr","year":"2011","journal-title":"Malar J"},{"issue":"2","key":"10.1016\/j.medmal.2018.08.003_bib0460","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1378\/chest.11-2655","article-title":"Respiratory manifestations of malaria","volume":"142","author":"Taylor","year":"2012","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.medmal.2018.08.003_bib0465","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S2213-2600(17)30188-1","article-title":"Clinical trials in acute respiratory distress syndrome: challenges and opportunities","volume":"5","author":"Matthay","year":"2017","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.medmal.2018.08.003_bib0470","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1475-2875-12-306","article-title":"Extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome in severe malaria","volume":"12","author":"Alves","year":"2013","journal-title":"Malar J"},{"issue":"9","key":"10.1016\/j.medmal.2018.08.003_bib0475","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1086\/339810","article-title":"Exchange transfusion as an adjunct therapy in severe Plasmodium falciparum malaria: a meta-analysis","volume":"34","author":"Riddle MS1","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.medmal.2018.08.003_bib0480","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/cid\/cit429","article-title":"Exchange transfusion for severe malaria: evidence base and literature review","volume":"57","author":"Tan","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.medmal.2018.08.003_bib0485","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1586\/eri.10.90","article-title":"Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria","volume":"8","author":"John","year":"2010","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"2","key":"10.1016\/j.medmal.2018.08.003_bib0490","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.4081\/pr.2015.5859","article-title":"Acute disseminated encephalomyelitis after Plasmodium vivax infection: case report and review of literature","volume":"7","author":"Sidhu","year":"2015","journal-title":"Pediatr Rep"},{"issue":"9","key":"10.1016\/j.medmal.2018.08.003_bib0495","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/eri.11.96","article-title":"Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria","volume":"9","author":"Higgins","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"2","key":"10.1016\/j.medmal.2018.08.003_bib0500","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2174\/1574884712666170704144042","article-title":"Repurposing pharmaceuticals as neuroprotective agents for cerebral malaria","volume":"12","author":"Brooks","year":"2017","journal-title":"Curr Clin Pharmacol"},{"issue":"8","key":"10.1016\/j.medmal.2018.08.003_bib0505","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1073\/pnas.1504887113","article-title":"Composition of the gut microbiota modulates the severity of malaria","volume":"113","author":"Villarino","year":"2016","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["M\u00e9decine et Maladies Infectieuses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0399077X18305870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0399077X18305870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:18:12Z","timestamp":1759972692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0399077X18305870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":101,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0399077X18305870"],"URL":"https:\/\/doi.org\/10.1016\/j.medmal.2018.08.003","relation":{},"ISSN":["0399-077X"],"issn-type":[{"value":"0399-077X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of severe imported malaria in adults","name":"articletitle","label":"Article Title"},{"value":"M\u00e9decine et Maladies Infectieuses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medmal.2018.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}