{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:19:16Z","timestamp":1779905956994,"version":"3.53.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007654","name":"Ministry of Health, Czech Republic","doi-asserted-by":"publisher","award":["65269705"],"award-info":[{"award-number":["65269705"]}],"id":[{"id":"10.13039\/100007654","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["M\u00e9decine et Maladies Infectieuses"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.medmal.2019.09.013","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T17:49:57Z","timestamp":1570816197000},"page":"555-561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Increasing procoagulant activity of circulating microparticles in patients living with HIV"],"prefix":"10.1016","volume":"50","author":[{"given":"S.","family":"Snopkova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Matyskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Havlickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Jarkovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Svoboda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zavrelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Svacinka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Penka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Husa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.medmal.2019.09.013_bib0205","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.thromres.2013.08.016","article-title":"Chronic HIV disease and activation of the coagulation system","volume":"132","author":"Baker","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.medmal.2019.09.013_bib0210","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1177\/2047487312447843","article-title":"HIV infection and atherosclerosis: evaluating the drivers of inflammation","volume":"20","author":"Maniar","year":"2013","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.medmal.2019.09.013_bib0215","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/cid\/cir627","article-title":"Premature age-related comorbidities among HIV-infected persons compared with the general population","volume":"53","author":"Guaraldi","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.medmal.2019.09.013_bib0220","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/QAI.0000000000000311","article-title":"T-cell activation, both pre- and post-HAART levels, correlates with carotid artery stiffness over 6.5 years among HIV-infected women in the WIHS","volume":"67","author":"Karim","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.medmal.2019.09.013_bib0225","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11904-012-0118-8","article-title":"HIV and inflammation: mechanisms and consequences","volume":"9","author":"Hunt","year":"2012","journal-title":"Curr HIV\/AIDS Rep"},{"key":"10.1016\/j.medmal.2019.09.013_bib0230","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/COH.0000000000000019","article-title":"Markers of coagulation and inflammation often remain elevated in ART-treated HIV-infected patients","volume":"9","author":"Funderburg","year":"2014","journal-title":"Curr Opin HIV AIDS"},{"key":"10.1016\/j.medmal.2019.09.013_bib0235","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/jmv.23354","article-title":"Viral infection and mechanisms of thrombosis and bleeding","volume":"84","author":"Goeijenbier","year":"2012","journal-title":"J Med Virol"},{"key":"10.1016\/j.medmal.2019.09.013_bib0240","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/107602960401000311","article-title":"Thrombosis and hypercoagulable state in HIV-infected patients","volume":"10","author":"Shen","year":"2004","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.medmal.2019.09.013_bib0245","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1086\/652749","article-title":"Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection","volume":"201","author":"Neuhaus","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.medmal.2019.09.013_bib0250","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/QAI.0b013e3182910121","article-title":"Circulating levels of tissue factor microparticle procoagulant activity are reduced with antiretroviral therapy and are associated with persistent inflammation and coagulation activation among HIV positive patients","volume":"63","author":"Baker","year":"2013","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.medmal.2019.09.013_bib0255","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.4330\/wjc.v6.i11.1135","article-title":"Role of microparticles in endothelial dysfunction and arterial hypertension","volume":"6","author":"Helbing","year":"2014","journal-title":"World Cardiol"},{"key":"10.1016\/j.medmal.2019.09.013_bib0260","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2174\/1570161112666140423223148","article-title":"Microparticles as biomarkers of vascular dysfunction in metabolic syndrome and its individual components","volume":"12","author":"Agouni","year":"2014","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.medmal.2019.09.013_bib0265","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1538-7836.2012.04758.x","article-title":"Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa","volume":"10","author":"Van der Meijden","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.medmal.2019.09.013_bib0270","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.blre.2012.12.002","article-title":"Extracellular vesicles in physiological and pathological conditions","volume":"27","author":"Yuana","year":"2013","journal-title":"Blood Rev"},{"key":"10.1016\/j.medmal.2019.09.013_bib0275","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/aps.2014.73","article-title":"Microparticles: new light shed on the understanding of venous thromboembolism","volume":"35","author":"Zhou","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.medmal.2019.09.013_bib0280","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1007\/s00018-015-1906-2","article-title":"Extracellular vesicles and atherosclerotic disease","volume":"72","author":"Chistiakov","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.medmal.2019.09.013_bib0285","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.clinthera.2014.05.008","article-title":"Diagnostic and prognostic potential of extracellular vesicles in peripheral blood","volume":"6","author":"Revenfeld","year":"2014","journal-title":"Clin Ther"},{"key":"10.1016\/j.medmal.2019.09.013_bib0290","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/jth.12268","article-title":"Revisited role of microparticles in arterial and venous thrombosis","volume":"11","author":"Lacroix","year":"2013","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.medmal.2019.09.013_bib0295","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1177\/2047487312445001","article-title":"Endothelial microparticles: missing ling in endothelial dysfunction?","volume":"20","author":"Yong","year":"2013","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.medmal.2019.09.013_bib0300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrrheum.2009.229","article-title":"The role of microparticles in the pathogenesis of rheumatic diseases","volume":"6","author":"Beyer","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.medmal.2019.09.013_bib0305","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ki.2015.26","article-title":"Microparticles: markers and mediators of sepsis-induced microvascular dysfunction, immunosuppression, and AKI","volume":"87","author":"Souza","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.medmal.2019.09.013_bib0310","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1111\/j.1538-7836.2010.04007.x","article-title":"Circulating microparticles in cardiovascular disease: implications for atherogenesis and atherothrombosis","volume":"8","author":"Shantsila","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"27","key":"10.1016\/j.medmal.2019.09.013_bib0315","doi-asserted-by":"crossref","first-page":"E3564","DOI":"10.1073\/pnas.1507905112","article-title":"Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA","volume":"112","author":"Duchez","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.medmal.2019.09.013_bib0320","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/j.1538-7836.2012.04763.x","article-title":"Making contact with microparticles","volume":"10","author":"Shapiro","year":"2012","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.medmal.2019.09.013_bib0325","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.medmal.2012.05.011","article-title":"Microparticles and infectious diseases","volume":"42","author":"Delabranche","year":"2012","journal-title":"Med Mal Infect"},{"key":"10.1016\/j.medmal.2019.09.013_bib0330","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/CIRCRESAHA.110.226456","article-title":"Microparticles: protagonists of a novel communication network for intercellular information exchange","volume":"107","author":"Mause","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.medmal.2019.09.013_bib0335","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/CIRCULATIONAHA.111.068833","article-title":"Developmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium","volume":"125","author":"Dasgupta","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.medmal.2019.09.013_bib0340","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1097\/QAD.0b013e32834980f4","article-title":"Imbalance between endothelial progenitor cells and microparticles in HIV-infected patients na\u00efve for antiretroviral therapy","volume":"25","author":"Da Silva","year":"2011","journal-title":"AIDS"},{"key":"10.1016\/j.medmal.2019.09.013_bib0345","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/QAI.0b013e3182439355","article-title":"Increased platelet and microparticle activation in HIV infection: upregulation of P-selectin and tissue factor expression","volume":"59","author":"Mayne","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.medmal.2019.09.013_bib0350","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/QAI.0b013e3181c8f4c9","article-title":"Increased levels of platelet microparticles in HIV-infected patients with good response to highly active antiretroviral therapy","volume":"54","author":"Corrales-Medina","year":"2010","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.medmal.2019.09.013_bib0355","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1160\/TH06-06-0313","article-title":"Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets","volume":"97","author":"Sinauridze","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.medmal.2019.09.013_bib0360","doi-asserted-by":"crossref","first-page":"35928","DOI":"10.1038\/srep35928","article-title":"Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses","volume":"6","author":"Marcoux","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.medmal.2019.09.013_bib0365","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1097\/QAD.0000000000001109","article-title":"Inflammation, immune activation, and cardiovascular disease in HIV","volume":"30","author":"Nou","year":"2016","journal-title":"AIDS"},{"key":"10.1016\/j.medmal.2019.09.013_bib0370","first-page":"223","article-title":"Endothelial dysfunction in HIV infection\u00a0\u2013\u00a0the role of circulating endothelial cells, microparticles, endothelial progenitor cells and macrophages","volume":"14","author":"L\u00f3pez","year":"2012","journal-title":"AIDS Rev"},{"key":"10.1016\/j.medmal.2019.09.013_bib0375","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.10.001","article-title":"Systemic effects of inflammation on health during chronic HIV infection","volume":"39","author":"Deeks","year":"2013","journal-title":"Immunity"},{"issue":"Suppl 1","key":"10.1016\/j.medmal.2019.09.013_bib0380","first-page":"9","article-title":"Highly active antiretroviral therapy\u00a0\u2013\u00a0related mechanisms of endothelial and platelet function alterations","volume":"15","author":"Gresele","year":"2014","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.medmal.2019.09.013_bib0385","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1538-7836.2011.04242.x","article-title":"Persistently raised plasma levels of platelet-derived inflammatory mediators in HIV-infected patients during highly active antiretroviral therapy","volume":"9","author":"Landro","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.medmal.2019.09.013_bib0390","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1089\/apc.2008.0010","article-title":"Thromboses among HIV-infected patients during the HAART era","volume":"22","author":"Crum-Cianflone","year":"2008","journal-title":"AIDS Patient Care STDS"},{"key":"10.1016\/j.medmal.2019.09.013_bib0395","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-0033-1334868","article-title":"A case series of HIV-seropositive patients and hypercoagulable state\u00a0\u2013\u00a0is it difficult to treat even with therapeutic anticoagulation?","volume":"22","author":"Sule","year":"2013","journal-title":"Int J Angiol"},{"key":"10.1016\/j.medmal.2019.09.013_bib0400","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1097\/QAD.0000000000000701","article-title":"Activated platelet\u2013T-cell conjugates in peripheral blood of patients with HIV infection: coupling coagulation\/inflammation and T cells","volume":"29","author":"Green","year":"2015","journal-title":"AIDS"}],"container-title":["M\u00e9decine et Maladies Infectieuses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0399077X18309442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0399077X18309442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T01:19:44Z","timestamp":1759972784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0399077X18309442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0399077X18309442"],"URL":"https:\/\/doi.org\/10.1016\/j.medmal.2019.09.013","relation":{},"ISSN":["0399-077X"],"issn-type":[{"value":"0399-077X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increasing procoagulant activity of circulating microparticles in patients living with HIV","name":"articletitle","label":"Article Title"},{"value":"M\u00e9decine et Maladies Infectieuses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.medmal.2019.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}